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JPS54138575A - Preparation of isoquinoline alcohols - Google Patents

Preparation of isoquinoline alcohols

Info

Publication number
JPS54138575A
JPS54138575A JP4528478A JP4528478A JPS54138575A JP S54138575 A JPS54138575 A JP S54138575A JP 4528478 A JP4528478 A JP 4528478A JP 4528478 A JP4528478 A JP 4528478A JP S54138575 A JPS54138575 A JP S54138575A
Authority
JP
Japan
Prior art keywords
isoquinolylethyl
isoquinoline
acetate
alcohols
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4528478A
Other languages
Japanese (ja)
Inventor
Kenzo Watanabe
Akira Otsu
Seiji Kurozumi
Toshio Wakabayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP4528478A priority Critical patent/JPS54138575A/en
Publication of JPS54138575A publication Critical patent/JPS54138575A/en
Pending legal-status Critical Current

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Abstract

PURPOSE: To prepare an isoquinoline alcohol derivative useful as an antiphlogistic, analgesic, antithrombogenetic agent, easily and in high yield, by hydrolyzing a specific ester, e.g. 3-isoquinolylethyl acetate, etc.
CONSTITUTION: The compound II [R1 is monofunctional substitution group; n is 0W2; when n is 0, (R1)n is H, and when n is 2, two R1s may together form a ring; R2 is H, lower alkyl; R3 is lower alkyl] is prepared by the hydrolysis of an ester I, e.g. 3-isoquinolylethyl acetate, 3-isoquinolylethyl propionate, etc., in a solvent such as water, methanol, etc., in the presence of a mineral acid such as HCl, or an alkali such NaOH, at 0W120°C.
COPYRIGHT: (C)1979,JPO&Japio
JP4528478A 1978-04-19 1978-04-19 Preparation of isoquinoline alcohols Pending JPS54138575A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4528478A JPS54138575A (en) 1978-04-19 1978-04-19 Preparation of isoquinoline alcohols

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4528478A JPS54138575A (en) 1978-04-19 1978-04-19 Preparation of isoquinoline alcohols

Publications (1)

Publication Number Publication Date
JPS54138575A true JPS54138575A (en) 1979-10-27

Family

ID=12715002

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4528478A Pending JPS54138575A (en) 1978-04-19 1978-04-19 Preparation of isoquinoline alcohols

Country Status (1)

Country Link
JP (1) JPS54138575A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57203068A (en) * 1981-06-08 1982-12-13 Teikoku Hormone Mfg Co Ltd Novel 1-phenylisoquinoline derivative

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57203068A (en) * 1981-06-08 1982-12-13 Teikoku Hormone Mfg Co Ltd Novel 1-phenylisoquinoline derivative
JPH0118899B2 (en) * 1981-06-08 1989-04-07 Teikoku Hormone Mfg Co Ltd

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