JPH0994298A - Guide wire - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a guide wire, especially a guide wire to be used for an endoscope, which facilitates marker recognition, prevents exfoliation, and reduces elution of materials. SOLUTION: This guide wire comprises a core 4 which is formed of a superelastic alloy line, a depth marker 5 printed on the core 4, a forward tip 6 of the core 4, a first resin coating 1 which covers the depth marker 5 and is virtually transparent, and a second resin coating 2 which covers the main body 7 of this guide wire.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a catheter, and more particularly to a guide wire for advancing the catheter while confirming its course under an endoscope.

[0002]

2. Description of the Related Art A guide wire with a marker has been developed as a guide for the insertion condition into a catheter.
For example, FIG. 5 shows a guide wire described in Japanese Utility Model Laid-Open No. 4-108556. This guide wire 20 has an inner core 11
Is covered with a coating layer 12, and a plurality of marks 13 are provided at a predetermined distance from the tip of the coating layer. By reading the marks 13 at the catheter insertion port, the length of the catheter inside the catheter can be increased. It is an estimate as to whether or not it is included.

In addition, treatment using an endoscope has recently been developed,
Diagnosis and treatment of not only the stomach but organs such as the pancreas that are difficult to reach with endoscopic catheters have come to be performed. In such a case, it was necessary to advance the endoscope catheter to the target site while confirming the guide wire that precedes with the endoscope. Therefore, advancing the endoscopic catheter while grasping how long the guide wire is from the tip of the endoscopic catheter is very advantageous in operation.
It was strongly desired.

In the guide wire described in Japanese Utility Model Laid-Open No. 4-108556, the distance from the catheter to the guide wire must be estimated by estimating how far the guide wire is from the tip of the catheter.
Further, when the length of the distal end portion is inferred while observing under an endoscope, it is sometimes difficult to know how much the distal end of the guide wire is protruding because the image is enlarged.

Further, since the mark 13 is provided on the outer side of the coating layer 12, there is a problem of peeling of the mark and elution, and it is necessary to pay sufficient attention to the selection of the material.

[0006]

Therefore, with the guide wire of the present invention, the length of the distal end portion can be immediately grasped by observation under an endoscope, and there are problems such as peeling of markers and eluates. It is an object to provide a guide wire that does not have any.

[0007]

The guide wire of the present invention has the structure described in the following claims.

(1) An elastic linear core composed of a tip having a taper portion tapering toward the tip and a body, and a depth marker provided on the tip of the core. A guide wire comprising the tip of the core and a substantially transparent first coating resin that covers at least the depth marker.

(2) The first coating resin is the guide wire according to (1), wherein at least a part from the tip is coated with a hydrophilic resin.

(3) The main body is the guide wire according to (2) above, which is coated with a second coating resin of a material different from that of the first coating resin.

(4) The guide wire according to any one of (1) to (3) above, wherein the guide wire is used with an endoscope catheter.

With the structure of (1) above, since the depth marker is covered with the coating resin and the depth marker does not come into direct contact with a liquid such as body fluid, the elution of the ink component into the body does not occur. The visibility of the depth marker does not deteriorate, and the tip of the guide wire has a taper shape, so the tip of the guide wire is flexible, and since the core uses an elastic wire, it has excellent kink resistance and push-in characteristics. Therefore, the operability is improved while visually observing the depth marker with an endoscope.

Further, according to the above configuration (2), the tip end portion has a high slidability in the body and the operability is improved.

According to the above configuration (3), since the coating resin is composed of the first coating resin that covers the front end portion of the core and the second coating resin that covers the rear end portion, the guide wire of the front end portion and the main body portion is formed. The surface properties of can be changed. The tip is made of a coating resin with high biocompatibility to contact the inner wall of the body, and the main body has excellent slidability with the lumen wall to move the lumen of a catheter such as an endoscope catheter. The optimum resin can be applied depending on the target site such as good.

The guide wire having the above-mentioned constitutions (1) to (3) is very suitable for operation while being visually recognized under an endoscope, and is very useful as a guide wire for an endoscope. .

