JPH08133936A - Hair-growth suppressing agent for external application to skin - Google Patents
Hair-growth suppressing agent for external application to skinInfo
- Publication number
- JPH08133936A JPH08133936A JP29378794A JP29378794A JPH08133936A JP H08133936 A JPH08133936 A JP H08133936A JP 29378794 A JP29378794 A JP 29378794A JP 29378794 A JP29378794 A JP 29378794A JP H08133936 A JPH08133936 A JP H08133936A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- skin
- bisabolol
- external application
- growth suppressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003779 hair growth Effects 0.000 title claims abstract description 20
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims abstract description 14
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract description 14
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims abstract description 14
- 229940036350 bisabolol Drugs 0.000 claims abstract description 14
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003860 topical agent Substances 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 9
- 230000003660 hair regeneration Effects 0.000 abstract description 7
- 239000003795 chemical substances by application Substances 0.000 abstract description 6
- 239000006071 cream Substances 0.000 abstract description 4
- 239000006210 lotion Substances 0.000 abstract description 4
- 239000000843 powder Substances 0.000 abstract description 4
- 230000000638 stimulation Effects 0.000 abstract description 3
- 239000000443 aerosol Substances 0.000 abstract description 2
- 239000003963 antioxidant agent Substances 0.000 abstract description 2
- 239000000306 component Substances 0.000 abstract description 2
- 239000003921 oil Substances 0.000 abstract description 2
- 239000002674 ointment Substances 0.000 abstract description 2
- -1 pack Substances 0.000 abstract description 2
- 239000000049 pigment Substances 0.000 abstract description 2
- 239000003755 preservative agent Substances 0.000 abstract description 2
- 239000004094 surface-active agent Substances 0.000 abstract description 2
- 239000002562 thickening agent Substances 0.000 abstract description 2
- 239000000341 volatile oil Substances 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000003086 colorant Substances 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 239000003002 pH adjusting agent Substances 0.000 abstract 1
- 239000002304 perfume Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 230000000979 retarding effect Effects 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 8
- 239000002699 waste material Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 4
- 240000003538 Chamaemelum nobile Species 0.000 description 3
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 3
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 206010053759 Growth retardation Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000002951 depilatory effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000003659 hair regrowth Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 208000019300 CLIPPERS Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 208000033830 Hot Flashes Diseases 0.000 description 1
- 206010060800 Hot flush Diseases 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 229940119217 chamomile extract Drugs 0.000 description 1
- 235000020221 chamomile extract Nutrition 0.000 description 1
- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000003662 hair growth rate Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明はビサボロールを含有して
成る、皮膚への負担及び刺激がなく、毛再生の遅延効果
に優れた発毛抑制皮膚外用剤に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dermal external preparation containing bisabolol, which suppresses hair regrowth, has no burden and irritation on the skin, and has an excellent effect of delaying hair regeneration.
【０００２】[0002]
【従来の技術】一般に体毛、特にムダ毛といわれている
毛を処理する場合、大きく分けると剃毛、脱毛、除毛の
３つの方法が行われている。すなわち、カミソリによる
剃毛、脱毛テープやワックス等の物理的な力による脱毛
及び化学処理による除毛方法が用いられている。脱毛に
ついては上記の方法の他に、エステティックサロン等で
は高周波装置を用いる場合もある。また、男性に特有の
髭の処理は殆どがカミソリまたは電気カミソリによる剃
毛である。2. Description of the Related Art Generally, when treating body hair, especially hair which is said to be waste hair, there are three main methods: shaving, hair removal and hair removal. That is, a shaving method using a razor, a hair removing method using a physical force such as a hair removing tape or wax, and a hair removing method using a chemical treatment are used. In addition to the above method for hair removal, a high frequency device may be used in an esthetic salon or the like. Most of the beard treatments peculiar to men are shaving with a razor or an electric razor.
