JPH10158151A - Ointment containing sugar alcohols - Google Patents

Abstract

(57) [Summary] [Problem] Conventional ointments are oily ointments, emulsion ointments, water-soluble ointments, etc., each of which is easy to extrude from a filled tube, easy to spread, adsorptive to the skin and washing. There were drawbacks in the usability, such as properties, and the pharmaceutical properties, such as properties, spreadability and water absorption. An ointment containing 30 to 90% by weight of one or more of maltitol, sorbitol, mannitol, xylitol, lactitol, erythritol or trehalose solves the above-mentioned disadvantages.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an ointment containing maltitol, sorbitol, mannitol, xylitol, lactitol, erythritol or trehalose, and is useful as a base for drug-containing ointments and cosmetics.

[0002]

2. Description of the Related Art

Ointments are roughly classified into oily ointments, emulsion ointments and water-soluble ointments depending on the base.
The oil-based ointment uses an oil-based base such as oils and fats, fatty oils, vaseline, paraffin, the emulsion-based ointment uses a surfactant to emulsify water and the oil-based base, and the water-soluble ointment uses Macrogol. Using a water-soluble base such as or macrogol,
Water, alcohol and the like are gelled with a water-soluble polymer gelling agent before use.

Oily ointments have a skin softening action, a crust softening action, and a granulation action, but they are difficult to disperse water-soluble drugs, have no ability to retain aqueous secretions of the skin, and have good detergency. There was a disadvantage that it was bad.

[0004] Emulsion ointments are white and have a beautiful appearance and a clean feeling, and are preferred by users because of their good detergency, and are well mixed with aqueous and oily skin secretions. There is a drawback that it does not have the ability to hold for a sufficient period.

[0005] Water-soluble ointments have excellent solubility of water-soluble drugs,
In addition, since it has high hygroscopicity, the ability to absorb aqueous secretions is high. However, the phenolic compound is inactivated by complex formation and the drug is degraded by active oxygen generated by oxidative decomposition, and heat is generated at the time of adsorption of aqueous secretions, so that the affected part is heated.

Therefore, an ointment which solves the above problems is desired.

[0007] Ointments containing sugar alcohols include:
An external preparation for the skin (JP-A-6-24957) for synergistically improving the skin roughening effect of vitamin A, and enhancing the stability of interferon comprising tri- or higher-valent sugar alcohol and organic acid mixed with interferon. External preparations (JP-B-3-9883, JP-B-3-9884,
JP-A-3-98885), a skin external preparation containing a sugar alcohol for stabilizing a water-soluble blueberry extract (JP-A-63-145235), a protein unstable in water, for example, human cancer Necrosis factor, human interleukin I
A hydrophilic polymer powder and a sugar or sugar alcohol mixed to obtain a ready-to-use external gel (Japanese Unexamined Patent Publication No. 3-99)
No. 77), and erythritol alone or in combination with epsilon aminocaproic acid to improve skin roughness and provide a skin external agent that gives skin moisture and gloss (Japanese Patent Laid-Open No. 4-12)
No. 4118) is known.

Further, a skin external preparation (Japanese Patent Application Laid-Open No. 61-194007) which is excellent in color and odor utilizing the emulsifying power of sugar alcohol fatty acid esters, and is applied to skin and eyes containing sugar alcohol derivatives. An external preparation for skin with low irritation and no stickiness (Japanese Patent Application Laid-Open No. 4-169512) is known.

However, all of the above techniques utilize sugar alcohols as stabilizers or humectants for specific drugs, or utilize derivatives of sugar alcohols as surfactants. It is not a technique relating to a sugar alcohol-based ointment which can incorporate any drug which has improved various disadvantages.

[0010]

An ointment is an external preparation which is applied to the skin which has an appropriate consistency and is made into a semi-solid form of uniform quality and is desired to have the following characteristics. It has affinity for the skin, and has a high ability to mix with and retain oily and aqueous secretions of the skin.It has good detergency.It is stable without rancidity.It has good flexibility and good spreadability. Non-irritant Can be combined with various drugs and cosmetics, and do not affect their properties and efficacy.Absorb moisture, liquid drugs and cosmetics well. .

