JPH11113530A - Health food containing ceramide - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a health food capable of being orally administered to exhibit beauty effects such as a skin-moisturizing effect, a skin-protecting effect, a skin roughness-preventing effect, and a skin wrinkle-preventing effect by including ceramide as an active ingredient. SOLUTION: The health food is obtained by adding 0.001-2 wt.%, preferably 0.01-1 wt.%, of ceramide to a food. The ceramide is extracted from bovine brain, wheat, rice, soybeans, spinach, yeast or the like. The ceramide is administered at a daily dose of 1-1000 mg, preferably 5-100 mg. The health food is produced in the form of tablets, capsules, powders or liquids, and may be added to confections, breads or drinks.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a health food containing ceramide which has a cosmetic effect such as moisturizing, beautiful skin, prevention of rough skin, and prevention of wrinkles by oral ingestion.

[0002]

2. Description of the Related Art Ceramide is one of the constituents of human skin.
Attention has been paid to its bioregulatory functions, such as moisturizing and protecting the skin, and preventing and improving skin roughness. Cosmetics using ceramide include ceramides such as ceramide, glucosylceramide, and galactosylceramide and diisopropylamine dichloroacetate or γ-
A skin cosmetic containing aminobutyric acid is known (Japanese Patent Laid-Open No. 1-2810). Also, a hair-growing cosmetic composition containing vitamin E and ceramides such as ceramide, glucosylceramide, and galactosylceramide is known (JP-A-63-243016). Conventionally, for the purpose of cosmetic effects such as moisturizing, beautiful skin, prevention of rough skin, and prevention of wrinkles, a method of adding natural or synthetic ceramide to skin cosmetics, hair nourishing cosmetics, bath additives, etc. and replenishing from the epidermis has been adopted. Have been.

[0003]

However, ceramide supplied to the skin is blocked by epidermal lipids and cannot be absorbed into the skin, or causes rash and inflammation due to cosmetics and bath ingredients other than ceramide. The problem was pointed out. An object of the present invention is to provide a health food which has a cosmetic effect such as moisturizing and protecting skin, preventing and improving skin roughness and preventing wrinkles by orally ingesting ceramide in order to solve these problems. .

[0004]

Means for Solving the Problems The present inventors have found that oral ingestion of ceramide has cosmetic effects such as moisturizing, beautiful skin, prevention of rough skin, and prevention of wrinkles in the same manner as transdermal administration. Completed. That is, the first aspect of the present invention is a health food characterized by containing ceramide as an active ingredient. A second aspect of the present invention is a health food whose form is a tablet, capsule, powder or liquid. A third aspect of the present invention is a health food, wherein the food is a confectionery, a bread or a beverage.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The ceramide used in the present invention has a structure in which sphingosine, fatty acid and sugar are bonded, and is a ceramide derived from nature, for example, extracted from animal-derived bovine brain, plant-derived ceramide. Examples include those extracted from wheat, rice, soybean, maize, spinach, and the like, and those extracted from microorganisms such as yeast. This ceramide can be obtained by a known method. For example, there is a method in which wheat or rice bran is used as a raw material and extracted using a polar solvent such as ethanol, acetone and water, and recrystallized in an organic solvent.

[0006] The form of the health food of the present invention is a powder such as a tablet, a capsule or a powder or a liquid such as a beverage. Also,
Specific examples of foods include sweets such as candy, drops, tablets, chewing gum, jelly, etc .; breads such as cookies, bread, confectionery bread; lactic acid bacteria drinks, alcohol-
Drinks, vitamins and mineral drinks. In the present invention, the ratio of ceramide in food is 0.1%.
001 to 2% by weight, preferably 0.01 to 1% by weight. If the amount of ceramide added is less than 0.001% by weight,
It is difficult to exhibit the beauty effects such as moisturizing, beautiful skin, preventing rough skin, preventing wrinkles, etc. Also, if it exceeds 2% by weight, the viscosity at the time of food production will increase, and the coloring and odor of the food will deteriorate, making it edible It is not preferable because it is not suitable. The dose of ceramide as the health food of the present invention is 1 mg to 1000 mg, preferably 5 mg to 100 mg per adult day. With a dosage of less than 1 mg per adult per day, there are few cosmetic effects such as moisturizing, beautiful skin, preventing rough skin, and preventing wrinkles.
If it exceeds 00 mg, digestion and absorption may not be possible.