【０００３】そして、これらムダ毛の処理及び髭剃りの
後には、皮膚に潤いを与えたり、ほてりを静めることを
目的として化粧水やクリーム等を塗布し、肌を整えるこ
とが任意に行われていた。特に髭剃りの後に用いる専用
化粧料は、男性化粧品の中では非常に一般的な化粧料の
一つである。After the treatment of the waste hair and the shaving, the skin is optionally conditioned by applying lotion, cream or the like for the purpose of moisturizing the skin or calming hot flashes. It was Especially, the dedicated cosmetics used after shaving are one of the most common cosmetics among men's cosmetics.
【０００４】[0004]
【発明が解決しようとする課題】しかしながら、ムダ毛
の処理は次に挙げるような欠点を有している。すなわち
剃毛については皮膚に微小な傷が多数生じること、脱毛
については処理に技術を要し痛みが伴う他、高周波装置
を用いる場合は非常に高価であること、また除毛につい
ては化学物質により毛を溶解することから皮膚刺激を伴
う場合があること等である。However, the treatment of waste hair has the following drawbacks. In other words, when shaving, many small scratches are generated on the skin, when removing hair, it takes a lot of technology to process it and it is painful.When using a high frequency device, it is very expensive. For example, it may cause skin irritation because it dissolves hair.
【０００５】髭剃りについてもムダ毛の処理同様、カミ
ソリによる微小な傷が生じ、またカミソリ負けのような
皮膚の炎症が起こることもある。Similar to the treatment of waste hair, shaving also causes minute scratches by a razor, and may cause skin irritation such as razor loss.
【０００６】更に、剃毛・除毛は皮膚表面部の毛を除去
したにすぎず、脱毛しても時間経過と共に、ムダ毛が再
生するため、上記の処理を繰り返すことになる。特に髭
に関しては、非常に成長速度が速いことから、人によっ
ては一日に２回から３回髭剃りを行わなくてはならな
い。Furthermore, shaving / hair removal merely removes the hair on the surface of the skin, and even if the hair is removed, waste hair is regenerated with the lapse of time, and the above-mentioned processing is repeated. Especially for beards, some people have to shave two to three times a day because they grow very fast.
【０００７】また、ムダ毛の処理は、毛成長に対する刺
激作用が強いため、成長速度を高めたり、休止期毛を活
性化させるという問題がある。[0007] Further, since the treatment of waste hair has a strong stimulating effect on hair growth, there are problems that the growth rate is increased and the hair at rest period is activated.
【０００８】従って、皮膚に対する負担が大きいこと
や、処理自体の手間や経費の問題があることから処理頻
度の減少化が強く望まれていた。Therefore, since the burden on the skin is large and there are problems of labor and cost of the treatment itself, it has been strongly desired to reduce the treatment frequency.
【０００９】[0009]
【課題を解決するための手段】かかる実情に鑑み、鋭意
研究を行った結果、本発明者らはビサボロールにムダ毛
や髭の再生を遅延化させる効果のあることを見いだし、
本発明を完成した。In view of such circumstances, as a result of intensive studies, the present inventors have found that bisabolol has an effect of delaying the regeneration of waste hair and beard,
The present invention has been completed.
【００１０】すなわち、本発明はビサボロールを含有す
ることを特徴とする発毛抑制皮膚外用剤を提供すること
を目的とするものである。That is, an object of the present invention is to provide a hair growth-suppressing external preparation for skin, which is characterized by containing bisabolol.
【００１１】以下、本発明を詳細に説明する。本発明に
用いられるビサボロール（Ｃ15Ｈ26Ｏ）はカミツレ〔Ｍ
ａｔｒｉｃａｒｉａ ｃｈａｍｏｍｉｌｌａ Ｌ．（Ｃ
ｏｍｐｏｓｉｔａｅ）〕の花の精油中の成分であり、本
発明では化学合成によるもの、あるいはビサボロールを
高濃度に含むカミツレ抽出物が用いられる。カミツレは
西洋では昔から抗炎症、防腐の目的で広く利用されてお
り、うがい薬、湿布薬としても用いられる。カミツレの
抗炎症作用は主としてビサボロールによることが一般に
言われていたが、ビサボロールが発毛抑制効果をもつ事
は知られていなかった。The present invention will be described in detail below. The bisabolol (C 15 H 26 O) used in the present invention is chamomile [M
atricaria chamomilla L. (C
ompositae)], which is a component in the essential oil of flowers, and which is obtained by chemical synthesis or a chamomile extract containing bisabolol at a high concentration is used in the present invention. Chamomile has been widely used in the West for anti-inflammatory and antiseptic purposes since ancient times, and is also used as a mouthwash and poultice. It was generally said that chamomile's anti-inflammatory action was mainly due to bisabolol, but it was not known that bisabolol has a hair growth suppressing effect.
