JPH1149655A - Skin lotion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject preparation capable of manifesting an effect on the roughened skin after sunburn while intercepting ultraviolet rays by including a well-known ultraviolet-protective agent and an extract of oolong tea and/or the extract of Rosa roburghii. SOLUTION: The subject preparation contains (A) one or not less than two kinds of ultraviolet-protective agents, preferably of 0.01-30.0 wt.% and (B) extracts of oolong tea and/or Rosa roburghii, preferable of 0.001-20.0 wt.%. A ultraviolet absorption agent such as p-aminobenzoic acid and a ultraviolet- protective agent such as titanium oxide, talc, etc., are cited as the component A. Each of the extracts of components B can be obtained by a well-known method. The composition is used as a sunscreen cosmetic, prevents the rough skin after the sunburn, and is expected to synergetically manifest the effect for raising the ultraviolet-protective activities.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin which protects the skin from ultraviolet rays and has an excellent action of adjusting the condition of the skin after sunburn.

[0002]

2. Description of the Related Art In recent years, the effects of ultraviolet rays on the skin have been discussed, and various sunscreen cosmetics have been developed for the purpose of protecting the skin from excessive ultraviolet rays. These sunscreen cosmetics,
The mainstream is one that mixes ultraviolet absorbers and ultraviolet scattering agents and blocks ultraviolet rays that reach the skin.However, even if the effect of preventing hot flashes, erythema and blackening is high, the skin becomes rough after sunburn It is the present situation that can not be escaped. This is believed to be the result of UV damage. on the other hand,
It is known that oolong tea extract has an ultraviolet erythema-suppressing action and an antioxidant action. In addition, it is known that the extract of Izayoibara has an antioxidant effect and a moisturizing effect. The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an external preparation for skin which is effective in blocking skin roughness after sunburn while shielding ultraviolet rays.

[0003]

Means for Solving the Problems The present inventors have conducted intensive studies in order to solve the above-mentioned problems, and as a result, have found that one or two of an ultraviolet protective agent conventionally used and an oolong tea extract or Izayoibara extract are used. It has been found that by containing a seed, it is possible to prevent rough skin after sunburn compared to a case where each is used alone without reducing the effect of the ultraviolet ray protective agent, thereby completing the present invention.

[0004] That is, the present invention is an external preparation for skin, characterized by containing one or more ultraviolet protective agents, and oolong tea extract and / or Izayobara extract. The external preparation for skin of the present invention is preferably used as a sunscreen cosmetic.

Hereinafter, the present invention will be described in detail. The ultraviolet ray protective agent used in the present invention includes both an “ultraviolet ray absorber” that is a substance that physically and chemically absorbs ultraviolet rays, and an “ultraviolet ray blocking agent” that is a substance that scatters and reflects ultraviolet rays by physical action. These can be used alone or in combination of two or more. The UV protection agents are listed below, but the UV protection agents that can be added to the skin external preparation of the present invention are not limited to these UV protection agents.

That is, as an ultraviolet absorber, para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA
Ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester,
Benzoic acid ultraviolet absorbers such as N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA amyl ester, anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate, amyl salicylate, menthyl salicylate, homo Menthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, salicylic acid UV absorbers such as p-isopropanol phenyl salicylate, octyl cinnamate, ethyl-4-isopropyl cinnamate,
Methyl-2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,
4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2 -Ethoxyethyl-
p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-
Phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, 3,4,5
Cinnamic acid-based ultraviolet absorbers such as 3-methyl-4- [methylbis (trimethylsiloxy) silyl] butyl trimethylcinnamate, 2,4-dihydroxybenzophenone,
2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2,4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, -Hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl -Benzophenone 2-carboxylate, 2-hydroxy-4-n-
Benzophenone ultraviolet absorbers such as octoxybenzophenone and 4-hydroxy-3-carboxybenzophenone, 3- (4'-methylbenzylidene) d, l-camphor, 3-benzylidene d, l-camphor, urocanic acid, ethyl urocanate Ester, 2-phenyl-5
-Methylbenzoxanol, 2,2-hydroxy-5-
Methylphenif benzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy-5'-methylphenylbenzotriazole, dibenzarazine, dianisoylmethane, 4-methoxy -4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one and the like.

Further, as an ultraviolet ray blocking agent, titanium oxide (TiO ₂ ), talc (MgSiO ₂ ), carmine (FeO ₂ ), bentonite, kaolin, zinc oxide (Z
nO) and the like.

