JPH11306233A - Overall production system for medical supplies manufacturing company - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an overall production system for a medical supplies manufacturing company to optimize a supply chain and also to integrate the common jobs by organizing a production system where plural offices are integrated. SOLUTION: This system includes an optimum production planning part 10 which receives the order information sent from a sales management department and the stock information sent from a logistic department, and decides an optimum production plan, a necessary quantity management part 20 which calculates a necessary quantity of row material based on the production plan decided at the part 10 and sends the calculated quantity of row material to a purchasing department, a manufacturing process management part 30 which manages every manufacturing process based on the production plan and the production facilities of a factory, and a factory shipment management part 40 which decides the time of shipment based on the products manufactured at the part 30 and the stock information given from the logistic department.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a control system used in a pharmaceutical production factory, and more particularly to an integrated production system which achieves further cost reduction and profit increase by realizing efficiency in the whole factory.

[0002]

2. Description of the Related Art Pharmaceutical production plants undergo the following automation processes. In the early 1980s, when a process control computer (PCS) was introduced to achieve automation of a single device and save labor for manufacturing workers. Around 1988, when a process control computer was introduced to manage a group of devices and to reduce the number of operation managers of the devices. In order to further reduce the number of operation monitoring personnel by integrating management of multiple manufacturing processes, and to speed up the information and reduce indirect operations by making sales order information online, the manufacturing execution system (MES) and process control computer Around 1991, when the integration was introduced.

[0003]

However, pharmaceutical manufacturing companies have been trying to further reduce their manufacturing costs due to pressure on profits due to drug price reductions and changes in the economic environment such as intensified competition for new contracts and increased development costs. The need to secure profits and continue to invest in new drug development has increased. In addition, GMP (good ma
nufacturing practice, which is an activity in accordance with the quality assurance regulations in pharmaceutical manufacturing, and FDA (food
It is necessary to respond to regulations of d drug administration).

The present invention solves the above-mentioned problems, and provides an integrated production system for a pharmaceutical manufacturing company that optimizes a supply chain and integrates common operations by constructing a production system integrating a plurality of business offices. The purpose is to do.

[0005]

In order to achieve the above object, an integrated production system for a pharmaceutical manufacturing company according to claim 1 of the present invention inputs order information from a sales management department and stock information from a distribution department. An optimal production plan drafting section 10 for formulating an optimal production plan, a required quantity management section 20 for calculating the required amount of raw materials from the production plan of the optimal production plan drafting section, and transmitting it to the purchasing department; A manufacturing process management unit 30 that manages each manufacturing process from a production plan of a planning unit and production equipment at a manufacturing factory, and a factory that determines a shipping time from products manufactured by the manufacturing process management unit and inventory information from a distribution department. And a shipping management unit 40.

In claim 1 of the present invention, the optimal production plan drafting section 10 formulates an optimal production plan from order information from the sales management department and inventory information from the distribution department. The required amount management unit 20 calculates the required amount of the raw material based on the optimal production plan and transmits the calculated amount to the purchasing department. The manufacturing process management unit 30 performs scheduling of production distribution between each factory and a subcontractor company, and manufacturing items and quantities of each manufacturing process, based on the situation of the production equipment and the production plan. The factory shipping management unit 40 determines the shipping time from the products to be manufactured and the stock information from the logistics department, and operates so as to avoid lack of stock and the like for the customer and to have no surplus stock.

[0007]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below with reference to the drawings. FIG. 1 is a diagram illustrating an information network of a pharmaceutical manufacturer having a plurality of factories to which the present invention is applied. The sales information system 1 collects order information of products from branches and agents. The integrated production management center 2 obtains the order information of the product, and in order to surely deliver the product to the customer, it is preferable to manufacture at each factory or the subcontracted factory in consideration of the optimization, and consider the load of each factory. Make an allocation. A scheduling simulator that determines the manufacturing cost at each factory by simulating the manufacturing sequence for load distribution at each factory, and a logistics / production integrated management server that secures optimal inventory by avoiding shortage and surplus inventory Have. The distribution center management system 3 manages the delivery to customers by grasping the stock status of each product in the warehouse.

