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JPS54138533A - Novel choline derivative - Google Patents

Novel choline derivative

Info

Publication number
JPS54138533A
JPS54138533A JP4509778A JP4509778A JPS54138533A JP S54138533 A JPS54138533 A JP S54138533A JP 4509778 A JP4509778 A JP 4509778A JP 4509778 A JP4509778 A JP 4509778A JP S54138533 A JPS54138533 A JP S54138533A
Authority
JP
Japan
Prior art keywords
choline
group
coo
derivative
benzene ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4509778A
Other languages
Japanese (ja)
Other versions
JPS6031819B2 (en
Inventor
Katsuyuki Watanabe
Tadahisa Hayashi
Hiroaki Hayashi
Toshio Tadano
Yoshiaki Shimizu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB8135047A priority Critical patent/GB2096989B/en
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP53045097A priority patent/JPS6031819B2/en
Priority to DE19792914721 priority patent/DE2914721A1/en
Priority to US06/029,517 priority patent/US4271310A/en
Priority to GB7912994A priority patent/GB2018988B/en
Priority to CA000325446A priority patent/CA1137508A/en
Priority to FR7909428A priority patent/FR2427600B1/fr
Priority to IT21922/79A priority patent/IT1113317B/en
Publication of JPS54138533A publication Critical patent/JPS54138533A/en
Priority to FR7927285A priority patent/FR2438030A1/en
Publication of JPS6031819B2 publication Critical patent/JPS6031819B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • C12Q1/46—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase involving cholinesterase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A choline derivative of the formula [A is methyl or methoxy group at the p-position of the benzene ring when B is alkenyl ester of -R-COO-(R is alkenyl group), or methyl group at the o-position of the benzene ring OH at the m- position of the ring when B is carboxyl group -COO-; X is halogen].
EXAMPLE: o-Methylbenzoylcholine.
USE: Substrates for choline esterase, having a low decomposition rate and improved storage stability.
PROCESS: An acid derivative, e.g. o-benzoyl chloride, is reacted with a halogenated choline, e.g. choline hydrochloride, to give the objective compound.
COPYRIGHT: (C)1979,JPO&Japio
JP53045097A 1978-04-17 1978-04-17 New choline derivative Expired JPS6031819B2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
GB8135047A GB2096989B (en) 1978-04-17 Choline derivatives and a process for their preparation
JP53045097A JPS6031819B2 (en) 1978-04-17 1978-04-17 New choline derivative
DE19792914721 DE2914721A1 (en) 1978-04-17 1979-04-11 METHOD FOR DETERMINING CHOLINESTERASE ACTIVITY AND CHOLINE DERIVATIVES USED FOR THIS METHOD
CA000325446A CA1137508A (en) 1978-04-17 1979-04-12 Method of determining cholinesterase activity and choline derivatives for use in the method
GB7912994A GB2018988B (en) 1978-04-17 1979-04-12 Determining cholinestenase activity
US06/029,517 US4271310A (en) 1978-04-17 1979-04-12 Method of determining cholinesterase activity and choline derivatives for use in the method
FR7909428A FR2427600B1 (en) 1978-04-17 1979-04-13
IT21922/79A IT1113317B (en) 1978-04-17 1979-04-17 PROCEDURE FOR DETERMINING THE ACTIVITY OF COLINESTERASE AND COLINA DERIVATIVES WHICH ARE EMPLOYED IN THE PROCEDURE
FR7927285A FR2438030A1 (en) 1978-04-17 1979-11-06 NEW CHOLINE DERIVATIVES, IN PARTICULAR FOR DETERMINING CHOLINESTERASIC ACTIVITY

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53045097A JPS6031819B2 (en) 1978-04-17 1978-04-17 New choline derivative

Publications (2)

Publication Number Publication Date
JPS54138533A true JPS54138533A (en) 1979-10-27
JPS6031819B2 JPS6031819B2 (en) 1985-07-24

Family

ID=12709790

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53045097A Expired JPS6031819B2 (en) 1978-04-17 1978-04-17 New choline derivative

Country Status (2)

Country Link
JP (1) JPS6031819B2 (en)
GB (1) GB2096989B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155825A2 (en) * 1984-03-21 1985-09-25 Nitto Boseki Co., Ltd. Novel choline derivatives
US4983756A (en) * 1988-02-24 1991-01-08 Nitto Boseki Co., Ltd. Novel choline derivative and method for detemining serum cholinesterase activity using the same

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2037562A1 (en) * 1990-06-18 1991-12-19 Robert P. Hatch Detection assays having chromogenic and nonchromogenic, hypochromogenic, bathochromogenic or hypsochromogenic substrates
CN112213421A (en) * 2020-09-29 2021-01-12 中国人民解放军军事科学院军事医学研究院 Method for measuring content of acetylcholinesterase in serum

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155825A2 (en) * 1984-03-21 1985-09-25 Nitto Boseki Co., Ltd. Novel choline derivatives
EP0155825A3 (en) * 1984-03-21 1986-09-17 Nitto Boseki Co., Ltd. Novel choline derivatives
US4983756A (en) * 1988-02-24 1991-01-08 Nitto Boseki Co., Ltd. Novel choline derivative and method for detemining serum cholinesterase activity using the same

Also Published As

Publication number Publication date
JPS6031819B2 (en) 1985-07-24
GB2096989B (en) 1983-04-20
GB2096989A (en) 1982-10-27

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