JPH1045530A - Emulsion system containing small amount of ethoxylated emulsifier - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition useful for whitening the skin, comprising the subject specific emulsion system with limited content of an ethoxylated compound, a placental extract as an active ingredient for enhancing whitening, and a carrier. SOLUTION: A cosmetic composition comprising (A) about 1-10wt.% of this emulsion system selected from the group consisting of ethoxylated alcohols selected from the group of 1-0 EO-bearing 12-20C fatty acid polyethylene glycol esters and glucose-based nonionic emulsifiers each bearing 7-12C fatty acid pendant chain and virtually free from any ethoxylated alcohol, (B) about 0.5-10wt.% of a placental extract and (C) about 1-99wt.% of a carrier permissible as cosmetic, can be stabilize by virtue of this emulsion system even in the presence of cosmetic ingredient(s) acting as electrolyte during storage of the composition. Besides, this emulsion system has low pH value, therefore being effective.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

FIELD OF THE INVENTION The present invention relates to emulsifying systems containing relatively small amounts of ethoxylated emulsifiers for cosmetic compositions, in particular cosmetic compositions for enhancing the skin whitening effect.

[0002]

2. Description of the Related Art Various whitening cosmetics have been described for removing freckles and other stains appearing on the skin and for showing the whitening effect of the entire skin. Recent formulations include the placenta extract component alone or as another agent, such as a small portion, as a whitening enhancing active ingredient, such as kojic acid (US Pat. No. 4,696,813 to Sansho Pharmaceutical KK), an isoflavone glycoside component. (JP-7-157,494) and ascorbic acid (JP-4-041,409, 1992).

[0003] However, when other cosmetic ingredients such as water-soluble vitamins are incorporated into these whitening agents, high levels of electrolytes are formed in the composition. An emulsifier is added to the formulation to stabilize the product and to act as an emollient that, when applied to the skin, is pleasant and aesthetically pleasing when applied to the skin and provides a mild and good feel. Is done. Low pH emulsifier systems are:
It is particularly sensitive to instability in high electrolyte environments.
The product tends to separate into a water soluble phase and a water insoluble phase.

[0004] In prior art pharmaceutical compositions, formulators have used ethoxylated materials as emulsifiers to form liquid crystals in the liquid oil phase to stabilize the product. Ethoxylated emulsifiers work well, but result from synthesis and require careful handling on a commercial scale.
Recently, emulsifying substances of plant origin and having low toxicity and ecological effects have been developed.

[0005] For applications such as the whitening cosmetic compositions of the present invention, there remains a need for emulsifying systems that can be produced commercially and provide stable and aesthetically pleasing products.

[0006]

SUMMARY OF THE INVENTION It is therefore an object of the present invention to provide an emulsifying system for cosmetic compositions, in particular compositions which are aesthetically pleasing and mild to consumers and are useful for skin whitening. is there.

It is another object of the present invention to provide an emulsifying system for a cosmetic composition that remains stable in the presence of cosmetic ingredients that act as electrolytes during storage.

[0008] Another object of the present invention is to provide an emulsifying system for cosmetic compositions that are effective at low pH.

[0009] These and other objects will become more apparent in the following detailed description and examples.

[0010]

SUMMARY OF THE INVENTION A cosmetic composition useful for enhancing the whitening effect on the skin is provided. The composition is free of (a) (i) ethoxylated alcohols selected from the group consisting of C ₁₂ -C ₂₀ fatty acid polyethylene glycol esters having from 1 to 20 of EO, and (ii) substantially the ethoxylated alcohol About 1 to about 10% by weight of an emulsifying system selected from the group consisting of: a glucose-based nonionic emulsifier; (b) about 0.5 to about 10% by weight of a placenta extract; and (c) cosmetically acceptable. 1 to 99% by weight of the resulting carrier.

The emulsifying system is based on a relatively small amount of ethoxylated material and is effectively formulated to provide a stable and aesthetically pleasing whitening composition.