[0011] The ointment of the present invention has all of the above characteristics. That is, the present invention provides an ointment that is excellent in detergency even when any drug or cosmetic is added, absorbs oily and aqueous secretions on the skin lesion surface, is nonirritating, and is chemically inert. I do. The ointment can be used as a base for drug-containing ointments and cosmetics.

The ointment of the present invention comprises maltitol, sorbitol, mannitol, xylitol, lactitol,
It is an ointment containing one or more erythritol or trehalose as a main base, and contains 30 to 90% by weight of the total composition, preferably 40 to 80% by weight.
It is an ointment containing 10% by weight.

The sugar alcohol and trehalose used in the ointment of the present invention desirably have a particle diameter of 20 to 150 μm, preferably 20 to 100 μm for the purpose of not giving a feeling of roughness during use.

The ointment of the present invention comprises maltitol, sorbitol, mannitol, xylitol, lactitol,
One or more of erythritol or trehalose is used, and a solvent is added thereto to produce the product. The solvent to be added to the present invention contains 10 to 50% by weight of the total composition, preferably 20 to 40% by weight.

The solvent used in the ointment of the present invention includes a substance having a polyoxyethylene chain, for example, polyoxyethylene lauryl ether, macrogol 200, macrogol 300, macrogol 400, etc., or ethanol, glycerin, Alcohols such as 1,3-butylene glycol and propylene glycol are exemplified.

The ointment of the present invention contains polysorbate 80 and polyoxyethylene hydrogenated castor oil 6 to impart more appropriate skin affinity, flexibility and spreadability more effectively.
0, a surfactant such as polyoxyethylene (160) polyoxypropylene (30) glycol, stearic acid,
Macrogol 4000, palmitic acid, purified lanolin,
Beeswax, thickeners such as cetanol, olive oil, soybean oil, liquid paraffin, squalene, softeners such as medium-chain fatty acid triglyceride, humectants such as urea and methylcellulose, polyvinylpyrrolidone, gum arabic, pullulan,
A base such as xanthan gum can be added as needed.

In order to enhance the usefulness of the ointment of the present invention, antioxidants such as tocopherol, dibutylhydroxytoluene and sodium ascorbate, stabilizing agents such as disodium ethylenediaminetetraacetate, methyl paraoxybenzoate, paraoxybenzoate, etc. Preservatives such as ethyl acetate and propyl paraoxybenzoate, flavors and the like can be added as necessary.

The ointment of the present invention includes steroid anti-inflammatory agents such as prednisolone, dexamethasone and hydrocortisone butyrate, non-steroidal anti-inflammatory agents such as ibuprofenpiconol and indomethacin; local anesthetics such as lidocaine and dibucaine hydrochloride; ephedrine hydrochloride; Vasoconstrictors such as naphazoline, chlorpheniramine maleate, antihistamines such as diphenhydramine, kanamycin sulfate,
A drug-containing ointment can be prepared by mixing antibiotics such as erythromycin, tetracycline hydrochloride, chloramphenicol, and gentamicin sulfate, and other drugs that are preferably administered as ointments.

When the ointment of the present invention is used as a base for cosmetics, it is intended to be used as a basic cosmetic to prepare the skin surface and to moisturize it.

[0020]

BEST MODE FOR CARRYING OUT THE INVENTION The ointment of the present invention comprises one or more of maltitol, sorbitol, mannitol, xylitol, lactitol, erythritol or trehalose, and polyoxyethylene lauryl ether, macrogol 200, macrogol 300, Macro Goal 4
The solvent can be produced by adding one or more solvents, such as 00, ethanol, glycerin, 1,3-butylene glycol, and propylene glycol, as needed, and mixing them. Further, it is preferable to use an appropriate amount of purified water.

If necessary, the above-mentioned surfactants, thickeners, softeners, wetting agents, bases, antioxidants, stabilizers, preservatives or fragrances may be added. Maltitol to use,
Sorbitol, mannitol, xylitol, lactitol, erythritol or trehalose has a particle size of 2
It is preferable that the powder is pulverized and used by a usual method such as a mortar, a rotary mill, a hammer mill, a roll mill, a shear mill, a jet mill or the like so as to have a thickness of 0 to 150 μm. In addition, mixing can be performed by any method using an ointment plate, an ointment grinder, a stirring crusher, a stirring kneader, an automatic mortar, and a method using three rollers.

