JPH0852331A - Plasma collecting membrane and production thereof - Google Patents
Plasma collecting membrane and production thereofInfo
- Publication number
- JPH0852331A JPH0852331A JP7159452A JP15945295A JPH0852331A JP H0852331 A JPH0852331 A JP H0852331A JP 7159452 A JP7159452 A JP 7159452A JP 15945295 A JP15945295 A JP 15945295A JP H0852331 A JPH0852331 A JP H0852331A
- Authority
- JP
- Japan
- Prior art keywords
- membrane
- hydrophobic
- hydrophilic component
- water
- plasma collecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 56
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 5
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 11
- 230000005855 radiation Effects 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 6
- 229920001600 hydrophobic polymer Polymers 0.000 claims abstract description 5
- -1 polyethylene Polymers 0.000 abstract description 7
- 239000004698 Polyethylene Substances 0.000 abstract description 4
- 229920000573 polyethylene Polymers 0.000 abstract description 4
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 abstract description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract description 3
- 239000004743 Polypropylene Substances 0.000 abstract description 3
- 229920001155 polypropylene Polymers 0.000 abstract description 3
- 206010053317 Hydrophobia Diseases 0.000 abstract 1
- 206010037742 Rabies Diseases 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- 238000010438 heat treatment Methods 0.000 description 7
- 229920002492 poly(sulfone) Polymers 0.000 description 7
- 239000012510 hollow fiber Substances 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 230000035699 permeability Effects 0.000 description 5
- 210000002381 plasma Anatomy 0.000 description 5
- 229920000728 polyester Polymers 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 229920001477 hydrophilic polymer Polymers 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 229920000515 polycarbonate Polymers 0.000 description 3
- 239000004417 polycarbonate Substances 0.000 description 3
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 3
- 229920000131 polyvinylidene Polymers 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 229920002284 Cellulose triacetate Polymers 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 229920002239 polyacrylonitrile Polymers 0.000 description 2
- 229920000120 polyethyl acrylate Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 229920002689 polyvinyl acetate Polymers 0.000 description 2
- 239000011118 polyvinyl acetate Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000012661 block copolymerization Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
Landscapes
- Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、新規な採血漿膜および
その製造法に関する。TECHNICAL FIELD The present invention relates to a novel plasma collection membrane and a method for producing the same.
【０００２】[0002]
【従来の技術】従来、濾過処理や透析処理で用いられる
水処理用膜は、グリセリンなどの水溶性膜透過能維持
剤を用いた状態、膜素材として親水性高分子を用いた
状態、水を共存させた状態、などで供給されてきた。
しかし、では使用に先立って膜透過能維持剤を洗浄除
去する必要があり、即時使用ができないこと、では一
般にポアサイズが小さくなり、分子量数万以上の成分の
分離に使える膜ができにくいこと、では被処理液体が
血液である場合など、共存している水を予め被処理液体
に変質を与えない液体に置換する必要がある用途があ
り、即時使用できないことなど、それぞれに問題があ
る。2. Description of the Related Art Conventionally, water treatment membranes used in filtration and dialysis treatments use a water-soluble membrane permeability maintaining agent such as glycerin, a hydrophilic polymer as a membrane material, and water. It has been supplied in a coexisting state.
However, with, it is necessary to wash and remove the membrane permeability maintaining agent before use, and it is not possible to use immediately, and with that, the pore size is generally small, and it is difficult to form a membrane that can be used for separating components having a molecular weight of tens of thousands or more. For example, when the liquid to be treated is blood, there are applications in which coexisting water needs to be replaced in advance with a liquid that does not deteriorate the liquid to be treated, and there are problems in that it cannot be used immediately.
