JPH08322948A - Device for iontophoresis - Google Patents

Abstract

PURPOSE: To stably use an iontophoresis device and improve administration efficiency, by forming a rectangular pulse by means of a forming means and using this pulse as administration electric output. CONSTITUTION: An administration pulse is outputted to both of a switching transistor 6 and a NOT circuit 41, and a booster pulse is outputted to an AND circuit 42, respectively by means of a signal processing means 4. The switching transistors 6 and 5 are turned on when the administration pulse is high. Thereby, energy from a battery 1 and a capacitor 3 are outputted to an output terminal OUT and are impressed to an organism transcutaneously. On this occasion, the output of the NOT circuit 41 is low, and the condensor 10 and a resistance 13 are connected with the switching transistor 5 in parallel circuit. Therefore, the first transition becomes sharpe and the output pulse becomes more rectangular when the switching transistor 5 is turned on. The switching transistors 6 and 5 are turned off and administration pulse output is paused when the administration pulse becomes low.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a device for iontophoresis.

[0002]

2. Description of the Related Art The use of rectangular wave pulses in iontophoresis is preferable because it simplifies the circuit structure and makes it more compact. By the way, as an output circuit for outputting a rectangular wave pulse to a living body, for example, an amplifying switching means as shown in FIG. 3 is used. The output waveform is as shown in FIG. 3 (b). At the time of rising, the waveform is rounded (N), and under the present circumstances, a pulse different from the target rectangular wave pulse is output. This gives an uncertain factor between energization and medication, and hinders stable use, resulting in an influence on medication efficiency and the like.

[0003]

SUMMARY OF THE INVENTION In view of the above, the present invention has a stable structure including a rectangular wave pulse output means for outputting a rectangular wave pulse as a medication electrical output and a shaping means for shaping the output rectangular wave pulse. We proposed a device that conducts electricity, and realized an increase in medication efficiency. The portion shaped by the shaping means indicates at least the rising portion of a positive-polarity rectangular wave pulse and the falling portion of a negative-polarity rectangular wave pulse.

[0004]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS In FIG. 1, reference numeral (1) is a battery, which is a primary or secondary battery, and is a coin-type or button-type microminiature battery or an ordinary dry battery called AA to AA dry battery. Is shown. (2) is an output control means, and the output control means (2) mainly comprises a variable resistor, a microcomputer, etc., and controls the output voltage. (3) is a capacitor A, which is formed of an electrolytic capacitor or the like. (4) is a signal processing means, and the signal processing means (4) is mainly an oscillator and outputs a low-frequency and high-frequency dosing pulse and a boosting pulse. The dosing pulse oscillates at a lower frequency than the boosting pulse. For example, when the dosing pulse has a duty of 40% at 40 KHz and a duty pulse of 100 KHz and a duty of about 50%. Shown. (5), (6) and (7) are the switching transistors A, B and C, and the switching transistor A
(5) is a PNP type, and the other switching transistors B (6) and switching transistor C (7) are NPN.
Type transistor. These transistors are used for switching. (8) is an inductor, which is formed of a transformer, a coil, and the like. Reference numeral (9) is a diode, which is connected to one end of the inductor (8), the capacitor A (3) and the control means (2). The diode (9) is also a switch which is turned on only when the counter electromotive force generated in the inductor (8) is supplied to the capacitor (3) and the output control means (2). (10) The capacitor B, which is mainly for increasing the on / off speed of the transistor A (5). (11) and (12) are the speed-up circuits A and B, which are switching transistors B, respectively.
(6) and C (7) are intended to speed up the switching operation. (13) is a resistor and a capacitor B
(10) forms a parallel connection with transistor A
This is for speeding up (5). (4
1) is an inverter, which is formed by a NOT circuit or the like that inverts the output. (42) is an AND circuit for performing a general AND operation. Signal processing means (4), NOT circuit (41), AND circuit (4)
2) may be formed by one microcomputer depending on the type of drug and the mode of administration.

