JPH1133116A - Powder medicine multi-dosing device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a powder medicine multi-dosing device which is portable, easy to operate and use, and is produced relatively at a low cost. SOLUTION: This device consists of the main body 1, an outlet part 4 attached movably at the main body, and a pump part 7 whose wall part is at least partly constituted as a flexible container or a bag. And a stock room 6 where a plural number of does of powder medicine can be stocked and a storing room 3 with a capacity of a single doses of medicine on the wall of the stock room 2. And a filter 6, which is permeated by air but not by the powder medicine, is attached to the storing room 3 on the opposite side of the stock room 2. And in addition, an air pathway 10 is formed so that air permeating the filter 6 can enter the pump part 1.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an apparatus and a method for quantitatively supplying a powder, and more particularly to a device for multi-dose administration of a powdered drug. More specifically, the present invention provides a method for dispensing a small amount of a single dose (unit dose) of powdered drug from a plurality of doses (multidose) of powdered drug stored in a container in a highly quantitative manner. Powder drug multi-dose administration device.

[0002] The present invention relates to a method for spraying or inhaling a unit dose of a powdered drug into a body cavity such as the nasal cavity, oral cavity, trachea, bronchi, alveoli, or other affected areas by continuously dividing the pharmaceutical agent in a quantitative manner. An object of the present invention is to provide a multidose-type powdered drug administration device that is convenient to carry, easy to use, and relatively inexpensive.

[0003]

2. Description of the Related Art Drugs in the form of powder are administered to body cavities, for example, the nasal cavity, oral cavity, trachea, bronchi, airways such as lungs, etc. by spraying or inhaling. For example, a powdered drug is administered to the nasal cavity or respiratory tract for a patient with nasal allergy or asthma. Also, recently, a drug delivery system that absorbs drugs into the bloodstream through mucous membranes such as the nasal cavity and lungs has attracted attention, and attempts have been made to administer powdered drugs to those mucous membranes, such as nasal allergy, asthma, BACKGROUND ART For patients with lichen planus, widespread erosive stomatitis, etc., treatments for administering a powdery drug to the nasal cavity, the oral cavity, and the respiratory tract have been performed.

[0004] In such drug administration, a powdered drug dispensing device or container is used, and such drug dispensing devices are roughly classified into two types according to a powder drug storage system.

[0005] In the first type, a powdered drug in an amount (unit dose) equivalent to a single administration operation is divided and stored in an appropriate container as one unit, and is administered in each administration operation for each unit dose. Unit dose dispensing device or container. In the second type, a plurality of administration operations (multi-dose) of powdered medicine are collected and stored in an appropriate container, and each time a single administration operation is performed, a unit dose of powdered medicine is collected. Multidose dispensing device or container that is dispensed accurately from the container in which it is stored. Further, as one of the former unit dose administration devices, there is a simple device that can be disposed of each time a single administration operation is performed, that is, a disposable container that also serves as a disposable device.

Hereinafter, in the present invention, the amount of a single dose operation of a powdered medicine is referred to as a unit dose, and the amount of a plurality of dose operations is referred to as a multi-dose. The administration of the powdered medicine at each unit dose may be referred to as a unit dose, and the administration of the powdered medicine stored at multiple doses at each unit dose may be referred to as a multidose.

Japanese Patent Application Laid-Open No. 59-34267 discloses an example of a unit-dose container for powdery medicines that enables spray administration into the nasal cavity. In these devices, generally, a holding portion of a unit dose container housed in a capsule or the like, a means for piercing the same, and a means for introducing an air flow for spraying the powdered drug from the pierced container into the nasal cavity of a patient or the like. And so on. Further, as an example of the disposable container, there is JP-A-2-500172. In the publication, a fine powder medicine is sealed, and a holding part configured to form an opening for spraying or inhaling the fine powder medicine at the head thereof, and an air introducing means, A powder medicine dispensing container is disclosed in which a bottom portion of the holding portion is connected to the air introducing means via the fine powder medicine impermeable and gas permeable diaphragm. Further, there is a powdered drug administration device in which this is improved (WO97 / 04826).