For example, maltitol is "Amalti" or "Resis" manufactured by Towa Kasei Kogyo Co., Ltd., sorbitol is "Sorbit" manufactured by Towa Kasei Kogyo Co., Ltd., and mannitol is manufactured by Towa Kasei Kogyo Co., Ltd. "Mannit" includes "xylitol" manufactured by Towa Chemical Industry Co., Ltd. as xylitol.

In the above, a drug-containing ointment useful as a pharmaceutical can be produced by adding and mixing the desired drug.

The cosmetic based on the ointment of the present invention may be prepared by adding a cooling agent such as ethanol or isopropanol, a protective agent for the stratum corneum, a wetting agent such as ester oil or polyhydric alcohol to the ointment of the present invention, It can be produced by appropriately selecting and adding a softening agent for the stratum corneum such as potassium or potassium carbonate, a fragrance and the like as needed.

Next, production examples of the ointment, drug-containing ointment and cosmetic of the present invention will be described with reference to examples, but the invention is not limited to these examples.

Example 1 (Ointment) Amalti 50 g Macrogol 400 40 g Purified water qs 100 g Amalti (pulverized with a hammer mill) and sieved with a sieve number 200 (nominal size 75 μm).
~ 75 μm), add Macrogol 400 and purified water,
This was stirred at room temperature using a stirring crusher until the whole material became uniform.

Example 2 (Ointment) Amalti 30 g Mannit 30 g 1,3-butylene glycol 20 g Purified water qs 100 g Pulverized by a rotary mill, sieve number 140 (nominal size 1)
06μm) Amalti sieved with a sieve (particle size 30 ~
100 μm) and mannite (particle size 30-100 μm)
m), add 1,3-butylene glycol and purified water,
The mixture was stirred at room temperature using a stirring kneader until the whole material became uniform.

Example 3 (Ointment) Sorbit 20 g Amalti 50 g Glycerin 10 g Medium-chain fatty acid triglyceride 10 g Purified water qs 100 g Sorbit (particle size: 80-1)
50 μm) and Amalti (particle size 80-150 μm)
Then, medium-chain fatty acid triglyceride, glycerin and purified water were added thereto, and the mixture was stirred at 40 ° C. using a stirrer until the whole material became uniform, and then cooled to 25 ° C. to produce a mixture.

Example 4 (Ointment) Amalti 30 g Mannitol 30 g Cetanol 2 g Tocopherol 0.1 g Macrogol 400 10 g Macrogol 4000 3 g Polysorbate 80 3 g Propylene glycol 7 g Proper amount of purified water 100 g Propylene glycol, macrogol in Macrogol 400 Gol 4000 and cetanol were added and dissolved by stirring at 60 ° C. Purified water and tocopherol previously dissolved in polysorbate 80 were added thereto, and emulsified at about 70 ° C. using an emulsifier. Further, amalti (particle size: 80 to 100 μm) and mannite (particle size: 80 to 100 μm) ground in advance by a rotary mill are added thereto, and the whole is homogenized at 50 ° C. using a stirring kneader until the whole quality becomes uniform. The mixture was stirred and then cooled to 25 ° C. to produce the mixture.

Example 5 (Ointment) Amalty 50 g Xylit 15 g Glycerin 1 g Polyvinylpyrrolidone 3 g Polyoxyethylene (160) polyoxypropylene (30) glycol 1 g 1,3-butylene glycol 20 g Xanthan gum 0.01 g Purified water Glycerin, polyvinylpyrrolidone and polyoxyethylene (160) polyoxypropylene (30) glycol were added to 100 g 1,3-butylene glycol, and the mixture was stirred and dissolved at about 60 ° C. Xanthan gum previously dissolved in purified water was added thereto, dissolved by stirring, and cooled to about 25 ° C. Further, the mixture was mixed with Amalti (particle size: 50 to 150 μm) and xylit (particle size: 30 to 100 μm) previously pulverized by a roll mill.
m), and the mixture was stirred at room temperature using an automatic mortar until the whole material became uniform.

