JPH08131532A - Tightening titanium wire for living body and manufacturing method thereof - Google Patents

Abstract

(57) [Summary] [Purpose] To obtain a titanium wire for living body, which is used for fastening human bones and artificial bones in vivo, can be easily and firmly fastened during surgery, and has high safety in vivo. . [Structure] The fastening titanium wire for living body is composed of a gas component of 300 ppm or less of oxygen, 130 ppm or less of hydrogen, 200 ppm or less of nitrogen, 400 ppm or less of carbon, 100 ppm or less of impurities excluding gas components, and the balance of titanium. Is 4 after the final cold drawing
It consists of annealing at 00 ° C to 900 ° C for 5 seconds to 5 hours.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a living body fastening titanium wire used for fastening human bones in a living body and a method for producing the same.

[0002] Such a titanium wire is required to be easily and firmly fastened during surgery and to be highly safe in vivo, but the present invention is as described below.
An excellent titanium wire suitable for such a purpose is provided.

[0003]

2. Description of the Related Art In recent years, in the fields of orthopedic surgery and oral surgery, artificial bones, artificial tooth roots, etc. have been implanted in a living body. Especially when it comes to bone damage,
Embed artificial bone in the damaged area or reinforce or fix it until the bone is healed. Bone transplantation is also performed in spinal surgery.

In general, stainless steel and chrome-cobalt materials are often used for such artificial bones or joint materials. However, there have been many reports that stainless steel was associated with malignant tumors after artificial joint replacement, and elution of toxic metal ions in vivo has recently been regarded as a problem.

As mentioned above, stainless steel is generally said to be a corrosion resistant material, but the corrosion resistant film (passive film) on the surface is partially destroyed due to the occurrence of scratches on the stainless steel itself during surgery and use, and In the atmosphere, the passive film rapidly regenerates, but due to the low oxygen partial pressure in the body, the dough is exposed for a long time and metal ions such as nickel, which is the main additive element element of stainless steel, elutes. It is possible that It has been reported that metallic nickel itself has toxicity as an allergic or carcinogenic substance.

As the metal to be embedded in the body as described above, a metal wire is used for fixing or reinforcing bones or bones and artificial bones or transplanted bones. As the metal wire, stainless steel wire is often used because of its high strength. However, there is a risk that galvanic corrosion will occur between the above-mentioned metallic artificial bone and the elution of metal ions will occur more easily. Due to the occurrence of such problems, the following properties are required for the living body fastening wire.

Biocompatibility No cytotoxicity or no toxicity per se Not elution as metal ion Good compatibility with living tissue No carcinogenicity or antigenicity No metabolic abnormality Do not cause blood coagulation or hemolysis

Mechanical properties Having appropriate static strength and ductility Having sufficient fatigue strength

[0009]

Because of the problems as described above, it has come to be avoided to use a toxic metal or an alloy material containing the toxic metal as a component.

As a result, a titanium material, which has excellent corrosion resistance and is lighter in weight, has come to be paid attention as a material replacing stainless steel and chromium-cobalt materials.

This titanium material is roughly classified into pure titanium and titanium alloy. The strength of pure titanium varies depending on the amount of oxygen, and the JIS standard specifies that the titanium has a low oxygen content and is classified into 1 to 3 types.

On the other hand, titanium alloys include V, Mo, Fe and Cr.
As the β-stabilizing element increases, the β-phase will exist up to room temperature, but depending on the presence or absence of this β-phase, α-type, α-
It is classified into β type and β type. Among the titanium alloys, Ti-6Al-4V is known for medical use. It is defined as a surgical implant material in American ASTM and ISO standards. However, this alloy contains V, which is said to exhibit strong cytotoxicity when used alone, and some researchers have pointed out the danger of this. Therefore, the development of V-free titanium alloys for biomedical purposes was also conducted. Has been done.

Regarding pure titanium, the content of impurities is 1500 ppm or less of oxygen, 500 ppm or less of nitrogen,
Iron content is 3000 ppm or less, hydrogen content is 130 ppm or less, etc., but it is considered that there is no particular concern for cytotoxicity with such an impurity content.

