JPS4987677A - - Google Patents
Info
- Publication number
- JPS4987677A JPS4987677A JP14179773A JP14179773A JPS4987677A JP S4987677 A JPS4987677 A JP S4987677A JP 14179773 A JP14179773 A JP 14179773A JP 14179773 A JP14179773 A JP 14179773A JP S4987677 A JPS4987677 A JP S4987677A
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00315836A US3839346A (en) | 1972-12-18 | 1972-12-18 | N-substituted pyridone and general method for preparing pyridones |
| US38065573A | 1973-07-19 | 1973-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS4987677A true JPS4987677A (en) | 1974-08-22 |
Family
ID=26980095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14179773A Pending JPS4987677A (en) | 1972-12-18 | 1973-12-18 |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS4987677A (en) |
| DE (2) | DE2366349C2 (en) |
| ES (1) | ES421598A1 (en) |
| FR (1) | FR2232316B1 (en) |
| GB (2) | GB1458049A (en) |
| NL (1) | NL7317316A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5350179A (en) * | 1976-10-15 | 1978-05-08 | Rikagaku Kenkyusho | Novel 2-pyridone compounds and their preparation |
| JP2004203795A (en) * | 2002-12-26 | 2004-07-22 | Kdl Inc | Solution-type pharmaceutical composition containing pyridone derivative |
| WO2009022899A1 (en) | 2007-08-14 | 2009-02-19 | Cell Therapy Technology, S.A. De C.V. | Gel containing pirfenidone |
| JP2012121931A (en) * | 2005-05-10 | 2012-06-28 | Intermune Inc | Pyridone derivative for modulating stress-activated protein kinase system |
| WO2013012307A1 (en) | 2011-07-19 | 2013-01-24 | Cell Therapy And Techonology S.A. De C.V. | Method for manufacturing a pharmaceutical composition in the form of extended-release tablets containing pirfenidone and use thereof in the regression of chronic renal insufficiency, breast capsular contracture and hepatic fibrosis in humans |
| WO2013147577A1 (en) | 2012-03-28 | 2013-10-03 | Cell Therapy and Technology S.A. DE C.V. | Semi-solid topical composition which contains pirfenidone and modified diallyl disulphide oxide (m-ddo) for eliminating or preventing acne |
| JP2017031192A (en) * | 2011-01-31 | 2017-02-09 | ジェノア ファーマシューティカルズ，インク． | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| JP2020530005A (en) * | 2017-07-31 | 2020-10-15 | ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | Pirfenidone derivative for regulation of B lymphocyte activity and organ protection |
| US12365651B2 (en) | 2018-07-31 | 2025-07-22 | Washington University | Use of pirfenidone and derivatives for modulation of B lymphocyte activity and organ protection from acute tissue damage |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1049411A (en) * | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
| CA3034994A1 (en) | 2008-06-03 | 2009-12-10 | Intermune, Inc. | Substituted aryl-2 pyridone compounds and use thereof for treating inflammatory and fibrotic disorders |
| AR092742A1 (en) | 2012-10-02 | 2015-04-29 | Intermune Inc | ANTIFIBROTIC PYRIDINONES |
| WO2015153683A1 (en) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
| ITUB20154832A1 (en) | 2015-10-29 | 2017-04-29 | Procos Spa | PROCESS FOR SYNTHESIS OF PYRPHENING |
| WO2022051984A1 (en) | 2020-09-10 | 2022-03-17 | 苏州富德兆丰生化科技有限公司 | Synthesis method for pirfenidone |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2947755A (en) * | 1959-02-05 | 1960-08-02 | Wallace & Tiernan Inc | Substituted 1-m-aminophenyl-2-pyridones |
| US3655897A (en) * | 1971-01-25 | 1972-04-11 | Merck & Co Inc | Anti-inflammatory agents |
-
1973
- 1973-12-18 ES ES421598A patent/ES421598A1/en not_active Expired
- 1973-12-18 GB GB4107475A patent/GB1458049A/en not_active Expired
- 1973-12-18 FR FR7345342A patent/FR2232316B1/fr not_active Expired
- 1973-12-18 DE DE19732366349 patent/DE2366349C2/en not_active Expired
- 1973-12-18 NL NL7317316A patent/NL7317316A/xx not_active Application Discontinuation
- 1973-12-18 DE DE19732362958 patent/DE2362958C2/en not_active Expired
- 1973-12-18 GB GB5864273A patent/GB1458048A/en not_active Expired
- 1973-12-18 JP JP14179773A patent/JPS4987677A/ja active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5350179A (en) * | 1976-10-15 | 1978-05-08 | Rikagaku Kenkyusho | Novel 2-pyridone compounds and their preparation |
| JP2004203795A (en) * | 2002-12-26 | 2004-07-22 | Kdl Inc | Solution-type pharmaceutical composition containing pyridone derivative |
| JP2012121931A (en) * | 2005-05-10 | 2012-06-28 | Intermune Inc | Pyridone derivative for modulating stress-activated protein kinase system |
| EP2591784A1 (en) | 2005-05-10 | 2013-05-15 | Intermune, Inc. | Pyridine-2-one-derivatives as modulators of stress-activated protein kinase system |
| WO2009022899A1 (en) | 2007-08-14 | 2009-02-19 | Cell Therapy Technology, S.A. De C.V. | Gel containing pirfenidone |
| JP2017031192A (en) * | 2011-01-31 | 2017-02-09 | ジェノア ファーマシューティカルズ，インク． | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| WO2013012307A1 (en) | 2011-07-19 | 2013-01-24 | Cell Therapy And Techonology S.A. De C.V. | Method for manufacturing a pharmaceutical composition in the form of extended-release tablets containing pirfenidone and use thereof in the regression of chronic renal insufficiency, breast capsular contracture and hepatic fibrosis in humans |
| EP2907506A1 (en) | 2011-07-19 | 2015-08-19 | Cell Therapy And Technology, S.A. De C.V. | Method for manufacturing a pharmaceutical composition in the form of extended-release tablets containing pirfenidone and use thereof in the regression of chronic renal insufficiency, breast capsular contracture and hepatic fibrosis in humans |
| WO2013147577A1 (en) | 2012-03-28 | 2013-10-03 | Cell Therapy and Technology S.A. DE C.V. | Semi-solid topical composition which contains pirfenidone and modified diallyl disulphide oxide (m-ddo) for eliminating or preventing acne |
| JP2020530005A (en) * | 2017-07-31 | 2020-10-15 | ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | Pirfenidone derivative for regulation of B lymphocyte activity and organ protection |
| US12365651B2 (en) | 2018-07-31 | 2025-07-22 | Washington University | Use of pirfenidone and derivatives for modulation of B lymphocyte activity and organ protection from acute tissue damage |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2232316A1 (en) | 1975-01-03 |
| GB1458049A (en) | 1976-12-08 |
| DE2362958C2 (en) | 1984-06-14 |
| NL7317316A (en) | 1974-06-20 |
| GB1458048A (en) | 1976-12-08 |
| DE2362958A1 (en) | 1974-06-27 |
| FR2232316B1 (en) | 1978-03-24 |
| DE2366349C2 (en) | 1986-03-27 |
| ES421598A1 (en) | 1977-01-01 |
| AU6374673A (en) | 1975-06-19 |