JPH10273423A - Cosmetic for hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject cosmetic having an excellent unhairing- preventing effect, an excellent trichogenous effect, and an excellent effect for preventing the itch and dandruff of scalp and further excellent in safety by compounding a glycyrrhetinic acid compound and/or a glycyrrhizic acid compound and a specific amineoxide. SOLUTION: This cosmetic contains (A) a glycyrrhetinic acid compound [glycyrrhetinic acid (glycyrrhizic acid aglycon extracted from glycyrrhiza) and glycyrrhetinic acid derivative (e.g. glycyrrhetinic acid glycerol ester)] and/or a glycyrrhizic acid compound [glycyrrhizic acid (an aglycon comprising the glycyrrhetinic acid and glucuronic acid) and a glycyrrhizic acid derivative (e.g. glycyrrhizic acid trisodium salt)], and (B) a dimethylamine oxide of the formula. In the objective cosmetic, the ingredients A and B are preferably contained in amounts of 0.001-5.0 wt.% and 0.001-2.0 wt.%, repectively, based on the whole amount of the cosmetic.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention belongs to the technical field of scalp hair cosmetics (hereinafter referred to as hair cosmetics). More specifically, it belongs to the technical field of hair cosmetics having excellent effects and excellent safety, and the hair cosmetics of the present invention are used particularly in the field of pharmaceuticals, quasi-drugs or cosmetics. .

[0002]

2. Description of the Related Art There are various types of hair cosmetics.
There are products for various scalp hair conditions. For example, products that can improve the current state of hair loss and the like by preventing dandruff and kayumi on the scalp depending on the scalp condition have been developed. Various troubles on the scalp
In today's aging society, social stress is increasing, and the demand for hair cosmetics corresponding to the scalp trouble is increasing rapidly. In general, the causes of baldness and hair loss on the head, thinning of hair, scalp Kayumi and dandruff are caused by activation of androgens in organs such as sebaceous glands of hair root, excessive sebum secretion, generation of lipid peroxide, hair follicles Blood flow to the skin and stress. In addition, when sufficient hair follicles cannot be supplied with nutrients to grow durable and beautiful hair, fine hair and thin hair may be caused. Decreased blood flow to the hair follicles leads to nutritional deficiency and reduced excretion of waste products.

[0003] From such a point of view, improving the horny layer turnover and excessive sebum secretion in the scalp improves the blood flow function at least in the scalp and solves problems in the scalp and hair. It is an indispensable point on the top. Conventional hair cosmetics generally contain a substance having an action of removing or reducing factors considered to be the cause of baldness and hair loss. For example, vitamins such as vitamin B and vitamin E,
Amino acids such as serine and methionine, assembly extract,
Contains vasodilators such as acetylcholine derivatives, anti-inflammatory agents such as purple root extract, female hormones such as estradiol, skin function enhancers such as cepharanthin, etc. I have.

[0004]

However, it is difficult to obtain a sufficient effect even if only a small amount of these components is incorporated into the cosmetic for hair. There is a tendency to have a feeling and redness,
Naturally, the amount was limited.

The problem to be solved by the present invention is to provide a cosmetic for hair which has excellent effects and is also excellent in safety.

[0006]

Means for Solving the Problems The present inventor has made intensive studies to solve this problem. As a result, by combining a specific anti-inflammatory agent and a specific amine oxide in combination, it has an excellent hair loss preventing effect, a hair growth effect, an effect of preventing scalp Kayumi and dandruff, and is also excellent in safety. The present inventors have found that a cosmetic for hair is provided and completed the present invention.

That is, the present invention relates to glycyrrhetinic acids and / or glycyrrhizic acids and dimethylamine oxide represented by the following formula (I):

Embedded image And a hair cosmetic composition comprising:

[0008]

Embodiments of the present invention will be described below. The hair cosmetic composition of the present invention is a hair cosmetic composition that exhibits desired effects by being combined with glycyrrhetinic acids and / or glycyrrhizic acids and the above-mentioned dimethylamine oxide (I).

The glycyrrhetinic acids and glycyrrhizic acids to be incorporated in the cosmetic for hair of the present invention will be described. In the present invention, glycyrrhetinic acids mean glycyrrhetinic acid and glycyrrhetinic acid derivatives.

Glycyrrhetinic acid is an aglycone of glycyrrhizic acid extracted from licorice, a triterpenoid compound belonging to the β-amyrin family, known as an anti-inflammatory agent, its production method is also known, and it is commercially available.
Examples of the glycyrrhetinic acid derivative include glyceryl glyceryl glyceryl acid, stearyl glycyrrhetinic acid, pyridoxine glycyrrhetinic acid and the like, and their production methods are known and all are commercially available.