In any case, since the titanium material is clearly superior to other materials in terms of its characteristics, the use as a biomaterial and the research of new materials are rapidly increasing in recent years.

However, if the artificial bone and the fastening wire for living body are used at the same place, the contact portion between them is soaked in the body fluid in the living body, so that there is a great risk of galvanic corrosion. This is especially noticeable when using dissimilar materials such as stainless steel. Therefore, when pure titanium or titanium alloy is used as a biomedical implant material such as artificial bone, it is desirable to use the same kind of titanium wire.

However, it is said that the titanium material is inferior in mechanical strength and elongation to the stainless steel wire, and it has not yet been concluded whether or not the titanium-based material is a material suitable as a biological fastening wire. Is the current situation.

Particularly, a problem with such a living body fastening wire is the fastening of the wire. When fixing bones with a wire, it is common to use a twist, but the fastening by this twist can be tightly wrapped around the object so that slack does not occur, and during and during the fastening It is necessary that the wire does not break even afterward.

As such a fastening wire, one kind of JIS standard pure titanium or two kinds J having increased strength by increasing oxygen
The IS standard has been proposed, and research reports have been made that show relatively good fastening properties. However, as shown above, JI
The S-standard pure titanium has a problem that it breaks after being twisted several times, or it breaks in a state where it is not tightly wrapped around an object and a gap is left. Pure titanium does not have a problem with cytotoxicity, but the actual situation remains such an unsolved problem.

Due to such problems, a fastening method has been devised and a mechanical fixing method by crimping has been proposed. However, in addition to many surgical tools, a special tool for crimping is required, and There is a drawback in that the fastening work is complicated because it requires a certain amount of skill, so it cannot be said to be a fundamental solution.

[0020]

Means for Solving the Problems As a result of earnest tests and studies on the above problems, the present inventors have further rigorously adjusted a trace amount of impurities contained in titanium to prevent slack when fastening a wire. The present invention has been accomplished by finding an excellent material that can be applied as a living body fastening wire without breakage.

That is, the first aspect of the present invention is that the gas components are oxygen 300 ppm or less, hydrogen 50 ppm or less, and nitrogen 2.
The present invention relates to a fastening titanium wire for living body, which has a content of 00 ppm or less, carbon of 400 ppm or less, impurities other than gas components of 100 ppm or less, and balance titanium.

Next, a second aspect of the present invention is a gas component in which the oxygen content is limited to a preferable range: oxygen 200 ppm or less, hydrogen 50 ppm or less, nitrogen 200 ppm or less, carbon 400 ppm or less, and impurities other than the gas component 100.
The present invention relates to a fastening titanium wire for living body in which the balance is not more than ppm and the balance is titanium.

Next, the third aspect of the present invention is that oxygen content of 100 p, which is a gas component in which the oxygen content is restricted to a more preferable range.
The present invention relates to a biological fastening titanium wire having pm or less, hydrogen 50 ppm or less, nitrogen 200 ppm or less, carbon 400 ppm or less, impurities excluding gas components of 100 ppm or less, and the balance titanium.

Next, a fourth invention relates to the inventions corresponding to each of the above 1 to 3 in which the hydrogen content is more preferably limited to 30 ppm or less.

Next, the fifth invention relates to the inventions corresponding to each of the above 1 to 3 in which the hydrogen content is more preferably limited to 20 ppm or less.

Next, the sixth invention relates to the inventions corresponding to each of the above 1 to 5 in which the nitrogen content is more preferably limited to 100 ppm or less.

Next, the seventh invention relates to the inventions corresponding to each of the above 1 to 5 in which the nitrogen content is more preferably limited to 50 ppm or less.

Next, the eighth invention relates to the inventions corresponding to each of the above 1 to 5 in which the nitrogen content is more preferably limited to 20 ppm or less.

Next, a ninth invention relates to the inventions corresponding to each of 1 to 8 above, in which the carbon content is more preferably limited to 200 ppm or less.

Next, a tenth invention relates to the inventions corresponding to each of the above 1 to 8 in which the carbon content is more preferably limited to 100 ppm or less.

