JPH09175994A - Calcium liquid agent, calcium drink and method for producing the same - Google Patents

Abstract

(57) [Abstract] [Problem] Conventionally, acetic acid and hydrochloric acid, which have strong dissolving power, have been used to dissolve shells such as calcium carbonate and boley powder. Therefore, it has a drawback that it is difficult to take and that the solubility of the calcium source is small when an organic acid or an inorganic acid other than the above is used. SOLUTION: The calcium source is malic acid or citric acid.
By dissolving with one or two kinds and lactic acid, a calcium solution and a calcium beverage having a high dissolution amount and an excellent flavor were obtained.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a calcium liquid agent containing a high concentration of calcium and having an excellent flavor, a calcium beverage containing the same as an active ingredient, and a method for producing the same.

[0002]

2. Description of the Related Art Compared with Europe and the United States, Japan has a lower proportion of limestone and a lower calcium content in soil and river water, so that the intake of calcium from vegetables and drinking water is low. Calcium is an important nutrient for the formation of bones and teeth.According to the results of epidemiological studies, calcium intake correlates with bone mass, and calcium intake in early life has a large effect on bone mass thereafter. Is known to give. In addition, calcium requirements are increased in pregnant and lactating women.

However, the abundance of dietary habits in recent years lowers the calcium intake of Japanese people, and as is clear from the National Nutrition Survey of the Ministry of Health and Welfare, the only calcium intake in the nutrients is below the required amount. There is. Therefore, in post-menopausal women, the onset of osteoporosis has become a problem, and it has recently been pointed out that frequent fractures in children occur. Therefore, many drugs and foods for the purpose of supplementing calcium are sold.

[0004] Calcium is provided by being added to medicines such as tablets, granules and liquid dosage forms, foods having a similar form, and confectionery. However, solid medicine must be taken with swallowing and water,
It is not easy to take for infants and the elderly. Addition of high-volume calcium to confectionery and foods impairs the original flavor of confectionery and foods, thus limiting the amount of calcium added. Further, it is known that calcium carbonate and calcium phosphate, which are often added to confectioneries and foods for the purpose of supplementing calcium, have poor calcium absorbability.

On the other hand, the liquid formulation is a formulation in which hardly absorbable calcium is relatively easily absorbed, and various formulations have been provided. For example, many liquid agents using calcium gluconate or calcium lactate, which have little unpleasant taste and high solubility, are commercially available. Further, JP-A-54-8767, JP-A-2-212, and JP-A2-1.
Patent publications such as 19761 also disclose liquid agents using calcium gluconate and calcium lactate.

Conventionally, acetic acid and hydrochloric acid, which have a strong dissolving power, have been used to dissolve shells of shells such as calcium carbonate and boley powder, but calcium solutions prepared from these acids have a pungent odor and salty taste. Therefore, there was a drawback that it was difficult to take. Further, there is a drawback that the solubility of the calcium source is small when an organic acid or an inorganic acid other than the above is used.

[0007]

SUMMARY OF THE INVENTION There has been a demand for a calcium liquid preparation having a high solubility of a calcium source and containing a high concentration of calcium, and having no pungent odor or salty taste and an excellent flavor.

[0008]

DISCLOSURE OF THE INVENTION The present invention provides a liquid preparation containing a high concentration of calcium and having no unpleasant flavor, a calcium beverage containing the liquid preparation, and a method for producing the same. As a result of intensive studies to solve the above-mentioned problems, the present inventors succeeded in dissolving calcium at a high concentration by using one or two kinds of malic acid or citric acid and lactic acid. The present invention has been completed by finding out that a calcium liquid preparation having no unpleasant flavor is produced.

In the calcium liquid preparation of the present invention, a shell of a shell such as calcium carbonate or boley powder is used as a calcium source. Malic acid, citric acid and lactic acid used are d-
Any of body, 1-body, and dl-body may be used. The amount of the acid used in the present invention is such that the molar equivalent ratio of one or two types of malic acid or citric acid and lactic acid is 1: 1 to 1: 2.
It is preferably 0. The calcium solution of the present invention is
Higher concentrations are obtained than when malic acid, lactic acid or citric acid is used alone. In addition, it does not show an irritating odor or an unpleasant odor as in the case of using acetic acid or hydrochloric acid.