[0008] Many devices have been proposed as unit dose inhalers for powdered medicines to be inhaled into the respiratory tract. For example, it is an inhaler using a capsule usually formed of a non-toxic material such as hard gelatin. Each of the capsules
A fixed amount of the powdered medicine of the unit dose to be inhaled is stored. This type of inhaler comprises a device for piercing the capsule inserted in the inhaler when needed, or more generally (by various means). The powder medicine contained in the capsule is inhaled through a hole formed in the capsule by the air flow generated by the suction action of the user. And
The emptied capsule is removed from the inhaler and is ready for a new capsule. In known types of inhalers (U.S. Pat. Nos. 3,906,950 and 4,013,075), the capsule is held stationary during inhalation when pierced at both ends. The powdered medicament is removed from the interior of the capsule by the air flow passing through the capsule as a result of inhalation.

[0009] Another type of inhaler (US Patent No. 3807)
No. 400), a capsule previously opened by suitable means is moved by the action of the air flow generated by inhalation, thereby completely emptying the capsule.

Furthermore, another type of known inhaler (EP-A-0211595) does not use a plurality of capsules, but is designed to be filled with a disc-shaped pack. A series of air bubbles near each other are equidistant from each other and from the center of the pack. These bubbles contain a fixed amount of powdered drug. This pack forms part of an inhaler and is placed on a circular tray that is rotatable about its central axis. The tray is provided with holes at locations for the individual bubbles so that when the individual bubbles are moved to a predetermined position where they can be broken by a suitable opening device, the powdered drug can be removed and inhaled.

On the other hand, WO 94/26338 is an example of a multi-dose administration container capable of spray administration. In the specification, a device main body and a plurality of administration operations (multi-dose) which are detachably attached to the device main body and are provided.
And a storage room having a capacity of a single dose operation (unit dose), and the storage room is communicated with the storage room at the filling position to allow the powder in the storage room to be stored. Drug dispensing means movably attached to the apparatus body to enable administration of the medicament, means for dispensing the dispensing means between a filling position and a dispensing position, and Pump means for injecting air into the storage chamber to agitate the powdered medicine in the storage chamber, wherein a certain amount of the powdered medicine after stirring is accommodated from the storage chamber by suction and / or gravity by the pump means. A device characterized by filling the chamber is disclosed.

An example of a multi-dose administration device for inhaling and administering a powdered drug into the respiratory tract is disclosed in (European Patent Publication No. 00/00).
No. 69715), in addition to a container containing a certain amount of drug, a device for taking out a powdered drug contained in the container and preparing for dosing. The dispensing / preparing device comprises a plate having a predetermined thickness and a predetermined number of through holes. The plate can be moved from a position where a portion of the through-hole is filled by mechanical means with powdered drug removed from the container to another position where the drug-filled hole is located in the passageway. As a result of the suction provided by the user through the inlet communicating with the passage, air enters the passage and removes the powdered medicament from the through-hole. A scraper device is also provided to level the side of the powdered medicament in the through-hole formed in the plate toward the container. According to the inventor of the European patent application, the scraper device results in a complete filling of the through-holes and thus guarantees a constant dose. Although the European patent specification states that the scraper is optional, it is considered essential for proper operation of the inhaler. Because without this scraper, the dose would be extremely different. Because the powdered drug used has poor flowability, it is frequently possible that individual through-holes are not completely filled with the powdered drug.

[0013]

As described above, although many drug dispensing apparatuses or containers have been devised, problems have been recognized in each of them. That is, JP-A-59-3
The unit dose dispensing device disclosed in Japanese Patent No. 4267 or the like needs to be provided with a means for piercing a drug container. For this reason, there is a problem that the size of the device is increased to some extent and it is inconvenient to carry. In addition, there is a problem in operability at the time of use, such as the necessity of an operation of putting a medicine container into the device for each administration operation, piercing, and removing after administration, which is complicated.

On the other hand, in the disposable container disclosed in WO 97/04826, the above-mentioned problems have been solved as a unit dose type device, but a plurality of containers must be carried to carry a plurality of doses. And there is a problem that it becomes bulky.

However, there are serious problems with the conventional powdered drug multi-dose dispensing apparatus. That is, as described above, it is possible to continuously and quantitatively divide and administer the amount of powdered drug necessary for a single administration operation from a large amount of aggregated powdered drug,
It is very difficult from the viewpoint of physical properties such as change in density and bias of the collected powdered medicine.