The eleventh invention relates to the inventions corresponding to each of the above 1 to 8 in which the carbon content is more preferably limited to 50 ppm or less.

Next, the twelfth invention relates to the inventions corresponding to each of the above 1 to 11 in which the impurities except the gas components are limited to 50 ppm or less.

Next, a thirteenth invention relates to the inventions corresponding to each of the above 1 to 12 in which impurities other than gas components are limited to 20 ppm or less.

Next, in the fourteenth invention, the average crystal grain size is 5 μm.
The present invention relates to the invention corresponding to each of the above 1 to 13 which is m to 150 μm.

Furthermore, the fifteenth aspect of the present invention is, as an optimum method for obtaining a fastening titanium wire for a living body, after the final cold drawing, a temperature range of 400 ° C. to 900 ° C., preferably 500 ° C.
~ 700 ° C temperature range, more preferably 550 ° C-650
1 to 14 characterized by annealing in a temperature range of ℃
The present invention relates to an invention of a method for manufacturing a fastening titanium wire for living body, which corresponds to (Here, the number of inventions to be counted in the "means for solving the problem" is omitted for convenience of explanation, and the actual number of inventions is a combination thereof, and is counted in the claims. It is what you do.)

[0036]

The operation of the present invention will be described in detail below. First, the reasons for limiting oxygen contained in the living body fastening titanium wire will be described in detail.

Oxygen (O): In the present invention, oxygen is 30
It should be 0 ppm or less. When oxygen exceeds 300ppm,
Ductility deteriorates, and the minimum required elongation is less than 30%.

Further, as will be described later, when twisting and fastening,
The root of the fixed object is not wound up and the gap is widened, or even if it is forcibly wound, it is broken before the winding is completed (breakage of type B in an explanatory diagram described later). In some cases, breakage occurs at the transition part with the single wire instead of the twisted part (breakage of type C in the explanatory diagram described later), and it is not suitable as a living body fastening wire.

When such a wire is used, in addition to insufficient fastening, breakage is likely to occur during the operation, and the operation has to be redone and takes a long time.

This oxygen is preferably less than 200 ppm,
It is more preferably 100 ppm or less. As a result, as shown in the test results described later, it has sufficient ductility (elongation) for winding up to the base of the object to be fixed, and is suitable as a living body fastening titanium wire.

Hydrogen (H): In the present invention, hydrogen is 50
It should be below ppm. Hydrogen affects ductility in a smaller amount than oxygen. If the hydrogen content exceeds 50 ppm, the ductility deteriorates sharply even if other impurities are reduced, and the minimum required elongation is less than 30%.

In the same manner as the oxygen described above, in the case of twisting and fastening as will be described later, the root of the object to be fixed is not wound and the gap is widened, or even if it is forcibly wound, it will not be wound. It breaks before it is completed (type B breakage in the explanatory diagram described later). In some cases, breakage occurs at the transition part with the single wire instead of the twisted part (breakage of type C in the explanatory diagram described later), and it is not suitable as a living body fastening wire.

When such a wire is used, not only the fastening is not sufficient, but also the breakage is apt to occur especially during the operation, and the operation has to be redone and takes a long time. This hydrogen is preferably 30 pp
m or less, more preferably 20 ppm or less.

As described above, as will be shown by the test results described later, it has sufficient ductility (elongation) to wind up to the base of the object to be fixed, and is suitable as a fastening titanium wire for living body.

Nitrogen (N): In the present invention, nitrogen is 20
It should be 0 ppm or less. Nitrogen has a ductility reduction of about 1.5 times that of oxygen. If the nitrogen content exceeds 200 ppm, the ductility deteriorates sharply even if other impurities are reduced,
The minimum required elongation is less than 30%.

In the same manner as the oxygen described above, in the case of twisting and fastening as will be described later, the root of the object to be fixed is not wound and the gap is widened, or even if it is forcibly wound, it will not be wound. It breaks before it is completed (type B breakage in the explanatory diagram described later). In some cases, breakage occurs at the transition part with the single wire instead of the twisted part (breakage of type C in the explanatory diagram described later), and it is not suitable as a living body fastening wire.