Example 6 (Ointment) Sorbit 20 g Amalti 40 g Disodium ethylenediaminetetraacetate 0.1 g Cetanol 2 g Macrogol 400 15 g Macrogol 4000 5 g Polysorbate 80 2.5 g Purified water qs 100 g Macrogol 400 to Macrogol 400 Add 4000 and cetanol and dissolve at about 60 ° C.
0 and disodium ethylenediaminetetraacetate were added and then cooled to about 30 ° C. Further, Amalti (particle size: 50 to 150 μm) and sorbite (particle size: 30 to 50 μm) previously pulverized by a shearing mill are added thereto, and kneaded with an ointment plate or ointment at room temperature until uniform quality is achieved. Made.

Example 7 (Ointment) Amalti 30 g Trehalose 30 g Cetanol 2 g Macrogol 400 10 g Macrogol 4000 3 g Polysorbate 80 3.5 g Liquid paraffin 3.5 g Methylcellulose 6 g Xanthan gum 0.05 g Purified water qs 100 g Macrogol 400 Approx. 6 with Macrogol 4000 added
The mixture was stirred and dissolved at 0 ° C. To this, methyl cellulose, polysorbate 80, liquid paraffin, cetanol and xanthan gum previously dissolved in purified water were added, and the mixture was emulsified at about 60 ° C. using an emulsifier, and then cooled to 25 ° C. Amalti (particle size: 50 to 100 μm) and trehalose (particle size: 50 to 100 μm) which were previously ground with a shear mill and sieved with a sieve number 140 (nominal size: 106 μm).
100 μm), and the mixture was stirred at room temperature using a stirrer until the whole material became uniform.

Example 8 (Ointment) Amalty 40 g Xylit 25 g Stearic acid 1 g Propyl parahydroxybenzoate 0.1 g Macrogol 400 10 g Polyoxyethylene hydrogenated castor oil 60 1 g Polyvinylpyrrolidone 2.5 g 1,3-butylene glycol 10 g Purified water stearate qs total amount 100g macrogol 400, polyvinylpyrrolidone, polyoxyethylene hydrogenated castor oil 60 and 1,3
-Butylene glycol was added and dissolved by stirring at about 60 ° C.
To this was added propyl paraoxybenzoate previously dissolved in purified water, and then cooled to 25 ° C. Amalti (particle size: 20-50 μm) pulverized by a roll mill
m) and xylit (particle size 20-50 μm),
The mixture was stirred using a stirring kneader at room temperature until it became uniform in quality.

Example 9 (Cosmetic) Sorbit 60 g 1,3-butylene glycol 10 g Macrogol 200 1 g Polyoxyethylene lauryl ether 2 g Ethanol 15 g Perfume Appropriate amount Purified water Appropriate amount Total amount 100 g Macrogol in 1,3-butylene glycol 200 and polyoxyethylene lauryl ether were added and dissolved by stirring. To this, a fragrance previously dissolved in ethanol was added, and further, sorbit (particle size 3), which had been ground in advance with a mortar and sieved with a sieve number 282 (nominal size 53 μm).
0 to 50 μm), and the mixture was stirred at room temperature using an ointment plate and an ointment until uniform quality was obtained.

Example 10 (Drug-containing ointment) Hydrocortisone butyrate 0.05 g Amalti 40 g Mannit 20 g Cetanol 2 g Macrogol 400 15 g Macrogol 4000 5 g Polyoxyethylene (160) polyoxypropylene (30) glycol 3 g Purified water To 100 g of Macrogol 400, Macrogol 4000, cetanol and polyoxyethylene (160) polyoxypropylene (30) glycol were added and dissolved by stirring at about 70 ° C. Purified water was added to this and emulsified at about 60 ° C.
The mixture was stirred and cooled to 5 ° C. Further, hydrocortisone butyrate was added thereto and pulverized by a roll mill.
Amalti (particle size 20-75 μm) and mannite (particle size 20) sieved with a sieve (nominal size 75 μm).
７５75 μm), and the mixture was stirred at room temperature using a stirring kneader until the whole material became uniform.

Example 11 (Drug-containing ointment) Indomethacin 0.75 g Amalti 65 g Glycerin 1 g Macrogol 4000 3 g 1,3-butylene glycol 20 g Xanthan gum 0.04 g Purified water qs 100 g Macrogol 4000 in 1,3-butylene glycol And dissolved by stirring at about 70 ° C., and glycerin and xanthan gum previously dissolved in purified water were added thereto.
The mixture was stirred and cooled. Further, indomethacin was added thereto, pulverized using a hammer mill, and amalti (particle size: 20 to 75 μm) sieved with a sieve having a sieve number of 200 (nominal size: 75 μm) was added thereto. It was made by stirring until the quality became uniform.

