JPH09286709A - Preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a preparation for external use for skin, excellent in improvement of chapped skin and chapped skin-preventing effect and useful as a material applied to cosmetics, medicines, quasi drugs and skin. SOLUTION: This preparation for external use for skin is obtained by blending a royal jelly extract with Panax Ginseng extract and a plant crude medicine. One or two or more kinds of natural extracts extracted from Oryza sativa Linne, Rosa roxburghii, Evenig primrose, Melilotus Officinals, Melissa officinalis L., Lavandaula officinalis, Paeonia lactiflora pallas and Glycyrrhiza glabra linne are preferably used as the plant crude medicine. Blend amounts of each component are preferably 0.0001-30wt.% royal jelly extract and 0.005-15wt.% Panax Ginseng extract.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation, and more particularly to a skin external preparation which is highly effective in preventing and improving skin roughness.

[0002]

2. Description of the Related Art Conventionally, various raw materials extracted from natural products such as proteins, polysaccharides, extracted extracts, and natural polymers have been used as skin external preparations because of their characteristic use effects. It has been blended. However, the effect is not yet sufficient, and a sufficiently excellent effect for preventing rough skin and improving rough skin has been desired.

[0003]

[Means for Solving the Problems] The inventors of the present invention have conducted diligent research as to whether or not there is a method for preventing skin roughness and enhancing the effect of improving skin roughness. As a result, an extract of royal jelly and ginseng (Pan)
The present invention has been completed by finding that this object can be achieved by blending an extract of ax ginseng) with one or two botanical herbs. That is, claim 1 of the present invention relates to royal jelly extract and ginseng (Pana)
xGinseng) extract and a botanical herbal medicine are blended together, which is an external preparation for skin. A second aspect of the present invention is the external preparation for skin according to the first aspect, wherein the herbal medicine is rice germ (Oryz.
a sativa Linne), yellow rose (Rosa roxburghii),
Evening primrose, Melilotus Of
ficinals), Melissa (Melissa officinalis L.), Lavender (Lavandaula officinalis), Peony (Paeonia)
lactiflora pallas), licorice (Glycyrrhiza glabra linn
An external preparation for skin, which is one or more natural extracts extracted from e).

The structure of the present invention will be described in detail below. The extract extracted from the royal jelly used in the present invention is royal jelly, which is a milky white mucous substance secreted from the secretory glands of the heads of young bees of bees, is alcohol, polyhydric alcohol, other various organic solvents, and water. It is preferable to blend a natural extract and / or extract further purified with an extraction solvent such as aqueous alcohol.

The ginseng extract used in the present invention is
Alcohol, polyhydric alcohol, other organic solvents,
A natural extract and / or extract extracted with an extraction solvent such as water or aqueous alcohol. Among these solvents, ethanol is particularly preferable.

The amount of the royal jelly extract and ginseng extract used in the present invention is 0.0001 to 30% by weight, preferably 0.005 to 15% by weight, based on the total amount of the skin external preparation. If it is less than 0.0001% by weight, the effect is difficult to be exhibited, and if it exceeds 30% by weight, the stability of the product is not preferable.

The botanical herbs used in the present invention include rice germ (Oryza sativa Linne) and Rosa rox (Rosa rox).
burghii), Evening primrose (Evenig primrose), Merrilot (Me
lilotus Officinals), Melissa (Melissa officinalis)
L.), lavender (Lavandaula officinalis), peony (Paeonia lactiflora pallas), licorice (Glycyrrhizagl)
a natural extract extracted from abra linne) is most suitable.
With respect to these botanical herbs, it is preferable to use rice germ, seeds for evening primroses, fruits for Izayoi rose, leaves for melilot and melissa, flowers for lavender, roots for peony and licorice. These plant crude drugs may be blended in a pulverized form, but natural extracts and / or extracts extracted with alcohols, polyhydric alcohols, other organic solvents, water, extraction solvents such as aqueous alcohol, etc. were further purified. It is preferable to blend one.

[0008] Of the herbal medicines in the present invention, one kind or two or more kinds can be blended. The blending amount of the botanical crude drug in the present invention is 0.0001 to 30% by weight, preferably 0.005 to 15% by weight, based on the total amount of the skin external preparation. If it is less than 0.0001% by weight, the effect is difficult to be exhibited, and if it exceeds 30% by weight, the stability of the product is not preferable.

In addition to the above-mentioned essential components, the external preparation for skin of the present invention contains other components which are usually used in external preparations for skin such as cosmetics and pharmaceuticals, such as avocado oil, palm oil, peanut oil, beef tallow, jojoba oil, and carnauba wax. , Beeswax, candelilla, lanolin, liquid paraffin, squalane, microcrystalline wax, stearic acid, lauric acid esters, myristic acid esters, oil components such as isostearyl alcohol, glycerin, sorbitol, polyethylene glycol, pyrrolidonecarboxylic acid and salts thereof, Moisturizers such as collagen, hyaluronic acid and its salts, chondroitin sulfate and its salts, UV absorbers such as amyl paradimethylaminobenzoate, urocanic acid and ethyl diisopropylcinnamate, ascorbic acid, α-tocopherol, dibutyrate Antioxidants such as hydroxytoluene and parahydroxyanisole, sodium stearyl sulfate, diethanolamine cetyl sulfate, polyoxyethylene sorbitan monolaurate, polyethylene glycol isostearate, surfactants such as acylmethyltaurine, preservatives such as ethylparaben and butylparaben ,
Extracts such as Oataku, Oren, Sikon, Assemblies, Birch, Loquat, Glycyrrhizic acid derivatives, Glycyrrhetinic acid derivatives, Salicylic acid derivatives, Hinokitiol, Zinc oxide, Allantoin and other anti-inflammatory agents, Placenta extracts, Glutathione, Yukinoshita extracts, Ascorbic acid Derivatives, whitening agents such as arbutin, extracts such as aloe, mallow, iris, grapes, yoquinin, loofah, lily, photosensitizer,
Cholesterol derivatives, activators such as various amino acids, saffron, senkyu, ginger, extract of Hypericum, Ononis, rosemary, garlic, etc., γ-oryzanol, dextran sulfate, blood circulation promoters, sulfur, thianthol, etc. Antiseborrheic agent, fragrance, water, alcohol, thickener such as carboxyvinyl polymer, lactic acid,
A pH adjusting agent such as citric acid or glycolic acid, a coloring agent such as titanium yellow, carsamine, or safflower red can be appropriately blended as necessary.

The external preparation for skin of the present invention comprises cosmetics, pharmaceuticals,
Refers to quasi-drugs and those applied to the outer skin, and the dosage forms are aqueous system, solubilization system, emulsion system, powder system, oil liquid system, gel system, ointment system, water-oil two-layer system, water. It can take a wide variety of forms such as an oil-powder tri-layer system.

[0011]

EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.
In addition, the blending amount is represented by wt% unless otherwise specified. [Rough skin improvement test] The back skin of a healthy man was treated with a 3% sodium dodecyl sulfate aqueous solution to prepare rough skin. After 2 hours, 20 μl of each sample was applied in an open manner. This was repeated for 5 days, and the condition of rough skin was visually observed on the 6th day, and was scored according to the criteria in Table 1. The higher the evaluation, the higher the effect of improving rough skin.

(Table 1) ───────────────────────────────── Rating criteria The criteria for rating ──── ───────────────────────────── 1 A wide range of stratum corneum dryness, swelling, and strong erythema are observed. 2 Dry, swelling and moderate erythema on the stratum corneum. 3 Dryness of the stratum corneum is observed, but no curling is observed. Weak erythema. 4 Dryness and turning of the stratum corneum are not observed, but some erythema is observed. 5 Dryness, swelling and erythema of the stratum corneum are not observed. ─────────────────────────────────

Each male group consisted of 10 persons, and the skin roughening improving effect of each sample was judged based on the average value of the scores of 10 persons. Judgment ◎: Average rating is 4 or more ○: Average rating is 3 or more and less than 4 Δ: Average rating is 2 or more and less than 3 ×: Average rating is less than 2 (Table 2) ────────── ─────────────────────────── Actual examples Comparative examples Samples 1 2 3 4 5 6 7 8 9 9 10 1 2 ──── ──────────────────────────────── Royal Jelly Extract 5 5 5 5 5 5 5 5 5 5 5 5 5 0 Ginseng Extract 5 5 5 5 5 5 5 5 5 5 5 5 0 Rice germ extract 3 0 0 0 0 0 0 0 0 0 0 0 0 0 Izayoba rose extract 0 3 0 0 0 0 0 0 0 0 0 0 0 0 Evening primrose extract 0 0 3 0 0 0 0 3 0 0 3 Meliroth extract 0 0 0 3 0 0 0 0 0 0 0 0 0 Melissa extract 0 0 0 0 3 3 0 0 0 0 3 3 0 0 Lavender extract 0 0 0 0 3 0 0 0 0 0 0 0 Peony extract 0 0 0 0 0 0 0 3 3 0 3 0 0 0 Licorice extract 0 0 0 0 0 0 0 0 0 3 0 3 0 0 POE (20) Sorbetane monolauric acid ester 0.5 「 undefined undefined undefined undefined undefined undefined undefined undefined POE (15) lauryl alcohol ether 0.5 undefined undefined undefined undefined undefined undefined undefined undefined undefined undefined undefined alcohol 8 undefined undefined undefined undefined undefined undefined undefined undefined undefined undefined undefined perfume qs undefined undefined undefined undefined undefined undefined undefined undefined 〃 〃 〃 Preservative 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 〃 ───────────────────── Evaluation ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ △ △

From Table 2, it can be seen that the combination of the natural extract extracted from royal jelly and the natural extract extracted from ginseng hardly improves the rough skin, but one or more of the above herbal medicines are used. It is understood that the blended system synergistically increases the rough skin improving effect.

[Actual Use Test by Replica Method] The skin surface morphology of the face of a healthy female panelist was taken using a replica method using a silicone resin, and a skin replica was taken and observed under a microscope (17 times). From the state of the skin pattern and the peeling state of the stratum corneum, the skin roughness was evaluated based on the criteria shown in Table 3, and the panelists judged to have a score of 1 or 2 were 20 persons per group,
The lotion of Formulation Example 1 or 2 shown in Table 4 was applied to the right half of the face, and the lotion of Comparative Example 1 was applied to the left half twice a day. Two weeks later, a replica was taken again and the skin condition was observed and evaluated in the same manner as above.

(Table 3) ──────────────────────────────────── Rating Standards of Rating ─────────────────────────────────── 1 Disappearance of skin crevices, cuticles, and widening of the stratum corneum Is recognized. 2 Unsmooth skin groove and crust, and horny turn of the stratum corneum. 3 There are pits and ridges, but they are flat. 4 Clear skin grooves and ridges. 5 Crusts and ridges are clear and well organized. . ────────────────────────────────────

In the corner group, the rough skin improving effect was determined as follows. Judgment: The proportion of panelists who were evaluated as 4 or 5 was 75.
% Or more △: The proportion of panelists evaluated as 4 or 5 is 25
% Or more and less than 75% x: The proportion of panelists evaluated as 4 or 5 is 25
The results are shown in Table 4. (Table 4) ──────────────────────────────────── Component Example 11 Example 12 Comparative example 3 ──────────────────────────────────── Royal Jelly Extract 1.5 1.5-Ginseng Extract 1 .5 1.5-Iizaibara extract 1.0 1.0-Melissa extract 1.0-Melito extract-1.0-Glycerin-5.0 Jojoba oil 1.0 1.0 1.0 Propylene glycol 1. 0 1.0 1.0 Citric acid 0.2 0.2 0.2 Ethanol 10.0 10.0 10.0 10.0 POE (60) hydrogenated castor oil 0.5 0.5 0.5 Perfume proper amount proper amount purified water Residual Residual Residual ──────────────────────────────────── ○ ○ △

As can be seen from Table 4, the external preparation for skin according to the present invention is an external preparation for skin excellent in the effect of improving rough skin.

When the following external preparations for skin of Examples 13 to 16 were prepared by a conventional method, they were excellent external preparations for skin that exhibited rough skin prevention and improvement effects.

Example 13 Nutrition cream Squalane 2.0 Cetyl isooctanoate 5.0 Decamethylcyclopentasiloxane 15.0 Dimethylpolysiloxane 5.0 Organically modified clay mineral 2.0 Diglyceroldiolate 2.0 Propylene glycol 10.0 Sodium hyaluronate 0.1 Korean ginseng extract 1.0 Royal jelly extract 1.0 Licorice extract 0.5 Arbutin 3.0 Rice germ extract 0.5 Preservatives proper amount Fragrance proper amount Trisodium edetate 0.05 Purified water Residue

Example 14 Emulsion Squalane 5.0 Jojoba oil 2.0 Oleyloylate 3.0 Vaseline 2.0 Stearic acid 1.0 Self-emulsifying glyceryl monostearate 0.8 POE (5) glyceryl monostearate 1. 2 Ethanol 3.0 Glycerin 5.0 Dipropylene glycol 5.0 Carboxy vinyl polymer 0.2 Potassium hydroxide 0.1 Glycyrrhizinate 0.1 Ginseng extract 3.0 Royal jelly extract 5.0 Isaioba rose extract 0.5 Evening primrose extract 1.0 Perfume Suitable amount Preservative Suitable amount Purified water Residual

Example 15 Emulsion Stearic acid 0.5 Vaseline 2.0 Liquid paraffin 3.0 Glycerin 4.0 1,3-butylene glycol 3.0 Octyl methoxycinnamate 0.5 Hexamethyldicycloxane (8 cSt) 1.5 Hexamethylcyclopolysiloxane (6cSt) 2.0 Alkyl-modified carboxyvinyl polymer 0.1 Carboxyvinyl polymer 0.2 Potassium hydroxide 0.1 Porous spherical silica powder 3.0 α-Tocopherol acetate 0.05 Koryo Ginseng extract 6.0 Royal jelly extract 3.0 Iza yoibara extract 1.0 Peony extract 1.5 Lavender extract 5.0 Perfume proper amount Preservative proper amount Purified water Residual

Example 16 Lotion lotion Ethanol 10.0 1,3 Butylene glycol 6.5 Glycerin 1.0 Jojoba oil 0.5 POE (5) oleyl alcohol ether 0.3 POE (20) sorbitan monostearate 1. 5 dl-α-tocopherol 2-L-ascorbic acid phosphoric acid diester potassium salt 0.1 ginseng extract 10.0 royal jelly extract 3.0 sodium hyaluronate 0.5 peony extract 1.5 fragrance proper amount preservative proper amount purified water residual

[0024]

EFFECT OF THE INVENTION The external preparation for skin of the present invention is a combination of an extract extracted from royal jelly, an extract extracted from ginseng, and a botanical herb for preventing rough skin and for improving the rough skin. The agent is provided.

Claims (2)

[Claims] 1. A royal jelly extract and ginseng (Pana)
x Ginseng) extract, and a botanical herbal medicine are blended, and a skin external preparation. 2. The external preparation for skin according to claim 1, wherein the botanical herb is rice germ (Oryza sativa Linne), Rosa roxburghii, Evening primrose, Melililotus Officinals, Melissa o.
fficinalis L.), lavender (Lavandaula officinali
s), peony (Paeonia lactiflora pallas), licorice (G
An external preparation for skin, which is one or more natural extracts extracted from lycyrrhiza glabra linne).