JPH08133959A - Skin cosmetic - Google Patents

Abstract

PURPOSE: To obtain a skin cosmetic having such effects as to prevent the skin from getting brownish and rapidly thin the brownish color of skin, also having skin chapping-preventive, corneum-improving, skin aging-preventive and skin beautifying effects, thus capable of keeping the skin healthily. CONSTITUTION: This skin cosmetic contains, as active ingredients, at least one kind of substrate selected from deproteinized serum, 2-18C α- hydroxycarboxylic acids, Swerlia japonica extract, vitamin E-nicotinate, diisopropylamine dichloroacetate, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid and salts thereof, and a solvent extract of Pyracantha fortuneana fruits, a kind of Rosaceae Pyracantha.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention prevents dark skin,
The present invention relates to a skin cosmetic capable of rapidly lightening dark skin, exhibiting an excellent effect of preventing rough skin, an effect of improving keratin, an effect of preventing aging and an effect of beautiful skin, and keeping the skin healthy.

[0002]

BACKGROUND OF THE INVENTION Conventionally, whitening cosmetics for the purpose of preventing or treating spots and freckles on the skin include L-ascorbic acid and its derivatives,
Hydroquinone derivatives, pyrones such as kojic acid, and placenta extracts such as placenta extract are included.

These substances are widely known as substances having a whitening effect because they have the effects of suppressing the production of melanin, light-color bleaching action of the produced melanin and the like. However, when these substances are used alone, for example, when L-ascorbic acid and its derivative are blended, the storage stability is insufficient and the effect is not sufficiently exerted, and the hydroquinone derivative has a safety problem. I was not completely satisfied.

The fruit of the Chinese name "fire thorn" is the Chinese name "red proton"
As, it is known to have a medicinal effect such as keeping the spleen healthy and treating indigestion. In addition, it has tyrosinase activity inhibitory effect and melanin production inhibitory effect,
A whitening cosmetic composition containing this extract has been proposed (JP-A-5-58870). However, the thyrosinase activity-inhibiting effect and the melanin production-inhibiting effect of the mixture containing these alone are not observed, but the rough skin preventing effect, the keratin improving effect and the aging preventing effect are not recognized. In this way, it is possible to prevent dark skin, lighten the dark skin quickly, develop an excellent skin roughening prevention effect, keratin improving effect, anti-aging effect and beautiful skin effect, and keep the skin healthy. The reality is that skin cosmetics have not yet been developed.

Therefore, in view of such a situation, the present inventor has considered
As a result of intensive research, serum deproteinization, α-hydroxycarboxylic acid having 2 to 18 carbon atoms, assembly extract, vitamin E-nicotinate, diisopropylamine dichloroacetate, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid and the Dermocosmetics containing one or more selected from salts and a solvent extract of the fruit of the Chinese name "Fire spine" which is one of the genus Pyracanta in the family Rosaceae quickly eliminates melanin present in the epidermis. , Synergistic action of a component that has an excellent whitening effect such as newly suppressing the formation of melanin in the skin and has a blood circulation promoting action or a cell activating action and a moisturizing component contained in the extract from fire thorns. Due to
The inventors have found that they exhibit an excellent effect of preventing rough skin, an effect of improving keratin, an effect of preventing aging and an effect of beautiful skin, and have completed the present invention.

The object of the present invention is to prevent dark skin and to lighten dark skin quickly, and also to provide excellent skin roughening prevention effect, keratin improving effect, anti-aging effect and beautiful skin effect. An object of the present invention is to provide a skin cosmetic that has and keeps the skin healthy.

[0007]

Means for Solving the Problems The present invention which achieves the above-mentioned object is to provide a serum deproteinized product, α-hydroxycarboxylic acid having 2 to 18 carbon atoms, cembly extract, vitamin E-nicotinate, diisopropylamine dichloroacetate, γ-.
At least one selected from the group consisting of aminobutyric acid, γ-amino-β-hydroxybutyric acid, and salts thereof, and a genus Rosaceae Pyracant
Ha) is a kind of Chinese name "Pyracant"
It is a skin cosmetic containing a solvent extract of the fruit of ha fortuneana).

The structure of the present invention will be described in detail below. The serum deproteinized protein used in the present invention can be made from blood such as calf, serum, lymph, placenta extract, and the like. From these raw materials, the target extract is obtained by a conventional method such as deproteinization treatment, low temperature treatment, and fat-soluble component removal treatment. The obtained extract has a solid content of 4 to 5%, contains peptides having a molecular weight of 3000 or less, amino acids, organic acids, sugars, etc. as an organic substance, and is excellent in the tissue respiration promoting action by activating mitochondrial respiratory ability. , Has a high moisturizing property.
These extracts can be purchased as Solcoceryl (manufactured by Solco Basel) or S-71 (manufactured by BOTTGER).