The company network 4 is a communication line for connecting the sales information system 1, the integrated production management center 2, the distribution center management system 3, and the production management servers 5 and 6 of each factory and subcontracted factories. Upon receiving a manufacturing request from the integrated production management center 2, the manufacturing management servers 5 and 6 of the respective factories and the outsourced factories send specific instructions related to manufacturing to the respective processes and manufacturing lines of their own factory equipment. The factory equipment includes a machine tool, a crusher, an electric furnace, and the like, and corresponding lower-level control devices such as a programmable controller are provided.

FIG. 2 is a block diagram illustrating the configuration of the integrated production management center. The optimal production plan drafting unit 10 inputs the order information from the sales management department 1 and the stock information from the distribution department 3 to formulate an optimal production plan. The optimal production plan consists of a periodical production plan drafting department corresponding to the fiscal year such as year, period and month, and a latest production plan drafting the latest production plan such as weekly and daily and transmitting it to the manufacturing process management department. A part may be provided. The quarterly production plan drafting department roughly determines the operation status of factory equipment in accordance with the management plan. Depending on the operation status of the factory, it may be necessary to newly establish or destroy the factory. The latest production planning unit serves as a scheduling function 12 for daily operations.

The required amount management unit 20 calculates the required amount of the raw material from the production plan of the optimal production planning unit 10 and transmits it to the purchasing department 7. The required amount management unit 20 may determine the time and amount for optimizing the purchase cost from the time and amount at which the raw materials are needed and the purchase price, and place an order with the supplier.

The production process management unit 30 manages each production process based on the production plan of the optimal production plan drafting unit 10 and the production equipments 5 and 6 in the production factory. The information is transmitted to the process management unit 50. The manufacturing process management unit 30 determines the allocation of production equipment and the personnel plan and the number of batch production lots, which are optimal production plans, and performs production distribution between the production equipment of the own company and the production equipment of the contractor.

The factory shipping management unit 40 includes the manufacturing process management unit 3
The shipping time is determined from the product manufactured in step 0 and the stock information from the distribution department 3, and the shipping time is determined so as to maintain the optimal stock in the distribution department. Thus, in response to an order from a wholesaler, the goods are delivered from the distribution center without any shortage, and there is no danger of having a large quantity of undesired goods due to excess stock.

FIG. 3 is a configuration block diagram showing an example of an information network in an individual factory. The office system network 60 receives a production plan sent from the manufacturing process management unit 30 via the company-wide network 4 and manages the entire factory so as to perform operations corresponding to the production plan. Server 62 that manages the state of equipment maintenance in the company, and document management server 63 that manages accounting documents, personnel documents, manufacturing quality information for each product lot specific to pharmaceuticals, etc.
have. By using the equipment maintenance server 62, a production capacity and a maintenance plan for each manufacturing process can be formulated.

For example, in the tablet manufacturing process, a mixing step 701 for mixing raw materials such as medicinal ingredients at a predetermined ratio, a granulation step 702 for converting powder into granules having a predetermined weight, Since there are a tableting step 703 for processing into tablets, a coating step 704 for easily processing sugar on the tablet surface, and a packaging step, mechanical equipment is provided for each step. In the packaging process, there are a PTP packaging line, an injection packaging line, a subdivision packaging line, and the like, and an automatic container washing facility is also provided.

The existing control system 70 is connected to a programmable controller and a signal input / output unit for executing control commands for each machine and equipment. The process server 71 is connected to the process server 71 in order to control the entire manufacturing process.
Connected through. The process server 71 grasps the operation status of each machine equipment from the control information from the existing control system 70, and cooperates with the factory integrated management server 61.