In the present invention, glycyrrhizic acids mean glycyrrhizic acid and glycyrrhizin derivatives. Glycyrrhizic acid is extracted from licorice,
A glycoside consisting of 1 mol of glycyrrhetinic acid and 2 mol of glucuronic acid, which is known as an anti-inflammatory agent, has a known production method, and is commercially available.

Examples of the glycyrrhizic acid derivative include, for example, trisodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, methyl glycyrrhizinate, and monoammonium glycyrrhizinate, and their production methods are known. , And all are commercially available. Any one of these glycyrrhetinic acids and glycyrrhizic acids can be used alone in the cosmetic for hair of the present invention, but they can also be used in combination of two or more.

The amount of the glycyrrhetinic acid and / or glycyrrhizic acid in the hair cosmetic of the present invention is 0.001% by weight or more based on the whole hair cosmetic.
5.0% by weight or less; 0.01% by weight or more;
It is preferably 0% by weight or less.

If the amount is less than 0.001% by weight based on the total weight of the cosmetic for hair, a sufficient anti-inflammatory effect cannot be exerted, so that it is not preferable. If the amount exceeds 5.0% by weight, inconvenience is caused in the preparation. There is a possibility that a problem may arise from the aspect of safety, such as an increase in the tendency and further skin irritation.

The above-mentioned dimethylamine oxide (I) to be mixed with the above-mentioned glycyrrhetinic acids and / or glycyrrhizic acids in the hair cosmetic composition of the present invention can be produced according to a generally known method for producing an amine oxide. If an example is shown, it can be manufactured generally according to the following steps.

[0016]

Embedded image Usually, the dimethylamine oxide (I) thus produced is incorporated into the cosmetic for hair of the present invention through a purification step by a generally known purification method such as a recrystallization method.

The amount of the dimethylamine oxide (I) in the cosmetic for hair of the present invention is 0.0001% by weight or more and 20.0% by weight or less based on the total amount of the cosmetic for hair. It is preferably from 05% by weight to 5.0% by weight.

If the amount is less than 0.0001% by weight based on the total weight of the cosmetic for hair, a sufficient anti-inflammatory effect cannot be exerted, which is not preferable. The tendency to cause inconvenience becomes stronger,
Further, it is not preferable from the point that skin irritation occurs.

Thus, by combining the anti-inflammatory component with the dimethylamine oxide (I) in combination, it has an excellent hair loss preventing effect and hair growth effect, and a scalp Kayumi and dandruff preventing effect. The present invention also provides a hair cosmetic composition which is excellent in safety.

In the hair cosmetic composition of the present invention, the medicinal component usually incorporated in the hair cosmetic composition is used in order to exert the general effect of the medicinal component. It is also possible to mix as long as the effect of the period is not impaired.

For example, amino acids such as serine, methionine and arginine; vitamins such as vitamin B ₆ and biotin; pantothenic acid or derivatives thereof; and female hormones such as esladiol are incorporated into the cosmetic for hair of the present invention. Can also.

Also, plant extracts, such as Altea extract, yoquinin extract, which are usually incorporated in hair cosmetics,
Peppermint extract, ginkgo biloba extract, capsicum extract, aloe extract, wolfberry extract, mugwort extract, rice extract, mankeishii extract, mannenwa extract, kossaiho extract, enishida extract, gentian extract, tangsin extract , Luffa extract, fennel extract, pine extract, kudin extract, touki extract, safflower extract, barberry extract, areca extract, eucalyptus extract, kagosou extract, mokusou extract, gossip extract, Psycho extract, tea extract, licorice extract, hop extract, chrysanthemum extract, senega extract, sesame extract, senkyu extract, cashew extract, cuckoo extract, Maikaika extract, saffron extract, rosemary An extract, a dirt extract, a mallow extract, and the like can be incorporated into the cosmetic for hair of the present invention.

Zinc or a derivative thereof; lactic acid or an alkyl ester thereof; organic acids such as citric acid;
Protease inhibitors such as tranexamic acid; olive oil,
Oils such as squalane, liquid paraffin, isopropyl myristate, higher fatty acids and higher alcohols; polyhydric alcohols such as glycerin and propylene glycol; other surfactants, humectants, thickeners, fragrances, antioxidants, ultraviolet absorbers, Antibacterial agents, cooling agents, pigments, ethanol, water and the like can be appropriately compounded within a range that does not impair the intended effects of the present invention.

The form of the cosmetic for hair of the present invention is not particularly limited as long as it can be applied to the outer skin such as liquid, emulsion, ointment and the like. Of the present invention can be prepared. Further, the cosmetic for hair of the present invention can be applied in various fields such as pharmaceuticals, quasi-drugs, and cosmetics.