The guide wire having the above contents has the following specific construction. That is, the guide wire has a core, and this core is made of an elastic metal material such as Ni—Ti wire, stainless wire, and steel wire. Further, the core has a length of about 120 cm to 450 cm and an outer diameter of about 0.1 mm to 0.2 mm at the tip, and a taper portion with a taper shape from the tip to about 20 cm, followed by the same diameter of 10 to 30 cm. The tip has a tip portion having the same diameter portion as the tip, and has an outer diameter of approximately 0.35 mm to 0.8 mm after the tip portion.

The guide wire has a depth marker at the tip of the core. The main component of this marker is acrylic resin or another material. Markers are printed on the core. The width of each marker is about 3 mm (entire circumference), and the marker printing position is about 0 cm to 50 c from the leading edge.
m is attached at a predetermined interval. The guide wire has a first coating resin that is at least substantially transparent at the tip. Since the first coating resin is made of modified polyethylene and the first coating resin is transparent, the marker printed on the core can be seen through the first coating resin.

Although the entire core may be covered with the first coating resin, only the tip may be covered. When only the tip portion is covered, the remaining main body portion can be coated with another second coating resin so that the guide wire has physical properties different from those of the tip portion. By coating with different resins,
This is useful for improving operability. A urethane resin is typical as such a second coating resin.

The coating length of the second coating resin is about 25 to 95% of the length of the entire core from the rear end, preferably 6
It is 0 to 90%, and more preferably 85 to 90%. Outer diameter (outer diameter of the guide wire after coating the core)
Is about 0.018 inch to 0.038 inch (about 0.46 inch
mm-0.97 mm). The coating length of the first coating resin is 5 to 75% of the entire core from the leading edge, and preferably,
It is 10 to 40%, more preferably 10 to 15%. Outer diameter is about 0.4 mm to 0.8 mm at the tip, taper shape from the tip to about 20 cm, about 20 cm to 50
Up to cm is about 0.018 inch to 0.038 inch (about 0.46 mm to 0.97 mm).

The first coating resin of the guide wire is further coated with a hydrophilic resin. The hydrophilic resin can be selected from the following group.

Examples of Hydrophilic Resin <Natural Polymer> (1) Starch-based Example: Carboxymethyl Starch, Dialdehyde Starch (2) Cellulose-based Example: Carboxymethyl Cellulose (CMC) Methyl Cellulose (MC) Hydroxyethyl Cellulose (HEC) Hydroxy Propyl Cellulose (HPC) (3) Tannin, Nignin Example: Tannin, Nignin (4) Polysaccharide Example: Sodium alginate, gum arabic, guar gum, trangant gum, tamarind (5) Protein Example: Gelatin, casein, glue, Collagen <Synthetic water-soluble polymer> (1) PVA system Example: polyvinyl alcohol (2) Polyethylene oxide system Example: Polyethylene oxide, polyethylene glycol (3) Acrylic acid and its salt system Example: Polyac Sodium acetate, acrylic acid, methacrylic acid (4) Vinyl ether type Example: Methyl vinyl ether Maleic anhydride ammonium salt, vinyl ether (5) Phthalic acid type Example: Polyhydroxyethyl phthalate ester (6) Water-soluble polyester type Example: Poly Dimethyl roll propionate (7) Ketone aldehyde resin system Example: Methyl isopropyl ketone formaldehyde resin (8) Acrylamide / methacrylamide system Example: Dialkyl acrylamides (dimethyl acrylamide, diethyl acrylamide, methyl ethyl acrylamide, diisopropyl acrylamide, etc.), monoalkyl Acrylamides (methyl acrylamide, ethyl acrylamide, isopropyl acrylamide, etc.) Other acrylamides (2-methyl acrylamide Pansulphonic acid acrylamide, dimethylaminopropyl acrylamide, etc.), acrylamide, and corresponding methacrylamides of chemical structure (9) Vinyl heterocyclic ring system Example: Vinyl pyridines (2-vinyl pyridine, 4-vinyl pyridine, etc.) Vinyl Pyrrolidone, N-1,2,4-triazolyl ethylene, etc. (10) Polyamine type Example: Polyethyleneimine (11) Polyelectrolyte Example: Polystyrene sulfonate, polyacrylamide quaternized product, sodium polyvinylsulfonate (12) Acrylate / meth Acrylate-based example: Polyalkylene glycol acrylates (glyceryl acrylate, etc.), hydroxyalkylene acrylates (hydroxyethyl acrylate, hydroxypropyl acrylate, etc.), and corresponding chemical structures (13) Other examples: Water-soluble nylon Among these, cellulose-based polymer (hydroxypropyl cellulose), polyethylene oxide-based polymer (polyethylene glycol), maleic anhydride-based polymer (methyl) A maleic anhydride copolymer such as vinyl ether maleic anhydride copolymer), an acrylamide polymer (polydimethylacrylamide), and water-soluble nylon are preferable because a low friction coefficient can be stably obtained.

