JPH09235215A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition high in an effect for depressing a cariogenic bacterium, Streptomyces mutans, in oral cavities, and useful for tooth pastes, mouth washes, etc. SOLUTION: This composition for oral cavities comprises xylitol (preferably in an amount of 5-20wt.% based on the whole amount of the composition) and hydroxyapatite (preferably in an amount of 3-15wt.% based on the whole amount of the composition). The hydroxyapatite preferably has a high purity comprising a Ca10 (PO4 )6 (OH)2 content of >=95wt.% and an average particle size of 3-20μm. The composition preferably further contains a nonionic germicide (e.g. triclosan) in an amount of 0.001-1wt.% based on the whole amount of the composition.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a caries-causing bacterium, particularly Streptococcus mutans (S. mutan).
s) The present invention relates to a composition for oral cavity, which has a high effect of inhibiting bacteria in the oral cavity and an excellent effect of preventing dental caries.

[0002]

2. Description of the Related Art
Various oral compositions having an inhibitory effect on caries-causing bacteria have been proposed, but the inhibitory effect on caries-causing bacteria of conventional oral compositions still has room for study, and further caries-causing bacteria. There is a demand for the development of a safe oral composition having an improved inhibitory effect on the above.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a composition for oral cavity which is excellent in the inhibitory effect of caries-causing bacteria.

[0004]

Means for Solving the Problems and Modes for Carrying Out the Invention As a result of extensive studies conducted by the present inventor to achieve the above-mentioned object, by combining xylitol and hydroxyapatite in a composition for oral cavity, Surprisingly, the number of Streptococcus mutans (S. mutans), which is a caries-causing bacterium in the oral cavity, can be significantly reduced, and therefore, an oral composition having an excellent caries-preventing effect can be obtained. It was found that the present invention has been completed.

It should be noted that the composition for the oral cavity contains xylitol (see JP-A-50-12144) and hydroxyapatite (JP-A-55-55).
No. 57514 and No. 56-73014) are known, respectively, but it is a new finding of the present inventor that the above-mentioned special effects can be obtained by using both of these components in combination.

Therefore, the present invention provides a composition for oral cavity, which is characterized by using xylitol and hydroxyapatite in combination.

The present invention will be described in more detail below. The oral composition of the present invention comprises various toothpastes such as toothpaste and liquid toothpaste, dental creams or gels, mouthwashes and mouthwashes. It can be prepared and used as described above, and contains xylitol and hydroxyapatite as active ingredients.

The hydroxyapatite used in the present invention is at least 90% by weight, preferably 9% by weight.
High-purity hydroxyapatite containing 5% by weight or more of Ca ₁₀ (PO ₄ ) ₆ (OH) ₂ is desirable. Specifically, there is "Sekisui apamicron" manufactured by Sekisui Plastics Co., Ltd.

As the particle size of hydroxyapatite, any particle size can be used, but when the composition of the present invention is used in an appropriate amount, it can be satisfactorily cleaned without damaging the tooth surface. Is preferably used. The average particle size of such hydroxyapatite is about 1 to 100 μm, more preferably 2 to 50 μm.
m, and more preferably 3 to 20 μm.

In the present invention, the compounding amount of hydroxyapatite is 1 to 50% (% by weight, the same applies hereinafter) of the entire composition, more preferably 2 to 20%, and further preferably 3 to.
15% is preferred. If the blending amount is less than 1%, a satisfactory effect may not be obtained, and if it exceeds 50%, toothpaste may be too hard.

On the other hand, the compounding amount of xylitol is preferably 0.1 to 80%, more preferably 1 to 40%, further preferably 5 to 20% of the total composition. If it is less than 5%, the combined effect with hydroxyapatite may not be sufficiently exerted, and if it exceeds 80%, the taste and usability may deteriorate.

Further, in the composition of the present invention, it is preferable to blend a non-cationic bactericide such as halogenated diphenyl ether, phenol compound or halogenated carbanide together with the above-mentioned active ingredients xylitol and hydroxyapatite. Particularly preferred. Specific examples of these non-cationic bactericides include triclosan, isopropylmethylphenol, p-hydroxybenzoic acid and trichlorocarbanilide.

The content of the non-cationic bactericide is preferably 0.001 to 1%, especially 0.01 to 0.5% of the total composition, and if it is less than 0.001%, the bactericidal effect is not sufficiently exhibited. In some cases, if it exceeds 1%, the taste may deteriorate.

The composition for oral cavity of the present invention may contain appropriate components in addition to the above-mentioned components depending on the kind thereof. For example, in the case of toothpaste, silica, calcium phosphate, aluminum hydroxide and other abrasives, sorbitol, glycerin, propylene glycol, polyethylene glycol and other thickeners, as well as binders, surfactants, sweeteners, flavors and colorants. Can be mixed. In any of these cases, conventionally used components can be used in a usual amount.