Several proposals have been made to address this problem. For example, as disclosed in the above-mentioned European Patent, there is a method in which a predetermined amount of a through-hole is continuously filled with a powdered medicine while being pressed with a scraper or the like. However, according to this method, for example, the bulk density of the powdered drug changes due to vibration applied to the entire dispensing device,
As a result, there is a disadvantage that the amount of the powdered drug administered to the living body is not constant.

Japanese Patent Publication No. 47190/1989 discloses a multi-dose dispensing apparatus for compressing a large amount of powdered medicine and continuously and quantitatively dividing and compressing the resulting powdered medicine compact. Have been. In this method, the powder medicine is compressed to ensure the quantitativeness of the medicine to be divided.However, even in this method, the density of the compressed powder medicine changes due to the influence of vibrations applied to the entire dispensing device, and the As a result, there is a disadvantage in that the weight of the powdered medicine compact to be removed changes, and the amount of the powdered medicine to be administered into a living body is not constant.

[0018] In addition, the multi-dose dispensing apparatus disclosed in WO94 / 26338 or the like causes the collected powdered medicine to flow in the storage chamber space by passing an air flow through the collected powdered medicine in the storage chamber immediately before each dividing operation. This prevents a change in the density of the powdered medicine, and continuously and quantitatively divides the powdered medicine for a single administration operation by accommodating the powdered medicine of the unit dose in the powdered medicine storage chamber by suction and / or gravity. However, since it is composed of a storage unit, a single dose medicine storage chamber, a medicine fixed amount dividing means, a pump means and the like, there is a problem that it is considerably large and inconvenient to carry.

That is, in the conventional powder medicine dispensing apparatus or administration device, portability due to miniaturization, easy operation, quick operation, quantitative operation, simple manufacturing process,
At present, none of them satisfies the minimization of the number of parts and the low price. Particularly when it is considered that portability and simplicity are important, a multidose type dispenser which has a simple manufacturing process, is inexpensive, and has excellent quantitative properties is strongly desired.

[0020] Further, in a powdered drug administration device intended for a disease of the nasal cavity, it is required that the powdered drug can be sprayed evenly into both nasal cavities.

Here, in order to uniformly spray and administer the medicine to both nasal cavities using a unit dose type powder medicine applicator or an administration device, two administration devices, one for each nose, are used. It is conceivable to use a device having two spray ports so that a single device can simultaneously administer a drug into both nasal cavities. Also, using only one powder medicine administration device having only one spray port, the powder medicine contained therein is sprayed alternately into both nasal cavities, and the medicine is evenly administered into both nasal cavities. It is possible to do. Considering conditions such as portability, simplicity, and low price,
A method using two administration devices or a device having two spray ports is not preferable. Using only one administration device,
It is desirable that the powdered drug contained therein is sprayed alternately into both nasal cavities and the drug is evenly administered to the nasal cavities. For this purpose, for example, right, left, left, right, etc. It is conceivable to administer the drugs intranasally in order.
At this time, about 6 to 10 spraying operations are required,
It is very complicated.

Therefore, there is a strong demand for a multi-dose type powder drug dispensing apparatus or a dispensing device capable of spraying a dose for one nose in one to several spraying operations.

[0023]

SUMMARY OF THE INVENTION In view of the above-described problems and problems in the prior art, the present invention provides a multidose type powder drug administration device as described below. That is, an object of the present invention is to provide a multi-dose having portability, simplicity and speed of operation, simplicity of a manufacturing process, economical efficiency such as minimization and low cost of parts, and / or quantitative sprayability. It is to provide a type powder drug administration device.