[0007] The health food of the present invention can be used after mixing and homogenizing ceramide and various raw materials, and then mixing a tablet or capsule with a surfactant if necessary. As these surfactants, for example, sorbitan fatty acid ester, glycerin fatty acid ester, propylene glycol fatty acid ester, sucrose fatty acid ester, lecithin and the like can be used.

[0008]

The health food containing the ceramide according to the present invention has a cosmetic effect such as moisturizing, protecting action, preventing / improving skin roughness and preventing wrinkles by directly ingesting ceramide orally. In addition, the same cosmetic effect can be obtained by oral ingestion as a health food such as confectionery, bread and beverage containing ceramide.

[0009]

【Example】

Production Example 1 10 kg of flour was charged into a Soxhlet extractor together with 50 liters of ethanol, and the mixture was heated and refluxed for 20 hours. The obtained extract was dried under reduced pressure and dissolved in 5 liters of acetone. The precipitate was removed by filtration, and the filtrate was evaporated to dryness using a rotary evaporator to obtain 432 g of light brown ceramide.

Production Example 2 To 10 kg of rice bran, 50 liters of an ethanol: acetone = 1: 1 (volume ratio) solution was added and left for 10 days. This was charged into a Soxhlet extractor and heated under reflux for 20 hours. The obtained extract was dried under reduced pressure and dissolved in 5 liters of acetone. The precipitate was removed by filtration and the filtrate was evaporated to dryness on a rotary evaporator to give a light brown ceramide 30.
1 g was obtained.

Example 1 (Tablets) 2 g (2% by weight) of ceramide of Production Example 2, 96 g (96% by weight) of dried constarch (manufactured by Japan Food Processing Co., Ltd.)
1.8 g (1.8% by weight) of talc (manufactured by Wako Pure Chemical Industries, Ltd.) and 0.2 g (0.2% by weight) of calcium stearate (manufactured by NOF CORPORATION) are mixed and mixed with a rocking mixer for 10 minutes. Using a tableting machine, a tablet weighing 0.52 g was prepared. Thirty women in their 18s and 50s took this tablet one tablet a day between meals for one month, and a questionnaire survey was conducted by all the following evaluation criteria. Table 1 shows the cosmetic effects.

[Evaluation Criteria] "Skin condition improved.""Skin condition improved slightly.""Nochange.""Unknown." [Questionnaire result] "Skin condition improved." 7 "" Skin condition improved a little. "12" No change "7" Unknown "4 Beauty effect 63.3% Beauty effect:" Skin condition improved. "
A total of 63.3% of those who felt that "the skin condition was slightly improved." And those who felt that "the skin condition was slightly improved."

[0013]

[Table 1]

Example 2 (Capsule) 5 g (3.7% by weight) of ceramide of Production Example 1, 35 g (26.2% by weight) of crystalline cellulose (manufactured by Asahi Kasei Kogyo Co., Ltd.), dried constarch (Nippon Food Processing Co., Ltd.) 6)
7 g (50% by weight), lactose (manufactured by Wako Pure Chemical Industries, Ltd.) 22
g (16.4% by weight), 2 g (1.5% by weight) of calcium stearate (manufactured by NOF CORPORATION), and 3 g (2.2% by weight) of polyvinylpyrrolidone as a binder, powdered, and then gelatin hard capsules Was filled. 1 tablet 3
00 mg capsules were made. Thirty women in their 18s and 50s took this capsule for 6 months a day between meals for 1 month, and observed the skin surface. The evaluation criteria for the skin surface were evaluated by the following methods. Table 1 shows the results.
It was shown to. [Evaluation method] A commercially available fluid silicon precision printing material and a silicon printing hardening material were mixed, and a diameter of 40 was applied to the center of each person's face forehead.
This mixed solution was applied in a circular shape of about mm, completely cured, and then peeled off to prepare a mold for the surface skin. The molds before and after the start of the capsule intake test were compared and observed with a microscope.