When such a wire is used, not only is the fastening insufficient, but also breakage easily occurs during the operation, and the operation has to be redone and takes a long time.

This nitrogen is preferably 100 ppm or less,
It is more preferably 50 ppm or less. It is more preferably 20 ppm or less. As described above, as shown in the test results described later, it has sufficient ductility (elongation) to wind up to the base of the object to be fixed, and is suitable as a fastening titanium wire for living body.

Carbon (C): In the present invention, carbon is 40
It should be 0 ppm or less. Carbon exists as an interstitial solid solution element in Ti and acts to increase the strength of Ti.
On the contrary, this is about 0.75 times less ductility than that of oxygen at the same concentration.

When the carbon content exceeds 400 ppm, the ductility deteriorates sharply even if other impurities are reduced, and the minimum required elongation becomes less than 30%. Further, like the oxygen described above, at the time of twist fastening as will be described later, the root of the fixed object is not wound up and the gap is widened, or even if it is forcibly wrapped, the winding is not completed. Will break (breaking of type B in the explanatory diagram described later). In some cases, breakage occurs at the transition part with the single wire instead of the twisted part (breakage of type C in the explanatory diagram described later), and it is not suitable as a living body fastening wire.

When such a wire is used, not only the fastening is insufficient, but also the breakage is apt to occur especially during the operation, and the operation is forced to be redone and takes a long time.

The carbon content is preferably 200 ppm or less,
It is more preferably 100 ppm or less. It is more preferably 50 ppm or less. As described above, as shown in the test results described later, it has sufficient ductility (elongation) to wind up to the base of the object to be fixed, and is suitable as a fastening titanium wire for living body.

Impurities other than the above gas components: In the present invention, the impurities other than these gas components are 100 ppm or less.

If the amount of impurities other than the gas component exceeds a certain amount, the ductility deteriorates sharply, and the minimum required elongation is less than 30%. Then, similar to the oxygen described above, at the time of twist fastening as will be described later, the root of the object to be fixed is not wound and the gap is widened, or even if it is forcibly wound, the winding is not completed. Will break (breaking of type B in the explanatory diagram described later). In some cases, breakage occurs at the transition part with the single wire instead of the twisted part (breakage of type C in the explanatory diagram described later), and it is not suitable as a living body fastening wire.

When such a wire is used, not only the fastening is insufficient, but also the breakage is likely to occur especially during the operation, and there is a problem that the operation has to be redone and takes time. Impurities other than this gas component are preferably 50 ppm or less, more preferably 20 ppm or less.

As described above, as shown in the test results described later, it has sufficient ductility (elongation) to wind up to the root of the object to be fixed, and is suitable as a fastening titanium wire for living body.

Description of tensile strength and proof stress (yield stress) of the wire In the above, the limitation of impurities of the titanium wire for biological fastening is described, but it is sufficient as a biological fastening wire because it is used for fixing or fastening bone. Tensile strength and proof strength are required. It is desirable that the tensile strength and the proof stress be 180 MPa and 70 MPa or more, respectively.

The presence of some is rather preferred, since the impurities described above usually result in an increase in the strength of titanium to a greater or lesser extent. However, the presence of excess tends to lose the properties of high ductility and suppleness required for biofastening wires. If the ductility is sacrificed and the strength is increased, there is a risk of breaking the fastening wire, which must be avoided.

As described above, high ductility is indispensable for the living body fastening wire. Generally, if the tensile strength and the proof stress are respectively 180 MPa and 70 MPa, there is no practical inconvenience and it is suitable as a living body fastening wire.

When it is desired to increase the strength as much as possible in the case of using for joining bones to which a large load is applied, the wire diameter should be increased or several wires should be braided into a fastening wire with increased strength. It is also possible to adopt such a method as needed. The biological fastening titanium wire of the present invention sufficiently satisfies the above conditions.

Next, the average crystal grain size will be described. In the present invention, the average crystal grain size is 5 μm to 150 μm.
It is desirable to set m. The smaller the crystal grain size, the higher the toughness. However, in reality, if the grain size is less than 5 μm, it is difficult to manufacture, and even if it is manufactured, a part of the strain remains and the ductility value decreases.
On the other hand, when the average crystal grain size is large, particularly when it exceeds 150 μm, the number of crystal grains becomes small with respect to the wire diameter and the ductility is locally deteriorated.