【００１２】本発明の発毛抑制皮膚外用剤におけるビサ
ボロールの含有量は特に限定されるものではないが、発
毛抑制効果の点から０．００１〜３．０％が好ましく、
更に好ましくは０．０１〜１．０％である。The content of bisabolol in the external preparation for hair growth suppression of the present invention is not particularly limited, but 0.001 to 3.0% is preferable from the viewpoint of the hair growth suppression effect,
More preferably, it is 0.01 to 1.0%.
【００１３】本発明の発毛抑制皮膚外用剤は、化粧水、
乳液、クリーム、パック、軟膏、エアゾール、粉末等様
々な剤形とすることが可能であり、特に限定されるもの
ではない。The external preparation for suppressing hair growth of the present invention is a lotion,
It may be in various dosage forms such as emulsion, cream, pack, ointment, aerosol, powder and is not particularly limited.
【００１４】本発明の発毛抑制皮膚外用剤の配合成分は
通常用いられる公知の原料、即ち化粧品、医薬部外品、
医薬品に用いられる水性成分、界面活性剤、油剤、保湿
剤、粉末成分、アルコール類、ｐＨ調整剤、防腐剤、酸
化防止剤、増粘剤、色素、顔料、香料等を必要に応じて
適宜選択することにより調製される。The compounding ingredients of the hair growth-suppressing external skin preparation of the present invention are known raw materials usually used, that is, cosmetics, quasi drugs,
Aqueous components, surfactants, oils, moisturizers, powder components, alcohols, pH adjusters, preservatives, antioxidants, thickeners, dyes, pigments, fragrances, etc. used in pharmaceuticals are appropriately selected as necessary. It is prepared by
【００１５】[0015]
【実施例】以下に実施例を挙げ、本発明を具体的に示す
が、本発明は特にこれらの実施例に限定されるものでは
ない。また、本発明において使用した評価方法及び項目
は下記の通りである。尚、比較例、実施例の処方は表１
に示す。表中の％とは重量％である。The present invention will be specifically described below with reference to examples, but the present invention is not particularly limited to these examples. The evaluation methods and items used in the present invention are as follows. The formulations of Comparative Examples and Examples are shown in Table 1.
Shown in In the table,% means% by weight.
【００１６】[0016]
【表１】 [Table 1]
【００１７】（１）マウスによる発毛抑制試験方法 Ｃ３Ｈマウスのオス（７週齢）を１０匹１群とし、背部
皮膚を試料塗布前日にバリカン及びシェーバーにて毛刈
りした。１日１回、０．２ｍｌの実施例１及び比較例１
の試料を毛刈り部位に、１４日間の連続塗布を行った。(1) Hair Growth Inhibition Test Method Using Mice C1H males (7 weeks old) were made into a group of 10 and their back skin was shaved with a clipper and a shaver on the day before application of the sample. 0.2 ml of Example 1 and Comparative Example 1 once a day
This sample was continuously applied to the shaved area for 14 days.
【００１８】〔評価方法１〕塗布開始１４日目にマウス
背部皮膚の写真撮影を行い、画像解装置（ＮＥＸＵＳ６
４００）により画像処理を行い、毛刈り面積及び発毛面
積を算出した。次の計算式より発毛率（％）を算出し、
マウス１０匹の平均値±標準偏差により発毛抑制効果の
評価を行った。値が低い程、発毛抑制効果があると判断
できる。[Evaluation Method 1] On the 14th day from the start of application, a photograph of the skin of the back of the mouse was taken, and an image resolution device (NEXUS6) was used.