【０００３】一方、膜素材として、ポリエチレン、ポリ
プロピレン、ポリカーボネート、ポリアクリロニトリ
ル、ポリスルホン、ポリエステル、ポリ２弗化ビニリデ
ン、ポリ４弗化エチレン、ポリメチルメタクリレート、
セルローストリアセテートなどの疎水性高分子を主たる
素材とした膜が濾過膜や透析膜として提供されている
が、これらの疎水性膜ではやの状態にしておかない
と直ちには本来の透過能を発揮できず、したがって前記
のように即時使用できない問題は疎水性膜の宿命とされ
てきた。また、疎水性膜に対して親水性成分を導入し、
固着させることで即時使用を可能にするいう例（例え
ば、特開昭６１−１２０６０２、特開昭６１−１２５４
０５、特開昭６１−１２５４０８、特開昭６１−１２５
４０９、特開昭６１−１３３１０２、特開昭６１−１３
３１０５など）もみられるが、これらでは親水性高分子
の固着が不充分で、使用中に膜から親水性成分が溶出し
てくるなどの問題がある。On the other hand, as film materials, polyethylene, polypropylene, polycarbonate, polyacrylonitrile, polysulfone, polyester, poly (vinylidene difluoride), poly (tetrafluoroethylene), polymethylmethacrylate,
Membranes mainly composed of hydrophobic polymers such as cellulose triacetate are provided as filtration membranes and dialysis membranes, but these hydrophobic membranes can immediately exhibit their original permeability unless they are left in a bald state. Therefore, the problem that the hydrophobic membrane cannot be used immediately has been destined for the hydrophobic membrane. Also, by introducing a hydrophilic component into the hydrophobic membrane,
Examples of enabling immediate use by fixing (for example, JP-A-61-120602 and JP-A-61-1254)
05, JP-A-61-125408, JP-A-61-125
409, JP-A-61-133102, JP-A-61-13
3105), but these have a problem that the hydrophilic polymer is not firmly fixed and the hydrophilic component is eluted from the membrane during use.
【０００４】[0004]
【発明が解決しようとする課題】本発明者らは、かかる
状況に鑑み、溶出性成分を伴わずに疎水性膜を即時使え
るようにするには如何にすべきかにつき鋭意検討を重ね
たところ本発明に到達した。In view of the above situation, the inventors of the present invention have made extensive studies as to how to immediately use the hydrophobic membrane without the eluting component. The invention was reached.
【０００５】[0005]
【課題を解決するための手段】即ち、疎水性高分子を主
たる素材とした疎水性膜へ、該膜の製造工程中で放射線
または／および熱により水不溶化する親水性成分を導入
することにより、溶出性成分を伴わずに疎水性膜を即時
採血漿膜として使えるようにしうることを見出した。[Means for Solving the Problems] That is, by introducing a hydrophilic component, which is water-insoluble by radiation or / and heat in the manufacturing process of the membrane, into a hydrophobic membrane mainly made of a hydrophobic polymer, It has been found that a hydrophobic membrane can be used as an immediate blood plasma membrane without elutable components.
【０００６】本手段を適用できる疎水性膜素材としては
特に限定するものではないが、ポリエチレン、ポリプロ
ピレン、ポリカーボネート、ポリアクリロニトリル、ポ
リスルホン、ポリエステル、ポリ２弗化ビニリデン、ポ
リ４弗化エチレン、ポリメチルメタクリレート、セルロ
ーストリアセテート、ポリスチレン、ポリエチルアクリ
レート、ポリ酢酸ビニル、ポリ塩化ビニルなど、および
これらの誘導体、あるいはこれら重合体の構成単量体間
の共重合体、さらにはこれらを主体とするが共重合成分
として親水性成分を少量含む重合体などが挙げられ、本
手段は平衡吸水率（２０℃、相対湿度６５％の雰囲気下
に１週間置いて測定した吸水率で、水重量／ポリマー重
量を％で表示した値）が５％以下、さらに望ましくは２
％以下の素材に適用できる。The hydrophobic membrane material to which the present means can be applied is not particularly limited, but polyethylene, polypropylene, polycarbonate, polyacrylonitrile, polysulfone, polyester, poly (vinylidene difluoride), poly (tetrafluoroethylene), polymethylmethacrylate. , Cellulose triacetate, polystyrene, polyethyl acrylate, polyvinyl acetate, polyvinyl chloride, etc., and derivatives thereof, or copolymers between the constituent monomers of these polymers, and further mainly these copolymerization components. Examples of the polymer include a polymer containing a small amount of a hydrophilic component, and this means is a water absorption rate measured by leaving it at equilibrium water absorption rate (20 ° C., relative humidity 65% for 1 week, water weight / polymer weight%). The displayed value) is 5% or less, more preferably 2
Applicable to less than% material.