The calcium solution of the present invention comprises, according to the purpose, riboflavin sodium phosphate, vitamins such as pyridoxine hydrochloride, herbal extracts such as carrot extract and sycamore extract, other physiologically active ingredients, benzoate and alkyl paraoxybenzoate. Preservatives such as sugars, fructose-glucose liquid sugar, reduced maltose starch syrup, refined sucrose, fructose, glucose, sucrose and other sweeteners and other additives are added as appropriate to give an oral calcium drink for pharmaceuticals and a calcium drink for foods. Can be provided as.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION The calcium liquid of the present invention is added to water as a calcium source, stirred, sufficiently dispersed, and one or two kinds of malic acid or citric acid and lactic acid are added to the calcium solution to give 50-
It can be produced by heating and stirring at 100 ° C. The amount of acid used is such that the molar equivalent ratio of one or two types of malic acid or citric acid and lactic acid is 1: 1 to 1: 1.
It is preferably 1:20. If necessary, the above-mentioned additives are appropriately added to the calcium liquid thus obtained to give a calcium liquid for internal use in medicine and a calcium drink for food.

[0012]

Next, the present invention will be described with reference to examples.
It is not limited to these.

Example 1 100 g (excess amount of dissolution) of boll powder was placed in a container, 500 ml of purified water was added, and the boll powder was dispersed with stirring.
To this, 200 g of 50 w / w% 1-lactic acid aqueous solution and 60 w
/ V% dl-citric acid aqueous solution 33 ml (molar equivalent ratio; l-
(Lactic acid: dl-citric acid = 4: 1, total amount of acid: 1.4 molar equivalent) was added, and the amount was adjusted to 1000 ml with purified water. This liquid 9
The mixture was heated and stirred to 0 ° C., cooled, and then filtered to obtain a calcium liquid agent. After filtration, reduced maltose syrup (75%) was added to the filtrate.
1000 g was added to make 3500 ml with purified water, 100 ml was filled in a glass bottle, capped and heat sterilized to obtain a calcium beverage.

Example 2 100 g of calcium carbonate (excessive amount of dissolution) was placed in a container,
Purified water (500 ml) was added, and calcium carbonate was dispersed while stirring. Add to this 50 w / w% dl-lactic acid aqueous solution 25
0 g, 60 w / v% dl-citric acid aqueous solution 20 ml and 6
20 ml of 0 w / v% dl-malic acid aqueous solution (molar equivalent ratio;
dl-lactic acid: dl-citric acid: dl malic acid = 8: 1:
1, the total amount of acid: 1.75 molar equivalents), and add 1 with purified water.
It was 000 ml. This liquid was heated and stirred to 70 ° C., cooled, and then filtered to obtain a calcium liquid agent. After filtration, 450 g of purified sucrose was added to the filtrate to make 3500 ml with purified water, 100 ml was filled in a glass bottle, capped, and then heat sterilized to obtain a calcium beverage.

Example 3 100 g of calcium carbonate (dissolved excess amount) was placed in a container,
Purified water (500 ml) was added, and calcium carbonate was dispersed while stirring. 50 w / w% dl-lactic acid aqueous solution 30
0 g and 47 ml of a 60 w / v% dl-malic acid aqueous solution (molar equivalent ratio; dl-lactic acid: dl-malic acid = 4: 1, total amount of acid: 2.1 molar equivalents) were added to make up to 1000 ml with purified water. This liquid was heated and stirred to 60 ° C., cooled, and then filtered to obtain a calcium liquid agent. After filtration, add 560 g of fructose-glucose liquid sugar (75%) to the filtrate and add 3500 ml of purified water.
Then, 100 ml was filled in a glass bottle, capped, and then heat sterilized to obtain a calcium beverage.

Example 4 100 g of calcium carbonate (excessive amount of dissolution) was placed in a container,
Purified water (500 ml) was added, and calcium carbonate was dispersed while stirring. Add to this 50 w / w% dl-lactic acid aqueous solution 15
7 g and 98 w of 60 w / v% dl-malic acid aqueous solution (molar equivalent ratio; dl-lactic acid: dl-malic acid = 1: 1, total amount of acid: 1.75 molar equivalent) were added, and 1000 ml of purified water was added.
And The liquid was heated and stirred to 100 ° C., cooled, and then filtered to obtain a calcium liquid agent. After filtration, add 1000 g of reduced maltose syrup (75%) to the filtrate and add 35 with purified water.
The amount was set to 00 ml, 100 ml was filled in a glass bottle, and the bottle was stoppered and sterilized by heating to obtain a calcium beverage.