[0012] The emulsifying system of the composition according to the invention is in particular at about pH
It is useful at 6.8 to pH 1, more preferably 6 to 3.
The composition also contains whitening agents such as placenta extract and water-soluble vitamins.

The cosmetic composition of the present invention can be applied mainly as a cosmetic for skin such as lotions, creams, emulsions, packs and the like. The emulsifying system of the present invention is prepared in combination with a whitening agent, and this mixture is incorporated into a base conventionally used in cosmetics.

The optimal emulsification system of the present invention consists of two components. That is, a relatively small amount of ethoxylated alcohol and a nonionic emulsifier material based on glucose.

The first essential element is a polyethylene glycol ester of a C ₁₂ -C ₂₀ fatty acid having an EO of 1 to 20, preferably 1 to 10. This ester is available as a product of the trade name Xalifin ^(R) from Vevy company. This material is used in a relatively small range of about 0.2 to about 5% by weight, preferably about 0.5 to about 3% by weight, most preferably about 0.8 to about 2% by weight.

The second essential element of the emulsification system is a nonionic emulsifier, preferably based on glucose from plants. The emulsifier material is substantially free of ethoxylated groups. Fatty chains from about C ₇ -C _24, preferably about C
Side chains from glucose-based materials with _{10- C18} chain bonds. A preferred material is polyglyceryl-3methol glucose distearate, Goldschmidt Chemical Corp., Virginia.
available from Oration as Tegocare 450 ^(R) .

The ratio of the two essential components of the emulsifying system will be from about 1.5: 1 to about 5: 1, preferably from 2: 1 to about 3: 1.

The placenta extract used in the present invention includes a whitening agent obtained by any method conventionally used in this field, such as the method described in US Pat. No. 4,696,813. Placenta extract comprises about 0.5 to about 10% by weight of the composition;
Preferably from 1 to about 5% by weight, most preferably from about 2 to about 5%
It should be present in a weight percent amount.

Various thickeners are also present in the present invention. Scleroti, preferably polymerized glucose
um) Rubber (CTFA name) is incorporated. This encapsulated β-D-glucan can be produced from a variety of fungi grown in media containing glucose or sucrose as a carbon source, and a complex nitrogen source supplemented with mineral oil. Sc
In the case of lerotium Glucincum, glucans having a degree of polymerization of about 100 are roughly obtained.
Glucan having a degree of polymerization of about 800 can be obtained from the ium Rolfsiii strain. Products include Scrollrot
spore rubber derived from ium Rolfsii was purchased from Alban Muller / TriK of France as an Ami
Available under the trade name gel ^(R) . The amount of this substance may range from about 0.05 to about 1% by weight, preferably from about 0.01 to
It is about 0.5% by weight, most preferably about 0.05-0.3% by weight.

The compositions of the present invention may include an aqueous phase, or may be completely aqueous. Advantageously, the pH of such aqueous systems is between about pH 8.0 and 1.0, preferably between about 6.8 and about 4, most preferably between about 5.5 and 3.

[0021] Water soluble vitamins that act as electrolytes may also be incorporated into the present invention. The term [water soluble] means at least 0.1% by weight, preferably at least 1% by weight,
Most preferably at least 5% by weight means a substance which is soluble in water. Examples of water-soluble vitamins, niacin, vitamin B _2, vitamin B _6, vitamin C, and include biotin. The total amount of vitamins in the composition is
About 0.001 to about 1% by weight, preferably about 0.01 to about 0.6% by weight, most preferably about 0.1 to 0.5% by weight
It is.

[0022] Two types of keratolytic agents are effectively used in the compositions of the present invention. As representative of the first type, there is a C ₇ -C ₃₀ beta-hydroxycarboxylic acids and salts thereof. Examples of this category include salicylic acid and its alkali metal and ammonium salts. An appropriate amount of salicylic acid or salt is from about 0.001 to about 1
0%, preferably from about 0.8 to about 2.5%, most preferably from about 1 to 1.5% by weight.