The injection process server 72 supervises monitoring and inspection information on the manufacturing process of the injection. The oral preparation process server 73 manages monitoring and inspection information on the manufacturing process of oral preparations such as tablets and powders. The wireless portable terminal 74 is carried by the inspector and inputs the operating state of each process. The existing control system 70 may be extended to handle monitoring inspection information in addition to control information. The weighing system server 75 is provided because the use of medicine as a medicine is an important application, and an electronic balance 76 is connected thereto.

The distribution network 80 manages inventory using a distribution server in the factory and terminals provided in each warehouse, and exchanges outgoing information and incoming information with the factory shipping management unit 40. In the warehouse, the raw material and intermediate goods warehouse 8
2. There are a material warehouse 83 and a product warehouse 84, each of which has an automatic warehouse management system.

The new drug development network 90 is suitable for developing a new drug having high efficacy and low toxicity. The new drug development network 90 is a document / information management system, an animal experiment system, a test management system, a safety management system, a statistical analysis system, and a toxicity data system. A collection system, a clinical management system, and the like are provided in the new drug development server 91. Quality control network 100
Has a quality management server 101 that handles quality control data of pharmaceuticals manufactured by manufacturing equipment.

In the apparatus configured as described above, since the purchase management is performed centrally at the integrated production management center, the number of personnel is reduced by half compared to the case where the purchase management personnel are provided at each factory and the head office as in the past. In addition to the following, it is possible to reduce material costs by purchasing materials at the company level.

Further, since the production planning work is performed centrally at the integrated production management center, the number of staff members is less than half, and the company-wide production planning work is required at each factory and the head office. Inventory reduction can be achieved by optimal scheduling at the level. Inventory reduction reduces inventories, generates profits equivalent to interest rates, and suppresses defective inventory of dead-skin products. Further, by optimizing the entire cycle of material purchase → product processing → product shipment, manufacturing costs can be further reduced.

In the above embodiment, a case of a relatively large pharmaceutical manufacturing enterprise having a plurality of factories has been described. However, the present invention is not limited to this, and a single factory may be used. Applicable when cooperating with a contractor. Furthermore, not only when factories are installed in Japan, but also when factories are dispersedly arranged in Asia, North America, Europe, etc., it is useful for achieving world-best production.

[0022]

As described above, according to the integrated production system of the pharmaceutical manufacturing company of the first aspect, the optimal production planning unit 10 performs the optimal production based on the order information from the sales management department and the inventory information from the distribution department. Since the plan is formulated, the leveling of the load and the speed of inventory adjustment can be made faster than when individual factories individually formulate the production plan. Since the required amount management unit 20 calculates the required amount of the raw material based on the optimal production plan and transmits the calculated amount to the purchasing department, the bargaining power for the delivery destination by the collective purchase of the material is increased. The manufacturing process management unit 30 schedules the production distribution between each factory and the outsourcing company and the production items and quantities of each manufacturing process based on the situation of the production equipment and the production plan. Can concentrate on manufacturing. The factory shipping management section 40 determines the shipping time from the manufactured products and the inventory information from the distribution department, and operates to avoid shortage of goods and to have no surplus inventory for customers.
Low inventory requirements.

According to the second aspect of the present invention, the optimal production planning unit includes a period-based production planning unit corresponding to an accounting period such as year, period, or month based on the inventory space and cost simulation of the logistics department. If it is configured to have a latest production plan drafting department that drafts another recent production plan and transmits it to the manufacturing process management department, the financial information necessary for corporate management and the latest production plan required for daily production are Can be formulated without contradiction.

According to a third aspect of the present invention, the required amount management unit determines the time and amount for optimizing the purchase cost from the time and amount of the raw material and the purchase price, and places an order with the supplier. Then, the efficiency of company management can be improved. In this case, the purchaser can grasp the demand trend in advance from the required quantity management unit, and can smoothly operate the factory.