Next, the operation of FIG. 1 will be described in detail with reference to FIG. The signal processing means (4) outputs the medication pulse shown in FIG. 2 (a) to the switching transistor B (6) and NO.
It outputs to the T circuit (41), and further outputs the boosting pulse shown in FIG. 2 (c) to the AND circuit (42). When the dosing pulse is high, switching transistor B (6) turns on and switching transistor A (5) turns on. When the switching transistor A (5) is turned on, the energy controlled by the control means (2) based on the energy of the battery (1) and the capacitor A (3) is output (OUT).
And is transcutaneously applied to the living body. Further, when the dosing pulse is high, the output of the NOT circuit (41) becomes low (FIG. 2 (b)). At this time, capacitor B (10)
And resistor (13) are switching transistor A (5)
On the other hand, since the parallel circuit configuration is the same as that of the speed-up circuits A (11) and B (12), the rising time when the switching transistor A (5) is turned on becomes steep,
The pulse output given to the living body becomes more rectangular. N
When the output of the OT circuit (41) is low, the AND circuit (4
The output of 2) is low regardless of whether the other input terminal is high or low.
(7) is off. When the dosing pulse becomes low, the switching transistor B (6) is turned off, the switching transistor A (5) is also turned off, and the dosing pulse output to the living body is stopped. Since the output of the NOT circuit (41) is in the high state, the output of the AND circuit (42) performs the output according to the input at the other end. Ie AND
The other end of the circuit (42) is connected to the signal processing means (4) from FIG.
Since a pulse having a frequency higher than that of the medication pulse as shown in (c) is input, the AND circuit (42) outputs a pulse according to this pulse as a boosting pulse. This boosting pulse is applied to the switching transistor C.
Input to (7). When the boosting pulse is high, the switching transistor C (7) is turned on, and the charge accumulated in the living body flows to the inductor (8). When the boosting pulse is low, the switching transistor C (7) is turned off, but at this time, a counter electromotive force due to the exciting current of the inductor (8) is generated. This back electromotive force is boosted as shown in FIG. It is preferable that the boost amount is at least higher than the battery voltage. The amount of boosting may be adjusted by adjusting the on-time of the switching transistor C (7), and by adjusting the pulse width of the boosting pulse output from the signal processing means (4). Further, since the power source for generating the boosting pulse uses the electric charge remaining in the living body, when the boosting pulse is repeatedly generated and consumed, the residual electric charge of the living body is also reduced and the amplitude of the boosting pulse is also reduced. It is preferable that the pulse width of the boosting pulse (FIG. 2 (c)) input to the switching transistor C (7) is gradually widened to lengthen the on-time. This boosting pulse turns on the diode (9) and is supplied to and accumulated in the capacitor A (3). Furthermore, when the medication drive pulse of the signal processing means (4) becomes high, the switching transistor A (5) also becomes high, and the charge accumulated in the capacitor A (3) together with the battery voltage is also supplied to the living body. It When a DC resistor is connected to the output terminal (OUT), the voltage waveform that appears between the output terminals (OUT) is as shown in Fig. 2 (e). As shown by the rising edge (S) in FIG. 2E, a shaped rectangular wave can be output. 2 (e) shows a voltage waveform in an unloaded state, while FIG. 2 (f) shows
It is a voltage waveform when a living body is connected to an output terminal (OUT) through a conductor (electrode). The rectangular wave pulse output means has various circuit configurations other than the one shown in FIG. It suffices if it includes a circuit that functions to shape the.

[0006]

As described above in detail, according to the present invention, it is possible to output a rectangular wave whose rising or falling is shaped, and as a result, it is possible to use it in a stable manner and improve the dosage efficiency. It has an effect.

[Brief description of drawings]

FIG. 1 is a diagram showing an embodiment of the present invention.

FIG. 2 is a diagram showing the operation of the embodiment shown in FIG.

FIG. 3 is a diagram showing a conventional example.

[Explanation of symbols]

1 Battery 2 Output Control Means 3 Capacitor A 4 Signal Processing Means 5 Switching Transistor A 6 Switching Transistor B 7 Switching Transistor C 8 Inductor 9 Diode 10 Capacitor B 11 Speed-up Circuit A 12 Speed-up Circuit B 41 Inverter 42 AND Circuit Ref Buffer Resistance

Claims (1)

[Claims] 1. A device for iontophoresis comprising a rectangular wave pulse output means for outputting a rectangular wave pulse as an electric output for medication and a shaping means for shaping the output rectangular wave pulse.