The second type of keratolytic agent is C ₂ -C ₂₅ α.
-Hydroxyalkanoic acid. Examples of this group of substances include glycolic acid, lactic acid, α-hydroxyoctanoic acid and salts thereof. Salts may be selected from alkali metal, ammonium and C ₁ -C ₂₀ alkyl or alkanolammonium counterions. the level of α-hydroxyalkanoic acid is from about 0.001 to about 10% by weight;
Preferably about 0.2-1% by weight, most preferably about 0,1%.
4 to 0.5% by weight.

The compositions of the present invention are aqueous or anhydrous.
Preferably the composition is aqueous, especially W / O or O /
W-type water and oil emulsion. When water is present, its amount is from about 5 to about 90%, preferably from about 35 to about 65%, most preferably from about 40 to 50% by weight.

In addition to water, relatively volatile solvents may be incorporated into the compositions of the present invention. Most preferred is C ₁
~C is a ₃ alkanol. These include ethyl alcohol, methyl alcohol, and isopropyl alcohol. The amount of monohydric alkanol is from about 5 to about 50%,
Preferably from about 15 to about 40%, most preferably from about 25 to
About 35% by weight.

Emollients in the form of silicone oils and synthetic esters may also be incorporated into the compositions according to the invention. The amount of emollient may range anywhere from about 0.1 to about 30%, preferably from about 1 to about 20% by weight.

[0027] Silicone oils are divided into volatile and non-volatile types. The term "volatile" as used herein refers to a substance that has a measurable vapor pressure at room temperature. The volatile silicone oil preferably has about 3 to about 3 silicon atoms.
9, preferably from about 4 to about 5 cyclic or linear polydimethylsiloxanes.

The linear volatile silicone material is generally 2
The viscosity at 5 ° C. is about 5 cSt or less. On the other hand, cyclic materials typically have viscosities of less than about 10 cSt.

Non-volatile silicone oils useful as emollients include polyalkylsiloxanes, polyalkylarylsiloxanes, polyethersiloxane copolymers. Essentially non-volatile polyalkylsiloxanes useful herein include, for example, those having a viscosity at 25 ° C of from about 5 to about 10
There is a polydimethylsiloxane of 000 cSt. A preferred non-volatile emollient useful in the compositions of the present invention is a polydimethylsiloxane having a viscosity at 25C of about 10 to about 400 cSt.

Ester emollients include: (1) Alkenyl or alkyl esters of fatty acids having 10 to 20 carbon atoms. Examples are isononyl isonanonoate, oleyl myristate, oleyl stearate, and oleyl oleate.

(2) Ether esters such as fatty acid esters of ethoxylated fatty alcohols.

(3) Polyhydric alcohol esters. Ethylene glycol mono- and di-fatty acid esters, diethylene glycol mono- and di-fatty acid esters, polyethylene glycol (200-6000) mono- and di-fatty acid esters, propylene glycol mono- and di-fatty acid esters, polypropylene glycol 200
0 monooleate, polypropylene glycol 2000
Monostearate, ethoxylated propylene glycol monostearate, glyceryl mono- and di-fatty acid esters, polyglycerol poly-fatty acid esters, ethoxylated glyceryl monostearate, 1,3-butylene glycol monostearate, 1,3-butylene Glycol distearate, polyoxyethylene polyol fatty acid esters, sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters are satisfactory polyhydric alcohol esters.

(4) Wax esters such as beeswax, spermaceti, myristyl myristate, and stearyl stearate.

(5) Sterol esters such as cholesterol fatty acid esters.

The most preferred ester is octyldodecyl neopentanoate (Elefac 1-205® ⁾
And isononyl isononanoate.

[0036] Fatty acids having 10 to 30 carbon atoms may also be included in the compositions of the present invention. Examples of this category include pelargonic, lauric, myristic, palmitic, stearic, isostearic, hydroxystearic, oleic, linoleic, ricinoleic, arachiic, behenic, and erucic acids.

