JPH1024088A - Transfusion container - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a transfusion container to which a vial of medicine or the like can be easily connected in the condition where sterilization is assured. SOLUTION: A transfusion container 1 comprises a resin container 4 including plural chambers in which at least part of a partition protrusion 7 between the chambers is formed of a peel seal part or weak seal part which can be opened from the outer side, and liquid medicine 6 is contained in the first chamber 4, while a filler container for medicine 12 to be mixed with the liquid medicine 6 is connected to the second chamber 9 at least. A cover body or film body provided at an aperture of the filler container is provided to be pushed into the filler container by push from the outer side of the second chamber 9, so by pushing the cover body or film body in, the inside of the second chamber 9 is communicated with the inside of the filler container.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an infusion container, and more particularly, to a transfusion container having a plurality of chambers, wherein at least a part of an isolation strip between the chambers can be opened from the outside. The present invention relates to an infusion container comprising a resin container formed of a part, which can be used by aseptically mixing and adjusting a medicine and a drug solution immediately before use. In particular, the present invention relates to an infusion container which can assure sterility and can easily connect a filling container filled with a drug or the like.

[0002]

2. Description of the Related Art Bags for infusions and the like used for intravenous injection,
Infusion containers such as containers are generally resin containers. Some infusions are mixed with antibiotics or the like at the time of use and injected by infusion. Conventionally, a syringe is used for such mixing, and the lysate is placed in the vial containing the antibiotic via the syringe. The antibiotic and the lysis solution are mixed, and the mixture is drawn from the vial with a syringe. And
The syringe is pierced into the outlet of the infusion container, and the mixed solution is filled in the infusion container. Recently, an infusion container and a vial have been proposed. Such an infusion container is provided with a connection port, and the vial is connected with the rubber stopper of the vial facing the connection port. A communication needle is provided between the connection port and the vial, and the communication needle pierces the rubber stopper during use, so that the inside of the vial and the inside of the infusion container can be aseptically communicated. These structures are derived from the fact that drugs such as antibiotics are unstable and cannot withstand storage when dissolved in an infusion, and that antibiotics and other drugs cannot be sterilized by high-pressure steam as in infusion. In recent years, an infusion container called a double bag has been proposed, and such an infusion container is configured such that a storage room for an amino acid agent and a storage room for a sugar are divided. A part or the whole of the isolation strip or the isolation wall between the chambers is formed as a peel seal or a weak seal, and is an isolation strip which can be opened from the outside when used. For this reason, in such a double bag, amino acids and sugars that react with each other during production and storage are separated and stored,
It can be easily mixed aseptically when used.

[0003]

However, infusion containers provided with conventional drug vials have the following problems. In the conventional infusion container, a communication needle is required for the vial support capsule and the connection port, and the connection mechanism is extremely complicated, so that manufacturing cannot be easily performed. Also, aseptic connections such as vials are not sufficiently achieved. In the conventional infusion container, the operation requires the operation of piercing the communication needle, and the piercing operation may cause coring contamination from the rubber stopper. In view of this, there has recently been provided one in which a second chamber utilizing a double bag is directly aseptically filled with a freeze-dried product (JP-A-5-3904, etc.). This prevents the freeze-dried product from sticking to the container wall and hindering the dispensing of a fixed amount. However, such an infusion container has not completely eliminated the risk of contamination in the aseptic filling operation. In addition, a method of dispensing a large amount of lyophilized product into a filling chamber using a predetermined quantitative spoon can be considered, but in such a method, the cake of the lyophilized product is necessarily distributed while maintaining a uniform titer. Not necessarily. Accordingly, an object of the present invention is to provide an infusion container in which a vial or the like of a medicine is simply connected in a state where sterilization is guaranteed.

