JPH10338613A - Transparent cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a preparation for external use for skin having excellent aging stability and usability by including an acrylic acid-alkyl methacrylate copolymer and an anionic surfactant. SOLUTION: The objective composition is produced preferably in the form of a transparent aqueous agent by including (A) 0.01-10 wt.% of a copolymer of acrylic acid and a 10-30C alkyl methacrylate, (B) 0.01-10 wt.% of an anionic surfactant preferably composed of a fatty acid soap, a higher fatty acid amide sulfosuccinate, an alkylol hydrolyzed collagen or their salts, etc., and as necessary, (C) hydrocarbons, esters, triglycerides, higher alcohols, fatty acids, polyhydric alcohols, nonionic surfactants, anionic surfactants, ethanol, thickeners, colorants, powders, etc. The component A can be produced by polymerizing acrylic acid and a methacrylic acid 10-30C alkyl ester using benzoyl peroxide, etc. as a polymerization initiator.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an external preparation for skin suitable for cosmetics and external medicine for skin.

[0002]

2. Description of the Related Art In a composition for external use on the skin, an aqueous transparent dosage form such as an aqueous gel has various merits such as a refreshing feeling, not staining clothes, etc. Its application is widespread in the field of medicine.
However, such a system has a drawback that transparency may be impaired by a change in temperature or a change with time, and a drawback such that there is a limit to components that can be blended transparently. As the composition of such an aqueous gel, it is usual to use a gel produced by an aqueous thickener such as a carboxyvinyl polymer or a gel produced by a gel forming agent such as gelatin or agar. An aqueous gel skin external preparation using an alkyl methacrylate (C10-C30) copolymer as a gelling agent has not yet been known. Furthermore, acrylic acid / alkyl methacrylate (C10-C3
0) It was not known at all that a combination of a copolymer and an anionic surfactant resulted in a transparent aqueous gel skin external preparation having excellent stability over time and excellent usability.

[0003]

DISCLOSURE OF THE INVENTION The present invention has been made in view of such circumstances, and an object of the present invention is to provide a transparent aqueous gel skin external preparation excellent in stability over time and usability. I do.

[0004]

In view of such a situation, the present inventors have considered that
As a result of diligent studies in search of an aqueous gel skin external preparation excellent in both aging stability and usability, an aqueous solution containing an acrylic acid / alkyl methacrylate (C10-C30) copolymer and an anionic surfactant was used. They found that the gel preparation had such characteristics, and completed the invention. Hereinafter, the present invention will be described in detail focusing on embodiments.

(1) Acrylic acid / alkyl methacrylate (C10-C30) copolymer used in the present invention
The 10-C30) copolymer can be obtained by polymerizing acrylic acid and alkyl methacrylate (C10-C30) using benzoyl peroxide or the like as a polymerization initiator. By changing the ratio of acrylic acid to alkyl methacrylate, copolymers having various balances of hydrophilicity and lipophilicity can be obtained. Such copolymers can be produced in this way, but some are already commercially available and can be used, and considering the availability, it is difficult to use them. preferable. Such commercially available products include PEMULEN TR-1 and PEMULEN T manufactured by Goodrich.
R-2 and the like can be exemplified. The preferred content of the acrylic acid / alkyl methacrylate (C10-C30) copolymer in the skin external preparation of the present invention is 0.01 to 10% by weight, more preferably 0.05 to 5% by weight, and 0.1 to 5% by weight. 05-1
% By weight is more preferred.

(2) Anionic surfactant used in the present invention The anionic surfactant used in the present invention can be used without any particular limitation as long as it is an anionic surfactant usually used in an external preparation for skin. Examples of such anionic surfactants include, for example, fatty acid soaps, alkyl sulfates, alkyl phosphates, sulfosuccinates, polyoxyethylene alkyl sulfates, fatty acid amide sulfosuccinates, N-acyl sarcosine, N-acyl glutamic acid, N- Methyl taurine, α-olefin sulfonic acid, higher fatty acid ester sulfonic acid, higher alcohol sulfate, allyl ether sulfate, alkyl allyl ether sulfate, fatty acid monoglyceride sulfate, higher fatty acid alkylolamide sulfate, polio Examples thereof include ethylene glycol ether phosphate, fatty acid hydrolyzed collagen, alkylol hydrolyzed collagen, and physiologically acceptable salts thereof. Among these, fatty acid soap, higher fatty acid amide sulfosuccinic acid, and alkylol hydrolyzed collagen In addition, those salts which are physiologically acceptable are particularly preferred.
Here, as the salt, alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, organic amine salts such as triethanolamine and aminomethylpropanediol, basic amino acid salts such as arginine and lysine, Ammonium salts and the like can be suitably exemplified, and among these, alkali metal salts and organic amine salts are particularly preferable. The anionic surfactant has a function of transparently and stably blending a nonionic surfactant or the like which sometimes causes turbidity only with an acrylic acid / alkyl methacrylate (C10 to C30) copolymer. The preferred content of the anionic surfactant in the skin external preparation of the present invention is 0.01 to
It is 10% by weight, preferably 0.05 to 5% by weight, more preferably 0.05 to 1% by weight. These anionic surfactants can be contained alone or in combination of two or more.