Example 12 (Ointment containing drug) Lidocaine 0.5 g Glycyrrhetinic acid 0.3 g Benzalkonium chloride 0.01 g Amalti 30 g Mannit 30 g Glycerin 2 g Macrogol 400 10 g Macrogol 4000 3 g Cetanol 4 g Polysorbate 80 3 g Polyoxy Ethylene (160) polyoxypropylene (30) glycol 1 g Xanthan gum 0.05 g Purified water qs 100 g To Macrogol 400, add Macrogol 4000, cetanol, glycerin and polyoxyethylene (160) polyoxypropylene (30) glycol to about 70 At 0 ° C., xanthan gum and benzalkonium chloride previously dissolved in purified water were added thereto, and the mixture was stirred for about 7
Emulsified at 0 ° C. Thereafter, the mixture was stirred and cooled to 25 ° C., and lidocaine and glycyrrhetinic acid previously dissolved in polysorbate 80 were added and stirred. Further, amalti (particle size: 20 to 100 μm) and mannite (particle size: 20 to 100 μm) pulverized using a roll mill were added thereto, and the mixture was stirred at room temperature using a stir kneader until the whole material became uniform.

Next, a production example of a conventional ointment will be described as a comparative example. Comparative Example 1 (Oil-based ointment) Liquid paraffin 7 g Salami beeswax 45 g Sorbitan sesquioleate 18 g White petrolatum Appropriate amount 100 g To white beeswax, white petrolatum, liquid paraffin, and sorbitan sesquioleate were added and stirred and dissolved at about 70 ° C. Thereafter, the mixture was stirred and cooled to 40 ° C., and stirred at room temperature using a mortar until the whole material became uniform.

Comparative Example 2 (Oil-based ointment) Purified lanolin 50 g Paraffin 40 g Cetostearyl alcohol 0.5 g White vaseline qs 100 g Paraffin, white petrolatum and cetostearyl alcohol were added to purified lanolin and stirred and dissolved at about 70 ° C. Thereafter, the mixture was stirred while being cooled to 25 ° C. using a stirring kneader.

Comparative Example 3 (Oil-based ointment) White beeswax 5 g Sorbitan sesquioleate 2 g White petrolatum qs 100 g White petrolatum and sorbitan sesquioleate were added to white beeswax and stirred and dissolved at about 70 ° C. Thereafter, the mixture was stirred while being cooled to about 30 ° C. using a stirring kneader.

Comparative Example 4 (Emulsion ointment, W / O type) White petrolatum 40 g Cetanol 10 g Salami beeswax 5 g Sorbitan sesquioleate 5 g Lauromacrogol 0.5 g Methyl parahydroxybenzoate 0.1 g Purification of propyl paraoxybenzoate 0.1 g Water qs 100 g white petrolatum, cetanol, beeswax, sorbitan sesquioleate and lauromacrogol
The mixture was stirred and dissolved at 0 ° C. To this, methyl paraoxybenzoate and propyl paraoxybenzoate previously dissolved in purified water were added, and emulsified at about 70 ° C. using an emulsifier. Thereafter, the mixture was cooled to about 30 ° C. or lower while stirring to produce the product.

Comparative Example 5 (Emulsion ointment, O / W type) White petrolatum 25 g Stearyl alcohol 20 g Propylene glycol 12 g Polyoxyethylene hydrogenated castor oil 60 4 g Glycerin monostearate 1 g Methyl parahydroxybenzoate 0.1 g Propyl paraoxybenzoate 0 0.1 g purified water qs 100 g stearyl alcohol, polyoxyethylene hydrogenated castor oil 60 and glyceryl monostearate were added to white petrolatum and dissolved at about 70 ° C with stirring. To this were added propylene glycol, methyl paraoxybenzoate and propyl paraoxybenzoate previously dissolved in purified water, and emulsified at about 70 ° C. using an emulsifier. Thereafter, the mixture was cooled to about 30 ° C. while stirring to produce the product.

Comparative Example 6 (Water-soluble ointment) Macrogol 4000 70 g Macrogol 400 30 g Total 100 g Macrogol 400 was added to Macrogol 400 to obtain about 6
The mixture was dissolved by stirring at 0 ° C., and then cooled to about 25 ° C. with stirring to produce the product.

