JPS54128583A - Thiosemicarbazone derivative - Google Patents
Thiosemicarbazone derivativeInfo
- Publication number
- JPS54128583A JPS54128583A JP3449978A JP3449978A JPS54128583A JP S54128583 A JPS54128583 A JP S54128583A JP 3449978 A JP3449978 A JP 3449978A JP 3449978 A JP3449978 A JP 3449978A JP S54128583 A JPS54128583 A JP S54128583A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- thiosemicarbazone
- derivative
- bond
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003584 thiosemicarbazones Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- KJAPRUUWBMNSHL-UHFFFAOYSA-N 3-(oxomethylidene)quinolin-2-one Chemical class C1=CC=CC2=NC(=O)C(=C=O)C=C21 KJAPRUUWBMNSHL-UHFFFAOYSA-N 0.000 abstract 1
- -1 8-Hydroxy-5-formylcarbostyril-thiosemicarbazone Chemical compound 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 239000003005 anticarcinogenic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- BRWIZMBXBAOCCF-UHFFFAOYSA-N hydrazinecarbothioamide Chemical compound NNC(N)=S BRWIZMBXBAOCCF-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical group C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A thiosemicarbazone derivative of formula I: (R1 is H or lower alkyl group; R2 is H, lower alkyl, lower alkenyl, or cycloalkyl group; R3 is H or OH; the C-C bond at the 3- and 4- positions of the carbostyril skeleton is single or cloukle bond).
EXAMPLE: 8-Hydroxy-5-formylcarbostyril-thiosemicarbazone.
USE: Anticarcinogens and antivirial agents.
PROCESS: A carbonylcarbostyril derivative of formula II is reacted with a thiosemicarbazide of formula III in a solvent, e.g. dioxane or THF, at 0W200°C, preferably 50W150° for 1W12 hr, to give the objective compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53034499A JPS6038384B2 (en) | 1978-03-24 | 1978-03-24 | Thiosemicarbazone derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53034499A JPS6038384B2 (en) | 1978-03-24 | 1978-03-24 | Thiosemicarbazone derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS54128583A true JPS54128583A (en) | 1979-10-05 |
| JPS6038384B2 JPS6038384B2 (en) | 1985-08-31 |
Family
ID=12415937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53034499A Expired JPS6038384B2 (en) | 1978-03-24 | 1978-03-24 | Thiosemicarbazone derivatives |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6038384B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440771A (en) * | 1982-02-12 | 1984-04-03 | The United States Of America As Represented By The Secretary Of The Army | 2-Acetyl quinoline thiosemicarbazones useful in treatment of gonorrhea, malaria or bacterial infections |
| WO1993000902A1 (en) * | 1991-07-03 | 1993-01-21 | Otsuka Pharmaceutical Co., Ltd. | Apoptosis regulator |
| WO1994004504A1 (en) * | 1992-08-19 | 1994-03-03 | Otsuka Pharmaceutical Co., Ltd. | Apoptosis regulator |
-
1978
- 1978-03-24 JP JP53034499A patent/JPS6038384B2/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440771A (en) * | 1982-02-12 | 1984-04-03 | The United States Of America As Represented By The Secretary Of The Army | 2-Acetyl quinoline thiosemicarbazones useful in treatment of gonorrhea, malaria or bacterial infections |
| WO1993000902A1 (en) * | 1991-07-03 | 1993-01-21 | Otsuka Pharmaceutical Co., Ltd. | Apoptosis regulator |
| WO1994004504A1 (en) * | 1992-08-19 | 1994-03-03 | Otsuka Pharmaceutical Co., Ltd. | Apoptosis regulator |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6038384B2 (en) | 1985-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS56103168A (en) | Thiazole derivative, its preparation, and antihistaminic agent containing the same | |
| IE792329L (en) | Thiazaheterocyclics and process for preparing pyrrolidine¹and piperidine derivatives. | |
| JPS55162777A (en) | 11*naphthyllnnpropyl*imidazole derivative* its manufacture and medicinal composition containing same | |
| JPS5543078A (en) | Preparation of 1,3-dithiolan-2-ylidenemalonate derivative | |
| JPS54128583A (en) | Thiosemicarbazone derivative | |
| JPS5649364A (en) | Carbostyril derivative | |
| JPS5528955A (en) | Novel glycerophosphoric acid derivative, its salt, their preparation, and carcinostatic agent containing the same. | |
| DE3070768D1 (en) | 1-((substituted-naphthyl)ethyl)-imidazole derivatives, pharmaceutical compositions containing them and methods of making them | |
| JPS5531022A (en) | Hydroxamic acid derivative and its preparation | |
| JPS5585520A (en) | Remedy for peptic ulcer | |
| JPS5579370A (en) | Carbostyril derivative | |
| JPS5655383A (en) | Amizine derivative and its preparation | |
| JPS5754175A (en) | Novel 3-aminoindazole derivative | |
| JPS5711975A (en) | Aminophenyltetrazole derivative and salt thereof | |
| JPS5714574A (en) | Carbostyril derivative | |
| JPS5732260A (en) | Mercaptofatty acid derivative and its preparation | |
| JPS56125385A (en) | Novel piperidine derivative | |
| JPS565469A (en) | Novel amidine derivative and its preparation | |
| JPS5592363A (en) | New 2-azetidinone derivative | |
| JPS5520711A (en) | New 1,3,4-thiadiazol-5-ylthiol esters and their preparation | |
| JPS5535045A (en) | Imidazoline riboside derivative and its preparation | |
| JPS562957A (en) | N-adamantylthioamide derivative | |
| JPS54106473A (en) | Preparation of 4, 5, 6, 7-tetrahydro-benzimidazoline-2-thione | |
| JPS54109973A (en) | Novel imidazole derivative | |
| JPS5520738A (en) | Novel cyclohexanecarboxamide derivative |