The hair cosmetic of the present invention can be used for treating or preventing hair loss, dandruff, itch and the like, for example.
For example, it can be widely used for treatment and prevention of androgenetic alopecia, treatment and prevention of diffuse alopecia common to women, treatment of alopecia areata and the like. In addition, the purpose shown here is an example,
The diseases applicable to the cosmetic for hair of the present invention are not limited to these objects.

The hair cosmetic composition of the present invention is generally administered by transdermal administration such as directly applying or spraying on the skin.
In the hair cosmetic of the present invention, the percutaneous absorption of the components is promoted by the combination of the above essential components). The dosage of the cosmetic for hair of the present invention should be appropriately determined according to individual differences such as age and the degree of hair loss and the form of the preparation, but the dosage for general adults is 1 kg body weight.
0.001-100 mg / day, preferably 0.1-1
0 mg / day, which can be administered in 2 to 4 times a day.

[0027]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the technical scope of the present invention should not be limited by these Examples and the like. First, prior to disclosure of each embodiment, a test for examining the hair growth effect and the like of each embodiment will be described.

1. Hair- growth effect test In order to examine the hair-growth effect of the cosmetic for hair of the present invention, a tricogram test was performed. The subjects were male, and the comparative example was 5 in each group and 4 in each of the examples. The test application period was 4 months, and 2 to 4 ml of the sample was applied to the scalp twice a day. Immediately before application and 4 months after application, 50 hairs were randomly extracted from the crown of each subject, and the roots of the extracted hairs were observed under a microscope, and the root rest period rate (%) was calculated from the state of the roots. did. The rate of increase or decrease in the telogen rate before and after the sample application was determined based on the following criteria.

<Judgment criteria> Remarkable effect (+): Hair root telogen rate decreased by 30% or more Weak effect (±): Hair root telogen rate reduced by 10% or more and less than 30% No effect (-): Hair root Pause rate reduced by less than 10%

2. Hair loss prevention effect test The hair loss prevention effect was determined by the change in the number of hair washes before and after use of the sample. The subjects were males, and the males were 8 in each comparative example and 4 in each example. Test period is 6
The first two months were the period during which no sample was applied, and the last four months were the period during which the sample was applied. During the sample application period, the sample was applied to the scalp twice to four times a day at a time. During the test period, the hair was washed every other day to collect the extracted hairs, and the number of hairs was counted for one week.

The display of the number of hair removals during each period is based on the data of the number of hair removals eight times in total during the two months when the sample is not applied, and the data of the number of hair removals eight times in the latter two months of the application of the sample. The results were summarized for each period and displayed as the number of hair removals per time in the form of average value ± standard deviation. Judgment of the effect
Judgment was made as follows from the difference between the average values in each period.

<Judgment Criteria> ++: The number of removed hairs was reduced by 70 or more, and a remarkable effect was recognized. +: The number of removed hairs was reduced by 40 or more, and a considerable effect was recognized. ±: The number of removed hairs was 10 or more. The number of hair loss was less than 10 and less than 50 hair removals were ineffective. The evaluation of the hair loss prevention effect was as follows: 50% or more subjects
Is valid when the value exceeds the limit, and invalid for the others.

3. Dandruff and itching prevention effect test The antidandruff effect was compared according to the change in the amount of protein in dandruff before and after use of the sample and the degree of itch. The subjects were four persons in each group in Examples and Comparative Examples. Sample application period is 3
The hair was washed once a day with the same shampoo containing no drug, and the test sample was washed twice a day, 2 to 4 ml each time.
Was applied to the scalp.

Immediately before the application and at the end of the application for 3 months, the head dandruff was collected from the test subject with a suction device before washing the hair, and the amount of protein in the dandruff was measured. The anti-dandruff effect of each sample was compared by increasing and decreasing the average amount of dandruff before and after sample application. After the test, each subject was examined for scalp itch, and the degree of itch was expressed by the following score.

Anti-dandruff effect +: remarkable effect ±: weak effect-: no effect

Itching score 3: Strong itching 2: Itching 1: Slight itching 0: No itching

Examples 1 to 6 and Comparative Examples 1 to 3 Lotions of the components shown in Table 1 (Examples 1 to 6 and Comparative Examples 1 to 3) were prepared according to the production methods described below, and the above-mentioned tests were performed. Was done.

[0038]

[Table 1]

<Production Method> Each compounding agent, propylene glycol, hydrogenated castor oil ethylene oxide (40 mol) adduct, succinic acid and fragrance were dissolved in 95% ethanol (ethanol phase). Next, a dye was added to purified water, dissolved, and added to the ethanol phase, followed by stirring to obtain a clear liquid lotion.

