JPH11228423A - Lavaging composition for intestinal tract - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition which is mode easy-to-table without impairing intestinal tract lavaging effect and safety by adding at least two flavors of citrus fruits to lavaging composition for an intestinal tract. SOLUTION: This composition is obtained by including components (A) to (E) and also at least two flavors of citrus fruits where A is 55-63 g macrogol 4000, B is 1.3-1.6 g sodium chloride, C is 0.67-0.82 g potassium chloride, D is 5.1-6.3 g sodium sulphate and E is 1.5-1.9 g sodium bicarbonate within relative weight range based on 1L lavage. The flavors of citrus fruits are preferably a combination of the grapefruit flavor and the orange flavor. The flavors of the grapefruit and orange re added each at a rate of 1-20 mg to the composition of components A to E (1L aqueous solution). The sweetener is preferably saccharin sodium and is preferably added at 7-50 mg per 1L aqueous solution of composition.

Description

DETAILED DESCRIPTION OF THE INVENTION TECHNICAL FIELD OF THE INVENTION

[0001] The present invention relates to a composition for preparing an intestinal lavage fluid which is easy to take.

[0002]

2. Description of the Related Art In recent years, gastrointestinal cancer,
In particular, colorectal cancer tends to increase, and the importance of colonoscopy and colorectal surgery is increasing from the viewpoint of early detection and early treatment of cancer. The intestinal tract must be thoroughly cleaned before performing these tests and operations, and in clinical practice, Davis et al. (GR Davis et al., Gastroen
terology, 78, 991 (1980))
(Soluble mass contained in liter) is widely used because of its high effect and safety. Polyethylene glycol 4000 59.0 g Sodium chloride 1.47 g Potassium chloride 0.743 g Anhydrous sodium sulfate 5.69 g Sodium bicarbonate 1.69 g

[0003]

The cleaning liquid is usually
It is necessary to take a large amount of 2-3 liters, but it is difficult to take salty, oily, slimy,
At present, patients take a prescribed amount over a long period of time while putting up considerable pain. Therefore, the development of an intestinal lavage solution that is easy to take is not only for patients, but also for doctors, nurses,
There is a strong demand from pharmacists.

[0004]

Means for Solving the Problems The present inventors did not impair the intestinal cleansing effect and safety of the above-mentioned formulation, namely,
Without drastically changing the prescription, it is thought that the problem can be solved by adding a small amount or a small amount of a flavor or a sweetener.First, various flavors, sweeteners, and flavors are added to the prescription, and each of them is drunk. I checked for ease. As a result, citrus essential oils (flavors) are preferred, and there is a tendency that it is more preferable to use at least two flavors than one flavor, and in particular, a combination of a grapefruit flavor and an orange flavor has a remarkable effect. It was further found that the addition of a small amount of a sweetener made it easier to drink. Further studies have been made based on this finding, and the present invention has been completed. That is, the present invention
(1) The following components are blended in the following relative weight ranges, and at least two citrus fragrances are added to the composition for intestinal lavage, polyethylene glycol 4000 55.0 to 63.0 g sodium chloride 1.3 to 1.6 g chloride Potassium 0.67 to 0.82 g Sodium sulfate 5.1 to 6.3 g Sodium bicarbonate 1.5 to 1.9 g (2) The composition for intestinal cleansing liquid according to (1), wherein the two citrus flavors are a grapefruit flavor and an orange flavor. 3) The composition for intestinal lavage according to the above item (1), further comprising at least one sweetener. (4)
The composition for intestinal lavage fluid according to the above (3), wherein the sweetener is a sodium salt of saccharin, and (5) the composition according to the above (4), wherein the following flavors and sweeteners are added in the following relative weight ranges. 1 to 20 mg of grapefruit flavor, 1 to 20 mg of orange flavor, and 7 to 50 mg of sodium salt of saccharin.

[0005]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Polyethylene glycol 4000, which is a main component of the present invention, sodium chloride, potassium chloride,
There is no particular difficulty in preparing sodium sulfate and sodium hydrogencarbonate, and a predetermined amount of each component may be mixed according to a conventional method. Examples of the citrus flavors used in the present invention include not only essential oils obtained by squeezing, steam distillation, etc., but also grapefruits containing synthetic flavors alone or other aromatic compounds and additives, buntan, summer tangerines,
Pomelo such as Hassaku, oranges such as oranges, oranges and navels, and so-called citrus-like flavors such as lemon, lime, yuzu, kabos, and perfume citrus such as Sudachi, among which grapefruit and orange flavors Combinations are preferred. Polyethylene glycol 4000
Composition for intestinal lavage, consisting of water and electrolyte (for 1 liter)
The amount of these flavors added to the essential oil or synthetic flavor is preferably about 1 to 20 mg by net calculation. Further, the sweetener used in the present invention may be any of natural sweeteners and synthetic sweeteners, but those which exert a trace amount of strong sweetness such as sodium salt of saccharin, stevia, aspartame, thaumatin, and the like, among which, The sodium salt of saccharin is particularly preferred. The amount of the sweetener added per liter of the composition is preferably an amount that gives a sweet taste that is easy to drink in accordance with the salty taste based on the main component, for example, about 7 to 50 mg in the case of saccharin sodium salt.