As the derivative of the above-mentioned polymer substance,
It is not limited to a water-soluble substance, and if the water-soluble polymer substance is used as a basic constituent, there is no particular limitation, and even if it is insolubilized, it has a degree of freedom in the branched chain and it contains water. I wish I had it.

For example, esterification products, salts, amidation products, anhydrides, halides, etherification products, hydrolysates, acetalization products, formalization products obtained by condensation, addition, substitution, oxidation, reduction reactions of the above-mentioned polymer branches. , Alkylol compound, quaternary compound, diazo compound, hydrazide compound, sulfonate compound, nitrate compound, ion complex, diazonium group, azido group, isocyanate group, acid chloride group, acid anhydride group, iminocarbonic acid ester group, amino group, Carboxyl group, epoxy group, hydroxyl group, arhydride group, etc.
Examples thereof include a cross-linked product of a substance having two or more reactive functional groups, a vinyl compound, acrylic acid, methacrylic acid, a diene compound, and a copolymer of maleic anhydride.

In the above-mentioned hydrophilic resin, the guide wire of the present invention is often used for observing the inside of the stomach and the inside of the pancreas with an endoscope, and the guide wire under acidic or alkaline environment such as gastric juice or pancreatic juice is used. It is preferable that the wire does not deteriorate the slidability of the wire in the application.

Further, when the hydrophilic resin is coated, it is preferable to cover the tip portion, and the other portion is coated as necessary.

Further, this guide wire is manufactured by the following method.

The tip portion of the tip portion of the core made of a superelastic alloy wire is processed into a taper shape by a conventionally known method such as polishing and chemical etching.

Next, a depth marker is directly printed on the tip of the core at a predetermined interval to form the depth marker. As the printing method, pad printing, ink jet printing, or any other known method is used.

In the case where only the first coating resin is used as the guide wire, the entire coating is carried out by the wire coating method, and then the guide wire is peeled off leaving only the necessary portions.

Further, in the case of coating with two kinds of resins of the first coating resin and the second coating resin, after the second coating resin is once coated by the wire coating method, the first coating resin is applied from the tip end portion. The second coating resin having the length of the portion coated with the coating resin is peeled off. The peeling method is a method such as dissolution with a solvent. Second
The peeled end of the coating resin of (1) is formed into a taper shape by dissolution with a solvent or other method. Next, the first coating resin is coated using an extrusion slide base machine.

At this time, the drive direction of the slide base machine is reversed to make the joint between the first coating resin and the second coating resin relatively smooth.

As the second method, the first coating resin and the second coating resin are used.
The coating resin of 1. is simultaneously coated.

[0033]

EXAMPLES The present invention will be described in detail with reference to examples.

[0034]

Example 1 FIG. 1 shows a guide wire 10 of the present invention. It is a fragmentary sectional view of the present invention, and shows a cross section of the tip portion 6.
The guide wire 10 has a core 4 made of a super elastic alloy wire of nickel titanium alloy. The core 4 has a length of about 450 cm and an outer diameter of about 0.2 mm at the tip 9 and has a taper shape from the tip 9 to about 20 cm.
After that, the outer diameter is about 0.7 mm.

The guide wire 10 has a depth marker 5. The main component of the depth marker 5 is acrylic resin. The depth marker 5 is printed on the core 4. The width of each marker is about 3 mm and is printed on the entire circumference of the core. The printing position of the depth marker 5 is about 5c from the leading edge.
m, 10 cm, 15 cm, and 20 cm are placed at 1, 2, 3, and 4, respectively. By confirming the number of the depth markers 5 at each position with the endoscope, it is possible to confirm how far the distal end portion of the guide wire is from the distal end of the endoscope catheter.