[0004]

SUMMARY OF THE INVENTION The present invention has a plurality of chambers, and at least a part of a separation strip between the chambers is formed by a peel seal or a weak seal which can be opened from the outside. A resin container, wherein the first chamber contains a drug solution, and at least another of the second chambers is connected to a container filled with a drug mixed with the drug solution, and a lid provided at an opening of the container. The body or the membrane is provided so as to be able to be pushed into the filling container by pressing from the outside of the second chamber, and the second chamber and the inside of the filling container are communicated by pushing the lid or the membrane. The above object has been achieved by providing an infusion container that performs the following.

[0005] The chemical solution contained in the infusion container is generally an electrolyte solution. For example, it is a solution such as Ringer's solution containing lactic acid, acetic acid, bicarbonate and the like, and a high calorie infusion containing sugar, amino acid, peptide, fat and the like. Further, the chemical solution may be a simple solution or dilution of the lyophilized drug, and such a chemical solution may be simple sterile water. The chemical is subjected to autoclave sterilization after being stored in a first chamber in a resin container in a liquid-tight manner. Autoclave sterilization is 105 ℃ ～ 14
It is performed in the range of 0 ° C. The resin container is a non-constant volume container having at least a flexible wall. The resin container is formed from a sheet or a film, directly blow-molded, or injection-molded. The resin used for the container is a general-purpose resin such as a polyolefin resin, a vinyl chloride resin, and a polyester resin. In particular, polyolefin resins, for example, linear low-density polyethylene, high-density polyethylene, polypropylene, ethylene-vinyl acetate Copolymers and the like.

[0006] The plurality of chambers of the resin container are limited to two chambers, and three or more chambers are formed. In addition, part or all of the isolation strip is a peel seal portion or a weak seal portion,
Such an isolation strip is formed of one or more strips. The sealing strength of the isolation strip is a strength that allows peeling and opening from the outside, and the internal pressure of the chamber of the infusion container is 0.02 to 0.15 kgf /
It is desirable to peel off when the pressure is increased in the range of cm ² . With the sealing strength of the isolation strip in such a range, the seal can be easily opened from the outside, and the two chambers can be easily communicated with each other. The wall thickness of the resin container, that is,
The wall thickness of the second chamber differs depending on the sterilization method in the second chamber. The sterilization treatment in the second chamber is performed by irradiation sterilization. If the irradiation sterilization is γ-ray irradiation, the wall thickness of the second chamber is not so limited. If the irradiation sterilization is a simple electron beam irradiation, the thickness is desirably 1600 μm to 10 μm. If irradiation sterilization is ultraviolet light, 100 μm to 1
It is desirable that the thickness be in the range of 0 μm. Within such a range, the second chamber can be easily sterilized, and the way of mass production or the like can be easily opened.

The filling container connected to the second chamber is usually
Vials, which may be glass or resin. At the opening of the filling container, a rubber stopper, a plastic stopper, or a plastic film body formed with an easy-open cut or the like is provided. The lid or the membrane can be dropped into the vial by pressing, so that the lid or the membrane comes off the opening and the vial is opened. The thickness of each wall of the vial is 1 mm or more, especially 3 m
m and a certain degree of transparency are desirable. When the thickness is in the above range, the effect on the contents during irradiation sterilization of the outer wall surface, particularly during the above-mentioned electron beam sterilization, is extremely reduced. The resin used for the plastic vial is preferably the same or similar to the material used for the resin container. This is because if the resins are the same or similar, they have high compatibility and can easily be thermally welded to each other. Therefore, it is desirable that the resin of the vial is also a polyolefin resin. Drugs are generally susceptible to deterioration by irradiation sterilization, and are susceptible to deterioration and change by ultraviolet rays, electron beams, X-rays generated by electron beams, and the like. In particular, it is a lyophilized drug such as an antibiotic whose titer is a problem.

