JPH10216220A - Medical treatment implement - Google Patents

Abstract

PROBLEM TO BE SOLVED: To lower the sliding resistance at the time of insertion and to improve operability by varying the friction resistance of the base end side and front end side of a medical treatment implement having the lubricative resin coatings. SOLUTION: The lubricative resin coating 5 of about 0.6% in concn. is applied on the base end side part of a guide wire 1. The lubricative resin coating 6 of about 0.2% in concn. is applied on the front end side thereof. A concn. gradient is further preferably imparted to the boundary between both lubricative resin coatings 5, 6. Natural water-soluble high polymers, such as carboxyl methyl starch, and synthetic water-soluble high-polymer materials, etc., such as polyvinyl alcohol, are usable for the lubricative resin coatings 5, 6. The front end side and the base end side may be coated with the different lubricative resin. The friction resistance of the base end 5 is preferably set >=2 times and <2.0 times the friction resistance of the front end 6. The good operability is obtd. and the smooth operation is made possible by such constitution.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical device having a surface coated with a lubricating resin.

[0002]

2. Description of the Related Art Medical devices such as catheters inserted into the respiratory tract, trachea, digestive tract, urethra, blood vessels, and other body cavities or tissues, and guidewires and stylets inserted into these and inserted into the body. Various medical tools such as
Smoothness is required that does not damage the tissue and ensures that it can be inserted to the target site.Furthermore, it may damage the mucous membrane or cause inflammation due to friction while placed in the tissue In order to avoid this, it is required that the surface has excellent lubricity. In order to satisfy such a demand, a water-soluble polymer such as a maleic anhydride-based polymer substance is covalently bonded to the entire surface of the base material of a medical device to be inserted into the body to form a coating of a lubricating resin. (JP-A-59-81341, JP-A-1-195863, and JP-B-1-33181) are known.

However, when a coating is formed on the entire surface of the base material as in these conventional techniques, the frictional resistance inside the body is reduced, and the frictional resistance at the operation portion at the proximal end outside the body is also reduced. The hand becomes slippery and the operability decreases. For this reason, the surgeon has to be careful not to wet the operation part or to use a special adapter for operation as disclosed in JP-A-3-82478.

In view of these problems, a guide wire having no lubricating resin coating on the proximal side (Japanese Patent Publication No. 4-45189) and a guide wire having a lubricity-eliminating treatment applied thereto (Japanese Patent Publication No. Hei 4-45189). No. 7-83761), but if the non-lubricating part is taken longer, the non-lubricating part of the guide wire will generate high frictional resistance in the catheter when introducing or removing the catheter, If only the short portion on the hand side is used for the portion without the gap, the operator has more chances to touch the lubricating portion, and there is a drawback that the operability is reduced.

[0005]

SUMMARY OF THE INVENTION An object of the present invention is to overcome the above-mentioned drawbacks of the prior art, and to further reduce and reduce the sliding resistance upon insertion into the body and without impairing the sliding performance. Another object of the present invention is to provide a medical device with improved operability.

[0006]

This and other objects are achieved by the present invention which is defined below as (1) to (13).

(1) In a medical device for insertion into a body cavity having a lubricating resin coating having lubricity when wet, a frictional resistance between the base end side and the distal end side of the lubricating resin coating on the medical device is different. A medical device characterized by that:

(2) The medical device according to (1), wherein the lubricating resin coating covers the entire medical device.

(3) The medical device according to (1), wherein the lubricating resin coating is coated at a higher density on the distal end side than on the base end side.

(4) The medical device according to (1), wherein the frictional resistance of the lubricating resin coating is reduced in three or more steps from the base end to the tip end.

(5) The medical device according to (1), wherein a frictional resistance at a base end side of the lubricating resin coating is smaller than a frictional resistance of a surface of the medical device not having the lubricating resin coating. .

(6) The frictional resistance at the base end of the lubricating resin coating is 1.2 times or more and less than 20 times the frictional resistance at the tip end of the lubricating resin coating. Medical tools.

(7) The medical device according to the above (1), wherein the resin coating contains a water-soluble polymer substance or a derivative thereof.

(8) The medical device according to (7), wherein the water-soluble polymer is a maleic anhydride-based polymer.

(9) The water-soluble polymer substance is covalently bonded to a reactive functional group present on the surface of the substrate.
The medical device according to any one of (1) to (8).

(10) In the above resin coating, a crosslinked product or a high molecular compound of a water-soluble or water-swellable polymer forms an interpenetrating network structure on the surface of a substrate of a medical device.
A medical device according to claim 1.

(11) The medical device according to the above (1), wherein the polymer is a block polymer having an epoxy group.

(12) The medical device according to the above (1), wherein the polymer is a macromonomer.

(13) A polymer solution is prepared by dissolving a water-soluble or water-swellable polymer in a solvent that swells the base of a medical device, and immersed in the solution to swell the base of the medical device. ,
The medical device according to the above (1), wherein the polymer is further crosslinked or polymerized on the substrate surface.

[0020]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, a specific configuration of the present invention will be described in detail.

The water-soluble polymer substance used for forming the lubricating resin coating of the medical device of the present invention is preferably fixed on the medical device substrate by covalent bonding. Such water-soluble polymer are in principle no crosslinking a chain-like as the polymer is _{-OH, -CONH 2, -COOH, -NH} 2, -COO -, -SO 3 -,
-NR ₃ ⁺ those having a hydrophilic group such as the specific natural water-soluble polymers, carboxymethyl starch, starch such as dialdehyde starch-based, cellulose-based, such as carboxymethyl cellulose, tannin, Nigunin system, alginic acid, Gum arabic, guar gum, tragacanth gum,
Tamarind species, polysaccharides such as chitin and chitosan, gelatin, casein, glue, and proteins such as collagen synthetic water-soluble polymers are conceivable. Synthetic water-soluble polymer substances include polyvinyl alcohol, polyethylene oxides such as polyethylene oxide and polyethylene glycol, acrylics such as sodium polyacrylate, maleic anhydrides such as methyl vinyl ether maleic anhydride copolymer, Phthalic acid such as hydroxyethyl phthalate; water-soluble polyester such as polydimethyllol propionate; ketone aldehyde resin such as methyl isopropyl ketone formaldehyde resin; acrylamide such as polyacrylamide; polyvinylpyrrolidone; polyamine; polyelectrolyte; Nylon and the like are conceivable. Among these, maleic anhydride-based polymer substances, cellulose-based polymer substances, polyethylene oxide-based polymer substances, and water-soluble nylon are particularly preferred because of their high lubricity when wet and their sustainability.

Such effects are extremely high especially when a maleic anhydride-based polymer is used. In this case, the maleic anhydride-based polymer substance may be a maleic anhydride homopolymer or a copolymer. Among these, a methyl vinyl ether maleic anhydride copolymer is particularly preferred. Some of these include GANTRE from GAF Corporation.
An approximately 1: 1 copolymer commercially available as ZAN (trade name) may be mentioned.

The derivative is not limited to water-soluble, and is not particularly limited as long as the above-mentioned water-soluble polymer is used as a basic structure. What is necessary is just a thing which contains water. For example, esterification products, salts obtained by condensation, addition, substitution, oxidation, reduction reaction and the like of the water-soluble polymer substance,
Amidates, anhydrides, halides, ethers, hydrolysates, acetalates, formalides, alkylolates, quaternaries, diazoides, hydrazides, sulfonates, nitrates, ion complexes; diazonium groups, azide groups , Isocyanate group, acid chloride group, acid anhydride group, imino carbonate group, amino group, carboxyl group, epoxy group, hydroxyl group, aldehyde group, etc.
Crosslinked product with a substance having two or more reactive functional groups; vinyl compound, acrylic acid, methacrylic acid, diene compound,
There are copolymers with maleic anhydride and the like.

Such a water-soluble polymer substance is well dissolved in water, and when the solution is allowed to exist between certain objects, the frictional resistance between the two can be significantly reduced, and can be used as a lubricant. . In addition, derivatives obtained by condensation or addition reaction or substitution reaction of these water-soluble polymer substances, and those partially cross-linked or the like are also effective as lubricants. By covalently bonding these to a reactive functional group present or introduced in the substrate or on the substrate surface, it is possible to obtain a lubricating layer supported on the substrate, and to provide a sustainable A lubricious surface can be obtained. The average molecular weight of these water-soluble polymer substances is not particularly limited, but those having about 1 to 5,000,000 have high lubricity, have an appropriate thickness, and have a lubricating layer which does not have a remarkably large swelling degree when containing water. It is preferred.

The reactive functional group present or introduced into the substrate or on the substrate surface is not particularly limited as long as it reacts with the above-mentioned water-soluble polymer substance and bonds or cross-links it to fix it. Is, diazonium group, azide group, isocyanate group, acid chloride group, acid anhydride group, imino carbonate group, amino group, carboxyl group, epoxy group, hydroxyl group, aldehyde group, etc., especially isocyanate group, amino group, Aldehyde groups and epoxy groups are preferred. Polyurethane, polyamide and the like are suitable as the reactive functional group-containing substrate.

Further, as the base material constituting the outer wall, the inner wall and the like of various medical devices, those not containing these reactive functional groups are usually used. In such a case, treatment with a substance having a reactive functional group is performed as described above, the reactive functional group is made to exist on the substrate, and a water-soluble polymer substance is covalently bonded thereon. The bonding form is a covalent bond, an ionic bond,
There are various things such as physical adhesion, but considering the point of persistence,
Covalent bonds are most preferred. As the substance having such a reactive functional group, for example, ethylene diisocyanate, hexamethylene diisocyanate, xylene diisocyanate, toluene diisocyanate, diphenylmethane diisocyanate, naphthalene diisocyanate,
Diphenylmethane diisocyanate, phenylene diisocyanate, cyclohexylene diisocyanate, polyisocyanates such as tolphenylmethane triisocyanate, toluene isocyanate, and adducts or prepolymers of these polyisocyanates and polyols. 1,2-diaminopropane, tetramethylenediamine, 1,3-diaminobutane, 2,3-diaminobutane, pentamethylenediamine, 2,4-diaminopentane, hexamethylenediamine, octamethylenediamine, nonamethylenediamine,
Decamethylenediamine, undecamethylenediamine, dedocamethylenediamine, tridecamethylenediamine, octadecamethylenediacin, N, N-dimethylethylenediamine, N-diethyltrimethylenediamine, N, N-dimethyltrimethylenediamine, N , N-dibutyltrimethylenediamine, N, N, N'-triethylethylenediamine, N-methyltrimethylenediamine, NN-dimethyl-p-phenylenediamine, N, N-dimethylhexamethylenediamine, diethylenetriamine, triethylenetetramine , Tetraethylenepentamine, heptaethyleneoctamine, nonaethylenedecamine, 1,3-bis (2'-aminoethylamino) propane, bis (3-daminopropal) amine, N1,3-bis (3'-acinopropyl) Amino) propane, 1,2,3-triamino propane,
Tris (2-aminoethyl) amine, tetra (aminomethyl) methane, methyliminobispropylamine, methyliminobisethylamine, ethyliminobisethylamine, N-aminopropyl-2-morpholine, N-aminopropyl-2-pipecholine, N -(2-hydroxyethyl) trimethylenediamine, xylylenediamine, phenylenediamine, piperazine, N-methylpiperazine, N- (2-aminoethyl) ethanolamine, N-
Aminoethylpiperazine, N, N, N'N'-tetramethylethylenediamine, N, N, N'N'-tetramethyltetramethylenediamine, and the like. Examples of high molecular polyamines are [I] amine and alkylenedihalide or epichlorohydrin. Poly (alkylene polyamine) [Encyclopedia of Polymer Science and Technology
mer Science and Technology) 10, 616 pages], [I
I] ethyleneimine, alkyleneimine polymers obtained by ring-opening polymerization of alkyleneimines such as propyleneimine (Ensauclopidia of Polymer Science and Technology, Vol. 1, p. 734),
[III] In addition, polyamines such as polyvinylamine and polylysine, and further, glutaraldehyde, terephthalaldehyde, isophthalaldehyde, dialdehyde, starch, galloxal, malonaldehyde, succinic aldehyde, adipaldehyde, pimerin dialdehyde, suberin dialdehyde , Malealdehyde, 2-
Polyaldehydes such as pentene-1,5-dialdehyde,
Furthermore, there are polyepoxides such as ethylene glycol diglycidyl ether, polyethylene glycol diglycidyl ether, propylene glycol diglycidyl ether, polypropylene diglincidyl ether, hexanediol diglycidyl ether, and trimethylolpropane triglycidyl ether. Incidentally, among these, 4,4'-diphenylmethane diisocyanate,
An adduct (adduct) of tolylene diisocyanate and trimethylolpropane, an adduct of hexamethylene diisocyanate and trimethylolpropane, or a trimer thereof, and diethylenetriamine are most preferred.

In the present invention, there are very few restrictions on the material of the substrate used for the water-soluble polymer substance. Therefore, as the substrate to be used, for example, polyamide, polyester,
Polyvinyl chloride, polystyrene, polyacrylate, polymethacrylate, polyacrylonitrile, polyacrylamide, polyacrylic acid, polymethacrylic acid, polyethylene, polypropylene, polyvinyl alcohol, polymaleic anhydride, polyethyleneimine.
Polyurethane, polyvinyl acetate, silicone resin, various latexes, and various organic polymer base materials such as various copolymers and blends thereof, glass, ceramics,
Any of various inorganic or metal substrates such as stainless steel may be used. And these base materials may contain various additives as needed.

It is to be noted that organic polymer resins having particularly high lubricating sustaining effect as a base material are polyvinyl chloride-based, polyurethane-based, polyamide-based, latex-based and polyester-based ones, which have the highest effect. high.

Therefore, when these other resins, metals, glass, etc. are used as the base material, layers composed of various organic polymer resins similar to those used for the above-described base material are formed on the surface of the base material in advance. More preferable results can be obtained by providing a lubricating layer by introducing a reactive functional group or blending the resin with a substance having a reactive functional group.

The water-soluble or water-swellable polymer having lubricity when wet differs depending on the required mechanical strength and lubricity function, but has a block having an epoxy group which is crosslinked by heat treatment or addition of a catalyst. A polymer or a macromonomer to be polymerized is preferably used. It is a polymer that absorbs water at the patient's body temperature (30 to 40 ° C.) and exhibits lubricity, and has a water absorption of 1 when crosslinked or insolubilized.
It is less than 00%.

Further, the block polymer is desirably a block copolymer comprising a site exhibiting lubricity and a site having an epoxy group. The site exhibiting lubricating properties may be any as long as it exhibits lubricating properties in a body fluid or an aqueous solvent, but in consideration of ease of synthesis or operability, acrylamide, a polymer comprising an acrylamide derivative, Examples thereof include a polymer having a monomer having N, N-dimethylaminoethyl acrylate, a sugar, and a phospholipid in a side chain as a component or a maleic anhydride polymer. As the maleic anhydride polymer,
It is not limited to water solubility, and may be insolubilized as long as it contains a maleic anhydride-based polymer as a main component, as long as it exhibits lubricity when wet. Furthermore, in consideration of dissolving the polymer in a solvent that swells the substrate and coating the polymer, a polymer that is also soluble in an organic solvent, that is, an amphiphilic polymer is preferable.

On the other hand, in the macromonomer, it is desirable that the branch portion is a portion exhibiting lubricity and the trunk portion is a portion having a domain which is crosslinked or polymerized by heat treatment. Specifically, a macromonomer of glycidyl methacrylate and dimethylacrylamide, a macromonomer of glycidyl methacrylate and a maleic anhydride / hydroxyethyl methacrylate copolymer,
A macromonomer of glycidyl methacrylate and maleic anhydride / acrylamide copolymer is exemplified.
The base material may be any material as long as it swells with respect to the solvent, as long as the mechanical strength is not significantly changed in size, but preferably, the swelling ratio calculated by the equation 1 is: A combination of a substrate and a solvent that can coat the polymer under the conditions of 1 to 100%, preferably 5 to 40%, more preferably 10 to 30% is desired.

[0033]

(Equation 1)

The swelling ratio is measured by the following method.

(1) The base material constituting the medical device is 1 cm ×
The sheet is cut into a sheet of 3 cm × 0.3 mm (weight at this time is Wo) and immersed in 25 ml of a solvent.

(2) Immediately after immersion, the solvent existing on the surface is wiped off, and the change in weight (ΔW) is calculated. Regarding the immersion time, any time may be used as long as the dimensions of the base material do not significantly change and the required physical properties are maintained, but from the viewpoint of operability, 1 second to 10 minutes, preferably It is desired to be 10 seconds to 5 minutes, more preferably 30 seconds to 3 minutes.

Further, specific examples of the material include polyolefin, modified polyolefin, halogenated polyolefin, polyether, polyurethane, polyamide, polyester, or a block or graft copolymer thereof, an alloy molded product, or a multilayered product. It is a molded product, and does not need to contain an alkali metal alcoholate group, an amino group, an alkali metal amide group, a carboxylic acid group, a sulfonic acid group, a magnesium halide group and a fluorine-boron complex group, and may swell in the solvent used. .

The medical device according to the present invention, characterized in that it has a lubricating resin coating having different frictional resistance between the distal end side and the proximal end side, when inserted or slid when wet with an aqueous liquid. Also, it has a surface that requires low frictional resistance when placed in the body. Therefore, there are concretely the following.

1) Gastric catheter, feeding catheter, ED
Catheters that are inserted or placed in the digestive tract orally or nasally, such as tubes and endoscopes (for tube feeding), and guidewires therefor.

2) Oxygen catheter, oxygen cannula, endotracheal tube tube and cuff, tracheostomy tube tube and cuff, intratracheal suction catheter, and other oral or nasal catheters inserted or placed in the airway or trachea. Kind.

3) Outer surfaces of urethral or ureteral insertion or indwelling catheters such as urinary catheters, urinary catheters, balloon catheters and balloons.

4) Catheters for insertion or placement in various body cavities or tissues, such as suction catheters, drainage catheters, and rectal catheters.

5) Intravascular insertion or indwelling catheters such as indwelling needles, IVH catheters, thermodilution catheters, angiographic catheters, PTCA catheter dilators, introducers, and vascular ultrasonic probes. Alternatively, the outer surface of a guidewire, stylet, etc. for these catheters.

6) The surface of a medical device such as an outer surface of an endoscope for insertion into various organs, which requires low frictional resistance when inserted, slid or placed inside the body.

[0045]

The present invention will be described below in more detail with reference to Examples of the present invention. As described above, a typical example of a typical medical device that is inserted into the body and moved to a target site is a catheter and a guidewire for guiding the catheter. Here, the effect of the present invention is illustrated by taking a guide wire as an example.

The resin coating was formed as follows. To 72.3 g of adipic acid dichloride, 29.7 g of triethylene glycol was added dropwise at 50 ° C., and hydrochloric acid was removed under reduced pressure at 50 ° C. for 3 hours. To 22.5 g of the obtained oligoester, 4.5 g of methyl ethyl ketone was added, and water was added. 5 g of sodium oxide, 3
The solution was dropped into a solution consisting of 6.93 g of 1% hydrogen peroxide, 0.44 g of surfactant dioctyl phosphate and 120 g of water, and reacted at -5 ° C for 20 minutes. Washing the reaction product with water,
After repeating the methanol washing, drying was performed to obtain a polyperoxide having a plurality of peroxide groups in the molecule. 0.5 g of this polyperoxide as an initiator and 9.5 g of glycidyl methacrylate (GMA) were polymerized in 30 g of benzene with stirring at 80 ° C. for 2 hours under reduced pressure. The reaction product was purified using diethyl ether as the poor solvent and tetrahydrofuran as the good solvent to obtain polyglycidyl methacrylate (PPO-GMA) having a plurality of peroxide groups in the molecule. Then PPO-GMA
1.0 g of dimethylacrylamide (9.0 g) and dimethylsulfoxide (90 g) as a solvent were charged and sealed under reduced pressure, and then heated to 80 ° C. to perform a polymerization reaction for 18 hours. After the reaction, purification was performed using diethyl ether as the poor solvent and tetrahydrofuran as the good solvent to obtain a block polymer having an epoxy substrate in the molecule and exhibiting lubricity when wet. NMR and IR measurements of this polymer confirmed the presence of an epoxy group in the molecule.

The above block polymer was dissolved in chloroform at a weight ratio of 2%, and an appropriate amount of pyridine was added to the solution.
A guide wire having an outer diameter of 0.89 mm was immersed for several seconds by coating a thermoplastic polyurethane resin on a Ni-Ti core metal having an outer diameter of 0.6 mm, and dried at room temperature. Further, the coated guide wire was dried by heating at 60 to 100 ° C. to obtain a guide wire whose entire surface was lubricated. In addition, 1.5%, 1%, 0.5%, 0.4%, 0.3%, 0.16% of the block polymer dissolved in the block polymer solution at a weight ratio of 2%.
・ By each 0.08% block polymer solution
A guide wire whose entire surface was coated in the same manner was produced.

Each guide wire obtained by the above-mentioned method was inserted into the catheter “Heartcass” 5Fr manufactured by Terumo Corporation shown in FIG. 1, and the maximum resistance value of each was measured using a tensile tester (Shimadzu Autograph AGS-100D Shimadzu). (Manufactured by Seisakusho). At this time, the catheter was filled with tap water, and the insertion speed was 500 mm / min. FIG. 2 shows a power approximate curve obtained based on the results. From the results shown in FIG. 2, it can be seen that the insertion resistance changes depending on the coating concentration of the coating resin showing lubricity only when wet. The coating concentration appears as a resin density on the surface of the medical device after coating.

Therefore, as shown in FIG. 3, 0.6% is added to the portion of the guide wire 1 having a total length of 150 cm on the base end side (50 to 100 cm).
When the lubricating resin coating 5 having a concentration of 2% was applied, and the lubricating resin coating 6 having a concentration of 2% was formed on the front end side, the operability was extremely good. In addition, when a concentration gradient is provided between the 2% concentration lubricating resin coating and the 0.6% concentration lubricating resin coating, the outer diameter and frictional resistance smoothly transition without any level difference, and the operability is better. It became something. The guide wire is made of a Ni-Ti core 2 having an outer diameter of 0.6 mm coated with a thermoplastic polyurethane resin 3 to have an outer diameter of 0.89 mm. Then, a coil 4 of Pt, Au or the like was wound as an X-ray contrast marker. The polyurethane resin coating layer had a constant outer diameter even at the tip.

FIG. 4 shows another embodiment to which the present invention is applied. The tip is a platinum (Pt) coil 8 whose surface is coated with silicon.
It is wound around a 30 cm portion, and the other portion of the core metal 9 is coated with the thermoplastic polyurethane resin 7. Also,
Approximately 50-100 cm from the base end of the coil 8 of the cored bar 9 is coated with the same lubricating resin as in the above-described embodiment and has a lubricating resin coating 1 of 1.6% concentration.
0, and a lubricating resin coating 11 having a concentration of 0.4% was applied to the base side 40-90 cm. The most proximal 10 cm was not coated with a lubricating resin. The coil 8 at the distal end enables shaping (reshaping) of the distal end, and the portion of the proximal end not coated with the lubricating resin is so short that frictional resistance is not hindered when inserted into a catheter or the like. And it is provided to make the handling of the operator easier.

FIG. 5 shows a third embodiment to which the present invention is applied. In the present application, a Ni-Ti core metal 12 at the distal end and a stainless steel core 13 at the proximal end are connected by a stainless steel pipe 14. The tip of the core 12 is tapered similarly to the embodiment shown in FIG.
7 are provided, and the whole is coated with a thermoplastic polyurethane resin 16. Further, the pipe 14 is not coated with a resin, and has a spiral cut 18 in order to smoothly transfer the connection with the core metal 12 on the distal end side. The connection between the metal cores 12, 13 and the pipe 14 is made by soldering or the like. The surface of the metal core 13 is coated with the same polyurethane resin 15 as the tip. The lubricating resin coating has a 2.0% lubricating resin coating 19 on the distal end side and a 0.6% lubricating resin coating 20 on the proximal end side with the pipe 14 as a boundary. With such a configuration, a guide wire having high elasticity at the distal end and strong stiffness at the proximal end and excellent in operability can be obtained.

Although each of the above embodiments is directed to a guide wire, as described above, application to a catheter is also possible.

In each of the above-described embodiments, the concentration of the coated resin solution is changed in order to change the frictional resistance of the lubricating coating. May be carried out.

The ratio of the magnitude of the frictional resistance between the base end portion and the front end portion of the lubricating coating in the above three embodiments is shown in FIG.
As is clear from the magnitude of the sliding value, the ratio of the base end to the front end is about 1: 2. In consideration of operability and slidability without a catheter, this ratio is preferably in the range of 1: 1.2 and 1:20, and most preferably 1: 1.5.
It is preferable that the frictional resistance at the base end of the lubricating resin coating is 1.5 times or more and 4.5 times or less the frictional resistance at the front end. This makes it possible to realize a medical device that has high operability and high slidability and that shows the effects of the present invention more remarkably.

[0055]

According to the present invention, the frictional resistance of the part to be inserted into the body is small, and the frictional resistance of the hand part is large.
In addition, since the hand portion having a large frictional resistance also has a certain degree of lubricity, the operability of the medical device is greatly improved. In the present invention, the hydrophilicity or lubricity of the base end of a medical device coated with a lubricating resin coating of a water-soluble polymer substance is reduced in the concentration of the resin coating to reduce the lubricity, and the medical device gripping portion is less likely to slip. The operability has been improved.

[Brief description of the drawings]

FIG. 1 is a front view showing a test method of insertion resistance for confirming the effect of the present invention.

FIG. 2 shows a power approximate curve of a sliding resistance value and a block polymer concentration when the block polymer concentration is changed by a weight ratio.

FIG. 3 is a cross-sectional view illustrating a guide wire according to the first embodiment of the present invention.

FIG. 4 is a sectional view showing a guide wire according to a second embodiment of the present invention.

FIG. 5 is a sectional view showing a guide wire according to a third embodiment of the present invention.

[Explanation of symbols]

1: guide wire, 2: core metal, 3: polyurethane resin,
4: coil, 5.6: lubricating resin coating

Claims (6)

[Claims] 1. A medical device for insertion into a body cavity having a lubricating resin coating which has lubricity when wet, wherein the lubricating resin coating has different frictional resistance between a proximal end and a distal end on the medical device. Medical equipment characterized by the following. 2. The medical device according to claim 1, wherein the lubricating resin coating covers the entire medical device. 3. The medical device according to claim 1, wherein the lubricating resin coating is more densely coated on the distal side than on the base side. 4. The medical device according to claim 1, wherein the frictional resistance of the lubricating resin coating decreases in three or more steps from a base end to a tip end. 5. The medical device according to claim 1, wherein a frictional resistance at a base end side of the lubricating resin coating is smaller than a frictional resistance of a surface of the medical device not having the lubricating resin coating. 6. The lubricating resin coating according to claim 5, wherein the frictional resistance on the proximal end side is at least 1.2 times and less than 20 times the frictional resistance on the distal end side. Medical tools.