[Evaluation Criteria] "Effective for beautiful skin"; Skin roughness and wrinkles are greatly reduced. "Slightly effective for beautiful skin"; Skin roughness and wrinkles are slightly reduced. "No change"; Ingestion No change between before and after "Unknown"; No data available [Test results] "Effective for beautiful skin" 8 "Slightly effective for beautiful skin" 12 "No change" 6 "Unknown" 4 Beautiful skin Effect 66.7% Skin beautiful effect: The sum of those who are determined to be "effective for beautiful skin" and those who are determined to be "effective for beautiful skin" is 66.
7%, which was regarded as a beautiful skin effect.

Example 3 (Powder) A powder was prepared as a powder as follows. Ceramide (Production Example 2) 1 part by weight Lactose 9 parts by weight Powder mixing of the above-mentioned materials with a rocking mixer for 30 minutes,
Subdivided into 4.8g / package and ingested for 1 month between meals per day. Test the beauty effect according to Example 1 and conduct a questionnaire survey with the same evaluation criteria as Example 1. ,
The results are shown in Table 1.

Example 4 (Beverage) A syrup was prepared as a beverage as follows. Ceramide (Preparation Example 1) 0.01 part by weight Carboxymethylcellulose 20 parts by weight Single syrup 179.99 parts by weight With the above composition, a single syrup was added to carboxymethylcellulose and gradually added, and the ceramide of Preparation Example 1 was added thereto. And further mixed to obtain a uniform beverage syrup.
100 g of a beverage obtained by diluting this beverage syrup 5 times daily
Have a panelist drink for one month, and according to Example 1,
A cosmetic effect test was conducted, and a questionnaire survey was conducted using the same evaluation criteria as in Example 1. The results are shown in Table 1.

Example 5 (Bread) Bread was produced with the following composition and by the sponge method under the following working conditions. Ingredients Composition of "medium seeds" 70 parts by weight of flour 2 parts by weight of yeast 42 parts by weight of water Working conditions Mixing 2 minutes at low speed, 2 minutes at medium and high speed Fermentation 28 ° C, 4 hours Composition of "honeduri" 30 parts by weight of strong powder 5 parts by weight of white sugar Parts Salt 2 parts by weight Ceramide (Production Example 2) 0.1 parts by weight Margarine 5 parts by weight Water 25 parts by weight Working conditions Mixing low speed 2 minutes, medium and high speed 5 minutes Fermentation 28 ° C, 4 hours Wheeler 38 ° C, 80%, 45 minutes Baking 200 ° C., 30 minutes This bread was eaten by a panel (70 g) every day, and a test of the beautiful skin effect was performed according to Example 2.
The beautiful skin effect was investigated using the same evaluation criteria as in Example 2, and the results are shown in Table 1.

[0019]

[Table 2]

Comparative Examples 1, 3, and 4 Comparative Examples 1, 3, and 4 were prepared by adding lactose instead of ceramide in the formulations of Examples 1, 3, and 4. Also,
A test was conducted in the same manner as in Example 1, and a questionnaire survey was conducted in the same manner as in Example 1. The beauty effect was evaluated, and the results are shown in Table 2.

Comparative Examples 2 and 5 Comparative examples 2 and 5 were prepared by adding lactose instead of ceramide in the formulations of Examples 2 and 5. Example 2
The test was carried out in the same manner as described above, and the beautiful skin effect was evaluated by the same evaluation method. The results are shown in Table 2.

From the above results, in the embodiment of the present invention,
A total of 63.3-70% of those who felt that "the skin condition had improved as shiny" and those who felt that "the skin condition had improved a little." Is "
The total of those who were determined to be and those who were determined to be "slightly effective for beautiful skin" was 63.3 to 66.7%. On the other hand, in the comparative example in which ceramide was not blended, the total of the person who felt that "the skin condition was improved as shiny." And the person who felt "the skin condition was slightly improved." 3 ~
It is 10%, and the total of the person judged as "effective for beautiful skin" and the person judged as "slightly effective for beautiful skin" is 0 to 3%, and the health of the present invention. It can be seen that the food has a beautiful skin effect.

Claims (3)

[Claims] 1. A health food comprising ceramide as an active ingredient. 2. The health food according to claim 1, which is in the form of a tablet, capsule, powder or liquid. 3. The health food according to claim 1, wherein the food is a confectionery, a bread or a beverage.