In the case of manufacturing such an infusion container, first, a blow-molded resin container or a sheet-formed resin container having an outlet is prepared, and an isolation strip is formed on a predetermined body of the resin container. The isolation strip portion may be entirely a peel seal portion or a weak seal portion, or such a seal portion may be partially formed. After the formation of the isolation strip, the first chamber is filled with a drug solution from the outlet, and the outlet is sealed with a rubber stopper. Then, the chemical solution is subjected to autoclave sterilization together with the resin container. On the other hand, when the vial is washed and gas-sterilized, and the container is filled with a lyophilized product or the like, the solution of the drug is aseptically filled through a sterilization filter or the like. Then, this is freeze-dried, the freeze-dried drug is stored in the vial, and the vial is sealed. The vial is connected to the autoclave-sterilized resin container under a sterile, dust-free environment. After insertion, the vial is sealed by heat sealing the insertion opening.

[0009] In the infusion container constructed as described above, at the time of use, first, the lid or the membrane of the vial is pressed with a finger from the outside of the second chamber, and the lid or the membrane is placed in the vial. Push in. Next, the isolation strip is opened from the outside. As a result, the drug solution penetrates into the vial and dissolves the drug to form a mixed solution. Therefore, the mixed solution is infused from the outlet. In this case, aseptic connection of the filling container is possible in the second chamber, but in order to increase the assurance of sterilization, γ-ray,
Irradiation with electron beams and ultraviolet rays can be easily performed. Especially,
Electron beam irradiation sterilization does not require a large-scale facility like γ-ray irradiation sterilization, and has higher assurance of sterilization than ultraviolet irradiation sterilization. Further, it is also possible to design such that the medicine can be sufficiently protected by the second container during the irradiation sterilization. Furthermore, the aseptic mixing of the drug solution and the drug does not use a communication needle or the like, and is superior in terms of the number of parts, operability, and the like. Further, since the vial is directly connected to the second chamber, the freeze-dried material does not stick to the wall of the freeze-drying container as in the related art, and does not hinder the dispensing. There is no need to worry about a uniform titer distribution as in the method of dispensing a large amount of freeze-dried product into a filling chamber using a predetermined measuring spoon.

[0010] The infusion container according to claim 2 of the present invention comprises:
An object of the present invention is to provide reliable sterilization of the second chamber of the infusion container according to claim 1, wherein the second chamber of the infusion container is sterilized by irradiation with γ-rays, electron beams, or ultraviolet rays from the outside. The above object has been achieved by being characterized by having been performed. The infusion container according to claim 3 of the present invention aims at simplifying the sterilization treatment of the second chamber of the infusion container according to claim 2 in terms of manufacturing. That is, in the infusion container according to claim 3 or 6, the thickness of the resin container wall is 1600 μm.
The above object has been attained by being characterized in that the second chamber is an irradiation sterilization chamber which is sterilized by electron beam irradiation and is within a range of from 10 to 10 μm. An infusion container according to a fourth aspect of the present invention is intended to allow the infusion container according to the first aspect of the present invention to more quickly process the mixing of a drug or the like. That is, the infusion container according to claim 4, wherein the isolation strip is opened after irradiation sterilization in the second chamber, and the first chamber and the second chamber communicate with each other. Is achieved.

[0011]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of an infusion container according to the present invention will be described below in detail with reference to the accompanying drawings. FIG. 1 is a sectional view of a first embodiment of an infusion container according to the present invention. FIG. 2 is a sectional view of the infusion container of the first embodiment at the time of use. FIG. 3 is a sectional view of the infusion container of the first embodiment at the time of use. FIG. 4 is a schematic view of an electron beam apparatus for sterilizing the second chamber of the infusion container of the first embodiment.

As shown in FIGS. 1 to 4, the infusion container 1 of the present embodiment has a plurality of chambers 5 and 9, and a separation strip 7 between the chambers 5 and 9 can be opened from outside. It is a resin container 4 formed by a part. The first chamber 5 contains a drug solution 6, and at least another second chamber 9 contains a drug 1 mixed with the drug solution 6.
2 filling containers 8 are connected and the opening 14
Is provided so as to be able to be pushed into the filling container 8 by pressing from the outside of the second chamber 9, and the inside of the second chamber 9 and the inside of the filling container 8 are communicated by pushing the lid 15. is there.