The content of the serum deproteinized product is preferably 0.0001 to 0.5% by weight, more preferably 0.00% by weight, as a dry solid content, based on the total amount of the prescription components of the cosmetic composition.
It is within the range of 01 to 0.1% by weight.

The α-hydroxycarboxylic acid used in the present invention is not particularly limited as long as it has 2 to 18 carbon atoms. For example, glycolic acid, lactic acid, sodium lactate, citric acid, sodium citrate, Malic acid,
Examples thereof include tartaric acid, α-hydroxyoctanoic acid, α-hydroxypalmitic acid and α-hydroxystearic acid, and among them, those having 2 to 8 carbon atoms are preferable.

The blending amount thereof is preferably 0.01 to 20% by weight based on the total amount of the cosmetic.

The method for producing the assembly extract used in the present invention is not specified, but the outline is as follows.

[Method for producing assembly extract] Assembly (S
(Wertia Japana Makino) is an extract obtained by digesting a dried and pulverized whole plant of flowering whole plants in ethanol or hydrous ethanol and filtering. The extract obtained by the following method was used in the examples.

50 g of crushed assembly product was added to 250 ml of water-containing ethanol (90 wt% of ethanol) at a temperature of 40-50.
After the mixture was digested at ℃ and filtered, the residue was digested again in the same manner several times to obtain 1.5 liters of the extract. 100 ml of purified water was added to the residue obtained by concentration under reduced pressure, the mixture was aged for 1 week, the insoluble material was filtered off, and the obtained extract was concentrated under reduced pressure. Then, ethanol was added to the extract so that the ethanol content was 4%.
It was adjusted to be 0 wt% to obtain 100 ml of seaweed extract.

As the γ-amino-β-hydroxybutyric acid salt used in the present invention, γ-amino-β-hydroxybutyric acid is caustic potash, caustic soda, or calcium hydroxide,
Examples include potassium salt, sodium salt, calcium salt, and magnesium salt of γ-amino-β-hydroxybutyric acid neutralized with magnesium hydroxide, all of which promote blood circulation to the same extent as γ-amino-β-hydroxybutyric acid. It has an action or a cell activation action.

The desirable compounding amounts of the assembly extract, vitamin E-nicotinate, diisopropylamine dichloroacetate, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid and salts thereof used in the present invention are shown in Table 1.

[0017]

[Table 1]

The active ingredient (hereinafter abbreviated as "fire thorn extract") of the Chinese medicine name "red proton" which is a fruit of Chinese name "fire thorn" used in the present invention is water or methanol, ethanol, propanol and the like. It is extracted with a lower alcohol or a mixed solution thereof. The extract can be directly blended in cosmetics, but it is preferable to use it by pulverizing it by a freeze-drying method or a spray-drying method. It is also possible to mix the liquid or powdered product by purifying the extract liquid by means of liquid-liquid distribution, adsorption chromatography or the like.

The blending amount thereof is preferably 0.001 to 5% by weight, more preferably 0.01 to 2% by weight in terms of extract based on the total amount of the cosmetic.

In the cosmetic of the present invention, in addition to the above-mentioned raw materials, pigments, fragrances, preservatives, surfactants, pigments, antioxidants, humectants, ultraviolet absorbers, etc. are achieved to achieve the object of the present invention. It can be appropriately blended within the range.

Examples of the dosage form of the cosmetic of the present invention include cream, emulsion, lotion, pack, day essence and the like. For example, in the case of an emulsion or the like, this cosmetic can be produced by an ordinary method of emulsifying and dispersing an oily phase and an aqueous phase, which are dissolved by heating, and cooling.

[0022]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. In addition,% shown in the examples is% by weight. Skin color lightness recovery test method described in Examples, method for measuring turnover rate of stratum corneum (anti-aging effect), method for measuring rough skin improving effect, sensory test (skin beautiful effect is as follows. The method for preparing the fire thorn extract used in Step 1 is as follows.

(Preparation method of fire thorn extract) 5.00 g of dried fruits of fire thorn are immersed in 50 ml of hot water at 90 ° C., boiled for 3 hours and then filtered, and the obtained extract is Diaion HP-
20 (Mitsubishi Chemical Industries Co., Ltd.) column (φ3 cm × 1)
1 cm, Vt = 80 ml), then 800 ml of 10
% Aqueous solution of ethanol. Then, it was eluted with 400 ml of 40% aqueous ethanol solution, the eluate was concentrated under reduced pressure, and then freeze-dried to obtain 1.04 g of a solid matter.

