JPH09266954A - Therapy machine with electrode - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a therapy machine to enable to penetrate low concentration drug solution into an affected part in a short time, by equipping an electrode for penetrating drug solution into the affected part onto a main body of the therapy machine with the electrode to penetrate drug solution into the affected part by aligning the electrode to the affected part and charging a potential. SOLUTION: This therapy machine with an electrode for operation of glaucoma comprises a main body 1 laid on a bulb of eye E of the affected part and an electrode part 2, and the main body is integrally formed with a transparent lens part 3 at the bottom and a column part 4 to hold the lens part 3 and commonly used as the brephalostat. A suction hole 5 to suck the main body 1 to the bulb of eye E so as not to be shifted is formed on the column part 4. The electrode part 2 is equipped on the lens part 3, and an electrode 6 comprising a positive electrode 6a and a negative electrode 6b is attached on the eye front side. A retaining member 9 is set between electrodes 6a and 6b and pulses are applied to the electrode 6 to penetrate drug solution into a cell after retaining drug solution to a retaining material 9.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a therapeutic device with electrodes. More specifically, the present invention relates to an electrode-equipped therapeutic instrument that makes it easier to allow a drug solution to penetrate into an affected area by aligning an electrode with the affected area and applying a voltage.

[0002]

2. Description of the Related Art Currently, trabeculectomy is widely used as a surgical treatment for glaucoma. This is about 3 x 4m
It is a method of reducing the pressure by filtering the aqueous humor in the eye to the outside of the eye through the scleral corneal wound of m. Often recognized. It is known that this is because the fibroblasts under the conjunctival Tenon's capsule proliferate, and various fibroblast proliferation inhibitors have been tried to prevent this. For example, postoperative subconjunctival injection of 5-fluorouracil and intraoperative administration of mitomycin C (about 400 mg / ml) to a scleral wound.

[0003]

However, the above-mentioned drugs have strong cell membrane permeability, and their cytotoxicity has a risk of affecting the surrounding normal tissues, and their future effects on the tissues are unknown. Is.

In view of the above circumstances, an object of the present invention is to provide an electrode-equipped therapeutic instrument which allows a low-concentration drug solution to penetrate into an affected area in a short time.

[0005]

The therapeutic device with an electrode of the present invention is characterized in that an electrode for permeating a medicinal solution into the trunk is attached to the main body placed on the affected area.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION A therapeutic instrument with electrodes of the present invention will be described below with reference to the accompanying drawings.

FIG. 1 is a sectional view showing an embodiment of the therapeutic device with electrodes of the present invention, FIG. 2 is a perspective view of the therapeutic device with electrodes in FIG. 1, FIG. 3 is a bottom view of the electrode part in FIG. 1, and FIG. Figure 1
3 is a perspective view showing another embodiment of the main body in FIG. 5, FIG. 5 is a perspective view showing still another embodiment of the main body in FIG. 1, FIG. 6 is a plan view showing another embodiment of holding the chemical liquid, and FIG. 10 is a plan view showing another embodiment of the electrode in FIG. 8, FIG. 8 is a plan view showing still another embodiment of the electrode in FIG. 3, and FIG. 9 is a plan view showing still another embodiment of the electrode in FIG. 1 is a partial sectional view showing an embodiment of the electrode mounting structure in FIG. 1, FIG. 11 is a partial sectional view showing another embodiment of the electrode mounting structure in FIG. 1, and FIG. 12 is a sectional view of the electrode mounting structure in FIG. FIG. 13 is a partial sectional view showing still another embodiment.
14 is a partial sectional view showing still another embodiment of the electrode mounting structure in FIG. 14, and FIG. 14 is a partial sectional view showing still another embodiment of the electrode mounting structure in FIG.

The therapeutic instrument with electrodes of the present invention is particularly suitable for use in surgery for glaucoma, which is a disease of the eye, and as shown in FIGS. 1 to 3, a main body 1 placed on an affected eye E. ,
It is composed of an electrode portion 2 provided on the main body 1.