The infusion container 1 of this embodiment will be described in more detail. The resin container 4 used for the infusion container 1 is made of a linear low-density polyethylene, and is formed of a tubular resin sheet formed by inflation molding. In the present invention, it is not necessary to limit to a linear low-density polyethylene, and various resins known per se can be used as long as they are thermoplastic resins. For example, a highly flexible material such as a low-density polyethylene resin, a high-density polyethylene resin, a polypropylene resin, a soft polyester resin, a chlorinated polyethylene resin, a vinyl chloride resin, and an ethylene-vinyl acetate copolymer can be used. However, it is desirable to use an olefin-based resin as in this embodiment as a resin having little adverse effect on the six components of the chemical solution and the like. The wall of the resin container 4 may be a multilayer laminate of different resins. In particular, a resin layer having high gas barrier properties is desirable as the functional layer. Examples of such a resin include high-density polyethylene, vinylidene chloride, polyester, nylon, and vinylon. The resin container 4 does not need to be an inflation molded product as in the first embodiment, but may be an extruded product, a vacuum molded product, an injection molded product, a blow molded product, or the like.

The resin container 4 of this embodiment has a length of 200 mm.
And the width of the container 4 is formed to be 200 μm. In the present invention, the container 4
The thickness of the wall is 1600-10 μm, especially 800-30 μm
m is desirable. When the thickness of the container wall exceeds the above range, it is difficult to completely sterilize the second chamber 9 by irradiation with an electron beam irradiation device of simple equipment described later, and it is difficult to mount the container on a mass production line. Further, when the ratio is below the above range, there is a problem that the chance of breaking the container wall increases. The resin container 4 is formed by sealing both ends of a cylindrical resin sheet with each other by heat welding. The discharge port 2 is attached to a seal portion 3 at one end. An isolation strip 7 is formed in the middle of the resin container 4, and the isolation strip 7 is a weak seal or a peel seal. Therefore, the resin container 4 is formed with the first chamber 5 containing the chemical solution 6 and the second chamber 9 containing the second container 8 containing the medicine 15 with the isolation strip 7 as a boundary.

The drug solution 6 is an electrolyte solution for dissolving the drug 12, and the resin container 4 is subjected to high-pressure steam sterilization. The medicine 12 is obtained by freeze-drying the liquid medicine in the filling container 8, and the medicine 12 is an antibiotic, and the filling container 8 is aseptically filled. The filling container 8 includes a stopper 11, a plastic container 13, and a rubber stopper 15 capable of pressing and opening the outlet 14. The plug 11 is an elastomer, and the plastic container 13 is made of a polyethylene-propylene blend resin. The thickness of the container 13 is 4 mm, and the container 13 has transparency. Further, the container 13 is liquid-tightly connected to the end portion 10 by a heat-sealing seal at the time of molding the resin container 4, and a rubber stopper 15 is disposed in the second chamber 9. The rubber stopper 15 closes the outlet 14 in a liquid-tight manner. Further, a hanging holder 16 is attached to the plastic container 13, and the hanging holder 16 is formed with a hanging portion for drip. The interior of the second chamber 9 is sterilized from the outside by electron beam irradiation sterilization with the filling container 8 accommodated therein.

