JPS54128567A - 1-substituted-4-acyl-2-pyrrolecarboxylic acid derivative - Google Patents
1-substituted-4-acyl-2-pyrrolecarboxylic acid derivativeInfo
- Publication number
- JPS54128567A JPS54128567A JP3482878A JP3482878A JPS54128567A JP S54128567 A JPS54128567 A JP S54128567A JP 3482878 A JP3482878 A JP 3482878A JP 3482878 A JP3482878 A JP 3482878A JP S54128567 A JPS54128567 A JP S54128567A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- substituted
- acyl
- pyrrolecarboxylic acid
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- -1 1-(p-Methylphenetyl)-4-acetyl-2-pyrrolecarboxylic acid methyl ester Chemical compound 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- PLKKXWBJOVTVEU-UHFFFAOYSA-N pyrrolo[2,3-i][1]benzazepine Chemical compound C1=CC=NC2=C3C=CN=C3C=CC2=C1 PLKKXWBJOVTVEU-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pyrrole Compounds (AREA)
Abstract
NEW MATERIAL:1-Substituted-4-acyl-2-pyrrolecarboxylic acid derivative of formula I (R1 is 1W6C alkyl; R2 is OH, Cl, Br, 1W6C alkoxy; R3 is 1W6C alkyl, 1W6C alkoxy. 1W6C alkylthio, H, F, Cl, Br, CF3).
EXAMPLE: 1-(p-Methylphenetyl)-4-acetyl-2-pyrrolecarboxylic acid methyl ester.
USE: Intermediate of pyrrolobenzazepin acetica acid or its derivative useful as antiphlogistics.
PROCESS: The abjective compound IV is prepared by reacting a compound II (R211 is methyl, ethyl) with a compound III in the presence of a Lewis acid. The compound I (wherein R is para-substituted, and R2 is OH or Cl) can be derived from the compound IV by hydrolysis, and if necessary successive reaction with thionyl chloride, etc. The compound wherein R2 is Cl can be converted to a novel antiphlogistic agent of formula V.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3482878A JPS54128567A (en) | 1978-03-28 | 1978-03-28 | 1-substituted-4-acyl-2-pyrrolecarboxylic acid derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3482878A JPS54128567A (en) | 1978-03-28 | 1978-03-28 | 1-substituted-4-acyl-2-pyrrolecarboxylic acid derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS54128567A true JPS54128567A (en) | 1979-10-05 |
Family
ID=12425051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3482878A Pending JPS54128567A (en) | 1978-03-28 | 1978-03-28 | 1-substituted-4-acyl-2-pyrrolecarboxylic acid derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS54128567A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6110510A (en) * | 1984-05-25 | 1986-01-18 | アルベール ロラン エス．アー． | Immunity controlling novel medicinal composition |
| WO2003079339A1 (en) * | 2002-03-19 | 2003-09-25 | Bayer Chemicals Ag | Squarylium dyes as a light-absorbing compound in the information layer of optical data carriers |
-
1978
- 1978-03-28 JP JP3482878A patent/JPS54128567A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6110510A (en) * | 1984-05-25 | 1986-01-18 | アルベール ロラン エス．アー． | Immunity controlling novel medicinal composition |
| WO2003079339A1 (en) * | 2002-03-19 | 2003-09-25 | Bayer Chemicals Ag | Squarylium dyes as a light-absorbing compound in the information layer of optical data carriers |
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