That is, the apparatus main body (1), the lead-out section (4) movably attached to the apparatus main body (1), and at least a part of the wall thereof are formed of a flexible container or bag. And a multi-dose administration device for a powdered drug, comprising: A storage chamber (2) in which the powder medicine for a plurality of administration operations can be stored inside the apparatus main body (1), and a storage room having a dose for a single administration operation on the wall surface of the storage room (2). A filter (6) having (3) for allowing air to flow on the opposite side of the storage chamber (2) of the storage chamber (3) but not for flowing powdered medicine;
And an air flow passage (10) for communicating with the pump (7) following the filter (6). The outlet (4) is provided with a spray port (5) at the upper end and a discharge port (11) on a wall surface, and the spray port (5) and the discharge port (11) communicate with each other in a tubular structure. It is,
The outlet (11) further includes a position (filling position) where the storage room (3) communicates with the storage room (2), and the storage room (3).
Where the device communicates with the outside of the device body (1) (administration position)
And the powder medicine in the storage chamber (3) can be dispensed at the dispensing position. The pump section (7) communicates with the apparatus main body (1) through the air flow passage (10), and presses and relaxes a flexible portion to pass through the filter (6) into the storage chamber. (3) Air can be supplied and sucked. When the powder medicine is administered, the device main body (1) is placed in the state in which the storage chamber (3) faces downward (a) and the lead-out section (4).
Is moved to the filling position (b) (a → b) and the powdered medicine in the storage chamber (2) is moved to the storage chamber (3), so that the pressure in the storage chamber (2) is slightly reduced. Then, air flows into the storage chamber (2) from the pump section (7) through the storage chamber (3) to agitate the powdered medicine in the storage chamber (3) and the storage chamber (2). When the lead-out section (4) is moved (b → c) to the administration position (c), the storage chamber (2) becomes slightly positive pressure, so that the storage chamber (2) is moved to the storage chamber (3). By flowing air to the pump section (7) through the above, the powder medicine can be accurately quantified into the storage chamber (3) for a single administration operation.

[0025]

DESCRIPTION OF THE PREFERRED EMBODIMENTS In the present invention, the apparatus main body (1) is usually preferably formed of a polymer such as polyethylene, polystyrene, polypropylene, styrene-acrylonitrile polymer, acrylonitrile-butadiene-styrene polymer. It is not limited by.

The volume of the storage chamber (2), which is the internal space of the apparatus main body (1), is adjusted to obtain a uniform filling effect by utilizing the pressure change caused by sliding the outlet (4).
It is desirable that the volume at the filling position (b) be at least 1.2 times the volume at the administration position (c).
In addition, the size of the storage chamber (3) inside the apparatus main body (1) can be appropriately determined according to the volume of the powder medicine used once and the required number of times of administration. Considering that the apparent specific gravity of the commonly used powdered medicine is about 0.1 to 3.0 and that the single use amount of the powdered medicine is about 5 to 200 mg, the volume of the accommodation room (3) is about 2 to about 2 mg. ~
2000 mm ³ .

The filter (6) provided at one end of the storage chamber (3) has a size depending on the size of the particles of the drug and the excipient (in some cases, only the drug) constituting the powdered drug. A screen for sieving, a membrane filter, or the like can be appropriately used.

For example, for intranasal spray, the aperture is 5 to 3
A sieve mesh of 7 μm, preferably 5 to 10 μm, or a membrane filter with a pore size of 5 to 75 μm, preferably 5 to 25 μm is used.
The following membrane filters are used. Examples of the sieving mesh include those made of nylon and stainless steel, and examples of the membrane filter include those made of polypropylene, cotton, rayon, glass fiber, and sintered filter.

The lead-out section (4) of the present invention is preferably formed of a polymer such as polyethylene, polystyrene, polypropylene, styrene-acrylonitrile polymer, acrylonitrile-butadiene-styrene polymer, similarly to the apparatus main body (1). However, it is not limited by these.

The lead-out section (4) is movably attached to the apparatus body (1), and can slide back and forth between the filling position (b) and the administration position (c) by sliding. When attached to the main body (1), one end of the apparatus main body (1) located outside the main body (1) (upper end of the lead-out section)
And a spray port (11) at the other end (the wall of the draw-out section) located inside the apparatus body (1).

The lead-out section (4) and the apparatus main body (1)
In the administration position (c), the container (3) can communicate with the outside of the device main body, and the filling position (b)
In this configuration, the arrangement of the outlet (5) and the housing chamber (3) is displaced by sliding the outlet portion (4), so that the outside of the apparatus body and the housing chamber (3) are not communicated with each other. Has become.

That is, the storage chamber (3) can communicate with the outside of the apparatus main body only through the outlet portion (4) and at the administration position (c).

In addition, the outlet part (4) may be contaminated by body fluids or the like in the vicinity of the spray port during administration into the body cavity, which is not preferable from a hygiene point of view. Therefore, in order to facilitate cleaning, the spray port (5)
It is also possible to configure the vicinity as a removable nozzle.