The guide wire 10 has a first coating resin 1 on the tip portion 6 and a second coating resin 2 on the main body portion 7.
The second coating resin 2 is made of urethane resin. The coating length of the second coating resin 2 is about 400 cm from the rear end 3 and the outer diameter is about 0.035 inch (about 0.89 mm). The first coating resin 1 is made of modified polyethylene resin. The coating length of the first coating resin 1 is about 50 cm from the tip, the outer diameter is about 0.8 mm at the tip, the taper shape is about 20 cm from the tip, and about 0.035 inches (about 20 cm to 50 cm). 0.89 mm).

The guide wire 10 has a distal end portion 6 covered with a hydrophilic resin 8. The hydrophilic resin 8 is made of acrylamide polymer.

In the manufacturing method, first, about 20 cm from the tip end portion 9 of the core of a superelastic alloy wire having a length of about 450 cm and an outer diameter of about 0.7 mm is processed into a tapered shape. After processing, the outer diameter of the tip portion 9 is about 0.2 mm.

Subsequently, the entire length of the core 4 is changed to the second coating resin 2
After coating with, the tip 6 is immersed in a solvent to dissolve and peel off, and then about 5c from the tip 9 of the peeled tip.
At the positions of m, 10 cm, 15 cm, and 20 cm, depth markers 5 made of one, two, three, and four acrylic resins are printed. If there is only one depth marker 5, the center of its 3 mm width is located at a position 5 cm from the tip 9
In the case of 3, the distance between the depth markers is 3 mm, the center of the two depth markers is 10 cm from the tip, and in the case of 3, the center of the center depth marker is 15 cm from the tip. In the case of four, the depth markers are spaced by 3 mm, and the four depth markers are printed so that the centers of the four depth markers are located 20 cm from the leading edge. Then, the tip portion is coated with the first coating resin 1.

Subsequently, the tip portion 6 is dipped in a solution in which a hydrophilic resin is dissolved and dried to cover the hydrophilic resin 8.

When the inside of the stomach model was observed with an endoscope catheter using the guide wire 10 prepared in this example, it was possible to immediately confirm how far the tip of the guide wire 10 was out of the catheter tip. Also, the operability was very high, and because the tip portion was flexible, the stomach wall was not damaged even when hitting the stomach wall, and the operability at hand was very good.

[0042]

Example 2 A guide wire of Example 2 is shown in FIG.
The second embodiment has the same basic structure as the first embodiment except that the material and dimensions are different. Therefore, the same reference numerals as those in FIGS. 1 and 2 are used.

The guide wire 10 has a stainless steel wire core 4. The length of the core is about 300 cm, and the outer diameter is about 0.15 mm at the tip 9 and about 20 cm from the tip 9.
It has a tapered shape up to 20 cm and the outer diameter is about 0.
It is 4 mm.

The guide wire 10 has a depth marker 5. The depth marker 5 is mainly made of fluorine resin. Depth markers 5 are printed on the core 4. The width of each piece is about 3 mm and is printed on the entire circumference of the core 4. The printing position of the depth marker 5 is about 5 from the leading edge.
cm, 10 cm, 15 cm, 20 cm, 25 cm, 50
cm at 6 positions, 1, 2, 3, 4 respectively
One, five, one can be attached.

The guide wire 10 has a first coating resin 1 and a second coating resin 2. The second coating resin 2 is made of fluorine resin. The coating length of the second coating resin 2 is about 200 cm from the rear end 3 and the outer diameter is about 0.032 inch (about 0.81 mm). The first coating resin 1 is made of nylon resin. The coating length of the first coating resin 1 is about 100 cm from the leading edge, the outer diameter is about 0.75 mm at the leading edge, and the tapered shape is about 20 cm to about 20 cm from the leading edge.
Up to cm is about 0.032 inch (about 0.81 mm). The guide wire 10 has a hydrophilic resin. The hydrophilic resin 8 is made of an ester polymer. The coating length of the hydrophilic resin 8 is about 100 cm from the leading edge.

The manufacturing method is almost the same as that in the first embodiment.

Similar to Example 1, the operability and the visibility of the depth marker were confirmed using a stomach model, and good results were obtained.

[0048]

Third Embodiment FIG. 4 shows a guide wire of the third embodiment.
Similar to the second embodiment, the third embodiment has the same basic structure as the first embodiment except that the material and dimensions are different.
And use the same as in FIG.

The guide wire 10 has a core 4. The core 4 is made of steel wire. The core 4 has a length of about 120 cm and an outer diameter of about 0.1 mm at the tip 9 and has a taper shape from the tip 9 to about 20 cm.
After m, the outer diameter is about 0.35 mm.