Example 5 100 g (excess amount of dissolution) of boley powder was placed in a container, 500 ml of purified water was added, and the boley powder was dispersed with stirring.
To this, 300 g of 50 w / w% dl-lactic acid aqueous solution and 60
w / v% citric acid aqueous solution 9.7 ml (molar equivalent ratio; dl-
Lactic acid: citric acid = 20: 1, total amount of acid: 1.75 molar equivalent) was added, and the amount was adjusted to 1000 ml with purified water. 10 parts of this liquid
The mixture was heated and stirred to 0 ° C., cooled, and then filtered to obtain a calcium liquid agent. After filtration, the filtrate is fructose-glucose liquid sugar (75
%) 560 g was added to make 3500 ml with purified water, 100 ml was filled in a glass bottle, capped and heat sterilized to obtain a calcium beverage.

Next, a known method corresponding to each of the above-mentioned embodiments will be shown as a comparative example. Comparative Examples are experimental examples in which the acid used in the present invention is used alone, Comparative Examples 1a and 1b are used in Example 1, Comparative Examples 2a, 2b and 2c are used in Examples 2, 4 and 5, and Comparative Example 3a. And 3b correspond to Example 3, respectively. Comparative Examples 4 and 5 are experimental examples using acetic acid, which is a conventional method.

Comparative Example 1a 100 g of volley powder (excess amount of dissolution) was placed in a container, 500 ml of purified water was added, and the volley powder was dispersed with stirring.
To this was added 252 g (1.4 molar equivalents) of a 50 w / w% l-lactic acid aqueous solution, and the volume was adjusted to 1000 ml with purified water. This liquid was heated and stirred to 90 ° C., cooled, and then filtered to obtain a calcium liquid agent. After filtration, the filtrate is reduced maltose syrup (75
%) 1000 g and purified water to 3500 ml, 100 ml was filled in a glass bottle, and the bottle was stoppered and heat sterilized to obtain a calcium beverage.

Comparative Example 1b 100 g (excess amount of dissolution) of boll powder was placed in a container, 500 ml of purified water was added, and the volley powder was dispersed with stirring.
163 ml of 60 w / v% dl-citric acid aqueous solution
(1.4 molar equivalent) was added, and the volume was adjusted to 1000 ml with purified water. This liquid was heated and stirred to 90 ° C., cooled, and then filtered to obtain a calcium liquid agent. After filtration, 1000 g of reduced maltose starch syrup (75%) was added to the filtrate to make 3500 ml with purified water, 100 ml was filled in a glass bottle, stoppered and heat sterilized to obtain a calcium beverage.

Comparative Example 2a 100 g of calcium carbonate (dissolved excess amount) was placed in a container,
Purified water (500 ml) was added, and calcium carbonate was dispersed while stirring. Add to this 50 w / w% dl-lactic acid aqueous solution 31
5g (1.75 molar equivalent) was added and 1000ml with purified water
And After heating and stirring this liquid to 70 ° C. and cooling,
It was filtered to obtain a calcium liquid agent. After filtration, 450 g of purified sucrose was added to the filtrate to make 3500 ml with purified water, 100 ml was filled in a glass bottle, capped, and then heat sterilized to obtain a calcium beverage.

Comparative Example 2b 100 g of calcium carbonate (dissolved excess amount) was placed in a container,
Purified water (500 ml) was added, and calcium carbonate was dispersed while stirring. To this, 204 ml of 60 w / v% dl-citric acid aqueous solution (1.75 molar equivalents) was added, and 100% of purified water was added.
0 ml. This liquid was heated and stirred to 70 ° C., cooled, and then filtered to obtain a calcium liquid agent. After filtration, 450 g of purified sucrose was added to the filtrate to make 3500 ml with purified water, 100 ml was filled in a glass bottle, capped, and then heat sterilized to obtain a calcium beverage.

Comparative Example 2c 100 g of calcium carbonate (dissolved excess amount) was placed in a container,
Purified water (500 ml) was added, and calcium carbonate was dispersed while stirring. To this, 195 ml (1.75 molar equivalent) of a 60 w / v% dl-malic acid aqueous solution was added, and purified water was added to 100
0 ml. This liquid was heated and stirred to 70 ° C., cooled, and then filtered to obtain a calcium liquid agent. After filtration, 450 g of purified sucrose was added to the filtrate to make 3500 ml with purified water, 100 ml was filled in a glass bottle, capped, and then heat sterilized to obtain a calcium beverage.

Comparative Example 3a 100 g of calcium carbonate (dissolved excess amount) was placed in a container,
Purified water (500 ml) was added, and calcium carbonate was dispersed while stirring. Add to this 50 w / w% dl-lactic acid aqueous solution 37
8 g (2.1 molar equivalent) was added, and the volume was adjusted to 1000 ml with purified water. This liquid was heated and stirred to 60 ° C., cooled, and then filtered to obtain a calcium liquid agent. After filtration, add 560 g of fructose-glucose liquid sugar (75%) to the filtrate and add 3500 ml of purified water.
Then, 100 ml was filled in a glass bottle, capped, and then heat sterilized to obtain a calcium beverage.