In the present invention, it is preferable that the number of spray ports is one in terms of downsizing of the apparatus. However, for example, when spraying the powdered medicine into the nasal cavity, the spraying port is made into one place, or the spraying is divided into two near the spraying hole, and then the spraying port is provided at one end at each end, and a total of two places are provided. For example, a plurality of spray ports can be provided depending on the purpose.

The slide for reciprocating between the administration position (c) and the filling position (b) of the lead-out portion (4) is manually performed, but this positioning is performed by a click feeling and visual observation through the base. It is confirmed.

The pump section (7) of the present invention is an element for pressing air necessary for administering (spraying or inhaling) a powdered drug, and such a pump is made of a flexible material or a wall. Preferably, at least a portion is formed from a flexible material. Here, "at least a portion made of a flexible material" means that the powdered drug stored in the storage chamber (3) can be sprayed and inhaled by pressing and relaxing the portion made of the flexible material. It has the function of tightening. When the entire pump section (7) is made of such a flexible material, or for example, a portion of the pump section (7) other than the vicinity of the joint with the apparatus body (1) is made of a flexible material. It is also possible to use a non-flexible material.

Examples of such a flexible material include plastic having elasticity such as polyethylene and polypropylene, and natural or synthetic rubber.

The size of the pump section (7) of the present invention can be adjusted by, for example, pressing the pump section (7) one to several to ten times so that the powdered medicine stored in the storage chamber (3) is almost completely removed. It is preferable to have a sufficient amount of air to be exhausted.

The powder drug used in the present invention can be composed of a conventionally known excipient such as a drug, lactose, starch, cellulose, polyvinyl polymer, or the like.
Alternatively, it can be composed of a drug alone. Further, if necessary, additives such as conventionally known stabilizers and antioxidants can be appropriately added.

As described above, the present invention is convenient to carry, easy to use at the time of use, is capable of accurately spraying / inhaling a predetermined amount of powdered medicine, and is relatively inexpensive multidose type powdered medicine administration. This provides an excellent effect that a device can be provided.

The present invention is particularly suitable as a dispensing device in which a plurality of small doses of the powdered drug are contained in a container at a time.

[0042]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below with reference to embodiments based on the accompanying drawings, but the present invention is not limited thereto.

FIG. 1 is a cross-sectional view showing the overall configuration of the multidose powder drug administration device of the present invention. A cylindrical device main body (1) having an outer diameter of 22 mm and having a receiving chamber (3) having a diameter of 4 mm and a depth of 2.2 mm was molded from polypropylene and manufactured. The outer diameter of the spray port (5) is 4 mm, the diameter of the storage chamber (2) is 12 mm, the height is 10 mm at the administration position (c), and the height is 18 mm at the filling position (b). A cylindrical lead portion (4) having a maximum diameter of 12 mm was manufactured by molding with polypropylene. Next, the device body (1)
A polypropylene membrane filter (6) having a mesh size of 5 μm and a pump section (7) made of polyethylene were attached to the storage chamber (2), and 400 mg of a powder drug (9) having a particle size of 38 to 150 μm was filled into the storage chamber (2). After inserting the lead-out portion (4) into the device body (1), cover the spray port (5) with a lid (8) made of polypropylene (the height of the entire device is about 100 m).
m), which was the administration device of the present invention.

FIG. 2 is a sectional view of each component.

In use, the administration device of the present invention shown in FIG. 1 is operated in the order of (a) → (b) → (c) in FIG. However, the deriving section (4) is most pushed into the apparatus main body (1), and the state in which the powder medicine is not stored in the storage chamber (3) is a standby state (a). The storage room (2) which is most drawn out to the main body (1)
The state where the container (3) and the container (3) are in communication with each other is a filling position (b), and the lead-out portion (4) is most pushed into the apparatus main body (1), and the container (3) is connected to the outside. Are in communication with each other, and the state in which the powder medicine is stored in the storage chamber (3) is defined as an administration position (c).

First, the apparatus main body (1) is set in a standby state (a) in which the storage chamber (3) is on the lower side, and then the lead-out portion (4) is slid to the filling position (b). Thereby, the powder medicine (9) in the storage room (2) moves to the storage room (3) by gravity. At this time, when the outlet section (4) is in the state of (a), the storage chamber (2) is in a sealed state, and the outlet section (4) is slid to the filling position (b) to slide the storage chamber (2). The volume of (2) increases, and the pressure in the storage chamber (2) is slightly reduced.

