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JPH10510142A - Ｃｄ１分子によるｔ細胞に対する疎水性抗原の提示 - Google Patents

Ｃｄ１分子によるｔ細胞に対する疎水性抗原の提示

Info

Publication number
JPH10510142A
JPH10510142A JP8513411A JP51341195A JPH10510142A JP H10510142 A JPH10510142 A JP H10510142A JP 8513411 A JP8513411 A JP 8513411A JP 51341195 A JP51341195 A JP 51341195A JP H10510142 A JPH10510142 A JP H10510142A
Authority
JP
Japan
Prior art keywords
antigen
cells
presented
lam
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP8513411A
Other languages
English (en)
Japanese (ja)
Inventor
エル． モドゥリン，ロバート
エイ． シーリング，ピーター
ビー． ブレンナー，マイケル
ジェイ． ブレンナン，パトリック
エイ． ポーセリ，スティーブン
ティー． ファーロング，ステファン
Original Assignee
ブリガム アンド ウイミンズ ホスピタル
ザ ユニバーシティー オブ カリフォルニア，ロス アンゼルス
ザ コロラド ステイト ユニバーシティー リサーチ ファンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/322,979 external-priority patent/US5853737A/en
Priority claimed from US08/322,980 external-priority patent/US5679347A/en
Priority claimed from US08/501,600 external-priority patent/US6238676B1/en
Application filed by ブリガム アンド ウイミンズ ホスピタル, ザ ユニバーシティー オブ カリフォルニア，ロス アンゼルス, ザ コロラド ステイト ユニバーシティー リサーチ ファンデーション filed Critical ブリガム アンド ウイミンズ ホスピタル
Publication of JPH10510142A publication Critical patent/JPH10510142A/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP8513411A 1994-10-13 1995-10-13 Ｃｄ１分子によるｔ細胞に対する疎水性抗原の提示 Ceased JPH10510142A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US08/322,979 US5853737A (en) 1992-12-10 1994-10-13 Method for inducing a CD1-restricted immune response
US08/322,979 1994-10-13
US08/322,980 US5679347A (en) 1992-12-10 1994-10-13 Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods
US08/322,980 1994-10-13
US50149195A 1995-07-12 1995-07-12
US08/501,600 US6238676B1 (en) 1992-12-10 1995-07-12 Presentation of hydrophobic antigens to T-cells by CD1 molecules
US08/501,600 1995-07-12
US08/501,491 1995-07-12
PCT/US1995/013274 WO1996012190A2 (fr) 1994-10-13 1995-10-13 Presentation d'antigenes hydrophobes a des lymphocytes t par des molecules cd1

Publications (1)

Publication Number Publication Date
JPH10510142A true JPH10510142A (ja) 1998-10-06

Family

ID=27502254

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8513411A Ceased JPH10510142A (ja) 1994-10-13 1995-10-13 Ｃｄ１分子によるｔ細胞に対する疎水性抗原の提示

Country Status (7)

Country Link
EP (2) EP0786088B1 (fr)
JP (1) JPH10510142A (fr)
AT (1) ATE212129T1 (fr)
AU (1) AU694299B2 (fr)
CA (1) CA2202680A1 (fr)
DE (1) DE69525058D1 (fr)
WO (1) WO1996012190A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7063844B2 (en) 1992-12-10 2006-06-20 The Brigham And Women's Hospital, Inc. Presentation of hydrophobic antigens to T-cells by CD1 molecules
US6238676B1 (en) 1992-12-10 2001-05-29 Brigham And Women's Hospital Presentation of hydrophobic antigens to T-cells by CD1 molecules
WO1995028642A1 (fr) 1994-04-14 1995-10-26 Brown, Keith, Edwin, Frank Methode de detection de la presence d'une espece mycobacterium, kit et anticorps utilises dans cette methode
CA2302155A1 (fr) * 1997-09-12 1999-03-18 Brigham & Women's Hospital Antigenes synthetiques permettant de provoquer une reponse immunitaire limitee aux cd1
AU3558899A (en) * 1998-04-13 1999-11-01 Brigham And Women's Hospital Vaccine compositions comprising cd-1 antigens and t-cell stimulating compound and methods of use thereof
US20020071842A1 (en) * 2000-06-05 2002-06-13 Gumperz Jenny E. Soluble CD1 compositions and uses thereof
FR2819724B1 (fr) * 2001-01-22 2005-05-13 Inst Necker Moyens pour induire une reponse immune aux antigenes bacteriens polysccharidiques et aux structures proteiques des capsides de virus
US7253159B2 (en) 2003-04-18 2007-08-07 The Brigham And Women's Hospital, Inc. Methods and compositions for immunomodulation using CD1 antigens
GB0708874D0 (en) * 2007-05-08 2007-06-13 Univ The Of Birmingham Assay for detecting mycrobacterial infection
EP3833743B1 (fr) 2018-08-08 2024-01-24 NantBio, Inc. Cellules t recombinantes restreintes au cd1 pour le traitement de la tuberculose