The guide wire 10 has a depth marker 5. The main component of the depth marker 5 is a ketone solvent. Depth markers 5 are printed on the core 4. Each depth marker 5 has a width of about 3 mm and a core 4
Is printed all around. The depth marker 5 is printed at about 5 cm and 10 cm from the leading edge, one at a position and two at a position, respectively.
Can be attached individually. The guide wire 10 is the first coating resin 1
And a second coating resin 2. The second coating resin 2 is made of polypropylene resin. The coating length of the second coating resin 2 is about 100 cm from the rear end 3 and the outer diameter is about 0.018 inch (about 0.46 mm). The first coating resin 1 is made of vinyl chloride resin. The coating length of the first coating resin 1 is about 20 cm from the tip, the outer diameter is about 0.4 mm at the tip, and the taper shape is from the tip to about 20 cm. The guide wire has a hydrophilic resin 8. The hydrophilic resin 8 is made of vinylpyrrolidone polymer. The coating length of the hydrophilic resin 8 is about 50 cm from the leading edge.

The production procedure is almost the same as that of the first embodiment.

Similar to Example 1, the operability and the visibility of the depth marker were confirmed using a stomach model, and good results were obtained.

[0053]

The guide wire of the present invention is provided on the tip end portion of the core, and the elastic linear core including the tip end portion having the taper portion tapering toward the tip end and the main body portion. The depth marker is covered with the coating resin, and the depth marker is covered with the coating resin, and the tip portion of the core and the substantially transparent first coating resin that covers at least the depth marker are used. Since the depth marker does not come into contact with liquid such as body fluid, the elution of ink components into the body does not occur, the visibility of the depth marker does not decrease, and the tip of the guide wire has a tapered shape Since it is flexible and has excellent kink resistance and push-in characteristics because the core is made of elastic wire, the operability is improved while visually observing the depth marker with an endoscope.

Further, in the guide wire of the present invention, at least a part from the tip of the first coating resin is coated with the hydrophilic resin, so that the tip has a high slidability in the body and is operated. The property is improved.

Further, in the guide wire of the present invention, the main body is coated with the second coating resin of a material different from that of the first coating resin, so that the coating resin covers the tip portion of the core. Since it is composed of the first coating resin and the second coating resin that covers the rear end portion, the surface physical properties of the guide wire at the distal end portion and the main body portion can be changed. The tip is made of a coating resin with high biocompatibility to contact the inner wall of the body, and the main body has excellent slidability with the lumen wall to move the lumen of a catheter such as an endoscope catheter. The optimum resin can be applied depending on the target site such as good.

Finally, when the guide wire of the present invention is used together with an endoscope catheter, the visibility of the depth marker and the operability of the guide wire are very good, and the diagnostic treatment can be placed under the endoscope. The labor of is reduced.

[Brief description of drawings]

FIG. 1 is an overall view of a guide wire according to a first embodiment of the present invention.

FIG. 1 is a sectional view of a distal end portion of a guide wire according to a first embodiment of the present invention.

FIG. 3 is an overall view of a guide wire according to a second embodiment of the present invention.

FIG. 4 is an overall view of a guide wire according to a third embodiment of the present invention.

FIG. 5 is an overall view of a prior art guide wire.

[Explanation of symbols]

 10 ... Guide wire 1 ... 1st coating resin 2 ... 2nd coating resin 3 ... last end 4 ... core 5 ... depth marker 6 ... -Tip 7 ... Main body 8 ... Hydrophilic resin 9 ... Cutting edge 20 ... Guide wire 11 ... Inner core 12 ... Covering layer 13 ... Mark

Claims (4)

[Claims] 1. An elastic linear core comprising a tip portion having a taper portion tapering toward the tip, and a main body portion,
A guide wire comprising: a depth marker provided on the tip of the core; and a substantially transparent first coating resin that covers at least the tip of the core and the depth marker. . 2. The guide wire according to claim 1, wherein at least a part from the tip of the first coating resin is coated with a hydrophilic resin. 3. The guide wire according to claim 2, wherein the main body is coated with a second coating resin made of a material different from that of the first coating resin. 4. A guide wire according to any one of claims 1 to 3, wherein the guide wire is used for operating an endoscope catheter. wire.