【０００７】親水性高分子の水不溶化手段として放射線
を照射する方法と加熱する方法とがあるが、前者ではポ
リエチレン、ポリスルホン、ポリスチレン、ポリエステ
ル、ポリエチルアクリレート、ポリ酢酸ビニルなどを主
成分とする耐放射線性に優れた素材に対して、後者では
ポリカーボネート、ポリスルホン、ポリ２弗化ビニリデ
ン、ポリ４弗化エチレン、ポリエステルなどを主成分と
する耐熱性に優れた素材に対して好適に用いられる。ま
たさらに、ポリスルホン、ポリエステルなどのように耐
放射線性および耐熱性に共に優れた素材に対しては、両
手段を併用することも可能である。There are a method of irradiating with radiation and a method of heating as a means for insolubilizing a hydrophilic polymer in water. In the former, the resistance mainly composed of polyethylene, polysulfone, polystyrene, polyester, polyethyl acrylate, polyvinyl acetate, etc. The latter is preferably used for materials having excellent radiation resistance, and the latter is preferably used for materials having excellent heat resistance mainly composed of polycarbonate, polysulfone, poly (vinylidene difluoride), poly (tetrafluoroethylene), polyester and the like. Furthermore, for materials having both excellent radiation resistance and heat resistance such as polysulfone and polyester, it is possible to use both means in combination.
【０００８】放射線により水不溶化する親水性成分とし
ては、ビニルピロリドン、ヒドロキシエチルメタクリレ
ート、ビニルアルコール、エチレングリコール、メトキ
シポリエチレングリコールメタクリレートなど、および
これらの誘導体のモノマー、オリゴマー、ポリマーおよ
びこれらの間のコポリマー、あるいはペプタイド、アル
ブミン、コラーゲンなどの蛋白などが挙げられる。熱に
より水不溶化する親水性成分としては、ビニルピロリド
ン、ε−カプロラクタム、ビニルアルコール、エチレン
オキサイド、ヒドロキシエチルメタクリレートなど、お
よびこれらの誘導体のモノマー、オリゴマー、ポリマ
ー、およびこれらの間のコポリマー、あるいはペプタイ
ド、アルブミン、コラーゲンなどの蛋白などが挙げられ
る。As the hydrophilic component which becomes insoluble in water by radiation, vinylpyrrolidone, hydroxyethyl methacrylate, vinyl alcohol, ethylene glycol, methoxy polyethylene glycol methacrylate and the like, and monomers, oligomers, polymers and copolymers of these derivatives, Alternatively, proteins such as peptide, albumin and collagen may be used. As the hydrophilic component which is insoluble in water by heat, vinylpyrrolidone, ε-caprolactam, vinyl alcohol, ethylene oxide, hydroxyethyl methacrylate and the like, and monomers, oligomers, polymers of these derivatives, and copolymers between them, or peptides, Examples thereof include proteins such as albumin and collagen.
【０００９】水不溶化手段としての放射線としては、ガ
ンマー線、紫外線、電子線などが用いられるが、特にガ
ンマー線では浸透性が高いので単一膜だけでなく、膜集
合体や膜を組込んだモジュール状態でも親水性成分の水
不溶化処理が行なえるので好適に用いられる。水不溶化
手段としての加熱手段としては、乾熱、湿熱、温浴加熱
のいずれも用いることができる。加熱温度としては、疎
水性素材の軟化点や融点、親水性成分の熱分解温度など
を考慮する必要があるが、５０℃から２００℃が好まし
い。また、加熱処理を親水性成分を水不溶化する手段と
してだけでなく、ポアサイズの調整手段も兼ね合せた手
段として用いることも可能である。Gamma rays, ultraviolet rays, electron beams, etc. are used as the radiation as the water insolubilizing means. Especially, since the gamma rays have high penetrability, not only a single membrane but also a membrane aggregate or a membrane is incorporated. It is preferably used because the hydrophilic component can be treated to insolubilize water even in a module state. As the heating means as the water insolubilizing means, any of dry heat, wet heat and hot bath heating can be used. As the heating temperature, it is necessary to consider the softening point and melting point of the hydrophobic material, the thermal decomposition temperature of the hydrophilic component, etc., but 50 ° C. to 200 ° C. is preferable. Further, the heat treatment can be used not only as a means for making the hydrophilic component insoluble in water, but also as a means that also serves as a means for adjusting the pore size.