(3) The composition for external use of the skin of the present invention The composition for external use of the skin of the present invention contains an acrylic acid / alkyl methacrylate (C10 to C30) copolymer and an anionic surfactant. . Examples of the type of the composition for external use on the skin include, for example, skin care essence, under makeup gel, hair styling gel, cosmetics such as body care gel, estradiol gel,
Skin external medicines such as indomethacin gel and clotrimazole gel can be exemplified. These external compositions,
Although a transparent preparation or a preparation which is cloudy due to emulsification, powder dispersion, or the like is possible, it is particularly preferable to use the composition as a transparent preparation taking advantage of its high transparency. In the composition of the present invention, an optional component usually used in an external preparation for skin can be contained within a range not to impair the effects of the present invention. Examples of such optional components include hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, triglycerides such as tallow, olive oil, higher alcohols such as cetanol and oleyl alcohol, stearic acid, and olein. Fatty acids such as acids, polyhydric alcohols such as glycerin and 1,3-butanediol, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, thickeners such as ethanol and carbopol , Preservatives, ultraviolet absorbers, antioxidants, pigments, powders and the like. Of these, it is preferable to include a lipophilic component by taking advantage of the feature of a transparent gel that can also contain a lipophilic component, which is a feature of the preparation of the present invention. Such lipophilic components include ultraviolet absorbers such as para-aminobenzene derivatives, animal and vegetable oils such as olive oil, jojoba oil and horse oil, oil-soluble vitamins such as vitamin E, vitamin E nicotinate, vitamin D, retinoids and derivatives thereof, and estradiol. , Estriol, progesterone, clotrimazole, indomethacin, ketoprofen, ketotifen, bifonazole, terbinafine, butenafine and the like. Further, in order to enhance the effect of the present invention, a polymer or copolymer of acrylic acid or a derivative thereof, methacrylic acid or a derivative thereof, and a nonionic surfactant to which polyoxyethylene or polyoxypropylene is added are contained. Is preferred. The external preparation for skin of the present invention can be produced by treating these components by a usual method.

[0008]

The present invention will be described in more detail with reference to the following examples, but it goes without saying that the present invention is not limited to these examples.

Example 1 A transparent hair styling gel was prepared according to the following formulation. That is, A was heated and solubilized, neutralized by adding b, and stirred and cooled to obtain a hair styling gel. A product obtained by changing the alkyl methacrylate copolymer to a carboxyvinyl polymer (Comparative Example 1), a product obtained by changing potassium lauryl sulfate to polyoxyethylene (40) hydrogenated castor oil (Comparative Example 2), and a potassium lauryl sulfate Was replaced with water (Comparative Example 3), and the change with time under severe conditions at 40 ° C. was examined. Table 1 shows the results. This indicates that the preparation of the present invention has excellent stability over time.
Furthermore, the usability (freshness) was also evaluated by a specialized panelist. The evaluation criteria were ：: fresh, Δ: slightly fresh, ×: sticky. Table 1 shows the evaluation results.
Shown in It can be seen that the composition of the present invention has the same usability as before. B) ethanol 20 parts by weight polyvinyl alcohol 1 part by weight ethylenediamine diacetate 0.1 part by weight paraaminobenzoic acid isooctanoate 0.5 part by weight 1,3-butanediol 5 parts by weight polyoxyethylene (40) hydrogenated castor oil 5 parts by weight 10% aqueous solution of acrylic acid / dimethyldiallylammonium chloride / acrylamide copolymer 2 parts by weight Acrylic acid / alkyl methacrylate (C12-30) copolymer 0.4 part by weight Potassium lauryl sulfate 0.2 part by weight Retinol 0.1 parts by weight Water 50 parts by weight b Triethanolamine 0.5 parts by weight Water 19.7 parts by weight

[0010]

[Table 1]

