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JPS532404A - Elimination of thiol protectors - Google Patents

Elimination of thiol protectors

Info

Publication number
JPS532404A
JPS532404A JP7667676A JP7667676A JPS532404A JP S532404 A JPS532404 A JP S532404A JP 7667676 A JP7667676 A JP 7667676A JP 7667676 A JP7667676 A JP 7667676A JP S532404 A JPS532404 A JP S532404A
Authority
JP
Japan
Prior art keywords
thiol
protectors
elimination
methoxybenzyl
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7667676A
Other languages
Japanese (ja)
Other versions
JPS5848524B2 (en
Inventor
Masahiko Fujino
Tadashi Nishimura
Chieko Kitada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP51076676A priority Critical patent/JPS5848524B2/en
Priority to CA279,924A priority patent/CA1074300A/en
Priority to FR7719632A priority patent/FR2361347A1/en
Priority to GB26762/77A priority patent/GB1548101A/en
Priority to HU77TA1448A priority patent/HU178756B/en
Publication of JPS532404A publication Critical patent/JPS532404A/en
Publication of JPS5848524B2 publication Critical patent/JPS5848524B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: Thiol protectors are easily eliminated in high yield by treating the compounds having a thiol group protected with p-methoxybenzyl, adamantyl group, etc. with the mercury salt of a carboxylic acid.
COPYRIGHT: (C)1978,JPO&Japio
JP51076676A 1976-06-28 1976-06-28 Method for removing thiol protecting group Expired JPS5848524B2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP51076676A JPS5848524B2 (en) 1976-06-28 1976-06-28 Method for removing thiol protecting group
CA279,924A CA1074300A (en) 1976-06-28 1977-06-06 Method for removal of thiol-protecting groups
FR7719632A FR2361347A1 (en) 1976-06-28 1977-06-27 PROCEDURE FOR REMOVING GROUPS PROTECTING THIOL GROUPS PRESENT IN AMINO ACIDS AND PEPTIDES
GB26762/77A GB1548101A (en) 1976-06-28 1977-06-27 Method of removing thiolprotecting groups
HU77TA1448A HU178756B (en) 1976-06-28 1977-06-27 Process for cleaving thiol-protecting groups from aminoacids and peptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP51076676A JPS5848524B2 (en) 1976-06-28 1976-06-28 Method for removing thiol protecting group

Publications (2)

Publication Number Publication Date
JPS532404A true JPS532404A (en) 1978-01-11
JPS5848524B2 JPS5848524B2 (en) 1983-10-28

Family

ID=13612020

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51076676A Expired JPS5848524B2 (en) 1976-06-28 1976-06-28 Method for removing thiol protecting group

Country Status (5)

Country Link
JP (1) JPS5848524B2 (en)
CA (1) CA1074300A (en)
FR (1) FR2361347A1 (en)
GB (1) GB1548101A (en)
HU (1) HU178756B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62227053A (en) * 1986-03-28 1987-10-06 Sumitomo Special Metals Co Ltd High permeability magnetic alloy excellent in workability
JPS62227054A (en) * 1986-03-28 1987-10-06 Sumitomo Special Metals Co Ltd High permeability magnetic alloy excellent in workability
JPH02111838A (en) * 1988-10-21 1990-04-24 Nippon Steel Corp Fe-Ni magnetic alloy with excellent hot workability and magnetic properties
JPH04214832A (en) * 1990-07-30 1992-08-05 Nippon Yakin Kogyo Co Ltd Fe high-ni alloy excellent in surface property

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2451915A1 (en) * 1979-03-23 1980-10-17 Clin Midy NEW PROCESS FOR THE PREPARATION OF SOMATOSTATIN

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62227053A (en) * 1986-03-28 1987-10-06 Sumitomo Special Metals Co Ltd High permeability magnetic alloy excellent in workability
JPS62227054A (en) * 1986-03-28 1987-10-06 Sumitomo Special Metals Co Ltd High permeability magnetic alloy excellent in workability
JPH02111838A (en) * 1988-10-21 1990-04-24 Nippon Steel Corp Fe-Ni magnetic alloy with excellent hot workability and magnetic properties
JPH04214832A (en) * 1990-07-30 1992-08-05 Nippon Yakin Kogyo Co Ltd Fe high-ni alloy excellent in surface property
JPH0579741B2 (en) * 1990-07-30 1993-11-04 Nippon Yakin Kogyo Co Ltd

Also Published As

Publication number Publication date
GB1548101A (en) 1979-07-04
CA1074300A (en) 1980-03-25
HU178756B (en) 1982-06-28
JPS5848524B2 (en) 1983-10-28
FR2361347B1 (en) 1980-10-17
FR2361347A1 (en) 1978-03-10

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