(1) Skin color lightness recovery test method The back skin of 20 subjects was irradiated with ultraviolet rays in the UV-B region at twice the minimum erythema dose, and a sample application site and a non-application site were set to determine the skin of each skin. The standard lightness (V0 value, V0 'value) was measured. Subsequently, the sample is applied to the application site twice a day 15 times.
Lightness (Vn value, Vn 'of the skin at the application site and non-application site after 3, 6, 9, 12, 15 weeks after continuous application for a week
Value) was measured and the recovery of skin color was evaluated according to the following criteria. The brightness of the skin (V value of Munsell color system)
Was calculated from X, Y, and Z values obtained by measurement with a high-speed spectrocolorimeter. The evaluation was shown by the average value of the evaluation points after 3 weeks for 20 subjects.

(2) Measurement of turnover rate of stratum corneum An ointment was prepared by adding 5% by weight of a fluorescent dye, dansyl chloride, to white petrolatum and applied to the skin of the forearm of a subject.
Apply occluded for a time and permeate dansyl chloride into the stratum corneum. Thereafter, the test sample was applied to the same site twice a day (morning and evening), and the fluorescence of dansyl chloride was examined every day. The number of days until the fluorescence disappeared was defined as the turnover rate of the skin keratin. The normal turnover rate of the stratum corneum of the skin is 14 to 16 days, but in aged skin, it extends to around 18 days, and when the antiaging effect appears, it is shortened to around 12 days.

(3) Method for measuring the effect of improving rough skin The effect of continuous application for 4 weeks was examined on 20 middle-aged and elderly subjects who have rough skin on their lower legs. About 1 g of the sample was applied to the left lower leg test site of the test subject twice a day, and the condition of the skin before and after the start of the test was evaluated according to the following criteria. The lower right leg was not coated with the sample and served as a control. If the skin dryness is improved by two or more levels by comparing the judgment results of the test site before and after the test and the control site (eg; + →
−, ++ → ±) was defined as “valid”, a case of improvement by 1 level was defined as “slightly valid”, and a case of no change was defined as “invalid”.
The test results are shown by the number of subjects who were “valid” and “somewhat valid”.

(4) Sensory test Twenty test subjects evaluated the characteristics of the sample after continuously using the sample for 10 days. The evaluation was shown by the number of respondents who answered "skin became smooth", "a whitening effect was felt", and "tension occurred on the skin" for questionnaire items of smoothness, whitening effect, and elasticity. .

Examples 1 to 15 and Comparative Examples 1 to 13 Serum deproteinized products, α-hydroxycarboxylic acid having 2 to 18 carbon atoms, assembly extract, vitamin E-nicotinate, diisopropylamine dichloroacetate, γ-aminobutyric acid, A component having a blood circulation promoting action or a cell activating action selected from γ-amino-β-hydroxybutyric acid and a salt thereof and a fire thorn extract are mixed in the composition of Table 2, and a skin cream is prepared based on the following preparation method. did.

Composition

[Table 2]

Preparation Method (A) and (B) are uniformly dissolved at 70 ° C., (A) is stirred and (B) is poured into (A) to emulsify and disperse, and then the temperature is stirred at 30 ° C. Cool to prepare. Tables 3 and 4 show the results of tests conducted by the above-mentioned evaluation test using the skin cosmetics thus prepared as samples.

[0031]

[Table 3]

[0032]

[Table 4]

Properties The skin creams of Examples 1 to 15 of the present invention showed good results in the above tests. On the other hand, the skin creams of Comparative Examples 1 to 13 were inferior to those of the examples of the present invention because sufficient effects were not recognized.

[0034]

INDUSTRIAL APPLICABILITY As described above, the present invention has the effects of preventing dark skin and rapidly lightening dark skin, and further has excellent effects of preventing rough skin, improving keratin and preventing aging. It is obvious to provide an excellent skin cosmetic which exhibits the effect and the skin beautifying effect and can keep the skin healthy.

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Claims (2)

[Claims] 1. Serum deproteinized protein, α-containing 2 to 18 carbon atoms
Hydroxycarboxylic acid, assembly extract, vitamin E-
At least one selected from the group consisting of nicotinate, diisopropylamine dichloroacetate, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid and salts thereof, and Rosaceae Pyracanta (Rosaceae Pyra).
cantha), which is a kind of Chinese name "Pyra"
A skin cosmetic containing a solvent extract of the fruit of cantha fortuneana). 2. The skin cosmetic according to claim 1, wherein the extraction solvent for the "fire thorn" fruit is water, methanol, ethanol, propanol or a mixed solution thereof.