Example 2 A transparent hair styling gel was prepared according to the following formulation. That is, A was heated and solubilized, neutralized by adding b, and stirred and cooled to obtain a hair styling gel. About 40 ℃
When the change with time under severe conditions for three months was examined, no abnormality was found. This indicates that the preparation of the present invention has excellent stability over time. B) ethanol 20 parts by weight polyvinyl alcohol 1 part by weight ethylenediamine diacetate 0.1 part by weight paraaminobenzoic acid isooctanoate 0.5 part by weight 1,3-butanediol 5 parts by weight polyoxyethylene (40) hydrogenated castor oil 5 parts by weight 10% aqueous solution of acrylic acid / dimethyldiallylammonium chloride / acrylamide copolymer 3 parts by weight Acrylic acid / alkyl methacrylate (C12-30) copolymer 0.2 part by weight Disodium oleamide amide sulfosuccinate 0. 2 parts by weight ethinyl estradiol 0.1 parts by weight Olive oil 0.1 parts by weight Water 50 parts by weight 0.2 parts by weight of triethanolamine Water 19.1 parts by weight

Example 3 A transparent hair styling gel was prepared according to the following formulation. That is, A was heated and solubilized, neutralized by adding b, and stirred and cooled to obtain a hair styling gel. About 40 ℃
When the change with time under severe conditions for three months was examined, no abnormality was found. This indicates that the preparation of the present invention has excellent stability over time. B) ethanol 20 parts by weight polyvinyl alcohol 1 part by weight ethylenediamine diacetate 0.1 part by weight paraaminobenzoic acid isooctanoate 0.5 part by weight 1,3-butanediol 5 parts by weight polyoxyethylene (40) hydrogenated castor oil 5 parts by weight 10% aqueous solution of acrylic acid / dimethyldiallylammonium chloride / acrylamide copolymer 2 parts by weight Acrylic acid / alkyl methacrylate (C12-30) copolymer 0.4 part by weight Alkylol hydrolyzed collagen aminopropanediol salt 0.2 parts by weight Vitamin E nicotinate 0.1 parts by weight Water 50 parts by weight b Triethanolamine 0.5 parts by weight Water 19.7 parts by weight

Example 4 A transparent skin care essence gel was prepared according to the following formulation. That is, A was heated and solubilized, neutralized by adding b, and stirred and cooled to obtain a skicare essence gel. About this one,
When the change with time under severe conditions at 40 ° C. for 3 months was examined, no abnormality was found. This indicates that the preparation of the present invention has excellent stability over time. A Glycerin 10 parts by weight Sodium hyaluronate 0.2 parts by weight Methyl paraben 0.2 parts by weight Acrylic acid / alkyl methacrylate (C12-30) copolymer 0.2 parts by weight Polyoxyethylene methyl polysiloxane copolymer 0.5 Parts by weight POE (30) POP (6) decyltetradecyl ether 0.5 parts by weight Aloe extract 1 part by weight Vitamin E 0.1 parts by weight Alkylol hydrolyzed collagen aminopropanediol salt 0.2 parts by weight Water 60 parts by weight b Triethanolamine 0.3 parts by weight Water 26.8 parts by weight

Example 5 A transparent skin care essence gel was prepared according to the following formulation. That is, A was heated and solubilized, neutralized by adding b, and stirred and cooled to obtain a skicare essence gel. About this one,
When the change with time under severe conditions at 40 ° C. for 3 months was examined, no abnormality was found. This indicates that the preparation of the present invention has excellent stability over time. I Glycerin 10 parts by weight Sodium hyaluronate 0.2 parts by weight Methyl paraben 0.2 parts by weight Acrylic acid / alkyl methacrylate (C12-30) copolymer 0.8 parts by weight Polyoxyethylene methyl polysiloxane copolymer 0.5 Parts by weight POE (30) POP (6) 0.5 parts by weight of decyltetradecyl ether Aloe extract 1 part by weight Disodium oleate amide sulfosuccinate 0.2 part by weight Vitamin D 0.1 part by weight Water 60 parts by weight 0.8 parts by weight of potassium 25.7 parts by weight of water

Example 6 A cloudy under-makeup gel in which powder was dispersed was prepared according to the following formulation. That is, A was heated and solubilized, and C was dispersed therein, B was added thereto for neutralization, and the mixture was stirred and cooled to obtain an under makeup gel. When this was examined for changes over time under severe conditions at 40 ° C. for 3 months, no agglomeration of powder was observed. This indicates that the preparation of the present invention has excellent stability over time. A Glycerin 10 parts by weight Sodium hyaluronate 0.2 parts by weight Methyl paraben 0.2 parts by weight Acrylic acid / alkyl methacrylate (C12-30) copolymer 0.2 parts by weight Polyoxyethylene methyl polysiloxane copolymer 0.5 Parts by weight POE (30) POP (6) 0.5 parts by weight of decyltetradecyl ether 0.2 parts by weight of disodium amide amide sulfosuccinate 0.2 parts by weight of vitamin E 0.1 parts by weight of water 60 parts by weight 0.3 parts by weight of triethanolamine Parts water 27.6 parts by weight C titanium mica 0.1 parts by weight titanium dioxide 0.1 parts by weight