[0037] Wetting agents of the polyhydric alcohol type may also be included in the compositions of the present invention. Wetting agents help enhance the effect of emollients, reduce skin flaking, promote removal of accumulated scale, and improve skin feel. Typical polyhydric alcohols include glycerol, polyalkylene glycols, more preferably alkylene polyols and derivatives thereof, for example, propylene glycol,
Dipropylene glycol, polypropylene glycol,
Polyethylene glycol and derivatives thereof, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, 1,2,6
-Hexanetriol, ethoxylated glycerol, propoxylated glycerol and mixtures thereof. For best results, the wetting agent is preferably propylene glycol. The amount of humectant is between 0.
Any amount in the range of 5 to 30% by weight, preferably 1 to 15% by weight.

In general, water, solvents, silicones, esters, fatty acids, humectants and / or thickeners are considered cosmetically acceptable carriers for the compositions of the present invention. The total amount of carrier is about 1-99.9% by weight, preferably about 80-99% by weight.

The cosmetic composition of the present invention may be in any form. Forms include lotions, creams, roll-on formulations, mousses, aerosol sprays and pad application formulations.

[0040] Surfactants may also be included in the cosmetic compositions of the present invention. The total concentration of surfactant is about 0.1% of the total composition.
To about 40% by weight, preferably about 1 to about 20% by weight, most preferably about 1 to about 5% by weight. The surfactant is
It may be selected from the group consisting of anionic, non-anionic, cationic, and amphoteric surfactants. Particularly preferred non-anionic surfactants, C ₁₀ -C ₂₀ fatty alcohol or acid hydrophobe alkylene oxide 2 to 20 fused with a hydrophobic substance per mole of ethylene oxide or propylene oxide from about 2 to about 100 moles fused C ₂ -C ₁₀ alkyl phenols in a mole, of ethylene glycol mono - and di - fatty acid esters, fatty acid monoglycerides, sorbitan, mono - and di -C ₈ -C ₂₀ fatty acids, and polyoxyethylene sorbitan and combinations thereof .
Alkyl polyglycosides and saccharide fatty acid amides (eg, methyl gluconamide) are also suitable nonionic surfactants.

Preferred anionic surfactants include soaps, alkyl ether sulphates and sulphonates, alkyl sulphates and sulphonates, alkyl benzene sulphonates, alkyl and dialkyl sulphosuccinates, C ₈ -C ₂₀ amylisethionates, C ₈ -C there are ₂₀ alkyl ether phosphates and combinations thereof.

[0042] Sunscreen actives may also be included in the compositions of the present invention. Particularly preferred substances are, for example, Parsol M
Ethylhexyl p-methoxycinnamate, available as CX, and benzophenone-3, also known as Oxybenzone. Inorganic sunscreen actives may be used, such as microfine titanium dioxide, polyethylene and various other polymers. The amount of sunscreen generally ranges from about 0.1 to about 30% by weight, preferably about 2%.
To about 20% by weight, most preferably about 4 to about 10% by weight.

Preservatives are also preferably incorporated into the cosmetic compositions of the present invention to protect against the growth of potentially harmful microorganisms. A suitable conventional preservative used in the compositions of this invention is an alkyl ester of para-hydroxybenzoic acid. Other preservatives that have recently come into use include hydantoin derivatives, propionate salts, and various quaternary ammonium compounds. Cosmetic chemists are familiar with the appropriate preservatives and routinely choose preservatives that withstand preservative attack tests and provide material stability. Particularly preferred preservatives are phenoxyethanol, methyl paraben,
Propyl paraben, imidazolidinyl urea, sodium dehydroacetate and benzyl alcohol. Preservatives should be chosen with regard to the use of the composition and the potential for incompatibility of the preservative with other ingredients contained in the emulsion. Preservatives are preferably used in amounts of about 0.01 to about 2% by weight of the composition.