Next, details of the manufacturing method will be described.
A titanium material having predetermined components prepared is melt-cast to produce a titanium ingot. Gas components oxygen, nitrogen,
A vacuum arc melting method, an electron beam melting method, or the like can be used to remove impurities such as hydrogen and carbon to a predetermined amount or less. After forging the obtained titanium ingot as required, it is groove-rolled, swaged, and wire-drawn to obtain, for example, φ1.7, φ1.0, φ0.8, φ
A wire having a predetermined diameter such as 0.4 is produced. The diameter of the wire is adjusted by appropriately changing the diameter of the die and performing wire drawing. The cross-section reduction rate is about 30 to 90%.

Intermediate annealing (400-
The temperature range is 900 ° C., preferably 500 to 700 ° C., more preferably 550 to 650 ° C., for about 10 seconds to 5 hours).

In place of the above-mentioned manufacturing process, a plate-shaped product obtained by rolling is cut into a rectangular rod shape, further cut by a square grinder or the like of this rectangular rod, and then swaged and wire-drawn. You can also

After the final processing, a temperature range of 400 to 900 ° C., preferably a temperature range of 500 to 700 ° C., more preferably 5
Final annealing is performed in a temperature range of 50 to 650 ° C. for approximately 5 seconds to 5 hours. A predetermined crystal grain (for example, an average crystal grain size of 5 μm to 150 μm) is prepared through the above processing and annealing. The intermediate annealing and the final annealing can be either continuous or batch type. In this way, a titanium wire having a predetermined diameter is manufactured.

The biological fastening titanium wire of the present invention described above is used for fastening human bones and artificial bones in a living body, and has sufficient ductility (elongation) to wind up to the root of an object to be fixed. It has excellent characteristics that it can be easily and firmly fastened during surgery and that it is highly safe in vivo.

[0067]

EXAMPLES AND COMPARATIVE EXAMPLES Hereinafter, the present invention will be described by way of Examples (compared with Comparative Examples). A titanium ingot was prepared by melting and casting the titanium material with the prepared components. An electron beam melting method was used to remove impurities such as oxygen, nitrogen, hydrogen, and carbon, which are gas components.

After forging the obtained titanium ingot,
Groove roll rolling, swaging, wire drawing, φ
Wires with diameters of 1.0 and φ 0.8 were made. The cross-section reduction rate is about 30 to 90%. In the middle of this processing step,
Intermediate annealing was performed in the temperature range of 400 to 900 ° C. After the final processing, final annealing was performed in the temperature range of 400 to 900 ° C. The average crystal grain size was 5 μm to 150 μm.

Table 1 shows the component analysis values of the titanium wire test material thus prepared. The values shown in sample numbers (1 to 19) in Table 1 are average values of 20 samples. The component analysis values are rounded to one digit.

In addition, instead of the above manufacturing process, a plate-shaped product obtained by rolling is cut into a rectangular rod shape, and further cut with a square grinder or the like, and then swaged and drawn. I made a titanium wire,
There was no difference in characteristics when the component analysis values were within the range of the present invention.

Further, those which depart from the numerical range described as "more suitable range" in the description of the present invention due to the difference in the annealing temperature range 500 ° C to 700 ° C and 550 ° C to 650 ° C and the average crystal grain size, Although there is a tendency for the variation to be somewhat larger than the characteristic value in the “more preferable range”, there is no particular difference in the characteristics when the component analysis value falls within the range of the present invention.

For comparison, a titanium wire was prepared in which the components of impurities were adjusted through the same manufacturing process.

The component analysis values of the test material are also shown in Table 1. The values shown in sample numbers (20 to 30) in Table 1 are average values of 20 samples as in the examples of the present invention. Similarly, the component analysis values are rounded to the nearest single digit.

[0074]

[Table 1]

Next, the following tests were conducted using each of the test materials. (1) Tensile test (measurement of elongation) Gauge distance: 70 mm, tensile speed 10 mm / mi
n, the diameter between gauge points: 1.0 mm and 0.8 mm Two types of wires having a tensile test were conducted.