The main body 1 has a so-called contact lens shape whose inner surface is formed along the ocular surface, holds the transparent lens portion 3 at the hem and the lens portion 3, and is used during surgery. The cylindrical portion 4 also serving as the eyelid opener is integrally formed. Further, the columnar portion 4 may be provided with a suction hole 5 for adsorbing the main body 1 on the eyeball E and then adsorbing the eyeball E on the eyeball E so as not to be displaced during the operation. The electrode portion 2 is provided on the transparent lens 3, and an electrode 6 including a positive (+) electrode 6a and a negative (−) electrode 6b is attached to the eye surface side. A pulse voltage is applied to the electrode 6. The waveform of this voltage is rectangular, trapezoidal, saw-shaped or triangular.

As the electrode 6, gold, platinum, silver or alloys thereof, or those obtained by plating these can be used. The electrode lead wire 7 drawn out from the electrode 6 is connected to an external power source (not shown) through the insulating tube 8. A holding material 9 for holding a drug solution is provided between the pair of ± electrodes 6a and 6b, and a marking hole 10 for making a marking for determining the incision position penetrates therethrough. Also, the electrode part 2
An injection hole 11 for administration of the drug solution to the position of the eyeball E to be treated is formed therein, and an injection pipe 12 made of a soft material such as silicone rubber or Teflon is inserted therein. The injection hole 11 is formed at an intermediate position between the pair of ± electrodes 6a and 6b, but is formed in the vicinity of one of the electrodes, or one of the electrodes is formed so as to penetrate, or 2 You may make it provide more than one injection hole. Further, although the injection hole 11 is formed vertically in the electrode portion 2, it may be formed from the side surface of the electrode portion 2. By forming the injection hole on the side surface and pulling out the electrode lead wire from the side surface of the electrode portion, the incision position can be easily marked without being disturbed by the injection pipe and the insulating tube. As a material for the main body 1 and the electrode portion 2, an acrylic resin, a silicone resin, or the like, or a copolymer or a plastic thereof which does not adversely affect the human body or glass can be used.

In the present embodiment, the main body has a shape of a contact lens, but the present invention is not limited to this. For example, a round sheet 21 as shown in FIG. It may be a sheet type such as a square sheet, or a stick type such as a round bar 31 in which a main body and an electrode part are integrally molded as shown in FIG. When the main body is of the sheet type, a plastic film such as a silicone film, a polyester film, or a Teflon film can be used as the material. When the main body is of the stick type, the material used may be plastic such as acrylic or bakelite, or metal.

The holding material 9 is a member having water absorbability, and for example, water-containing plastic, sponge, paper or fiber can be used. This holding material is
As shown in FIG. 1, it is possible to absorb water by injecting a chemical solution or pre-immerse the chemical solution. When the chemical solution is soaked in advance in this way, the injection hole 11 can be omitted. Further, as shown in FIG. 6, a ring-shaped fence 12 may be provided so as to surround the electrode 6 to prevent the chemical solution from leaking.

Next, the electrode in the present invention will be described.

The electrode 6 is composed of a pair of rectangular + electrodes 6a and − electrodes 6b as shown in FIG. 3, but the present invention is not limited to this, and as shown in FIG. Two pairs of positive electrodes 26a, 36a and negative electrodes 26b, 36
b, or as shown in FIGS. 8 to 9, the electrodes in FIGS. 3 and 7 may be annularly attached. The electrode mounting structure is as shown in FIG.
As shown in FIG. 0, the electrode may be embedded flush with the inner surface 1a, or as shown in FIG. 11, it may be convex with the tip of the electrode protruding from the inner surface 1a. As shown in FIG. 12, a concave shape is embedded in the inner surface 1a, as shown in FIG. 13, an insulating convex shape in which the tip side surface of the electrode in FIG. 11 is insulated, or as shown in FIG. It may be a sticking type that is directly stuck to or a baking type that is baked.

Next, a method of using the therapeutic instrument with electrodes of the present invention will be described. As shown in FIG. 1, the main body 1 is placed on the eyeball E of a glaucoma patient, and the electrode 6 is fitted to the site where an incision operation is to be performed. Then, air is sucked out from the suction hole 5 and the main body 1 is sucked onto the eyeball E. Then, an anti-cancer agent such as bleomycin, which is a drug solution, is administered from the injection hole 11 at a dose of 10 μg / ml, and is held by the holding material 9, and then the voltage of 5 V is applied to the electrode 6.
Is applied eight times with an electric pulse of 50 msec. Although the molecular weight of bleomycin is as high as 1400 due to this electric pulse, it easily penetrates into cells. The present invention is not limited to the one in which the electric pulse is applied after the medical liquid is administered, and the medical liquid may be administered after the electric pulse is applied. After the application is completed, the incision site is marked with a dye from the marking hole 10, and then the suction is released to remove the main body 1. Next, a part of cells (sclera) at the marking site is incised by a normal operation.