The chemical solution 6 has been subjected to autoclave sterilization. The autoclave sterilization process is performed based on the steam sterilization standard of the Japanese Pharmacopoeia.
Temperature in an autoclave or the like. In the present embodiment, irradiation sterilization in the second chamber 9 is performed by electron beam irradiation sterilization. The irradiation sterilization treatment of the present invention may be irradiation sterilization treatment using gamma rays, electron beams, and ultraviolet rays. However, the following electron beam irradiation sterilization is desirable from the viewpoint of the certainty of sterilization, its economic efficiency, and adaptability to mass production. To ensure irradiation sterilization, the permeability of the electron beam container wall is a problem. The permeability of the electron beam is mainly determined by the accelerating voltage, and is up to 13000 g / m ² for the high energy type, which is based on water (specific gravity 1 g).
/ M ² ) is 13000 μm. However, when the accelerating voltage device is increased in size, the X-ray shielding equipment becomes large, and the resin material may be deteriorated. Therefore, in the low-energy type 1MeV or less, especially low-energy type 500KV following acceleration voltage device is desirable, from about 1500 g / m ² in medium energy type in such a device, about 800 g / m ² at low energy type in limits Therefore, the thickness of the electron beam transmission is 1600 μm, especially 800 μm for the resin material.
m is the optimal limit. Therefore, as described above, it is desirable that the thickness of the wall of the resin container 4 be within the above range.
In electron beam sterilization, if the accelerating voltage is less than 1 MeV, especially a low energy type of 500 KV to 50 KV, a predetermined permeability of the electron beam can be obtained, but almost no emission of X-rays or the like is obtained. And can be arranged compactly on the production line. That is, the acceleration voltage 5
The permeability of the electron beam at 00 KV is about 800 g / m ² or less, and particularly, the permeability at the thin resin portion of 800 μm or less can be sufficiently obtained.

As shown in FIG. 4, the electron beam irradiation device 50 is provided above a belt conveyor 51, and includes a machine frame 52, a window frame 53 formed in the machine frame 52, and a window foil 54 attached to the window frame 53. , An acceleration tube 55 covering the upper part of the window frame 53, and an electron beam generator 56 provided in a vacuum chamber in the acceleration tube 55. The electron beam generator 56 is connected to the grid 5
7, a gun frame 58, and a filament 59. The filament 59 is energized and heated to generate thermoelectrons. The thermoelectrons are accelerated between the filament 59 to which a predetermined voltage is applied and the grid 57, and the window foil 54
Irradiates the light onto the conveyor 51. Note that the machine casing 52 is shielded with lead to prevent external leakage of X-rays and the like generated secondary by irradiation with electron beams. Therefore, the irradiation electron dose can be adjusted by the speed of the conveyor 51 and the amount of current supplied to the filament 59, and the permeability of the electron beam can be adjusted by the acceleration voltage.

In FIG. 4, only the second chamber 9 of the resin container 4 is irradiated and sterilized by the electron beam irradiation device 50. In addition, electron beam irradiation is performed from both sides of the container 4. In disinfecting microorganisms, as described in JP-A-7-16286, B. pumilus (spore
s) E-601 has a D value of about 0.2 Mrad (2 kGy). 1 cm ² per Although bacteria typically 10 ⁰ order is attached, if sufficiently considering safety versa assumption that there is attached to the 10 ^two orders. The sterilization assurance level (SAL) has a survival rate of 10 ^-6 %. Therefore, in the electron beam irradiation device 50 in this embodiment, the inside of the second chamber 9 is 6 × 0.2 Mr.
The amount of electricity and the conveyor speed are adjusted so that sterilization is performed at a rate of at least ad, preferably at least 8 × 0.2 Mrad.

Next, a method of manufacturing the infusion container 1 will be described. The resin container 4 is formed by cutting an inflation-molded cylindrical linear low-density polyethylene sheet into a predetermined size. The cut sheet is fixedly sealed at the end 3 by a heat sealing seal, and at this time, the discharge port 2 is attached. Next, a single isolation strip 7 is provided at a predetermined position of the resin container 4.
(Peel seal portion) is formed, and the first chamber 5 is formed in the resin container 4. Specifically, a sheet of linear low-density polyethylene (density: 0.916 g / cm ³ , MI: 2) has a thickness of 200 μm, a length of 200 mm, and a width of 80 mm.
Into a cylindrical sheet. Next, in order to form the container, the end portion 3 is heat-sealed and sealed with an impulse sealer (Auto Sealer FA-300-5W manufactured by Fuji Impulse Co., Ltd.). The sealing conditions are a sealing time of 1.5 seconds and a cooling time of 5 seconds. The separating strip 7 (peel seal portion) is formed by being sandwiched for a long time by a holding body preheated at 120 to 140 ° C. so as to be peelable. In the present invention, a method of forming a peel seal portion known per se other than the above method may be used. Next, the first chamber 5 is filled with the chemical solution 6 from the outlet 2, and the outlet 2 is sealed with a rubber stopper. In this state, the above-mentioned autoclave sterilization is performed on the resin container 4 to sterilize the chemical solution 6.