According to a fourth aspect of the present invention, when the manufacturing process management unit is configured to formulate a production sequence for each product and to transmit the production sequence to the process management unit 50, the production plan performed by the integrated production management center can be quickly and accurately determined. It can be transmitted to the production management server of each factory. In addition, when the manufacturing process management section is configured to determine the allocation of production equipment and the personnel plan and the number of batch production lots to be an optimal production plan as in claim 5, the production planning function of each factory is greatly reduced. And contributes to a reduction in manufacturing cost.

According to a sixth aspect of the present invention, when the manufacturing process management section is configured to distribute production between its own production equipment and the production equipment of a contractor, it is possible to achieve optimal production as a whole company and The necessary products can be supplied at low cost and in the required amount at the required time. As described in claim 7, when the factory shipment management unit determines the shipment time so as to maintain the optimum stock for the distribution department, the distribution management from the warehouse to the customer is facilitated.

[Brief description of the drawings]

FIG. 1 is a diagram illustrating an information network of a pharmaceutical manufacturing company having a plurality of factories to which the present invention is applied.

FIG. 2 is a configuration block diagram illustrating functions of an integrated production management center.

FIG. 3 is a configuration block diagram of an information network in an individual factory.

[Explanation of symbols]

 10 Optimal Production Planning Dept. 20 Required Quantity Management Dept. 30 Manufacturing Process Management Dept. 40 Factory Shipping Dept.

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[Procedure amendment]

[Submission date] June 4, 1999

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Full text

[Correction method] Change

[Correction contents]

[Document Name] Statement

[Title of the Invention] Integrated production system of pharmaceutical manufacturing companies

[Claims]

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a control system used in a pharmaceutical production factory, and more particularly, realizes efficiency improvement in the whole factory to achieve further cost reduction and profit increase.
It relates to an integrated production system of a pharmaceutical manufacturing company .

[0002]

2. Description of the Related Art Pharmaceutical production plants undergo the following automation processes. In the early 1980s, when a process control computer (PCS) was introduced to achieve automation of a single device and save labor for manufacturing workers. Around 1988, when a process control computer was introduced to manage a group of devices and to reduce the number of operation managers of the devices. Manufacturing execution system (MES) and process control in order to further reduce the number of operation monitoring personnel by integrated management of multiple manufacturing processes, speed up information by online sales order information, and eliminate indirect work. Around 1991 when computer integration was introduced.

[0003]

However, in pharmaceutical manufacturing companies, production costs have been further reduced due to pressure on profits due to drug price reductions and changes in the economic environment such as intensified competition for new drug development and increased development costs. The need to secure profits and continue to invest in new drug development has increased. GMP (good m
In response to activities called “anufacturing practice”, which are in accordance with the rules of crystal quality assurance in drug production, and FDA (food)
and drug administration).

The present invention has solved the above-mentioned problems, and has
In addition to integrating the common operations of several factories into one location,
Company management by optimizing production distribution
Integrated manufacturing system for pharmaceutical manufacturing companies that has achieved efficiency
The purpose is to provide.

[0005]