[0006] The composition of the present invention is a solid, especially a powder, in which the respective components are mixed, a concentrated liquid prepared by adding an appropriate amount of water to the solid, and a concentration which can be taken as it is. The cleaning liquid may be in any form prepared by adding water, but a powdery liquid which can be prepared by adding water at the time of use from the viewpoint of storage and transportation is preferred. The composition of the present invention may be appropriately blended with excipients necessary for the preparation of a powder preparation, for example, dextrin and lactose, and further, a solubilizer for preparing an aqueous solution, for example, an appropriate amount of cyclodextrin.

[0007]

The present invention will be described below with reference to examples and test examples, but the scope of the present invention is not limited by these examples. Example 1 An aluminum bag was filled with the following components in the following amounts for the preparation of a 2 liter intestinal lavage solution and sealed. Polyethylene Golicol 4000 118.0 g Sodium chloride 2.93 g Potassium chloride 1.49 g Anhydrous sodium sulfate 11.4 g Sodium bicarbonate 3.37 g α-Cyclodextrin 5.0 mg Dextrin 55.0 mg Lactose 30.0 mg Grapefruit flavor (essential oil) 6.0 mg Orange flavor (essential oil) 3.0 mg Saccharin sodium salt 20.0mg

Example 2 For preparing 2 liters of intestinal lavage fluid, the following components were filled in the following amounts into aluminum bags and sealed. Polyethylene glycol 4000 118.0 g Sodium chloride 2.93 g Potassium chloride 1.49 g Anhydrous sodium sulfate 11.4 g Sodium bicarbonate 3.37 g α-cyclodextrin 5.0 g Dextrin 55.0 g Lactose 30.0 g Grapefruit flavor (essential oil) 5.0 g Orange flavor (essential oil) 5.0 g

Test Example 1 Preparation of test solution 1) Example 1 solution and Example 2 solution In order to evaluate the effect of the present invention by a sensory test, Example 1 was used.
Then, each bag of the composition of Example 2 was dissolved in distilled water, and 2 liters of each solution (Example 1 solution and Example 2 solution)
And 2) Control solution Polyethylene glycol 4000 118.0 g Sodium chloride 2.93 g Potassium chloride 1.49 g Anhydrous sodium sulfate 11.4 g Sodium bicarbonate 3.37 g

3) Comparative Examples 1 to 14 In the composition of Example 2, a composition containing no grapefruit flavor (essential oil) and orange flavor (essential oil) was added to a flavor (essential oil: Below, only described as perfume)
Was added, and 2 liters of an aqueous solution was prepared in the same manner as described above, to thereby obtain Comparative Examples 1 to 14.

[0011]

[Table 1]

Sensory Test A total of 16 kinds of test liquids, Comparative Liquids 1 to 14, Liquids of Example 1 and Liquids of Example 2, were divided into 4 sets of 4 types, and a control liquid was added to each set. The test solution was subjected to a sensory test as one test solution. On the first day, a sensory test was conducted for one set of test liquid groups at the scheduled time (10:00 am) with 23 panelists (age 2).
16 healthy boys and 7 girls aged 2 to 67 years old) drank 50 ml of the test solution, and a questionnaire format was given for each test solution, answering the following evaluation criteria. A: Very easy to drink. b: Easy to drink. C: OK. D: Difficult to drink. E: Very difficult to drink. On the following second to fourth days, sensory tests of the other three test liquid groups were carried out one day at a time by the same evaluation method using the same panelists, and the total results are shown in [Table 2].

[0013]

[Table 2] From the tabulation results [Table 2], Example 1 solution and Example 2 solution
An improvement in dysphagia was clearly observed relative to the control solution.

[0014]

According to the present invention, it is possible to provide an intestinal lavage solution which can remarkably improve the difficulty of taking the intestinal lavage solution, which is a problem of the conventional intestinal lavage solution, and which facilitates taking large quantities.

Claims (5)

[Claims] An intestinal cleansing composition comprising the following components in the following relative weight ranges, and at least two citrus fragrances added thereto. Polyethylene glycol 4000 55.0 to 63.0 g Sodium chloride 1.3 to 1.6 g Potassium chloride 0.67 to 0.82 g Sodium sulfate 5.1 to 6.3 g Sodium bicarbonate 1.5 to 1.9 g 2. The intestinal lavage composition according to claim 1, wherein the two citrus flavors are a grapefruit flavor and an orange flavor. 3. The composition for intestinal lavage according to claim 1, further comprising at least one sweetener. 4. The composition for intestinal lavage according to claim 3, wherein the sweetener is a sodium salt of saccharin. 5. The composition for intestinal lavage according to claim 4, wherein the following flavors and sweeteners are added in the following relative weight ranges. Grapefruit flavor 1-20mg Orange flavor 1-20mg Saccharin sodium salt 7-50mg