JPH09328406A - Fungicidal and antimicrobial agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a fungicidal and antimicrobial agent for food products and the like of a long life by allowing a specific porous ceramic which is of sustained release, excellent in handling strength to carry an isothiocyanic acid compound having strong fungicidal and antimicrobial activity and is very volatile. SOLUTION: An isothiocyanic acid compound is adsorbed to a porous ceramic fired at 300-1,000 deg.C in a proportion of 1-50wt.% based on the ceramic. The porous ceramic is, for example, enstatite, cristobalite, sepiolite, attapulgite or pearlite. Its shape is preferably spherical, platelet, pelletized or almond-like. This fungicidal and antimicrobial agent is sealed in a gas-impermeable film pouch, a plastic vessel or a metal vessel and a pin-hole or pin-holes are bored to allow the vapor of the active ingredient to gradually release through and the release rate is controlled with the number and the diameter of the pin-holes. The sustained release of the chemical can be confirmed by detecting the odor of the chemical. This fungicidal and antimicrobial agent is effective for freshness retention of food product, particularly in cupboards, drawers and the like.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to keeping freshness by vaporizing a gas, which is volatilized from a substance having antifungal and antibacterial activity, to foods, and is prone to mold and fungi, for example, a cupboard in a kitchen. , Maintenance of environmental hygiene such as drawers.

[0002]

2. Description of the Related Art Isothiocyanic acid compounds are substances extracted from Japanese yam and mustard vegetables, and are known to have strong antifungal and antibacterial activity. Therefore, commercialization utilizing this characteristic is performed, and a few products are on the market. However, since this substance is extremely volatile, a carrier is required to suppress the volatility and release it slowly. 4th to 5th
If the effect is good for a short period of time, a product that is kneaded with cyclodextrin or a polysaccharide such as starch and tableted is on the market, but this product is not a prepared food, such as bento or a side dish. Cannot be used. For products that can be used for a long period of about 30 days, there is a product that is kneaded with a betaine-based surfactant to form a jelly, but the shape is as large as an ice cream container, and the top lid of the container is fully opened. Because it may be mistaken for food.

[0003]

DISCLOSURE OF INVENTION Problems to be Solved by the Invention The inventors have focused on the fact that the isothiocyanic acid compound has an excellent antifungal and antibacterial activity, but have not been satisfied with the market. It was set like. (1) The antifungal and antibacterial activity does not decrease and the efficacy continues for at least 30 days. (2) The shape is as compact as possible and can be used in a narrow space. (3) The controlled release amount can be controlled according to the size of the space used and the gas concentration required in the space. (4) The user should be able to sensory confirm that an appropriate amount of gas with an apricot odor is volatilized from the product. (5) When the smell of Japanese horse mackerel disappears, it should be replaced as a reduction in efficacy.

[0004]

Means for Solving the Problems As a result of detailed investigations on the prior art, the inventors of the present invention have found that this strong protection is applied to a field suitable for maintaining the freshness of foods or maintaining a good hygienic environment such as a kitchen. It is essential to overcome the above-mentioned problems (1) to (5) in order to commercialize the isothiocyanic acid compound, which has mildew-bacterial activity and is extremely volatile, easily and effectively by the general public. As a result of intensive research and creation by the present inventors in order to overcome the problem, a carrier (carrier) for controlling volatility has a sustained release property, and porous ceramics excellent in handling strength are most suitable. I found out that.

That is, the polysaccharide-based carrier lacks the sustained-release property if it is processed so densely as to emphasize strength, and conversely disintegrates during handling if importance is attached to the sustained-release property. An inorganic mineral having a special crystal structure may be used as a carrier (carrier) having a sustained release property, but in reality, if an organic binder is not used, it will not retain its shape and will collapse during handling. When a binder is used, the sustained release property is significantly lost due to masking.

However, even if only porous ceramics were used as a carrier, the amount of volatilization was too large to obtain sustained release. Therefore, the present inventors tried to control the volatilization amount by wrapping it with various films having different gas barrier properties, which is a known prior art, but the concentration measurement data was conspicuous only in the excess and deficiency phenomenon, and a suitable sustained release property was expressed. It was not possible to find out the film that did.

Then, conversely, the porous ceramics on which the isothiocyanic acid compound has been adsorbed is sealed in a gas impermeable container, and a pinhole is opened in the container. The volatilized gas fills the container and is gradually released from the pinhole to the outside air. The sustained release amount can be controlled by the diameter and number of pinholes. With this method, the size of the space that requires antifungal and antibacterial properties and the gas concentration required by the space can be freely adjusted, and the lifetime of the effect is determined by the amount of antifungal and antibacterial agent enclosed in the container. Can be designed. When the nose was brought close to the pinhole of the antifungal antibacterial agent produced according to the present invention, there was a slight odor of radish. Two
It didn't smell because it spreads quickly at ~ 3 cm.

[0008] When the volatilization amount was measured by wrapping with various films having different gas barrier properties, it was not possible to make a sensory confirmation, so in this form the user can confirm the sustained release of gas. Before use, it may be sealed with a gas impermeable film, and in the case of plastics or a metal container, the lid may be used. Reseal or cover. When the smell of Japanese radish disappears from the pinhole, it is judged to be the limit of efficacy and it can be used as a guide to replace it with a new one.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION As a matter of course, the material of the porous ceramics used for the antifungal agent is porous, and it is required that the adsorption amount of the isothiocyanic acid compound is large.
In addition, materials that can be molded by pressure molding, extrusion molding, rolling granulation, etc., that is, one or more composites of enstatite, cristobalite, sepiolite, attapulgite, perlite, allophane, and diatomaceous earth. Selected from the inside.

The shape is made by using a jaw crusher or an impact crusher for crushed and sized products.
Crush with a general crusher and collect the target size with a vibrating screen. General crushers such as roller mills and hammer mills can be used for powder products, and rolling granulation products such as pan pelletizers for spherical products, pressure press machines for plates, and briquette machines for bales and almonds. Etc. Pellets are molded by an extrusion molding machine or the like, dried, and fired to obtain porous ceramics.

The antifungal and antibacterial base material can be specifically prepared by dipping and adsorbing a solution of an isothiocyanic acid compound previously diluted with a solvent such as ethanol to a predetermined concentration into the porous ceramics. If you put it in a bag with a pinhole and seal it by any method, it becomes a product of antifungal antibacterial agent, and if you peel off the seal when using it, the gas volatilized inside the bag will be gradually released from the pinhole to the outside air Functions as an agent.

In the case of a container, after the base material is enclosed, the product is an antifungal antibacterial agent if the inner lid with pinholes is closed and the upper lid is closed. When using, the vaporized gas inside the container becomes a pin. It functions as an antifungal and antibacterial agent by gradually releasing it from the hall to the outside air.

Alternatively, if a predetermined amount of the porous ceramics is sealed in a bag or container and then a predetermined amount of a solution of the isothiocyanic acid compound is injected with a pipette or the like to seal or cover the porous ceramics, the isothiocyanic acid compound is adsorbed by the porous ceramics. It becomes a product of antifungal antibacterial agent As for the method of use, in case of a bag, the seal may be peeled off, and in case of a container, the upper lid may be opened.

Further, a bag. When you pinch the container with your finger and press it lightly, the high-concentration gas filling the inside will be ejected from the pinhole, and you can temporarily increase the gas concentration in the target space, further increasing the antifungal and antibacterial atmosphere. It can be powerful.

[0015]

【Example】

Example 1 A cristobalite material was formed into a spherical shape by rolling granulation, dried and fired at 900 ° C. to form a spherical porous ceramic having a diameter of 5 mm. BED of this porous ceramics
The specific surface area according to the method was 50 m ² / g. A 30% solution of allyl isothiocyanate, which is a type of isothiocyanic acid compound, diluted with ethanol was attached to this to prepare an antifungal antibacterial agent.

A polyethylene cylindrical container having a heat of 1 mm, that is, a container having a diameter of 22 mm, a depth of 50 mm and an internal volume of 19 cm ³ , has 5.3 g of spherical porous ceramics having a diameter of 5 mm.
After the addition, 2.3 g of a 30% diluted solution of allyl isothiocyanate was instilled with a pipette and adsorbed on the porous ceramics. After that, the inner lid with a pinhole with a diameter of 1 mm was fitted, and the upper lid was fitted.

In the experiment, the upper lid of the container was always left open in the atmosphere, and the gas chromatography was used to measure 10
The container was sealed in a 0 ml gas bag. After 3 hours, a gas in which allyl isothiocyanate was volatilized was collected and the concentration was measured. This operation was performed at an arbitrary number of days and the decay state of the gas concentration was observed. From the known literature and data, it was aimed to maintain the gas concentration in the gas bag at 50 ppm or more. As a comparative example, the same amount and the same amount of antifungal antibacterial agent were enclosed in a gas permeable non-woven fabric at the same time and hermetically sealed. Incidentally, allyl isothiocyanate is said to exert an antibacterial effect from a concentration of 0.03 ppm, according to an evaluation by the Institute for Microbial Diseases Research and Hygiene Inspection Center of Osaka University. As a result, the gas concentration in the gas bag of the example of FIG. 1 has cleared 50 ppm or more even after 35 days have passed, and in FIG. 2 of the comparative example, after 5 days, the gas concentration has fallen below 50 ppm and the effect is obvious , Proved that the invention of controlling by the diameter and amount of pinholes, which was discovered by the unique idea of the inventor, is effective.

EFFECTS OF THE INVENTION It can be used for keeping the freshness of foods, especially for antibacterial and antibacterial use such as cupboards and drawers in the kitchen, and greatly contributes to prevention of food poisoning.

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[Procedure amendment]

[Submission date] August 26, 1996

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Brief description of drawings

[Correction method] Added

[Correction contents]

[Brief description of drawings]

FIG. 1 is a graph showing the contents of the embodiment. That is, antifungal antibacterial agent (30% of allyl isothiocyanate
Put the solution-impregnated porous ceramics) into a polyethylene container (with an inner lid having a pinhole with a diameter of 1 mm and an upper lid), take the upper lid and enclose it in a 100 ml gas bag, pinhole of the inner lid The result is that the gas of allyl isothiocyanate was gradually released and the concentration was measured every day, the vertical axis shows the concentration in the gas bag and the horizontal axis shows the number of days elapsed, which is below the target value of 50 ppm even after 35 days. It shows that there is no.

FIG. 2 is a graph showing the contents of a comparative example. That is, the same amount as the antifungal antibacterial agent used in the example, the same amount, sealed in a bag made of a gas permeable non-woven fabric and sealed, the results of an experiment conducted under the same conditions, the results are compared, the vertical axis is the gas The concentration in the bag and the horizontal axis indicate the number of days elapsed, which shows that the target value was less than 50 ppm after 5 days.

Claims (5)

[Applicant reference number] OA106 [Claims] 1. A preventive method characterized in that an isothiocyanic acid compound having antifungal and antibacterial properties is adsorbed in an amount of 1 to 50% by weight on a porous ceramics fired at 300 ° C. to 1000 ° C. and volatilized and gradually released into the atmosphere. Antifungal agent. 2. The antifungal agent according to claim 1, which is a gas-impermeable film bag. The bag is enclosed in a plastics container or a metal container. The container has a pinhole, and the volatile isothiocyanate compound is gradually released from the pinhole, and the sustained release amount can be controlled by the number and diameter of the pinholes. A fungicide antibacterial agent characterized by being able to be visually confirmed. 3. The material of the porous ceramics is one or a combination of two or more of enstatite, cristobalite, sepiolite, attapulgite, perlite, allophane and diatomaceous earth. Antifungal antibacterial agent. 4. The shape of the porous ceramics is powdery, crushed and sized irregularly shaped, and various artificially shaped shapes, that is, for example, spherical, plate-like, pellet-like, almond-like, etc. The antifungal antibacterial base according to claim 1. 5. A volatile substance of an isothiocyanic acid compound filled in the bag or container of the antifungal agent according to claim 4, is sprayed from a pinhole into a target space. Antifungal antibacterial agent.