[0008] These ultraviolet protective agents can be combined in the external preparation for skin according to the specific purpose and dosage form of the external preparation for skin to be prepared.

The amount of the ultraviolet protective agent can be appropriately changed according to the properties to be imparted to the external preparation for skin of the present invention, but usually 0.01 to 30.0% by weight based on the total amount of the external preparation for skin. And more preferably 0.1 to 20.0% by weight. If the amount is less than 0.01% by weight, the effect of preventing ultraviolet rays tends to be insufficient. 30.
Even when the amount is more than 0% by weight, there is a tendency that the ultraviolet ray prevention effect is not enhanced in proportion to the increase in the amount.

[0010] The skin external preparation of the present invention further contains an oolong tea extract and / or an Isayobara extract. The oolong tea extract and / or
Alternatively, by combining one or two of the Izayoibara extract, the effect of preventing rough skin is exhibited. This skin roughness prevention effect is even stronger when used in combination with an ultraviolet protective agent than when only the oolong tea extract and / or Izayobara extract is used.

The method for producing the oolong tea extract to be blended in the present invention is not particularly limited. For example, water, a hydrophilic organic solvent such as alcohol, a mixed solution of water and a hydrophilic organic solvent, glycerin, It is extracted by a mixed solution with a polyhydric alcohol such as 3-butylene glycol, and the extraction process is also performed through a generally known process, for example, a process commonly used in instant tea production such as a countercurrent extraction method or a two-stage extraction method. can do. Further, a commercially available oolong tea extract can also be used. Specifically, sun oolong (manufactured by Suntory Ltd.) can be used.

The method for producing the Izayobara extract to be blended in the present invention is not particularly limited. For example, water, a hydrophilic organic solvent such as alcohol, a mixed solution of water and a hydrophilic organic solvent, may be used from Izayobara fruit. Alternatively, it is extracted with a mixture of these and a polyhydric alcohol such as glycerin or 1,3-butylene glycol. Furthermore, a commercially available product can be used for the Izayoibara extract. Specifically, a bark extract BG (manufactured by Maruzen Pharmaceutical Co., Ltd.) can be used.

The amount of the oolong tea extract and / or the extract of Izayobara can be appropriately changed according to the dosage form of the external preparation for skin of the present invention and the degree of skin roughness prevention effect to be imparted. 0.001 to the total amount of the agent
20.0% by weight is desirable, more preferably 0.01%.
１10.0% by weight. If the blending amount is less than 0.001% by weight, the effect of preventing the rough skin by blending the oolong tea extract and / or the Izayoibara extract tends not to be exhibited. Further, even if the content exceeds 20.0% by weight, the effect of preventing skin roughness corresponding to the increase in the content tends to be not enhanced.

The external preparation for skin of the present invention may further comprise, in addition to the above essential components, various components generally used in cosmetics, pharmaceuticals and the like, if necessary, as long as the effects of the present invention are not impaired.
Humectants, surfactants, thickeners, preservatives, antioxidants, bactericides, drugs, fragrances, pigments, powder components, sequestering agents, oils and fats, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, Synthetic ester oil, silicone and the like can be blended, and it is manufactured according to a conventional method.

[0015]

EXAMPLES The present invention will be described more specifically with reference to examples, but the present invention is not limited to these examples. In addition, the following compounding amounts are% by weight unless otherwise specified. Prior to the examples, an evaluation method adopted in each example will be described.

(1) Evaluation of Sunburn Prevention Effect A sample was used by 20 specialized panels on a sunny day in May or June when ultraviolet rays were strong, and the sunburn prevention effect was evaluated. (Evaluation) ：: 16 or more out of 20 answered that they were good. ：: 12 or more out of 20 answered that they were good. Δ: 6 or more respondents answered that they were good. ×: Less than 6 out of 20 respondents answered good.

(2) Effect on Skin Roughness after Sunburn A replica of the skin of a healthy female subject was taken by a replica method using a millisin resin and observed with a microscope.
Each of the examples and comparative examples, and control example 1 were placed on the left and right sides of the face of 20 panelists who were evaluated as having a rough skin state “1” or “2” based on the criteria in Table 1 based on the skin crest state and the stratum corneum peeling state. Was applied twice a day for 2 weeks. Two weeks later, the skin condition was observed again by the replica method described above, and the skin condition was evaluated.