Image processing was performed according to 400), and the hair-cut area and the hair-growth area were calculated. Calculate the hair growth rate (%) from the following formula,
The hair growth inhibitory effect was evaluated by the average value ± standard deviation of 10 mice. It can be judged that the lower the value, the more effective the hair growth is.
【００１９】 [0019]
【００２０】〔評価方法２〕塗布開始１２日目からマウ
ス背部皮膚の毛の再生状態について経日的にスコアによ
る評価を行った。毛の再生状態のスコア評価は、表２に
示す評価基準に従って行い、マウス１０匹の平均値で評
価した。スコアが低い程、発毛抑制効果があると判断で
きる。[Evaluation Method 2] From the 12th day after the start of application, the state of hair regeneration on the back skin of the mouse was evaluated daily by scores. The score of the hair regeneration state was evaluated according to the evaluation criteria shown in Table 2, and the average value of 10 mice was evaluated. It can be judged that the lower the score, the more effective the hair growth is.
【００２１】[0021]
【表２】 [Table 2]
【００２２】〔評価結果〕表３に示した通り、本発明の
ビサボロール含有発毛抑制皮膚外用剤は、実施例１から
実施例４のいずれも比較例と比べて毛再生の遅延がみら
れ、明らかに発毛抑制効果を有することが分かった。[Evaluation Results] As shown in Table 3, in the bisabolol-containing external hair growth-suppressing agent of the present invention, delay in hair regeneration was observed in all of Examples 1 to 4 as compared with Comparative Examples. It was found to have a clear hair growth suppressing effect.
【００２３】[0023]
【表３】 [Table 3]
【００２４】（２）健常人による発毛抑制試験方法 健常人１０名を１グループとして、表４の条件で３グル
ープに対してそれぞれシェーバー、脱毛テープ、除毛ク
リームのいずれかを用いて試験部位のムダ毛の処理又は
髭剃りを行わせ１日１回試験部位に、試料を均一に塗布
させた。塗布条件は入浴後の清浄な状態の試験部位に、
グループの半数は右部に比較例、左部に実施例、残りの
半数は逆に右部に実施例、左部に比較例とし、それぞれ
の試料を適量とり、コットンまたは手で塗布を行わせ
た。(2) Hair Growth Inhibition Test Method by Healthy Subjects A group of 10 healthy subjects was tested on each of the three groups under the conditions shown in Table 4 using a shaver, a depilatory tape, or a depilatory cream. The sample was uniformly applied to the test site once a day by treating or shaving waste hair. The application conditions are as follows:
Half of the groups were the comparative example on the right side, the example on the left side, and the other half were the example on the right side and the comparative example on the left side.Take an appropriate amount of each sample and apply it with cotton or hand. It was
【００２５】[0025]
【表４】 [Table 4]
【００２６】〔評価方法〕Ａグループについては塗布開
始３日後、Ｂ及びＣグループは塗布開始１４日後に、発
毛抑制効果について各人に評価させた。評価方法は各自
左右の毛再生の状態を肉眼にて行い、表５の回答スコア
に従って評価させた。また、使用感・刺激についても各
人に左右比較評価させ、同様に表５の回答スコアによっ
て評価結果を得た。ここでの使用感とはべたつきがな
く、塗布時の感触に不快感を伴わないかどうかを評価し
たものを言う。[Evaluation Method] Each of the groups A was evaluated 3 days after the start of application, and groups B and C were evaluated 14 days after the start of application for the hair growth inhibitory effect. As for the evaluation method, the state of hair regrowth on the left and right of each person was visually observed and evaluated according to the answer scores in Table 5. Also, regarding the feeling of use / stimulation, each person was left-right compared and evaluated, and similarly, the evaluation result was obtained from the answer score in Table 5. Here, the feeling of use is not sticky and is evaluated by whether or not there is an unpleasant sensation during application.