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1564592A (en) * 1991-02-12 1992-09-07 Dynagen, Inc. Agglutination test for mycobacterial antigens in biological samples
WO1992014155A1 (fr) * 1991-02-12 1992-08-20 Dynagen, Inc. Anticorps monoclonaux diriges contre des antigenes mycobacteriens
DE69433115T2 (de) * 1993-06-21 2004-04-01 Brigham And Women's Hospital, Boston Verfahren zur isolierung von cda-präsentierten antigenen, cd1-präsentierte antigeneenthaltende impfstoffe und in besagten verfahren verwendbare zelllinien

Also Published As

Publication number Publication date
AU4277996A (en) 1996-05-06
DE69525058D1 (de) 2002-02-21
EP1170592A1 (fr) 2002-01-09
WO1996012190A2 (fr) 1996-04-25
WO1996012190A3 (fr) 1996-06-27
ATE212129T1 (de) 2002-02-15
EP0786088B1 (fr) 2002-01-16
AU694299B2 (en) 1998-07-16
CA2202680A1 (fr) 1996-04-25
EP0786088A2 (fr) 1997-07-30

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Publication Publication Date Title
US5679347A (en) Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods
Karakousis et al. Mycobacterium tuberculosis cell envelope lipids and the host immune response
US5853737A (en) Method for inducing a CD1-restricted immune response
Wetzler et al. Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate.
US6238676B1 (en) Presentation of hydrophobic antigens to T-cells by CD1 molecules
Johnston et al. B7-CD28 costimulation unveils the hierarchy of tumor epitopes recognized by major histocompatibility complex class I-restricted CD8+ cytolytic T lymphocytes.
Noll et al. Immunity against Yersinia enterocolitica by vaccination with Yersinia HSP60 immunostimulating complexes or Yersinia HSP60 plus interleukin-12
US20070286849A1 (en) Treatment of autoimmune disorders
US20120315269A1 (en) Immunoglobulin-like transcript (ilt) receptors as cd8 antagonists
ES2201078T3 (es) Metodos de aislar antigenos presentados por cd1, vacunas que comprenden antigenos presentados por cd1, y lineas celulares para usar en dichos metodos.
JPH10510142A (ja) Ｃｄ１分子によるｔ細胞に対する疎水性抗原の提示
JP2003231698A (ja) 自己免疫性を改善せしめるうえで有用なｍｈｃコンジュゲート
WO1996012190A9 (fr) Presentation d'antigenes hydrophobes a des lymphocytes t par des molecules cd1
Muthukkumar et al. Immunization with meningococcal polysaccharide–tetanus toxoid conjugate induces polysaccharide-reactive T cells in mice
WO1999052547A9 (fr) Compositions vaccinales comprenant des antigenes cd-1 et un compose de stimulation des cellules t, et procedes d'utilisation desdites compositions
US7063844B2 (en) Presentation of hydrophobic antigens to T-cells by CD1 molecules
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Legal Events

Date Code Title Description
A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20040607

A02 Decision of refusal

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Effective date: 20060221