[0044]

Next, the effects of the ointment of the present invention will be described in terms of usability and pharmacological properties.

(1) Usability The usability of the ointments of Examples and Comparative Examples was evaluated by using a panel of 20 persons in terms of ease of pushing out from an aluminum tube, ease of spreading, adhesion to skin, and cleanability. .
The ease of pushing out from the tube, the ease of spreading, and the adhesion to the skin were evaluated by extruding a certain amount of the ointment from the aluminum tube to the back of the hand, spreading it, and then washing it. The hand was moved inside and evaluated as the time until the applied ointment disappeared from the skin.

The evaluation criteria for ease of extrusion from a tube, ease of spreading, adhesion to the skin and detergency are as follows. The results are shown in Table 1. ◎ ◎ ・ ・ ・ ・ ・ ・ ・ 15 or more felt good ○ ・ ・ ・ ・ ・ ・ ・ 10 or more Fewer than 15 people felt good △ ... More than 5 people and less than 10 people felt good × ... More than 5 people felt good ────────── ────────────────

[0047]

[Table 1]

(2) Pharmaceutical Properties The pharmacological properties of the ointments of Examples and Comparative Examples were evaluated in terms of properties, spreadability and water absorption. The properties were evaluated by filling the samples into aluminum tubes and storing them at a temperature of 60 ° C. for 3 weeks or at a temperature of 40 ° C. for 6 months. The spreadability was measured by using a spread meter to measure the spread diameter of the sample, plotting the elapsed time on the horizontal axis (logarithmic axis), and plotting the spread diameter on the vertical axis, and calculating the slope of the straight line (Tanα).
Was evaluated. The water absorption was evaluated by weighing 3 g of a sample in a petri dish, storing the sample at a temperature of 25 ° C. and a relative humidity of 95% for one week, and measuring a change in weight.

The evaluation criteria are as follows. The results are shown in Table 2. Property evaluation criteria ◎ ◎ ・ ・ ・ ・ ・ ・ ・ Property did not change upon storage ○ ・ ・ ・ ・ ・ Property after storage Slightly changed △ ・ ・ ・ ・ ・ Property changed by storage × ・ ・ ・ ・ ・ Property changed significantly by storage ───────────────────── ──

Evaluation criteria for extensibility ◎ ◎ Is remarkably good (Tanα is 0.10 or more) ○ ··························· Elongation is good (Tanα is 0.05 or more and less than 0.10) △ ········· Slightly good at (with Tanα of at least 0.01) , Less than 0.05) × · · · · · poor elongation (Tanα is less than 0.01) ─────────────────────────── ────────

Evaluation Criteria for Water Absorption ─────────────────────────────────── ◎ ... Water absorption It has a remarkably good property and can significantly remove secretions from the skin (weight increase due to water absorption is 20% or more)... Good water absorption and can remove secretions from the skin (weight increase by water absorption is 10%). % Or more, less than 20%) △: Slightly good water absorption, and secretions from the skin can be removed slightly (weight increase by water absorption is less than 10%) ×: No water absorption, skin Cannot remove secretions from water (no weight increase due to water absorption) ───────────────────────────────────

[0052]

[Table 2]

As is clear from Tables 1 and 2, the ointment of the present invention is superior in usability and pharmacological properties to conventional ointments and is useful as a base for drug-containing ointments and cosmetics. is there.

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Yukiya Yamaguchi 2512-1 Numagami, Oshikiri, Konan-cho, Osato-gun, Saitama 1 Inside Zeria Shinyaku Kogyo Co., Ltd.

Claims (5)

[Claims] An ointment containing 30 to 90% by weight of one or more of maltitol, sorbitol, mannitol, xylitol, lactitol, erythritol or trehalose. 2. The ointment according to claim 1, wherein the particle size of maltitol, sorbitol, mannitol, xylitol, lactitol, erythritol or trehalose is 20 to 150 μm. 3. The ointment according to claim 1, further comprising maltitol. (4) A solvent is added to the ointment according to (1) or (2).
An ointment characterized by containing 0 to 50% by weight. 5. An ointment according to claim 4, wherein the solvent is one or two of a substance having a polyoxyethylene chain and alcohols.