JPH08179247A - Solution composition for contact lens and detergent for contact lens using the same - Google Patents

Abstract

PURPOSE: To easily remove the dirt of a contact lens by containing a surfactant and making osmotic pressure higher than a specific value. CONSTITUTION: This solution composition for contact lens contains a surfactant and has >=200mOsm osmotic pressure. As the surfactant, it is not restricted particularly, an anionic surfactant is preferably used. The surfactant solubilized and removes tear components stuck to the lens, particularly a lipid matter. Further, in the anionic surfactant, a sulfonate based surfactant is preferable and particularly one selected from the group consisting of alkyl benzene sulfonate, alkyl naphthalene sulfonate, dialkyl sulfosuccinate, alkyl sulfoacetate and α-olefin sulfonate is preferably used and is particularly effective for removing the tear components.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a contact lens solution composition for removing dirt adhering to a lens, a cleaning preservative using the same, and a contact lens cleaning method.

[0002]

2. Description of the Related Art When a contact lens is worn on the eye, an interaction occurs between various compounds such as lipids, proteins, and mucin contained in tears and the surface of the contact lens, and depending on the surface characteristics of the lens material. In some cases, these tear components tend to adhere. Polymethylmethacrylate has been widely used for hard contact lenses, but since it became clear that polymethylmethacrylate does not permeate oxygen, it has a significant physiological adverse effect on the eye. A variety of contact lenses using the above have been developed.

Silicone-based materials are widely used as such oxygen-permeable materials. For example, polymers having silyl-substituted methacrylate such as tris (trimethylsiloxy) silylpropyl methacrylate or modified polysiloxane as a constituent component have been developed. And utilized (Japanese Patent Application Laid-Open No. 60-142324, Japanese Patent Application Laid-Open No. 54-24047).
issue). In many cases, fluorine-containing monomers (mainly fluorine-substituted alkyl methacrylates) such as trifluoroethyl methacrylate and hexafluoroisopropyl methacrylate are used as copolymerization components in these polymers. As a result of the appearance of many contact lenses using such materials, it has been reported that components in tear fluid are more likely to adhere to the lenses than when only lenses using polymethylmethacrylate were used. It has become to. Therefore, as measures against this, various methods have been proposed for cleaning and storing after removing the contact lens from the eye. For example, the lens is washed with a cleaner containing fine particles (Japanese Patent Laid-Open No. 60-159721, etc.), and then immersed in a storage solution containing a surfactant and a hydrophilic polymer (Japanese Patent Laid-Open No. 61-69023). Etc.) or an enzyme agent (Japanese Unexamined Patent Publication No.
No. 0-121417, etc.) is added to dip the lens to remove dirt.

[0004]

However, in the above-mentioned conventional methods, since the components in the tear fluid are complex and easily adhere to the lens, it cannot be said that the stains are sufficiently removed. I had a problem. Therefore, the present invention is intended to solve the above-mentioned drawbacks of the prior art, and provides a contact lens solution composition capable of simply removing dirt on a contact lens, a contact lens cleaning agent using the same, and a contact lens cleaning method. The purpose is to provide.

[0005]

In order to solve the above problems, the present invention has the following constitution.

"(1) It contains a surfactant and has an osmotic pressure of 200.
A solution composition for a contact lens, which is at least mOsm.

(2) A cleaning agent for contact lenses using the solution composition according to the above item (1).

(3) A method of cleaning a contact lens using the solution composition according to the above item (1). In the present invention, a surfactant is used, but one kind or two or more kinds may be used. The surfactant used is not particularly limited, but anionic surfactants can be preferably used. This surfactant is used to solubilize and remove especially the lipid component of the tear fluid component adhered to the lens. For this purpose, an anionic one having excellent solubility is preferably used. Among the anionic surfactants, sulfonate-based surfactants are preferably used. Particularly, alkylbenzene sulfonate, alkylnaphthalene sulfonate, dialkylsulfocohalate, alkylsulfoacetic acid. Those selected from the group consisting of salts and α-olefin sulfonates are preferably used and are particularly effective in removing tear components.

In the contact lens solution composition of the present invention, it is essential that the osmotic pressure is 200 mOsm or more. In the conventional solution compositions containing a surfactant for contact lenses, those having a low osmotic pressure were generally used. This is because the ability to dissolve the component to be washed is diminished when the osmotic pressure is high, that is, when the salt concentration is high, but in the present invention, the osmotic pressure is 200 mOsm or more. Have found that the ability to remove tear components is excellent. When the osmotic pressure is low, it was revealed that the ability to remove the tear component is insufficient.

In adjusting the osmotic pressure, a buffer material or a suitable salt can be used. To give an example,
Disodium hydrogen phosphate-citric acid combination, disodium hydrogen phosphate-potassium dihydrogen phosphate, potassium dihydrogen phosphate-borax, borax-boric acid, sodium hydroxide-potassium dihydrogen phosphate, ethylenediamine Tetraacetic acid disodium salt-ethylenediaminetetraacetic acid tetrasodium salt and the like.

Further, in the present invention, other components may be added and used. Although a water-soluble polymer is usually added to adjust the viscosity of the solution, it is possible to adjust the viscosity also in the present invention by adding these.
Although any water-soluble polymer can be used, for example, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, carboxymethyl cellulose,
Examples thereof include carboxypropyl cellulose, isobutylene / maleic acid copolymer, polyvinyl alcohol, sodium polyacrylate, sodium alginate, carrageenan, gum arabic, and starch.