(2) Twisting (twisting) test Jig to be wound: jig for fixing a round bar having a diameter of 20 mm, rotation speed: 60 rpm, and two kinds of wires having wire diameters of 1.0 mm and 0.8 mm. A twist test was performed.

The results of the above tensile test (measurement of elongation) are shown in Table 1 and FIGS. 1 to 5. As is clear from Table 1, in each of Samples 1 to 19 of the present invention, the elongation is 30% or more, and good ductility is exhibited. In particular, the ductility is higher when the gas components are oxygen 200 ppm or less, hydrogen 30 ppm or less, nitrogen 100 ppm or less, carbon 100 ppm or less, and impurities other than gas components 50 ppm or less. More preferably, the oxygen content is 100 ppm or less, the hydrogen content is 20 ppm or less, the nitrogen content is 20 ppm or less, the carbon content is 50 ppm or less, and the impurities other than gas components are 20 ppm or less.

On the other hand, Sample 2 presented as a comparative example
It can be seen that in all of 0 to 30, the elongation is less than 30% and the ductility is extremely poor. Samples 20 to 30 of these comparative examples all had 300 ppm oxygen and 5 hydrogen.
0 ppm, 200 ppm of nitrogen, 400 ppm of carbon, and impurities other than gas components exceeding 100 ppm, which is an unsuitable material as a fastening titanium wire for living body.

FIG. 1 shows samples 1, 2, 3, 4 and comparative example 2.
It shows 0, 21, 22 and shows the change in elongation depending on the oxygen content.

FIG. 2 shows samples 1, 5, 6, 7 and comparative example 2.
3 and 24, showing the change in elongation depending on the carbon content.

FIG. 3 shows Samples 1, 8, 9, and 10 and Comparative Examples 25 and 26, showing changes in elongation depending on the nitrogen content.

FIG. 4 shows samples 1, 11, 12, and 13 and comparative examples 27 and 28, showing changes in elongation depending on the hydrogen content.

FIG. 5 shows samples 1, 14, 15, 16 and comparative examples 29, 30 and shows changes in elongation depending on the content of impurities other than gas components. It is obvious that the elongations of the examples of the present invention are better than those of the comparative examples.

The tensile strength and yield strength in the tensile test were 180 MPa and 70 MPa, respectively.
Since it possesses the above, there is no practical inconvenience and it is suitable as a living body fastening wire.

[0085]

[Table 2]

The results of the twisting test are shown in Tables 1 and 2, FIGS. 6 to 10, and FIG. 11 shows the classification of fracture forms.

As shown in FIG. 11, a twisting (twisting) test was applied to a round bar fixing jig having a diameter of 20 mm, and the number of rotations was 60 r.
The state wound by pm is shown. The type A shows a state in which the base of the jig is wound neatly with almost no gap (gap less than 1.0 mm).

When the fracture is reached (due to excessive winding), the fracture is in the middle of the twisted portion, that is, where the processing strain is concentrated, and shows a good fracture.

On the other hand, in the type B, fracture occurs when the base of the jig cannot be wound (gap of 1.0 mm or more). This case occurs when the ductility of the wire is not sufficient. In this case, loosening will occur in the fastening.

Further, in the type C, breakage occurs at the transition portion between the winding portion and the wire single wire (element wire). This state is completely unsuitable for a fastening wire.

As is clear from Table 2, in the samples 1 to 19 shown in the examples of the present invention, the 1.0 mm diameter and the 0.8 mm diameter both showed the type A fracture mode, and almost no gap was formed. (Gap is less than 1.0 mm) It shows that the root of the jig is wrapped neatly.

Details of the gap for winding around the jig are shown in Table 1 and FIGS. 6 to 10. As is clear from these, in each of Samples 1 to 19, the gap was 1.0 m.
It is less than m, and the more excellent the ductility is, the better. Depending on the sample, there is no gap, and there are even those that are tightly wrapped around the root.