On the other hand, the plastic container 13 of the filling container 8
A rubber stopper 15 is attached to the outlet 14 in advance, and a freeze-drying solution is filled through a sterilization filter. The lyophilization solution is freeze-dried in a sterile, dust-free tank and
Is stored in the filling container 8. Then, the opening of the container 13 is closed in a liquid-tight manner by the plug 11, and the filling container 8 is inserted into the second chamber 9. After the insertion, the end portion 10 of the resin container 4 is sealed by heat welding, and the inside of the second chamber 9 is formed as a liquid-tight chamber.
In this state, only the second chamber 9 of the resin container 4 is sterilized by the above-mentioned electron beam irradiation from both sides, and the infusion container 1 is provided.

In the thus constructed infusion container 1 of the present embodiment, the second chamber 9 is also completely sterilized, and the outer wall surface of the filling container 8 is once exposed to the outside world, but is sufficiently sterilized.
Therefore, sterilization of the first chamber 5 and the second chamber 9 of the resin container 4 is sufficiently ensured. In addition, during electron beam sterilization, the wall thickness of the filling container 8 is 4 mm, so that the electron beam does not reach the medicine 12 by medium- to low-energy electron beam irradiation.
Therefore, the drug 12 does not deteriorate during sterilization. The drug 12 is an antibiotic which is easily degraded due to the presence of oxygen, moisture and the like. However, since the filling container 8 itself has a thick wall and a high gas barrier property, there is little risk of deterioration during storage.
At the time of use, the rubber plug 15 is placed outside the second chamber 9 of the infusion container 1.
To remove it from the outlet 14. Next, the isolation strip 7 of the infusion container 1 is opened. In this case, the first chamber 5 is easily opened by pressing it from the outside. Thereby, the filling container 8 communicates with the second chamber 9, and the drug solution 6 enters the filling container 8 and dissolves the drug 12. After dissolution mixing, infusion container 1
Is applied to the infusion patient. In this case, lyophilized drug 1
In the case of No. 2, accurate titer and dissolution volume can be protected, and it is more accurate than a simple dispensing and filling of only a freeze-dried product with a spoon or the like, and the sterilization guarantee is sufficiently provided.

In this embodiment, the second chamber 9 of the infusion container 1 is used.
Although electron beam irradiation sterilization was performed for sterilization of the inside, the present invention is not limited to this. For example, γ-ray irradiation sterilization may be used if equipment conditions permit. Alternatively, the thickness of the sheet of the infusion container 1 may be selected, and ultraviolet sterilization may be performed. For example, a resin material is coated with an ultraviolet transmittance (wavelength:
m) is greater than 60% and the density is 0.95 to 0.85
g / cm ³ , and a sheet whose thickness is limited to a range of 100 μm to 10 μm. In the case of the infusion container 1 having a thin resin wall as described above, irradiation sterilization in the infusion container 1 can be performed by the ultraviolet irradiation device 61 shown in FIG. UV irradiation device 6
1 is provided above the belt conveyor 62, and a high-output ultraviolet lamp 63 is provided. High power UV lamp 63
Is a low-pressure mercury lamp, which has a high radiation intensity around a wavelength of 250 to 260 nm. The high-power ultraviolet lamp 63 is preferably 100 mWcm ² or more at the window surface of the irradiating section. Therefore, in order to make the apparatus compact, the ultraviolet lamp 63 preferably has a range of 200 w to 1 kW. Further, the distance B from the window surface of the irradiation unit to the belt conveyor is 25 mm or less, particularly 10 mm or less. If the distance B is 25 mm or less, about 70% of the irradiation rate of the window surface can be secured. UV irradiation device 61
Although not shown, one is further provided at the subsequent stage, and the container 1 is turned 180 degrees on the conveyor 62.