The present invention has the following structure.
It is an integrated production system of a successful pharmaceutical manufacturing company. (1) Sales information system that collects product order information
And obtain the order information of the product, and surely
Manufacture products at each factory or outsourced factory to deliver
Considering whether it is optimal to perform
Integrated production management system and each product in warehouse
Logistics that manages delivery to customers by ascertaining inventory status
Center management system and each factory
From the comprehensive production management system
Upon receiving a manufacturing request, the process and production line of own factory equipment
A production management server for sending a production instruction to the
Sales information system, integrated production management system,
Distribution center management system and manufacturing management server are connected
Medical network, comprising:
An integrated production system for a pharmaceutical manufacturing company. (2) The integrated production management system is used at each factory
In order to distribute the load, the production sequence is set
Scheduling Simulator for Determining Manufacturing Cost
And logistics that secures optimal inventory by avoiding shortage and excess inventory
And a production integrated management server.
(1) An integrated production system of a pharmaceutical manufacturing company according to (1). (3) The integrated production management system is
The order information from the logistics department and the inventory information from the logistics department.
An optimal production plan drafting department that formulates an optimal production plan
From the production plan of this optimal production planning department, the required amount of raw materials
Requirements management department that calculates and transmits
Production planning at the appropriate production planning department and production facilities at production plants
From the equipment, a manufacturing process management department that manages each manufacturing process,
Products manufactured by this manufacturing process management department
And a factory shipping reserve that determines the shipping time from the inventory information.
Of the pharmaceutical manufacturing company described in (1).
Integrated production system. (4) The above-mentioned optimal production plan drafting department
Year / period / month from source and cost simulation
Production planning department for each period corresponding to the fiscal year, and weekly and daily
Immediately drafting the latest production plan and transmitting it to the Manufacturing Process Management Department
(3) described, which has a near-production planning department
Pharmaceutical manufacturing companies integrated production system. (5) The required amount management unit determines when the raw materials are needed.
When to optimize purchase cost based on quantity and purchase price
It is characterized by determining the quantity and ordering from the supplier (3)
The integrated production system of the entire pharmaceutical manufacturing business described. (6) The manufacturing process management section formulates a production order for each product.
To the process management department, and
Allocation of production equipment, personnel planning and batch production
(3) The pharmaceutical product according to (3),
An integrated production system for a manufacturing company. (7) The manufacturing process management department has its own production facilities and contractors.
Characterized by performing production distribution with production equipment
(3) The integrated production system of the pharmaceutical manufacturing company as described in (8) The factory shipping reserve maintains the optimal inventory for the logistics department.
(3)
The integrated production system of the entire pharmaceutical manufacturing business described.

(9) Each factory has an information network
This information network includes the manufacture of injections
Injection process server that controls monitoring and inspection information for the process
Is connected to the medicament according to (3).
An integrated production system for all manufacturing operations. (10) Each factory has an information network
This information network includes information on the manufacturing process of oral drugs.
Is connected to the oral drug process server
Pharmaceutical manufacturing industry as described in (3), characterized in that
Integrated production system. (11) The operating status of each process is input to the individual factory.
Wireless mobile terminal is provided.
(3) The integrated production system of the pharmaceutical manufacturing company described in the above.

[0007]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below with reference to the drawings. FIG. 1 is a diagram illustrating an information network of a pharmaceutical manufacturer having a plurality of factories to which the present invention is applied. The sales information system 1 collects order information of products from branches and agents. Integrated production management
The system 2 obtains the order information of the product and distributes the load distribution of each factory in consideration of which one of the factories or the subcontractor factory is most suitable for the purpose of reliably delivering the product to the customer. Do. A scheduling simulator that determines the manufacturing cost at each factory by simulating the manufacturing sequence for load distribution at each factory, and a logistics / production integrated management server that secures optimal inventory by avoiding shortage and surplus inventory Have. The distribution center management system 3 manages the delivery to customers by grasping the stock status of each product in the warehouse.

The company network 4 is a communication line that connects the business information system 1, the integrated production management system 2, the distribution center management system 3, and the production management servers 5 and 6 of each factory and subcontracted factories. The production management servers 5 and 6 at each factory and subcontractor factory are integrated production management
Upon receiving a manufacturing request from the system 2, a specific command related to manufacturing is sent to each process or manufacturing line of the own factory equipment. The factory equipment includes a machine tool, a crusher, an electric furnace, and the like, and lower-level control devices such as a programmable controller are provided corresponding to these.

FIG. 2 is a block diagram illustrating the configuration of the integrated production management system . The optimal production plan drafting unit 10 inputs the order information from the sales management department 1 and the stock information from the distribution department 3 to formulate an optimal production plan. The optimal production plan consists of a periodical production plan drafting department corresponding to the fiscal year such as year, period and month, and a latest production plan drafting the latest production plan such as weekly and daily and transmitting it to the manufacturing process management department. A part may be provided. The quarterly production plan drafting department roughly determines the operation status of factory equipment in accordance with the management plan. Depending on the operation status of the factory, it may be necessary to newly establish or destroy the factory. The latest production planning unit serves as a scheduling function 12 for daily operations.