Small amounts of additional components may also be present in the composition. These include water-insoluble vitamins such as vitamin A palmitate, vitamin E acetate and D
There is L-panthenol.

Another additional component is an enzyme component. Particularly preferred are the Brooks Company of the United States.
y is a superoxide dismutase commercially available from Biocell SOD.

Natural plant substances from renewable resources are also often preferred as components of cosmetic compositions. For example, the cosmetic composition of the present invention is available from Nurt of Missoula, Montana.
ure Inc. Β-glucan derived from oats, sold by the company under the trade name Microat SF.

Colorants, fragrances, opacifiers, and abrasives can also be included in the compositions of the present invention. Each of these materials may be from about 0.05 to about 5% by weight, preferably 0.1 to 3% by weight.

[0048]

The following examples illustrate embodiments of the present invention in more detail. In this example, and all parts, percentages,
And percentages represent weight unless otherwise indicated.

EXAMPLE 1 A typical formulation of a whitening cream according to the present invention is shown below.

[0050]

[Table 1]

Example 2 The stability of the cream formulation of Example 1 was tested. However, DOW CORNING 2
00 (10 CST) instead of DOW CORNI
NG 200 (50 CST) and DOW C
DOWCORNIN instead of ORNING 1402
G 1401 and 1403 were used.

A sample of this formulation was prepared at room temperature, 25 ° C., 43
Prepared and stored at varying degrees C, 50 C, and temperature (at 4 C to 43 C).

The sample was observed to remain stable for at least 6 weeks even under extreme temperature conditions.

The foregoing description and examples illustrate selected embodiments of the present invention. The present invention will suggest various modifications to those skilled in the art, which are also included in the spirit of the present invention.

Claims (7)

[Claims] (A) (i) C having 1 to 20 EO
Ethoxylated alcohols selected from the group consisting of ₁₂ -C ₂₀ fatty acid polyethylene glycol esters, and (i
i) has a C ₇ -C ₁₂ fatty acid pendent chains and is substantially free of ethoxylated alcohol, from about 1 to about 10 wt% emulsifying system selected glucose nonionic emulsifier-based, from the group consisting of (B) about 0.5 to about 10% by weight of placenta extract; (c) about 1 to about 99 cosmetically acceptable carriers.
% By weight of a cosmetic composition. 2. The composition of claim 1, wherein the pH range of the final composition is less than about 6.8. 3. The method of claim 1, wherein the ethoxylated alcohol and the nonionic emulsifier are present in a ratio of about 1.5: 1 to about 5: 1.
The composition according to claim 1. 4. A water-insoluble vitamin having a content of about 0.001 to about 0.001.
The composition of claim 1, comprising about 1% by weight. 5. The composition according to claim 4, wherein the vitamin is selected from the group consisting of vitamin E acetate, vitamin A palmitate, and DL-panthenol. 6. (a) (i) C having 1 to 20 EO
Ethoxylated alcohols selected from the group consisting of ₁₂ -C ₂₀ fatty acid polyethylene glycol esters, and (i
i) has a C ₇ -C ₁₂ fatty acid pendent chains and is substantially free of ethoxylated alcohol, from about 1 to about 10 wt% emulsifying system selected glucose nonionic emulsifier-based, from the group consisting of Applying a cosmetic composition comprising (b) about 0.5 to about 10% by weight of a placenta extract; and (c) 1 to 99% by weight of a cosmetically acceptable carrier to the skin to enhance the skin whitening effect. A method of enhancing the skin whitening effect. 7. (i) C ₁₂ -C having EO of 1-20
An ethoxylated alcohol selected from the group consisting of ₂₀ fatty acid polyethylene glycol esters, and (ii) C
It has ₇ -C ₁₂ fatty acid pendent chains and is substantially free of ethoxylated alcohol, a cosmetic composition comprising glucose nonionic emulsifier based from the ratio of (i) :( ii) The emulsification system used in compositions wherein is from about 1.5: 1 to about 5: 1.