In sterilizing microorganisms, an irradiation dose of approximately 33.3 mW · sec / cm ² is required to sterilize 99.9% of B. subtilis (spores) resistant to ultraviolet rays. After avoiding adhesions of the order of 10 ^-3 , a sterility assurance level (SAL) of 10 ^-6 % survival is guaranteed. Therefore, the ultraviolet irradiation device 51 in this embodiment uses
To sterilize within seconds, at least 1.11 mW
The high-output ultraviolet irradiation device 61 is adjusted so that the amount of ultraviolet light of c / cm ² or more reaches. Therefore, if the properties and thickness of the resin material are within the above ranges, the second chamber 9 is sufficiently irradiated and sterilized by the ultraviolet irradiation device 61, but the second chamber 9 does not easily break. Further, in the above embodiment, the rubber stopper 15 is provided at the outlet 14 of the filling container 8, but the invention is not limited to this. For example, as shown in FIG. 6, the film body 18 may be a push-openable film body 18 having a cut strip formed on the bottom 8 </ b> A of the filling container 8. Further, in the above embodiment, the outlet 14 is provided in the filling container 8, but in the present invention, the opening of the filling container 8 may be an outlet.

[0024]

As described above, the infusion container according to the present invention has a plurality of chambers, and at least a part of the separating strip between the chambers and the chambers has a peel seal portion or an openable outer portion. A resin container formed by a weak seal portion, wherein a first chamber contains a drug solution, and at least another of the second chambers is connected to a drug filling container mixed with the drug solution. The lid or the membrane provided at the opening is provided so as to be able to be pushed into the filling container by pressing from the outside of the second chamber, and the second chamber and the inside of the filling container are communicated by pushing the lid or the membrane. Therefore, it is possible to easily connect a drug vial or the like in a state where the sterilization is guaranteed.

[Brief description of the drawings]

FIG. 1 is a sectional view of a first embodiment of an infusion container according to the present invention.

FIG. 2 is a side sectional view of the infusion container of the first embodiment.

FIG. 3 is a sectional view of the infusion container of the first embodiment at the time of manufacture.

FIG. 4 is a schematic view of an electron beam apparatus for sterilizing a second chamber of the infusion container of the first embodiment.

FIG. 5 is a schematic view of an ultraviolet irradiation device used for the infusion container of the present invention.

FIG. 6 is a cross-sectional view of a filling container used for the infusion container of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Infusion container 4 Resin container 5 First chamber 6 Chemical solution 7 Isolation strip 8 Second container 9 Second chamber 12 Drug

Claims (4)

[Claims] 1. A resin container having a plurality of chambers, wherein at least a part of a separation strip between the chambers is formed by a peel seal portion or a weak seal portion that can be opened from the outside, One chamber contains a drug solution, and at least another second chamber is connected to a container filled with a drug mixed with the drug solution, and a lid or film provided at an opening of the container is the second container. An infusion container, which is provided so as to be able to be pushed into the filling container by pressing from the outside of the chamber, and that the second chamber and the inside of the filling container are communicated by pushing the lid or the membrane. 2. The gamma ray, the electron beam,
The infusion container according to claim 1, wherein the container is sterilized by irradiation with ultraviolet rays. 3. The thickness of the resin container wall is 1600 μm or more.
3. The infusion container according to claim 2, wherein the second chamber is an irradiation sterilization chamber which is in a range of 10 [mu] m and is sterilized by electron beam irradiation. 4. The infusion container according to claim 2, wherein an isolation strip is opened after irradiation sterilization in the second chamber, and the first chamber and the second chamber communicate with each other.