The required amount management unit 20 calculates the required amount of raw materials from the production plan of the weekly production planning unit 10 and transmits it to the purchasing department 7. The required amount management unit 20 may determine the time and amount for optimizing the purchase cost from the time and amount at which the raw materials are needed and the purchase price, and place an order with the supplier.

The production process management unit 30 manages each production process based on the production plan of the weekly production planning unit 10 and the production facilities 5 and 6 in the production factory. For example, the production sequence is formulated for each product. To the process management unit 50. The manufacturing process management unit 30 determines the allocation of production equipment and the personnel plan and the number of batch production lots, which are optimal production plans, and performs production distribution between the production equipment of the own company and the production equipment of the contractor.

The factory shipping management unit 40 includes the manufacturing process management unit 3
The shipping time is determined from the product manufactured in step 0 and the stock information from the distribution department 3, and the shipping time is determined so as to maintain the optimal stock in the distribution department. Thus, in response to an order from a wholesaler, the goods are delivered from the distribution center without any shortage, and there is no danger of having a large amount of dead goods due to the surplus inventory.

FIG. 3 is a configuration block diagram showing an example of an information network in an individual factory. The office system network 60 receives a production plan sent from the manufacturing process management unit 30 via the enterprise network 4 and manages the entire factory so as to perform operations corresponding to the production plan. set to manage the facility maintenance state of the internal
It has a maintenance server 62 and a document management server 63 that manages accounting documents, personnel documents, manufacturing quality information for each product lot specific to pharmaceuticals, and the like. By using the equipment maintenance server 62, a production capacity and a maintenance plan for each manufacturing process can be formulated.

For example, in the tablet manufacturing process, a mixing step 701 for mixing raw materials such as medicinal ingredients at a predetermined ratio, a granulation step 702 for converting powder into granules having a predetermined weight, Since there are a tableting step 703 for processing into tablets, a coating step 704 for easily processing sugar on the tablet surface, and a packaging step, mechanical equipment is provided for each step. In the packaging process, there are a PTP packaging line, an injection packaging line, a subdivision packaging line, and the like, and an automatic container washing facility is also provided.

The existing control system 70 is connected to a programmable controller and a signal input / output unit for executing control commands for each machine and equipment. The process server 71 is connected to the process server 71 in order to control the entire manufacturing process.
Connected through. The process server 71 grasps the operation status of each machine facility from the control information from the existing control system 70, and cooperates with the factory integrated management server 61.

The injection process server 72 supervises monitoring and inspection information on the manufacturing process of the injection. The oral preparation process server 73 manages monitoring and inspection information on the manufacturing process of oral preparations such as tablets and powders. The inspector carries the wireless portable terminal 74 with the user, and inputs the operating state of each process. The existing control system 70 may be extended to handle monitoring inspection information in addition to control information. The weighing system server 75 is provided because the use of medicine as a medicine is an important application, and an electronic balance 76 is connected thereto.

The distribution network 80 manages inventory using a distribution server in the factory and terminals provided in each warehouse, and exchanges outgoing information and incoming information with the factory shipping management unit 40. In the warehouse, the raw material and intermediate goods warehouse 8
2. There is a crystallizing warehouse 84 as well as a material warehouse 83, each of which has an automatic warehouse management system.

The new drug development network 90 is suitable for developing a new drug having high efficacy and low toxicity. The new drug development network 90 is a document / information embedding system, an animal experiment system, a test management system, a safety management system, a statistical analysis system, a toxicity analysis system, and the like. The new drug development server 91 includes a data collection system, a clinical management system, and the like. Quality control network 100
Has a quality management server 101 that handles quality management data of pharmaceuticals manufactured by manufacturing equipment.