Preservatives can also be used. Preservatives are usually added to prevent the growth of bacteria during storage, examples include sorbic acid, potassium sorbate, sodium sorbate, methyl paraoxybenzoate, ethyl paraoxybenzoate, paraoxybenzoic acid. Examples thereof include propyl, butyl paraoxybenzoate, chlorhexidine gluconate and the like.

The solution composition for contact lenses of the present invention may be used in combination with other cleaning agents, etc., in addition to the method of immersing the contact lens removed from the original eye in the solution composition. It is possible. For example, the contact lens can be immersed in the solution composition of the present invention after cleaning the contact lens with a cleaner containing fine particles, or the contact lens can be immersed by adding a liquid cleaner containing an enzyme to the solution. is there. In this case, the ability to remove stains and lacrimal fluid components is further improved as compared with the conventional methods.

According to the present invention, it is possible to provide a contact lens solution composition having an excellent ability to remove dirt and tear components.

[0015]

The present invention will be described below with reference to examples, but the present invention is not limited to these examples.

Example 1 and Comparative Example 1 Hard type sodium sodium alkylbenzene sulfonate 0.5
g was dissolved in 100 ml of 0.2 M disodium hydrogen phosphate-0.1 M citric acid solution. The osmotic pressure of this solution was measured and found to be 400 mOsm. Similarly, hard type sodium alkylbenzene sulfonate 0.5
g was dissolved in 100 ml of 0.1 M sodium hydroxide-0.1 M potassium dihydrogen phosphate solution, and Roebling
The osmotic pressure measured by the osmometer manufactured by the company was about 120 mOsm.

On the other hand, a lens was prepared from a gas permeable polymer for a hard contact lens, which was composed of 45 parts of tris (trimethylsiloxy) silylpropyl methacrylate, 4 parts of trifluoroethyl methacrylate, 6 parts of ethylene glycol dimethacrylate and 5 parts of methacrylic acid. The two lenses were immersed in a solution of 0.1 g of lard and 0.1 g of olive oil in 100 ml of physiological saline at 50 ° C., stirred for 10 minutes, taken out, and cooled to attach oil.

Two kinds of the above-mentioned solutions containing the surfactant were put in different containers, and the lens to which the oil was adhered was dipped, and
It was left at 4 ° C. for 8 hours. When the lens was observed with a dark-field microscope just by rinsing it lightly with tap water, it was revealed that the lens was immersed in a 0.2 M disodium phosphate-0.1 M citric acid solution with high osmotic pressure. The oil was cleanly removed.

Example 2, Comparative Example 2 Soft type sodium sodium alkylbenzene sulfonate 0.3
g, 0.1 g of sodium α-olefinsulfonate was dissolved in 100 ml of a 0.2 M disodium hydrogen phosphate-0.1 M citric acid solution. The osmotic pressure of this solution was measured and found to be 400 mOsm. Similarly, soft type sodium sodium alkylbenzenesulfonate 0.3 g, α
-0.1 g of sodium olefinsulfonate, 0.1 g
When dissolved in 100 ml of M sodium hydroxide-0.1 M potassium dihydrogen phosphate solution, the osmotic pressure is about 120 m
It was Osm.

On the other hand, 0.5 g of tripalmitin, 0.5 g of cetyl alcohol, 0.5 g of palmitic acid, 0.5 g of oleic acid, 0.5 g of cholesterol, 0.5 g of cholesterol palmitate and 0.5 g of lecithin were added at 50 ° C. Two lenses obtained in the same manner as in Example 1 were immersed in a solution dispersed in 100 ml of a saline solution, stirred for 10 minutes, taken out, and cooled to attach simulated eye oil.

Two kinds of the solutions containing the above-mentioned surfactant were put in different containers, the lens to which the simulated eye oil was adhered was dipped, and left at 24 ° C. for 8 hours. The lens was taken out and rinsed with tap water only, and the lens was observed with a dark-field microscope. As a result, it was found that the lens was immersed in a 0.2 M disodium hydrogen phosphate-0.1 M citric acid solution having a high osmotic pressure. It was clearer that the simulated eye oil had been removed.

[0022]

According to the present invention, it is possible to provide a contact lens solution composition having a high stain removing ability and a cleaning agent using the same.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI technical display location G02C 7/04

Claims (6)

[Claims] 1. An osmotic pressure of 200 mOs containing a surfactant.
A solution composition for contact lenses, wherein the solution composition is at least m. 2. The contact lens solution composition according to claim 1, wherein the surfactant is an anionic surfactant. 3. The contact lens solution composition according to claim 2, wherein the anionic surfactant is a sulfonate surfactant. 4. The sulfonate surfactant is selected from the group consisting of alkylbenzene sulfonates, alkylnaphthalene sulfonates, dialkyl sulfosuccinates, alkyl sulfoacetates and α-olefin sulfonates. The solution composition for contact lenses according to claim 3, which is characterized in that. 5. A cleaning preservative for contact lenses, which comprises the solution composition according to claim 1. 6. A method of cleaning a contact lens using the solution composition according to claim 1.