Example 7 A skin external medicine (hormone preparation) was obtained according to the following formulation. That is, a
The mixture was heated to solubilize, neutralized by adding b, and cooled to obtain a gel external preparation for skin. A Propylene glycol 10 parts by weight Ethanol 20 parts by weight Polyoxyethylene (60) hydrogenated castor oil 0.5 part by weight Acrylic acid / alkyl methacrylate (C12-30) copolymer 1 part by weight Sodium lauryl sulfate 0.5 part by weight Estradiol 1 part by weight Water 50 parts by weight b Potassium hydroxide 1 part by weight Water 82 parts by weight

Example 8 A skin external medicine (anti-inflammatory preparation) was obtained according to the following formulation. That is, A was heated and solubilized at 80 ° C., neutralized by adding B, and cooled to obtain a gel external medicine. A Propylene glycol 10 parts by weight Ethanol 20 parts by weight Polyoxyethylene (60) hydrogenated castor oil 0.5 part by weight Acrylic acid / alkyl methacrylate (C12-30) copolymer 1 part by weight Sodium lauryl sulfate 0.5 part by weight Indomethacin 1 part by weight Water 50 parts by weight b Potassium hydroxide 1 part by weight Water 82 parts by weight

Example 9 A skin external medicine (antifungal preparation) was obtained according to the following formulation. That is, A was heated and solubilized at 80 ° C., neutralized by adding B, and cooled to obtain a gel external medicine. A Propylene glycol 10 parts by weight Ethanol 20 parts by weight Polyoxyethylene (60) hydrogenated castor oil 0.5 part by weight Acrylic acid / alkyl methacrylate (C12-30) copolymer 1 part by weight Sodium lauryl sulfate 0.5 part by weight Biphonazole 1 part by weight Water 50 parts by weight b Potassium hydroxide 1 part by weight Water 82 parts by weight

Example 10 According to the following formulation,
A skin external medicine (antifungal preparation) was obtained. That is, a
The mixture was heated to solubilize, neutralized by adding b, and cooled to obtain a gel external preparation for skin. A Propylene glycol 10 parts by weight Ethanol 20 parts by weight Polyoxyethylene (60) hydrogenated castor oil 0.5 parts by weight Acrylic acid / alkyl methacrylate (C12-30) copolymer 0.5 parts by weight Sodium lauryl sulfate 0.5 Parts by weight clotrimazole 2 parts by weight water 50 parts by weight b potassium hydroxide 0.5 parts by weight water 82 parts by weight

[0020]

According to the present invention, it is possible to provide a transparent aqueous gel skin external preparation excellent in stability over time and usability.

Claims (5)

[Claims] 1. An alkyl acrylate / alkyl methacrylate (C
10-C30) A composition for external use on the skin, comprising a copolymer and one or more selected from anionic surfactants. 2. An aqueous transparent dosage form,
The composition for external use on the skin according to claim 1. 3. The cosmetic according to claim 1, which is a cosmetic. 4. Anionic surfactants comprising fatty acid soaps, alkyl sulfates, alkyl phosphates, sulfosuccinates, polyoxyethylene alkyl sulfates, fatty acid amidesulfosuccinates, N-acyl sarcosine, N-acyl glutamic acid, N-methyl Taurine, α
-Olefin sulfonic acid, higher fatty acid ester sulfonic acid, higher alcohol sulfate, allyl ether sulfate, alkyl allyl ether sulfate, fatty acid monoglyceride sulfate, higher fatty acid alkylolamide sulfate, polyoxyethylene alkyl ether phosphate, fatty acid hydrolysis The composition for external use on the skin according to any one of claims 1 to 3, wherein the composition is any one of degraded collagen, alkylol hydrolyzed collagen, and a physiologically acceptable salt thereof. 5. The method according to claim 1, wherein the anionic surfactant is any one of fatty acid soap, higher fatty acid amide sulfosuccinic acid, alkylol hydrolyzed collagen, and a physiologically acceptable salt thereof. 2. The composition for external use on skin according to item 1.