[0018]

[Table 1] 評 Criterion of criterion ─────── １ 1 Skin sulcus, skin ridges disappeared, and widespread stratum corneum was observed. 2 Skin groove and skin ridges are unclear and horny layer is turned up. 3 Skin sulcus and skin ridge are recognized, but flat. 4 Skin sulcus and skin hills are clear. 5 Skin grooves and skin ridges are clear and well-organized. ─────────────────────────────────

Example 1 (O / W emulsion) (1) 2-ethylhexyl paradimethylaminobenzoate 1.0% by weight (2) Octylcinnamate 2.0 (3) Stearic acid 1.0 (4) Cetyl Alcohol 0.3 (5) Vaseline 2.0 (6) Polyoxyethylene (10) monooleate 2.0 (7) Vitamin E acetate 0.1 (8) Oolong tea extract 0.001 (Tea leaves 50% (Extracted with 1,3-butylene glycol solution) (9) Glycerin 5.0 (10) Paraben suitable amount (11) Flavor proper amount (12) Carboxyvinyl polymer 0.2 (13) Sodium hydroxide 0.1 (14) ) Purified water Residue (Production method) (8) to (14) were dissolved by heating and kept at 70 ° C (aqueous phase). Further, (1) to (7) were mixed, dissolved by heating and kept at 70 ° C. (oil phase). Next, the oil phase was added to the water phase to perform preliminary emulsification, and the mixture was homogenized uniformly with a homomixer. Thereafter, the mixture was rapidly cooled while stirring to obtain an emulsion.

Example 2 (O / W cream) (1) Cetostearyl alcohol 2.0% by weight (2) Reduced lanolin 3.0 (3) Liquid paraffin 20.0 (4) Palm kernel oil 2.0 (5 ) Polyoxyethylene (20) sorbitan monopalmitate 2.0 (6) monoglyceride stearate 3.0 (7) octyl methoxycinnamate 0.1 (8) fragrance appropriate amount (9) izayoibara extract 0.01 ( (Isayobara is extracted with 30% 1,3-butylene glycol) (10) Dynamite glycerin 5.0 (11) Dipropylene glycol 5.0 (12) Sorbitol 2.0 (13) Preservatives Appropriate amount (14) Purification Water Residue (Preparation method) (1) to (8) were dissolved by heating and kept at 70 ° C. (oil phase). (9) to (14) were dissolved by heating and maintained at 70 ° C. (aqueous phase). Next, the oil phase was added to the water phase to perform preliminary emulsification, and the mixture was homogenized uniformly with a homomixer. Thereafter, the mixture was rapidly cooled with stirring to obtain a cream.

Example 3 (W / O emulsion) (1) Decamethylcyclopentasiloxane 20.0% by weight (2) Silicone resin 2.0 (3) Poly (oxyethylene / oxyfluoropropylene) methylpolysiloxane copolymer・ Decamethylcyclopentasiloxane solution 2.0 (4) 2-Hydroxy-4-methoxybenzophenone 1.0 (5) Octyl methoxycinnamate 1.0 (6) Suitable amount of perfume (7) Suitable amount of preservative (8) Organic modification clay mineral (trade name: Bentone 38) 0.3 (9) hydrophobized titanium oxide 7.0 (10) hydrophobized zinc oxide 10.0 (11) EDTA-3Na · 2H 2 O qs (12) dipropylene Glycol 5.0 (13) Oolong tea extract 0.1 (Tea leaf extracted with 30% ethanol) (14) Izayobara extract 0.1 (Izayobara fruit extracted with 20% ethanol) (15) Ltd. water Balance to (Production Method) (1) to (8) were heated and dissolved at 70 ° C., (9), were dispersed and mixed with a disper was added (10) (oil phase). (11)-(13)
Was heated to 70 ° C., gradually added to the oil phase while stirring with a disper, uniformly mixed, and then cooled by stirring to obtain an emulsion.

Example 4 (W / O cream) (1) Decamethylcyclopentasiloxane 30.0% by weight (2) Pentaerythritol 5.0 (3) Silicone resin 2.0 (4) Perfume appropriate amount (5) Octyl Cinnamate 8.0 (6) Organically modified clay mineral (trade name: Benton 38) 0.5 (7) Hydrophobized zinc oxide 12.0 (8) Hydrophobized titanium oxide 10.0 (9) Glycerin 2. 0 (10) 1,3-butylene glycol 6.0 (11) Sodium hexametaphosphate 0.1 (12) Paraben suitable amount (13) Oolong tea extract 5.0 (Tea leaf extracted with 50% glycerin) (14) Izayobara extract 5.0 (Izayobara fruit extracted with 20% alcohol) (15) Purified water residue (Preparation method) (1) to (5) are heated and dissolved at 70 ° C, and (6), (7), (8)
Was added and dispersed and mixed with a disper (oil phase). (9)-(1
5) was heated and mixed at 70 ° C., and gradually added to the oil phase while stirring with a disper, mixed sufficiently uniformly, and stirred and cooled to obtain a cream.