Then, the lead-out section (4) is moved to the filling position (b).
When the storage chamber (2) is slid, the storage chamber (2) communicates with the storage chamber (3) and the pump section (7), and a slight pressure difference causes the air flow path (1) to pass from the pump section (7).
0) and the air flows into the storage chamber (2) via the storage chamber (3), and the powder medicine (9) being filled in the storage chamber (3) is stirred by the air flow. .

Next, the lead-out section (4) is connected to the filling position (b).
From the storage room (2) to the storage room (3) and from the storage room (2), as opposed to sliding the outlet portion (4) to the filling position (b) by sliding from the storage region to the administration position (c). The outflow of air to the pump section (7) through the air flow passage (10) causes the powder medicine (9) to be filled in the storage chamber (3) at a uniform density, Since the space between the chamber (3) and the storage chamber (2) is frayed, the powder medicine (9) is accurately and quantitatively stored in the storage chamber (3).

When the pump section (7) is pressed when the outlet section (4) is at the administration position (c), pressurized air is supplied to the storage chamber (3) which has already stored the powdered drug (9). The powder medicine (9) flows freely through the air flow passage (10), and the powdered medicine (9) passes through the outlet (4) together with the pressurized air, and the spray port (5) at the nozzle tip of the outlet (4). Is sprayed to the outside of the device main body, and is administered into a body cavity such as a nasal cavity.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view showing a configuration of a powdery drug multidose administration device of the present invention in an embodiment.

FIG. 2 is a cross-sectional view of each component. Reference numerals 1 to 11 in the figure respectively indicate the following contents.

3 (a) to 3 (c) show an operation procedure when using the powdered drug multi-dose administration device of the present invention.

[Explanation of symbols]

 1. 1. Device main unit Storage room 3. Containment room 4. Derivation unit 5. Spray port 6. Filter 7. Pump section 8. Lid 9. Powdered drug 10. Air flow passage 11. Outlet

Continued on the front page (72) Inventor Takao Fujii 4-2-2 Asahigaoka, Hino-shi, Tokyo Teijin Co., Ltd. Tokyo Research Center Co., Ltd.

Claims (3)

[Claims] 1. An apparatus main body (1), a lead-out section (4) movably attached to the apparatus main body (1), and at least a part of a wall thereof is constituted by a flexible container or bag. And a multi-dose administration device for a powdered drug, comprising: A storage chamber (2) in which the powder medicine for a plurality of administration operations can be stored inside the apparatus main body (1), and a storage room having a dose for a single administration operation on the wall surface of the storage room (2). A filter (6) having (3) for allowing air to flow on the opposite side of the storage chamber (2) of the storage chamber (3) but not for flowing powdered medicine;
And an air flow passage (10) for communicating with the pump (7) following the filter (6). The outlet (4) is provided with a spray port (5) at the upper end and a discharge port (11) on a wall surface, and the spray port (5) and the discharge port (11) communicate with each other in a tubular structure. It is,
The outlet (11) further includes a position (filling position) where the storage room (3) communicates with the storage room (2), and the storage room (3).
Where the device communicates with the outside of the device body (1) (administration position)
And the powder medicine in the storage chamber (3) can be dispensed at the dispensing position. The pump section (7) communicates with the apparatus main body (1) through the air flow passage (10), and presses and relaxes a flexible portion to pass through the filter (6) into the storage chamber. (3) Air can be supplied and sucked. When the powder medicine is administered, the device main body (1) is placed in the state in which the storage chamber (3) faces downward (a) and the lead-out section (4).
Is moved to the filling position (b) (a → b) and the powdered medicine in the storage chamber (2) is moved to the storage chamber (3), so that the pressure in the storage chamber (2) is slightly reduced. Then, air flows into the storage chamber (2) from the pump section (7) through the storage chamber (3) to agitate the powdered medicine in the storage chamber (3) and the storage chamber (2). When the lead-out section (4) is moved (b → c) to the administration position (c), the storage chamber (2) becomes slightly positive pressure, so that the storage chamber (2) is moved to the storage chamber (3). By flowing air to the pump section (7) through the above, the powder medicine can be accurately quantified into the storage chamber (3) for a single administration operation. 2. The device according to claim 1, wherein the device is disposable. 3. The multidose powder drug administration device according to claim 1, wherein the device is for intracavity administration.