Comparative Example 3b 100 g of calcium carbonate (dissolved excess amount) was placed in a container,
Purified water (500 ml) was added, and calcium carbonate was dispersed while stirring. To this, 235 ml (2.1 molar equivalents) of 60 w / v% dl-malic acid aqueous solution was added, and 1000 with purified water.
ml. This liquid was heated and stirred to 60 ° C., cooled, and then filtered to obtain a calcium liquid agent. After filtration, add 560 g of fructose-glucose liquid sugar (75%) to the filtrate and add 35 with purified water.
The amount was set to 00 ml, 100 ml was filled in a glass bottle, and the bottle was stoppered and sterilized by heating to obtain a calcium beverage.

Comparative Example 4 100 g (excess amount of dissolution) of calcium carbonate was placed in a container,
Purified water (500 ml) was added, and calcium carbonate was dispersed while stirring. To this, 350 ml of 30 w / v% acetic acid aqueous solution
(1.75 molar equivalent) was added, and the volume was adjusted to 1000 ml with purified water. This liquid was heated and stirred to 90 ° C., cooled, and then filtered to obtain a calcium liquid agent. After filtration, 560 g of fructose-glucose liquid sugar (75%) was added to the filtrate to make 3500 ml with purified water, 100 ml was filled in a glass bottle, stoppered, and heat sterilized to obtain a calcium beverage.

Comparative Example 5 69 g of volley powder was placed in a container, and 500 ml of purified water was added.
The volley powder was dispersed with stirring. 30w / v to this
% Acetic acid aqueous solution (350 ml, 1.75 molar equivalent) was added, and the amount was adjusted to 1000 ml with purified water. This liquid was heated and stirred to 90 ° C., cooled, and then filtered to obtain a calcium liquid agent. After filtration, 560 g of fructose-glucose liquid sugar (75%) was added to the filtrate to make 3500 ml with purified water, and 100 ml was filled in a glass bottle.
After being stoppered, it was sterilized by heating to obtain a calcium drink.

[0028]

The effect of the calcium liquid preparation and the calcium beverage of the present invention will be shown by a calcium dissolution amount and a flavor test.

(1) Calcium Dissolving Amount The calcium content in the calcium beverages of Examples and Comparative Examples was measured by the following method. About 3 ml of the calcium beverages obtained in Examples and Comparative Examples were taken and filtered with a 0.45 μm membrane filter to obtain a sample. Accurately take 1.5 ml of sample, 50 ml of purified water, potassium hydroxide (1 → 10)
15 ml and about 0.05 g of NN diluted powder (NN indicator) were added, and titrated with 0.05 M disodium ethylenediaminetetraacetate solution at the point where the color changed from red purple to blue as the end point, and the amount of calcium in the sample by the following formula Was calculated to determine the calcium content (mg / ml) in the beverage. 0.05M ethylenediaminetetraacetic acid disodium solution 1ml
= 20.0039 mgCa The results are shown in Table 1.

(2) Flavor Test 20 subjects tested the calcium beverages obtained in Examples and Comparative Examples. The results are shown in Table 1. The index of the frequency distribution (person) in the flavor test in Table 1 is as follows. * 1 Very easy to drink * 2 Easy to drink * 3 Difficult to drink * 4 Very difficult to drink

[0031]

[Table 1]

As is clear from Table 1, the calcium liquid preparation and the calcium beverage of the present invention show a marked increase in the amount of calcium dissolved as compared with the case where conventional lactic acid, citric acid and malic acid are used alone. It was proved that the flavor was superior to that when acetic acid was used alone. Therefore, the calcium liquid preparation and the calcium beverage of the present invention have excellent effects in terms of both calcium content and flavor.

Claims (5)

[Claims] 1. A calcium source comprising malic acid or citric acid.
Calcium liquid dissolved by one or two kinds and lactic acid. 2. The calcium liquid preparation according to claim 1, wherein the mixing molar equivalent ratio of one or two types of malic acid or citric acid and lactic acid is 1: 1 to 1:20. 3. The calcium liquid preparation according to claim 1, wherein the calcium source is calcium carbonate or boley powder. 4. Calcium characterized in that water is added to a calcium source and dispersed with stirring, then one or two kinds of malic acid or citric acid and lactic acid are added, and the mixture is heated and stirred to 50 to 100 ° C. Manufacturing method of liquid agent. 5. A calcium beverage containing the calcium liquid agent according to any one of claims 1 to 3 as an active ingredient.