【００１０】親水性成分を導入する製膜段階としては、
膜素材へのブロック共重合体化、製膜原液への混入、疎
水性膜製膜後の後処理など、いずれの段階でも良いが、
製膜原液への混入や後処理による導入が大きな孔を確保
しやすいという点、親水性成分の使用量を削減できると
いう点などで有利である。また、放射線照射や加熱処理
を膜や膜を組込んだモジュールの殺菌手段を兼ねたもの
とすることも可能である。The film-forming step of introducing the hydrophilic component is as follows:
At any stage, such as block copolymerization into the membrane material, incorporation into the membrane forming stock solution, post-treatment after formation of the hydrophobic membrane,
It is advantageous in that it is easy to secure large pores when it is mixed into the membrane forming solution or introduced by post-treatment, and the amount of hydrophilic component used can be reduced. Further, the irradiation of radiation and the heat treatment may also serve as a sterilizing means for the membrane or the module incorporating the membrane.
【００１１】本発明でいう膜の形態は特に限定するもの
ではなく、例えばシート状、中空糸状、マイクロカプセ
ル状の膜などが挙げられる。The form of the membrane in the present invention is not particularly limited, and examples thereof include a sheet-shaped, hollow fiber-shaped, and microcapsule-shaped membrane.
【００１２】以下、本発明の有効性を実施例をもって説
明する。そこで用いた測定法は次の通りである。The effectiveness of the present invention will be described below with reference to examples. The measuring method used there is as follows.
【００１３】(1) 透水性 中空糸膜の場合は、両端に環流液用の孔を備えたガラス
製のケースに該中空糸膜を挿入し、市販のポッティング
剤を用いて小型モジュールを作製し、３７℃に保って中
空糸内側に水圧をかけ膜を通して外側へ透過する一定時
間の水の量と有効膜面積および膜間圧力差から算出する
方法で透水性能を測定した。(1) Water-permeable In the case of a hollow fiber membrane, the hollow fiber membrane is inserted into a glass case having holes for reflux liquid at both ends, and a small module is prepared using a commercially available potting agent. The water permeability was measured by a method in which the water pressure was applied to the inside of the hollow fiber while maintaining the temperature at 37 ° C., and the amount of water permeating to the outside through the membrane for a certain period of time, the effective membrane area, and the transmembrane pressure difference were used to calculate.
【００１４】平膜の場合は、攪拌円筒セルを用いて同様
にして測定した。In the case of a flat membrane, the same measurement was carried out using a stirring cylindrical cell.
【００１５】(2) 溶出物 膜０．５ｇを７０℃温水５０ccで１時間加熱して試験液
を調製する。試験液の波長２２０〜３５０μｍにおける
吸光度を測定する。なお、透析型人工腎臓装置承認基準
では、本条件での規格を０．１以下としている。(2) Eluate A test solution is prepared by heating 0.5 g of the membrane with 50 cc of hot water at 70 ° C. for 1 hour. The absorbance of the test solution at a wavelength of 220 to 350 μm is measured. The dialysis-type artificial kidney device approval standard sets the standard under this condition to 0.1 or less.
【００１６】[0016]
実施例１ ポリスルホン（ユーデルポリサルホンP-3500）１５部、
ポリビニルビロリドン（K-90）８部、ジメチルアセトア
ミド７５部、水２部からなる原液から製膜した中空糸膜
を１７０℃、５時間乾燥処理し、親水化膜を作った。本
中空糸膜を膜面積０．１５ｍ2 になるよう束ね、モジュ
ール化後、２．５Mradγ線照射処理後乾燥し、ドライ膜
として牛血（ヘマトクリット値４０％、総タンパク濃度
６５g/dl）での血漿分離性能を測定したところ、温度３
７℃、膜間圧力差４７mmHg、血液流量５０ml/minで血漿
濾過流量１６ml/minの性能を得た。水がついていないた
め、初期からタンパク透過率（濾液中濃度／血液中濃
度）が９５％を越える優れたドライ採血漿膜としての性
能を認めた。Example 1 15 parts of polysulfone (Udel Polysulfone P-3500),
A hollow fiber membrane formed from an undiluted solution containing 8 parts of polyvinylpyrrolidone (K-90), 75 parts of dimethylacetamide and 2 parts of water was dried at 170 ° C. for 5 hours to form a hydrophilic film. The hollow fiber membranes were bundled to have a membrane area of 0.15 m 2 , modularized, dried with 2.5 Mrad γ-ray irradiation, and dried to obtain a dry membrane with bovine blood (hematocrit value 40%, total protein concentration 65 g / dl). When the plasma separation performance was measured, the temperature was 3
Performance of plasma filtration flow rate of 16 ml / min was obtained at 7 ° C., transmembrane pressure difference of 47 mmHg, and blood flow rate of 50 ml / min. Since there is no water, the performance as an excellent dry plasma membrane with protein permeability (concentration in filtrate / concentration in blood) exceeding 95% was recognized from the initial stage.