Next, the electrodes in the therapeutic instrument with electrodes of the present invention will be described with reference to animal experiment examples. The animals used in the experiment are five colored rabbits. Before the sclera incision, 10μ
A sponge soaked with g / ml bleomycin was placed on the sclera of one eye of each rabbit for 5 minutes, and then an electrode was placed on the same site, and a voltage of 5V was applied 8 times at 50 msec intervals for bleomycin. Permeated. Then, a scleral flap was formed at that site (hereinafter referred to as Example). Similarly, when only bleomycin was administered without performing the electric pulse, it was also performed (hereinafter referred to as a comparative example). The average intraocular pressure of 20 mmHg before the operation was lower than that of the preoperative one week after the operation, and was 11 mmHg in the case of Example and 12 mmHg in the case of Comparative Example. Further, two weeks after the operation, in the case of the example, clear cysts were formed, the average intraocular pressure was 12 mmHg, and in the case of the comparative example, it was 15 mmHg. Further, after 30 days from the operation, the intraocular pressure was stable and lower in the case of the example than in the case of the comparative example.

[0017]

INDUSTRIAL APPLICABILITY As described above, in the present invention, a drug can be used in combination with an electric pulse to penetrate into a target site. Therefore, the concentration of the drug can be lowered, and the safety to surrounding tissues is also improved. Currently, 10 μg / ml bleomycin is used in animal experiments using rabbits.

[Brief description of drawings]

FIG. 1 is a cross-sectional view showing an embodiment of a therapeutic instrument with electrodes of the present invention.

FIG. 2 is a perspective view of the therapeutic device with electrodes in FIG.

FIG. 3 is a bottom view of an electrode unit in FIG.

FIG. 4 is a perspective view showing another embodiment of the main body in FIG.

FIG. 5 is a perspective view showing still another embodiment of the main body in FIG.

FIG. 6 is a plan view showing another embodiment of holding a chemical liquid.

FIG. 7 is a plan view showing another embodiment of the electrode in FIG.

8 is a plan view showing still another embodiment of the electrode in FIG.

9 is a plan view showing still another embodiment of the electrode in FIG.

FIG. 10 is a partial cross-sectional view showing an example of an electrode attachment structure in FIG.

11 is a partial cross-sectional view showing another embodiment of the electrode mounting structure in FIG.

12 is a partial cross-sectional view showing still another embodiment of the electrode mounting structure in FIG.

13 is a partial cross-sectional view showing still another embodiment of the electrode attachment structure in FIG.

FIG. 14 is a partial cross-sectional view showing still another embodiment of the electrode attachment structure in FIG.

[Explanation of symbols]

1 Main body 2 Electrode part 3 Transparent lens part 4 Cylindrical part 5 Suction hole 6, 6a, 6b, 26a, 26b, 36a, 36b Electrode 9 Holding material 10 Marking hole 11 Injection hole 21 Round sheet (main body) 31 Round bar (main body) E eyeball

Claims (9)

[Claims] 1. A therapeutic device with an electrode, comprising an electrode for permeating a drug solution into an affected area, which is attached to a main body placed on the affected area. 2. The device of claim 1, wherein a voltage is applied by the electrodes. 3. The waveform of the voltage is a pulse.
The described instrument. 4. The device according to claim 1, 2 or 3, further comprising a holding material for holding the drug solution. 5. The device according to claim 1, wherein an injection hole is formed to administer the drug solution to the affected area. 6. The device according to claim 1, wherein a suction port is formed in the main body. 7. The method according to claim 1, which is used for eye surgery.
The device according to 3, 4, 5 or 6. 8. The instrument of claim 7, wherein the eye surgery is glaucoma surgery. 9. The device of claim 1, 2, 3, 4, 5, 6, 7 or 8 wherein said body is a transparent plastic lens.