[0015]

INDUSTRIAL APPLICABILITY The oral composition of the present invention contains Streptococcus mutans (S.
mutans), which can significantly reduce the number of bacteria, and has an excellent caries prevention effect.

[0016]

EXAMPLES The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In addition, all% in each example are weight%.

[Examples 1 and 2, Comparative Examples 1 and 2] Fifteen healthy people were divided into three equal groups, and each of the three types of toothpaste shown in Table 1 was used for 3 months. S. mu
The number of tans bacteria was measured by the following method. Table 2 shows the results. Bacteria count method : Unstimulated whole saliva was collected before and after the experimental period. 1 ml of whole saliva was collected, and ultrasonic waves were uniformly dispersed over this for 5 seconds, and serially diluted 10-fold with 0.05M phosphate buffer (pH 7.1) containing 0.4% potassium chloride. went. The diluted solution was mixed with 20% sucrose and 200 U / l bacitracin.
n) including MS (mitis salivalis)
It was applied to the medium. Plate the plate with 95% N ₂ , 5% CO _2.
Anaerobic culture was carried out at 37 ° C. for 48 hours at S. Mutans was identified morphologically and the number of bacteria was measured.

[0018]

[Table 1]

[0019]

[Table 2]

From the results shown in Table 2, the oral compositions of the present invention (Examples 1 and 2) were found to contain S. It was confirmed that it is effective in suppressing mutans bacteria.

[Example 3] Hydroxyapatite 5.0% Silica 10.0 Xylitol 15.0 Polyethylene glycol 400 3.0 85% Glycerin 8.0 Sodium carboxymethyl cellulose 1.2 Sodium lauryl sulfate 1.2 Monofluorophosphoric acid Sodium 0.76 Saccharin sodium 0.03 Fragrance 1.2 Water Residual 100.0%

Example 4 Hydroxyapatite 5.0% Viscosity-Enhanced Silica 3.0 Calcium Phosphate Dihydrate 35.0 Xylitol 25.0 Propylene Glycol 3.0 Sodium Carboxymethyl Cellulose 1.5 Sodium Lauryl Sulfate 1.0 Monofluoro Sodium phosphate 0.76 Sodium saccharin 0.03 Fragrance 1.0 Water Total balance 100.0%

Example 5 Hydroxyapatite 1.0% Thickening silica 3.0 Silica 10.0 Xylitol 60.0 Polyethylene glycol 400 5.0 70% Solbit 5.0 Sodium carboxymethylcellulose 1.0 Sodium lauryl sulfate 1 .3 Sodium fluoride 0.34 Triclosan 0.1 Sodium saccharin 0.01 Perfume 1.0 Water Residual 100.0%

Example 6 Hydroxyapatite 5.0% Viscosity-Enhanced Silica 2.0 Aluminum Hydroxide 40.0 Xylitol 25.0 Propylene Glycol 5.0 Sodium Carboxymethyl Cellulose 1.2 Sodium Lauryl Sulfate 1.2 Monofluoroline Sodium acid salt 1.14 Methyl p-hydroxybenzoate 0.2 Sodium saccharin 0.02 Perfume 1.0 Water Residual amount 100.0%

Example 7 Hydroxyapatite 10.0% Thickening silica 3.0 Calcium phosphate dihydrate 27.0 Xylitol 5.0 Propylene glycol 3.0 85% Glycerin 20.0 Sodium carboxymethylcellulose 1.3 Lauryl sulfate Sodium 1.2 Sodium monofluorophosphate 0.76 Sodium saccharin 0.03 Perfume 1.2 Water Residual 100.0%

[Example 8] Hydroxyapatite 5.0% Viscosity-enhancing silica 3.0 Silica 15.0 Xylitol 10.0 Propylene glycol 3.0 85% Glycerin 12.0 Carboxymethylcellulose sodium 1.2 Sodium lauryl sulfate 1. 0 Sodium fluoride 0.23 Triclosan 0.3 Sodium saccharin 0.03 Titanium dioxide 0.2 Perfume 1.0 Water Residual 100.0%

Example 9 Hydroxyapatite 15.0% Thickened silica 2.0 Aluminum hydroxide 30.0 Xylitol 20.0 Propylene glycol 5.0 Sodium carboxymethyl cellulose 1.2 Sodium lauryl sulfate 0.8 Monofluoroline Sodium acid salt 0.76 Saccharin sodium 0.02 Perfume 1.2 Water Residual amount 100.0%

[Example 10] Hydroxyapatite 3.0% Thickening silica 3.0 Silica 20.0 Xylitol 30.0 Polyethylene glycol 400 5.0 Sodium carboxymethyl cellulose 1.1 Sodium lauryl sulfate 0.5 Sodium fluoride 0 .23 Triclosan 0.02 Saccharin sodium 0.02 Fragrance 0.8 Water Residual total 100.0%

Claims (2)

[Claims] 1. An oral composition comprising xylitol and hydroxyapatite in combination. 2. A nonionic bactericide is added to the composition.
The oral composition according to any one of the preceding claims.