The results of the above tests are shown in Tables 2 and 3 (hair growth effect test), Tables 4 and 5 (hair loss prevention effect test) and Table 6 (dandruff and itching prevention effect test). Indicated.

[Table 2]

[0041]

[Table 3]

[0042]

[Table 4]

[0043]

[Table 5]

[0044]

[Table 6]

From these results, it is apparent that the lotion of the embodiment in which any one of the above-mentioned glycyrrhizic acids and glycyrrhetinic acids is blended with dimethylamine oxide (I) has a remarkable hair-growth effect, a hair loss-preventing effect, and a dandruff and itching-preventing effect. Although it was recognized, the hair growth lotion of Comparative Example in which only one of these anti-inflammatory components and dimethylamine oxide (I) was blended, even if these components were blended in a considerable amount,
These effects were remarkably inferior to the results of the above examples.

That is, in the hair cosmetic composition of the present invention in which the above glycyrrhizic acids or glycyrrhetinic acids are combined with dimethylamine oxide (I),
It was found that the synergistic hair-raising effect, hair loss prevention effect, dandruff and itching prevention effect were remarkably observed. This means that the desired effect can be obtained in the hair cosmetic of the present invention even with a small amount of the active ingredient, and the coating effect caused by blending the glycyrrhizic acids and glycyrrhetinic acids in a large amount can be obtained. This indicates that it has become possible to prevent unpleasant irritation and redness of the part and its peripheral part.

Hereinafter, still another formulation example of the hair cosmetic composition of the present invention will be described. [Example 7] Lotion (Blending components) Blending amount (% by weight) 95% ethanol 50.0 Dimethylamine oxide (I) 0.5 Monoammonium glycyrrhizinate 0.2 Glycerin 2.0 Hardened castor oil ethylene oxide (40 mol) Additive 0.8 Malic acid qs Flavor and pigment qs Purified water balance

<Production method> Dimethylamine oxide (I) and hydrogenated castor oil ethylene oxide (4%) in 95% ethanol
After dissolving the adduct and the fragrance (0 mol) (ethanol phase), other components were added to purified water, and this was added to the ethanol phase and stirred and dissolved to obtain a clear liquid lotion. When the above-mentioned test was conducted on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect, and a dandruff / kayumi-preventing effect were remarkably recognized.

Example 8 Lotion (Blending Components) Blending Amount (% by Weight) 95% Ethanol 90.0 Dimethylamine Oxide (I) 3.0 β-Glycyrrhetinic Acid 1.0 1,3-butylene glycol 5.0 Hardened castor oil ethylene oxide (50 mol) adduct 1.0 Sodium lauryl sulfate 0.5 Lactic acid qs Sodium lactate qs Perfume and pigment qs Purified water balance

<Preparation method> A hydrogenated castor oil ethylene oxide (50 mol) adduct and a fragrance are dissolved in 95% ethanol, and then purified water is added. Then, other components are added and stirred to dissolve. Obtained. When the above-mentioned test was conducted on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect, and a dandruff / kayumi-preventing effect were remarkably recognized.

[Example 9] Emulsion type cosmetic for hair (Blending components) Blending amount (% by weight) (1) Cetanol 1.6 (2) Stearic acid 1.0 (3) Palmitic acid 0.4 (4) Liquid lanolin 1.0 (5) Squalane 2.5 (6) Glyceryl monostearate 1.5 (7) POE sorbitan monostearate 0.5 (8) Dimethylamine oxide (I) 1.0 (9) Glycyrrhetinic acid Stearyl 0.1 (10) Dipropylene glycol 5.0 (11) Polyethylene glycol 400 1.0 (12) Triethanolamine 1.0 (13) Remaining purified water

<Production Method> The components (1) to (9) were mixed to prepare a mixture 1, and the components (10) to (13) were separately mixed to prepare a mixture 2. These mixtures are separately
After heating and dissolving at 0 ° C, the mixture was mixed and emulsified using an emulsifier, and then heat-exchanged and cooled to obtain a latex-type latex hair cosmetic. When the above-mentioned test was conducted on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect, and a dandruff / kayumi-preventing effect were remarkably recognized.

[0053]

Industrial Applicability According to the present invention, there is provided a hair cosmetic composition having an excellent hair loss preventing effect, a hair growth effect, an effect of preventing scalp kazumi and dandruff, and having excellent safety.

Claims (1)

[Claims] 1. Glycyrrhetinic acids and / or glycyrrhizic acids and dimethylamine oxide represented by the following formula (I): A hair cosmetic composition comprising: