JPH1017457A - Percutaneous absorption-stimulating preparation for external use for skin - Google Patents
Percutaneous absorption-stimulating preparation for external use for skinInfo
- Publication number
- JPH1017457A JPH1017457A JP18562296A JP18562296A JPH1017457A JP H1017457 A JPH1017457 A JP H1017457A JP 18562296 A JP18562296 A JP 18562296A JP 18562296 A JP18562296 A JP 18562296A JP H1017457 A JPH1017457 A JP H1017457A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- carboxylic acid
- percutaneous absorption
- preparation
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 238000010521 absorption reaction Methods 0.000 claims abstract description 20
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims abstract description 20
- 150000004676 glycans Chemical class 0.000 claims abstract description 10
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 10
- 239000005017 polysaccharide Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 230000001737 promoting effect Effects 0.000 claims description 10
- 230000000694 effects Effects 0.000 abstract description 20
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract description 12
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract description 7
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 5
- 229960002298 aminohydroxybutyric acid Drugs 0.000 abstract description 4
- 238000013329 compounding Methods 0.000 abstract description 4
- YQGDEPYYFWUPGO-UHFFFAOYSA-N gamma-amino-beta-hydroxybutyric acid Chemical compound [NH3+]CC(O)CC([O-])=O YQGDEPYYFWUPGO-UHFFFAOYSA-N 0.000 abstract description 4
- 239000000679 carrageenan Substances 0.000 abstract description 2
- 235000010418 carrageenan Nutrition 0.000 abstract description 2
- 229920001525 carrageenan Polymers 0.000 abstract description 2
- 229940113118 carrageenan Drugs 0.000 abstract description 2
- 239000002537 cosmetic Substances 0.000 abstract description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 39
- 230000000052 comparative effect Effects 0.000 description 10
- ILKBHIBYKSHTKQ-UHFFFAOYSA-N Diisopropylamine dichloroacetate Chemical compound OC(=O)C(Cl)Cl.CC(C)NC(C)C ILKBHIBYKSHTKQ-UHFFFAOYSA-N 0.000 description 3
- 229940084113 diisopropylamine dichloroacetate Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- -1 derivatives thereof Chemical compound 0.000 description 2
- 230000003779 hair growth Effects 0.000 description 2
- 239000008055 phosphate buffer solution Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 230000004215 skin function Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 1
- 229920002749 Bacterial cellulose Polymers 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N THREONINE Chemical compound CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000000010 aprotic solvent Substances 0.000 description 1
- 239000005016 bacterial cellulose Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は経皮吸収促進性皮膚
外用剤に関する。更に詳しくは、水溶性生理活性成分で
あるカルボン酸誘導体の皮膚における吸収を促進させ、
荒れ肌改善効果の優れた経皮吸収促進性皮膚外用剤に関
する。[0001] The present invention relates to a transdermal preparation for percutaneous absorption promotion. More specifically, it promotes the absorption of carboxylic acid derivatives that are water-soluble physiologically active ingredients in the skin,
The present invention relates to a percutaneous absorption promoting skin external preparation having an excellent effect of improving rough skin.
【０００２】[0002]
【従来の技術および発明が解決しようとする課題】水溶
性生理活性成分は油溶性生理活性成分に比較して一般に
皮膚の吸収速度が小さい事が知られている。本出願人
は、先に、γ−アミノ酪酸、γ−アミノ−βーヒドロキ
シ酪酸、及びそれらの誘導体（特公昭５８−２６７２６
号公報）や、ジイソプロピルアミンジクロロアセテート
（特開昭５３−１３６５２８号公報）など、水溶性生理
活性成分であるカルボン酸誘導体の皮膚機能改善による
老化防止効果や美肌効果を有することを見出し、提案し
た。BACKGROUND OF THE INVENTION It is known that water-soluble physiologically active ingredients generally have a lower skin absorption rate than oil-soluble physiologically active ingredients. The present applicant has previously described γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, and derivatives thereof (Japanese Patent Publication No. 58-26726).
And diisopropylamine dichloroacetate (Japanese Patent Application Laid-Open No. 53-136528) have been found to have an antiaging effect and a beautiful skin effect by improving the skin function of a carboxylic acid derivative which is a water-soluble physiologically active ingredient. .
【０００３】一方、現在に至るまで経皮吸収促進剤とし
てジメチルスルホキシドのような非プロトン溶媒や１−
ドデシルアザシクロヘプタン−２−オン（通称としてＡ
ＺＯＮＥ）、テルペン類、メントール類などが報告され
ており、本出願人は、先に、セスキテルペン類を配合し
た経皮吸収促進効果を有する養毛料の毛成長効果を有す
ることを見出だし、提案した（特開平６−１３５８２１
号公報）。しかしながら、これらを配合した製剤は表皮
にダメージを与えたり、刺激を感じるなど皮膚外用剤と
して好ましくない点がある。本発明は、荒れ肌改善効果
の優れた経皮吸収促進性皮膚外用剤を提供することを目
的とするものである。On the other hand, up to the present, as a transdermal absorption enhancer, an aprotic solvent such as dimethyl sulfoxide or 1-
Dodecylazacycloheptan-2-one (commonly referred to as A
ZONE), terpenes, menthols and the like have been reported, and the present applicant has previously found that hair growth effects of a hair restorer containing sesquiterpenes and having a percutaneous absorption-promoting effect have a hair growth effect. (Japanese Unexamined Patent Publication No. 6-135821)
No.). However, preparations containing these compounds are not preferable as external preparations for the skin, such as damaging the epidermis and causing irritation. An object of the present invention is to provide a percutaneous absorption-promoting skin external preparation having an excellent effect of improving rough skin.
【０００４】[0004]
【課題を解決するための手段】このような実情に鑑みな
されたものであって、本発明者は、上記の目的が、特定
のカルボン酸誘導体と、水と、多糖類から選ばれる一種
または二種以上とを配合してなる経皮吸収促進性皮膚外
用剤により達成されることを見出した。すなわち、本発
明は、カルボン酸誘導体と、水と、多糖類から選ばれる
一種または二種以上とを配合してなる経皮吸収促進性皮
膚外用剤である。SUMMARY OF THE INVENTION In view of such circumstances, the present inventor has set forth the above object as one or two or more selected from specific carboxylic acid derivatives, water and polysaccharides. It has been found that this can be achieved by a transdermal preparation for percutaneous absorption accelerating skin which comprises at least two or more species. That is, the present invention is a percutaneous absorption promoting skin external preparation comprising a carboxylic acid derivative, water, and one or more selected from polysaccharides.
【０００５】[0005]
【発明の実施の形態】以下、本発明の実施の形態を詳述
する。本発明の経皮吸収促進性皮膚外用剤に用いられる
カルボン酸誘導体としては例えばγ−アミノ酪酸、γ−
アミノ−βーヒドロキシ酪酸、及びそれらの誘導体やジ
イソプロピルアミンジクロロアセテートなど構造の一部
にカルボキシル基を有する有機化合物やその塩があげら
れる。カルボン酸誘導体の配合量は、０．０１〜５重量
％であることが望ましい。０．０１重量％未満では十分
な効果が発現しない場合があり、５重量％を超えると配
合量にふさわしい効果が発現しない場合がある。Embodiments of the present invention will be described below in detail. Examples of the carboxylic acid derivatives used in the transdermal absorption promoting skin external preparation of the present invention include, for example, γ-aminobutyric acid and γ-aminobutyric acid.
Organic compounds having a carboxyl group in a part of the structure, such as amino-β-hydroxybutyric acid, derivatives thereof, and diisopropylamine dichloroacetate, and salts thereof are exemplified. The compounding amount of the carboxylic acid derivative is desirably 0.01 to 5% by weight. If the amount is less than 0.01% by weight, a sufficient effect may not be exhibited. If the amount exceeds 5% by weight, an effect suitable for the amount may not be exhibited.
【０００６】本発明の経皮吸収促進性皮膚外用剤に用い
られる多糖類として、例えばキサンタンガム、グアーガ
ム、バクテリアセルロース、カラギニンなどがあげられ
る。多糖類の配合量は、０．０１〜２重量％であること
が望ましい。０．０１重量％未満では十分な効果が発現
しない場合があり、２重量％を超えると配合量にふさわ
しい効果が発現しない場合がある。[0006] Polysaccharides used in the transdermal preparation for promoting percutaneous absorption of the present invention include, for example, xanthan gum, guar gum, bacterial cellulose, carrageenan and the like. The compounding amount of the polysaccharide is desirably 0.01 to 2% by weight. If the amount is less than 0.01% by weight, a sufficient effect may not be exhibited. If the amount exceeds 2% by weight, an effect suitable for the amount may not be exhibited.
【０００７】本発明の経皮吸収促進性皮膚外用剤は、前
述の如く、カルボン酸誘導体と水と多糖類から選ばれる
一種または二種以上を配合してなるものであって、これ
らが相乗的に皮膚に作用して、カルボン酸誘導体の経皮
吸収を促進し、皮膚機能を亢進して、優れた荒れ肌改善
効果を短時間に発現し、持続する等、顕著な効果を表す
ものである。[0007] As described above, the percutaneous absorption promoting skin external preparation of the present invention comprises a mixture of one or more selected from carboxylic acid derivatives, water and polysaccharides. It acts on the skin to promote percutaneous absorption of the carboxylic acid derivative, enhances the skin function, and expresses a remarkable effect such as exhibiting and maintaining an excellent effect of improving rough skin in a short time.
【０００８】本発明の経皮吸収促進性皮膚外用剤は、例
えば、化粧料や医薬品として適用することができ、剤型
としてはローション類，乳液類，クリーム類，パック類
等に適用することができる。尚、本発明の経皮吸収促進
性皮膚外用剤には上記の他にワックス類、色素、香料、
防腐剤、界面活性剤、顔料、ビタミン類、キレート剤、
清涼剤、湿潤剤、乳化助剤、ホルモン類、抗酸化剤等を
本発明の目的を達成する範囲内で適宜配合することがで
きる。[0008] The percutaneous absorption promoting skin external preparation of the present invention can be applied, for example, as a cosmetic or pharmaceutical, and as a dosage form, it can be applied to lotions, emulsions, creams, packs and the like. it can. In addition, in addition to the above, the percutaneous absorption promoting skin external preparation of the present invention, waxes, pigments, fragrances,
Preservatives, surfactants, pigments, vitamins, chelating agents,
Cooling agents, wetting agents, emulsifying aids, hormones, antioxidants and the like can be appropriately compounded within a range that achieves the object of the present invention.
【０００９】[0009]
【実施例】以下、実施例及び比較例に基づいて本発明を
詳細に説明する。尚、実施例及び比較例に記載の成分の
配合量の単位は重量％である。経皮吸収試験方法は次の
通りである。フランツ型垂直拡散セルのアクセプター部
にリン酸緩衝液(150mM塩化ナトリウム含有、pH7.2)を満
たし、剥離したヘアレスラットの腹部皮膚を装着する。
下記実施例及び比較例に示した試料を皮膚上に供し、皮
膚を透過してアクセプター部のリン酸緩衝液中に蓄積し
たカルボン酸誘導体の量を高速液体クロマトグラフィー
により定量した。実験は３群で行い、平均値を算出し
た。その結果にもとづいて評価した。荒れ肌改善の官能
試験方法は次の通りである。荒れ肌、小じわ、乾燥肌を
訴える女子被験者（３５〜５５才）２０人に試料を１日
２回（朝、夕）、連続３ケ月間塗布して、２ケ月後の効
果を評価した。試験結果は、皮膚の柔軟性、平滑性、弾
力性の各項目を判断した結果、総合的に「皮膚に潤いが
生じた」、「皮膚が滑らかになった」、「皮膚に張りが
生じた」と回答した人数で示した。The present invention will be described below in detail based on examples and comparative examples. In addition, the unit of the compounding amount of the components described in Examples and Comparative Examples is% by weight. The percutaneous absorption test method is as follows. The acceptor part of the Franz vertical diffusion cell is filled with a phosphate buffer solution (containing 150 mM sodium chloride, pH 7.2), and the abdominal skin of a hairless rat that has been peeled off is mounted.
The samples shown in the following Examples and Comparative Examples were provided on the skin, and the amount of the carboxylic acid derivative that permeated the skin and accumulated in the phosphate buffer solution in the acceptor portion was quantified by high performance liquid chromatography. The experiment was performed in three groups, and the average value was calculated. The evaluation was based on the results. The sensory test method for improving rough skin is as follows. A sample was applied twice a day (morning and evening) to 20 female subjects (35 to 55 years old) who complain of rough skin, fine wrinkles, and dry skin for three consecutive months, and the effect after two months was evaluated. As a result of the test, the skin softness, smoothness, and elasticity were evaluated, and as a result, overall, "the skin was moistened", "the skin became smooth", and "the skin became taut" And the number of respondents.
【００１０】実施例１〜４、比較例１ カルボン酸誘導体を表１に記載の通りに配合し、下記の
組成で各々の皮膚外用剤を調製し、前記の実験を実施
し、８時間後のカルボン酸誘導体の透過量を求めた。
尚、ジイソプロピルアミンジクロロアセテートはＤＡＤ
Ａと略記する。Examples 1 to 4 and Comparative Example 1 Carboxylic acid derivatives were blended as shown in Table 1, each external preparation for skin was prepared with the following composition, and the above experiment was carried out. The permeation amount of the carboxylic acid derivative was determined.
Note that diisopropylamine dichloroacetate is DAD
Abbreviated as A.
【００１１】[0011]
【表１】 [Table 1]
【００１２】（１）調製方法 （Ａ）、（Ｂ）各々を室温にて均一に溶解し、撹拌下
（Ａ）に（Ｂ）を加え、乳化分散を行い調製する。(1) Preparation method Each of (A) and (B) is uniformly dissolved at room temperature, (B) is added to (A) with stirring, and emulsified and dispersed to prepare.
【００１３】（２）特性 各経皮吸収促進性皮膚外用剤の試験を実施した結果を表
１に記載した。表１に示すごとく、本発明の実施例１〜
４の皮膚外用剤は比較例１の皮膚外用剤よりもＤＡＤＡ
の吸収に於いて顕著な吸収促進効果が見られた。また、
荒れ肌改善効果においても本発明の実施例１〜４の皮膚
外用剤は比較例１の皮膚外用剤よりもすぐれていた。(2) Characteristics Table 1 shows the results of tests conducted on each transdermal absorption promoting skin external preparation. As shown in Table 1, Examples 1 to 5 of the present invention
DADA of the skin external preparation of Comparative Example 4 was higher than DADA of the skin external preparation of Comparative Example 1.
A remarkable absorption-promoting effect was observed in the absorption of. Also,
The skin external preparations of Examples 1 to 4 of the present invention were also superior to the skin external preparation of Comparative Example 1 in the rough skin improving effect.
【００１４】実施例５〜８，比較例２ カルボン酸誘導体を表２に記載の通りに配合し、下記の
組成で各々の皮膚外用剤を調製し、前記の実験を実施
し、４時間後のカルボン酸誘導体の透過量を求めた。こ
こで，γ−アミノ酪酸、γ−アミノ−βーヒドロキシ酪
酸をそれぞれＧＡＢＡ、ＧＡＢＯＢと略記する。Examples 5 to 8 and Comparative Example 2 Carboxylic acid derivatives were blended as shown in Table 2, each skin external preparation was prepared with the following composition, and the above experiment was carried out. The permeation amount of the carboxylic acid derivative was determined. Here, γ-aminobutyric acid and γ-amino-β-hydroxybutyric acid are abbreviated as GABA and GABOB, respectively.
【００１５】[0015]
【表２】 [Table 2]
【００１６】（１）調製方法 （Ａ）、（Ｂ）各々を室温にて均一に溶解し、撹拌下
（Ａ）に（Ｂ）を加え、乳化分散を行い調製する。(1) Preparation method Each of (A) and (B) is uniformly dissolved at room temperature, (B) is added to (A) with stirring, and emulsified and dispersed to prepare.
【００１７】（２）特性 各経皮吸収促進性皮膚外用剤の試験を実施した結果を表
２に記載した。表２に示すごとく、本発明の実施例５〜
８の皮膚外用剤は比較例２の皮膚外用剤よりもＧＡＢＡ
の吸収に於いて顕著な経皮吸収促進効果が見られた。ま
た、荒れ肌改善効果においても本発明の実施例５〜８の
皮膚外用剤は比較例２の皮膚外用剤よりもすぐれてい
た。(2) Characteristics Table 2 shows the results of tests of each transdermal absorption promoting skin external preparation. As shown in Table 2, Examples 5 to 5 of the present invention
8 is more GABA than the skin external preparation of Comparative Example 2.
A remarkable transdermal absorption-promoting effect was observed in the absorption of. Also, the skin external preparations of Examples 5 to 8 of the present invention were superior to the skin external preparation of Comparative Example 2 in the effect of improving rough skin.
【００１８】[0018]
【発明の効果】以上記載のごとく本発明が、本発明のカ
ルボン酸誘導体の皮膚における吸収を促進させ、荒れ肌
改善効果に優れた皮膚外用剤を提供することは明らかで
ある。As described above, it is apparent that the present invention provides an external preparation for skin which promotes the absorption of the carboxylic acid derivative of the present invention in the skin and is excellent in the effect of improving rough skin.
Claims (1)
選ばれる一種または二種以上とを配合してなる経皮吸収
促進性皮膚外用剤。1. A percutaneous absorption promoting external skin preparation comprising a carboxylic acid derivative, water and one or more selected from polysaccharides.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18562296A JP3710564B2 (en) | 1996-06-25 | 1996-06-25 | Transdermal absorption-promoting skin external preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18562296A JP3710564B2 (en) | 1996-06-25 | 1996-06-25 | Transdermal absorption-promoting skin external preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH1017457A true JPH1017457A (en) | 1998-01-20 |
| JP3710564B2 JP3710564B2 (en) | 2005-10-26 |
Family
ID=16174020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18562296A Expired - Fee Related JP3710564B2 (en) | 1996-06-25 | 1996-06-25 | Transdermal absorption-promoting skin external preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3710564B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003053466A1 (en) * | 2001-12-13 | 2003-07-03 | Shiseido Company, Ltd. | Skin barrier function repair accelerators |
| JP2012211160A (en) * | 2001-06-01 | 2012-11-01 | Neochemir Inc | Acidic composition for external use, cosmetic containing the same, hair growing agent, and agent for accelerating infiltration preparation for external us into skin or the like |
| JP2013506657A (en) * | 2009-09-30 | 2013-02-28 | 株式會社アモーレパシフィック | Cosmetic composition for massage |
-
1996
- 1996-06-25 JP JP18562296A patent/JP3710564B2/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012211160A (en) * | 2001-06-01 | 2012-11-01 | Neochemir Inc | Acidic composition for external use, cosmetic containing the same, hair growing agent, and agent for accelerating infiltration preparation for external us into skin or the like |
| US8778388B2 (en) | 2001-06-01 | 2014-07-15 | Neochemir Inc. | Acidic carrageenan composition for external use |
| WO2003053466A1 (en) * | 2001-12-13 | 2003-07-03 | Shiseido Company, Ltd. | Skin barrier function repair accelerators |
| JP2013506657A (en) * | 2009-09-30 | 2013-02-28 | 株式會社アモーレパシフィック | Cosmetic composition for massage |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3710564B2 (en) | 2005-10-26 |
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