Example 5 (W / O emulsion) (1) Octamethylcyclopentasiloxane 40.0% by weight (2) Cetyl isooctanoate 5.0 (3) Vitamin E acetate 0.05 (4) Squalane 2 0.0 (5) Distearyldimethylammonium chloride 0.2 (6) Paraben suitable amount (7) Octylcinnamate 12.0 (8) 2-Hydroxy-4-methoxybenzophenone 3.0 (9) Hydrophobized titanium oxide 5 0.0 (10) spherical polyethylene powder 3.0 (11) glycerin 5.0 (12) water-swellable clay mineral (trade name: smecton) 0.35 (13) sodium hexametaphosphate 0.03 (14) oolong tea extract 0.5 (Tea leaf extracted with 40% ethanol) (15) Purified water residue (Preparation method) Heat and dissolve (1) to (8) at 70 ° C, add (9) and (10) and disperse with disperser Mixed. (11) to (15) are mixed and
The mixture was heated to 0 ° C., gradually added to the oil phase while stirring with a disper, mixed and stirred sufficiently uniformly, and cooled.

Example 6 (W / O emulsion) (1) Decamethylcyclopentasiloxane 20.0% by weight (2) Octamethylcyclotetrasiloxane 25.0 (3) Trimethylcinnamate 0.1 (4) Methyl Polysiloxane 10.0 (5) Silicone resin 2.0 (6) Polyoxyethylene / methylpolysiloxane copolymer 3.0 (7) Paraben suitable amount (8) Fragrance proper amount (9) Dipropylene glycol 6.0 (10 ) EDTA · 3Na · 2H ₂ O 0.03 (11) Isaiyobara extract 10.0 (fruit extracted with 30% glycerin) (12) Purified water residue (production method) (1) to (8) at 70 ° C And dissolved by heating. (9)-(12)
And heated and dissolved at 70 ° C., gradually added to the oil phase while stirring with a disper, uniformly stirred and mixed, and cooled.

Comparative Example 1 (W / O emulsion) The emulsion was prepared in the same manner as in Example 3 except that 1.0% by weight of macadamia nut oil was used instead of 1.0% by weight of octyl methoxycinnamate in Example 3. Obtained.

Comparative Example 2 (W / O emulsion) Except that 0.1% by weight of oolong tea extract and 0.1% by weight of Izayobara extract in Example 3 were replaced by 0.2% by weight of Soapwort extract An emulsion was obtained in the same manner as in Example 3.

Control Example (W / O emulsion) (1) Octamethylcyclotetrasiloxane 20.0% by weight (2) Liquid paraffin 5.0 (3) Polyoxyethylene / methylpolysiloxane copolymer 5.0 (4 ) Squalane 7.0 (5) Paraben suitable amount (6) Fragrance proper amount (7) Organic modified clay mineral (Benton 38) 0.3 (8) 1,3-butylene glycol 8.0 (9) Sodium hexametaphosphate 0.1 (10) Glycerin 3.0 (11) Purified water residue (Preparation method) (1) to (6) were heated and dissolved at 70 ° C., (7) was added, and the mixture was dispersed and mixed with a disper. (8) to (11) mixed,
, And gradually added to the oil phase while stirring with a disper, sufficiently uniformly mixed and stirred, and cooled.

With respect to the external preparations obtained in Examples 1 to 6, Comparative Examples 1 and 2, and Comparative Example, the above-mentioned effects of preventing sunburn and rough skin were evaluated. Table 2 shows the results.

[0029]

[Table 2]

[0030]

As described in detail above, the external preparation for skin of the present invention has the effect of preventing rough skin after sunburn and synergistically enhancing the ultraviolet protective action.

Claims (3)

[Claims] (1) one or more sun protection agents;
An external preparation for skin, comprising an oolong tea extract and / or an Izayoibara extract. 2. The method according to claim 1, wherein the UV protection agent comprises one to three or more UV protection agents in an amount of 0.01 to 30.0% by weight, and the oolong tea extract and / or the Izayoibara extract in an amount of 0.001 to 20.0% by weight. Item 3. An external preparation for skin according to item 1. 3. The external preparation for skin according to claim 1, which is used as a sunscreen cosmetic.