【００１７】実施例２ 実施例１の中空糸膜の溶出物試験をしたところ、すべて
２２０nm〜３５０nmでの吸光度は０．１以下であった。Example 2 When the hollow fiber membrane of Example 1 was subjected to an eluate test, the absorbances at 220 nm to 350 nm were all 0.1 or less.
【００１８】[0018]
【発明の効果】本発明により、溶出性成分を伴わずに、
疎水性膜を用いた採血漿膜を提供することができる。EFFECTS OF THE INVENTION According to the present invention, without any elutable component,
A plasma collection membrane using a hydrophobic membrane can be provided.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ｃ０８Ｊ 7/04 ＣＥＺ Ｔ // Ｃ０８Ｌ 81:06 ─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. 6 Identification code Internal reference number FI Technical display area C08J 7/04 CEZ T // C08L 81:06
Claims (2)
分からなることを特徴とする採血漿膜。1. A plasma collection membrane comprising a hydrophobic component and a physically insolubilized hydrophilic component.
工程中で親水性成分を導入し該親水性成分を放射線また
は／および熱により水不溶化することを特徴とする採血
漿膜の製造法。2. A method for producing a plasma-collecting membrane, which comprises introducing a hydrophilic component in a process for producing a membrane containing a hydrophobic polymer as a main material and insolubilizing the hydrophilic component with radiation or / and heat. .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7159452A JPH0852331A (en) | 1995-06-26 | 1995-06-26 | Plasma collecting membrane and production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7159452A JPH0852331A (en) | 1995-06-26 | 1995-06-26 | Plasma collecting membrane and production thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61243372A Division JPH089668B2 (en) | 1986-10-14 | 1986-10-14 | Hydrophilized film and method for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0852331A true JPH0852331A (en) | 1996-02-27 |
Family
ID=15694075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7159452A Pending JPH0852331A (en) | 1995-06-26 | 1995-06-26 | Plasma collecting membrane and production thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0852331A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001205057A (en) * | 2000-01-27 | 2001-07-31 | Toyobo Co Ltd | Hollow fiber membrane |
| JP2007260592A (en) * | 2006-03-29 | 2007-10-11 | Toray Ind Inc | Method of manufacturing separation membrane, and method of manufacturing separation membrane module using the separation membrane |
| JP2008543546A (en) * | 2005-06-20 | 2008-12-04 | シーメンス・ウォーター・テクノロジーズ・コーポレーション | Cross-linking treatment of polymer film |
| JP2011092928A (en) * | 2009-09-30 | 2011-05-12 | Toray Ind Inc | Separation membrane and separation membrane module |
| US9868834B2 (en) | 2012-09-14 | 2018-01-16 | Evoqua Water Technologies Llc | Polymer blend for membranes |
| US10322375B2 (en) | 2015-07-14 | 2019-06-18 | Evoqua Water Technologies Llc | Aeration device for filtration system |
-
1995
- 1995-06-26 JP JP7159452A patent/JPH0852331A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001205057A (en) * | 2000-01-27 | 2001-07-31 | Toyobo Co Ltd | Hollow fiber membrane |
| JP2008543546A (en) * | 2005-06-20 | 2008-12-04 | シーメンス・ウォーター・テクノロジーズ・コーポレーション | Cross-linking treatment of polymer film |
| JP2007260592A (en) * | 2006-03-29 | 2007-10-11 | Toray Ind Inc | Method of manufacturing separation membrane, and method of manufacturing separation membrane module using the separation membrane |
| JP2011092928A (en) * | 2009-09-30 | 2011-05-12 | Toray Ind Inc | Separation membrane and separation membrane module |
| US9868834B2 (en) | 2012-09-14 | 2018-01-16 | Evoqua Water Technologies Llc | Polymer blend for membranes |
| US10322375B2 (en) | 2015-07-14 | 2019-06-18 | Evoqua Water Technologies Llc | Aeration device for filtration system |
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