[0019] In the apparatus configured as described above, integrated
Purchasing management is centralized in the joint production management system , so compared to the conventional case where purchasing management personnel are set up at each factory and headquarters, the number of employees is less than half, and the bulk purchasing of materials at the company level Material costs can be reduced.

In addition, since the production planning work is performed centrally by the integrated production management system , the number of personnel is reduced to less than half compared to the case where the production planning work staff is provided at each factory and the head office as in the past, and the company-wide the optimal scheduling in the level can achieve a reduction of inventory. Inventory reduction reduces inventories, generates profits equivalent to interest rates, and suppresses defective inventory of dead-skin products. Furthermore, by making the entire cycle of material purchase → product processing → product shipment more complete, manufacturing costs can be further reduced.

In the above embodiment, a case of a relatively large pharmaceutical manufacturing enterprise having a plurality of factories has been described. However, the present invention is not limited to this, and a single factory may be used. Applicable when cooperating with a contractor. Furthermore, not only when factories are installed in Japan, but also when factories are dispersedly arranged in Asia, North America, Europe, etc., it is useful for achieving world-best production.

[0022]

According to the present invention, the following effects can be obtained. Contract
According to the invention of claim 1, the business information for collecting order information
Information system and integrated production money for load distribution at each factory
Management system and distribution center to manage delivery
And the system in one place,
I manage the place. This enables common operations at multiple plants
Integrated into one place, and the optimal production
Improve the efficiency of corporate management by enabling production allocation
can do. According to the invention of claims 2 to 11,
Then, the following effect can be obtained in addition to the effect obtained in claim 1.
It is. According to the second aspect of the present invention, the manufacturing cost is taken into consideration.
Thus, the optimum load distribution can be performed for each factory.
Further, the warehouse can be kept in an optimal stock state.
According to the invention of claim 3, the following effects can be obtained. Optimal production plan planning department receives order information from sales management department
An optimal production plan from inventory information from the logistics department
When individual factories formulate individual production plans,
In comparison, load leveling and inventory adjustment can be speeded up. The requirements management department determines the location of raw materials based on the optimal production plan.
Since the required quantity is calculated and transmitted to the purchasing department,
The ability to negotiate prices with customers through bulk purchases increases. The manufacturing process management department, based on the situation of the production equipment and the production plan,
Production distribution with each factory and outsourced companies, products manufactured in each manufacturing process
Since scheduling of days and quantities is performed, individual factories
Can concentrate on manufacturing according to a set schedule
You. The Factory Shipment Management Department determines the shipping time from the manufactured products and the inventory information from the logistics department, and operates to avoid shortages for customers and to have no excess inventory. Less is needed.

According to the fourth aspect of the present invention, optimal production planning is established.
The planning department is the logistics department's inventory space and cost simulation.
From year to year, period, month, etc.
Develop the latest production plan, such as weekly and daily, with the Production Planning Department
Production planning department that communicates to the manufacturing process management department
Financial information necessary for business management
And the latest production plan necessary for daily production
Can be determined.

According to the fifth aspect of the present invention, the required amount management unit
Is based on the time and amount of raw materials needed and the purchase price.
Determine when and how much to optimize purchasing costs
To increase efficiency in corporate management.
It is. In this case, the supplier also requests demand from the requirements management department.
It can be grasped in advance and can operate the factory smoothly.

According to the invention of claim 6, the manufacturing process management section
Formulates a production sequence for each product and communicates it to the process management department
The integrated production management system
Production schedules are quickly and accurately performed at each factory.
To the management server. Also, manufacturing process management
The department is responsible for the allocation of production equipment and personnel for optimal production planning.
It is structured so that the number of production lots can be determined at the same level as the plan
As a result, the production planning function of each factory
And contributes to a reduction in manufacturing cost.