【００２７】[0027]
【表５】 [Table 5]
【００２８】尚、評価が公正に行われるように、被験者
には実施例、比較例の区別を知らせずに試料Ａ、試料Ｂ
として評価を依頼し、アンケートにも試料Ａ、試料Ｂで
回答してもらった。回収後、表５の採点スコアに従って
集計した。It should be noted that, in order that the evaluation can be conducted fairly, the test sample A and the test sample B were informed to the test subject without being informed of the distinction between the example and the comparative example.
As a result, the sample A and the sample B were also answered in the questionnaire. After collection, the results were tabulated according to the scoring scores in Table 5.
【００２９】〔評価結果〕表６に示した通り、本発明の
ビサボロール含有発毛抑制皮膚外用剤は、比較例と比べ
て毛再生の遅延がみられ、実用レベルにおいても発毛抑
制効果を有することが分かった。また、使用感・刺激に
ついては大きな影響はなく、比較例と差はないか若しく
は好ましい回答が得られた。[Evaluation Results] As shown in Table 6, the bisabolol-containing external agent for suppressing hair growth of the present invention shows delayed hair regeneration compared to Comparative Example, and has a hair growth suppressing effect even at a practical level. I found out. Further, there was no great influence on the feeling of use / stimulation, and there was no difference from the comparative example or a favorable answer was obtained.
【００３０】[0030]
【表６】 [Table 6]
【００３１】[0031]
【発明の効果】本発明の発毛抑制皮膚外用剤は皮膚への
負担、すなわち刺激がなく、優れた毛再生の遅延効果を
有し、極めて有用である。Industrial Applicability The external preparation for hair growth inhibition of the present invention is extremely useful because it has no burden on the skin, that is, no irritation, and has an excellent effect of delaying hair regeneration.
Claims (1)
る発毛抑制皮膚外用剤。1. A topical agent for suppressing hair growth, which contains bisabolol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29378794A JP3222025B2 (en) | 1994-11-02 | 1994-11-02 | External preparation for hair growth suppression skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29378794A JP3222025B2 (en) | 1994-11-02 | 1994-11-02 | External preparation for hair growth suppression skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH08133936A true JPH08133936A (en) | 1996-05-28 |
| JP3222025B2 JP3222025B2 (en) | 2001-10-22 |
Family
ID=17799170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP29378794A Expired - Fee Related JP3222025B2 (en) | 1994-11-02 | 1994-11-02 | External preparation for hair growth suppression skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3222025B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6747017B2 (en) | 1998-01-14 | 2004-06-08 | Kao Corporation | Method of inhibiting hair growth |
| US20100015071A1 (en) * | 2007-02-27 | 2010-01-21 | Biospectrum Inc. | Compositions for Improving Skin Conditions Comprising Alpha-Bisabolol as an Active Ingredient |
| JP2017505332A (en) * | 2014-02-06 | 2017-02-16 | ロベルテ ソシエテ アノニム | New use of toiletry compounds to prevent hair regeneration |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7162720B2 (en) * | 2019-12-04 | 2022-10-28 | 北京猫猫狗狗科技有限公司 | feeding device |
| JP7162721B2 (en) * | 2019-12-04 | 2022-10-28 | 北京猫猫狗狗科技有限公司 | pet food equipment |
| KR102754670B1 (en) * | 2022-02-09 | 2025-01-21 | 태형물산 주식회사 | Auto supply system for pet food of IoT based |
-
1994
- 1994-11-02 JP JP29378794A patent/JP3222025B2/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6747017B2 (en) | 1998-01-14 | 2004-06-08 | Kao Corporation | Method of inhibiting hair growth |
| US7041658B2 (en) | 1998-01-14 | 2006-05-09 | Kao Corporation | Method of inhibiting hair growth |
| US20100015071A1 (en) * | 2007-02-27 | 2010-01-21 | Biospectrum Inc. | Compositions for Improving Skin Conditions Comprising Alpha-Bisabolol as an Active Ingredient |
| JP2017505332A (en) * | 2014-02-06 | 2017-02-16 | ロベルテ ソシエテ アノニム | New use of toiletry compounds to prevent hair regeneration |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3222025B2 (en) | 2001-10-22 |
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