According to the seventh aspect of the present invention, the manufacturing process pipe filling portion is provided.
Means production between the company's own production equipment and the contractor's production equipment.
The allocation is configured so that the maximum
Proper production can be achieved, and necessary
We can supply only the required amount at the required time. In the invention of claim 8,
According to the factory management department, the logistics department maintains optimal inventory
The shipping time is set so that
Distribution management from warehouse to customer becomes easy. Claim 9
According to Ming, the injection process server monitors the injection process.
Defective injections due to control of visual inspection information
When you do, you can find out the cause accurately. The invention of claim 10
According to the oral drug process server, monitoring of the oral drug manufacturing process
Since the inspection information is controlled, defective oral products may occur.
The cause can be determined exactly when the error occurs. The invention of claim 11
According to the inspection, the inspector carries the wireless mobile terminal.
As a result, on-site information on the operation status can be obtained in real time. Less than
As described above, according to the present invention, common operations of multiple factories
Integrated into one place, and the optimal production
Improve the efficiency of corporate management by allocating production
To realize an integrated production system for pharmaceutical manufacturing companies
it can.

[Brief description of the drawings]

FIG. 1 is a diagram illustrating an information network of a whole pharmaceutical manufacturing business having a plurality of factories to which the present invention is applied.

FIG. 2 is a configuration block diagram illustrating functions of the integrated production management system .

FIG. 3 is a configuration block diagram of an information network in an individual factory.

[Description of Signs] 1 Sales Information System 2 Integrated Production Management System 3 Distribution Center Management System 4 Corporate Network 5, 6 Manufacturing Management Server 10 Optimal Production Planning Planning Department 20 Required Pipe Filling Section 30 Manufacturing Process Pipe Filling Section 40 Factory Shipping Management Part 72 Injection process server 73 Oral process server 74 Wireless portable terminal

[Procedure amendment 2]

[Document name to be amended] Drawing

[Correction target item name] Fig. 1

[Correction method] Change

[Correction contents]

FIG.

[Procedure amendment 3]

[Document name to be amended] Drawing

[Correction target item name] Figure 3

[Correction method] Change

[Correction contents]

FIG. 3

Claims (7)

[Claims] An optimal production plan drafting section (10) for inputting order information from a sales management section and stock information from a distribution section to formulate an optimal production plan, and a raw material based on the production plan of the optimal production plan drafting section. Requirement management unit (20) that calculates the required quantity of the product and transmits it to the purchasing department
A production process management unit (30) that manages each production process from the production plan of the optimal production plan planning unit and the production equipment in the production factory; and a product and logistics department manufactured by the production process management unit. Factory Shipping Management Department (40) that determines shipping time from stock information
An integrated production system for a pharmaceutical manufacturing company, comprising: 2. The optimal production planning unit, based on the inventory space and the cost simulation of the logistics department, calculates the year, period,
A claim that has a term-based production plan drafting department corresponding to a settlement period such as a month, and a latest production plan drafting department that drafts the latest production plan such as a weekly or daily schedule and transmits it to the manufacturing process management department. Item 1. An integrated production system of a pharmaceutical manufacturer according to Item 1. 3. The required amount management unit determines a time and an amount for optimizing a purchase cost from a time and an amount necessary for a raw material and a purchase price, and places an order with a supplier. 1. The integrated production system of the pharmaceutical manufacturing enterprise according to 1. 4. The integrated production system of a pharmaceutical manufacturing company according to claim 1, wherein said manufacturing process management unit formulates a production sequence for each product and transmits the production sequence to a process management unit (50). 5. The integrated production system of a pharmaceutical manufacturing company according to claim 4, wherein said production process management section determines the allocation of production equipment and the personnel plan and the number of batch production lots to be an optimal production plan. 6. The integrated production system of a pharmaceutical manufacturing company according to claim 1, wherein said production process management section performs production distribution between its own production equipment and a consignee's production equipment. 7. The integrated production system according to claim 1, wherein said factory shipment management section determines a shipment time so as to maintain an optimal stock in the distribution department.