On the other hand, in the samples 20 to 30 of the comparative example, the fractured form of type B or type C is shown, and as shown in Table 1 and FIGS. Breakage occurs at (gap of 1.0 mm or more) or breaks occur at the transition between the winding part and the wire single wire (element wire). These are unsuitable as fastening titanium wires for living bodies, and there is a risk that they will break during or after surgery and that fastening will not be sufficient.

[0094]

EFFECTS OF THE INVENTION Titanium is already known to be good in fatigue strength, tensile strength, corrosion resistance, and biocompatibility, but in the present invention, it is important to consider the fastening property which has been a problem in the past. It is a solution to the problem. Moreover, no toxic or soluble constituent elements are used in this solution.

As described above, the living body fastening titanium wire of the present invention is used for fastening human bones or artificial bones in a living body, and has sufficient ductility to wrap around the root of the object to be fixed ( Elongation, it can be easily and firmly fastened during surgery, and it has excellent characteristics of high safety in vivo. In particular, it exerts an excellent function also in fixing bone graft.

[Brief description of drawings]

FIG. 1 is an explanatory diagram of changes in elongation depending on oxygen content.

FIG. 2 is an explanatory diagram of changes in elongation depending on the carbon content.

FIG. 3 is an explanatory diagram of changes in elongation depending on the nitrogen content.

FIG. 4 is an explanatory diagram of changes in elongation depending on the hydrogen content.

FIG. 5 is an explanatory diagram of changes in elongation depending on the content of impurities other than gas components.

FIG. 6 is an explanatory diagram of changes in the gap depending on the oxygen content.

FIG. 7 is an explanatory diagram of changes in the gap depending on the carbon content.

FIG. 8 is an explanatory diagram of changes in the gap depending on the nitrogen content.

FIG. 9 is an explanatory diagram of changes in the gap depending on the hydrogen content.

FIG. 10 shows changes in the gap depending on the content of impurities other than gas components.

FIG. 11 is an explanatory diagram showing classification of fracture modes.

Claims (30)

[Claims] 1. A gas component of oxygen of 300 ppm or less,
Hydrogen 50ppm or less, nitrogen 200ppm or less, carbon 40
Impurities excluding 0 ppm and gas components are 100 pp
A fastening titanium wire for living body having m or less and the balance being titanium. 2. A gas component of oxygen of 200 ppm or less,
Hydrogen 50ppm or less, nitrogen 200ppm or less, carbon 40
Impurities excluding 0 ppm and gas components are 100 pp
A fastening titanium wire for living body having m or less and the balance being titanium. 3. A gas component of oxygen of 100 ppm or less,
Hydrogen 50ppm or less, nitrogen 200ppm or less, carbon 40
Impurities excluding 0 ppm and gas components are 100 pp
A fastening titanium wire for living body having m or less and the balance being titanium. 4. The biological fastening titanium wire according to claim 1, wherein the hydrogen content is 30 ppm or less. 5. The biological fastening titanium wire according to claim 1, wherein the hydrogen content is 20 ppm or less. 6. The biological fastening titanium wire according to claim 1, wherein the nitrogen content is 100 ppm or less. 7. The fastening titanium wire for a living body according to claim 1, wherein the nitrogen content is 50 ppm or less. 8. The biological fastening titanium wire according to claim 1, wherein the nitrogen content is 20 ppm or less. 9. The fastening titanium wire for a living body according to claim 1, wherein carbon content is 200 ppm or less. 10. The fastening titanium wire for a living body according to claim 1, wherein carbon content is 100 ppm or less. 11. The fastening titanium wire for a living body according to claim 1, wherein carbon content is 50 ppm or less. 12. The biological fastening titanium wire according to claim 1, wherein impurities other than gas components are 50 ppm or less. 13. The biological fastening titanium wire according to any one of claims 1 to 11, wherein impurities excluding gas components are 20 ppm or less. 14. The biological fastening titanium wire according to claim 1, wherein the average crystal grain size is 5 μm to 150 μm. 15. After the final cold drawing, 400 ° C. to 90 ° C.
Gas components characterized by annealing in a temperature range of 0 ° C. are oxygen 300 ppm or less, hydrogen 50 ppm or less, nitrogen 2
A method for producing a biologically fastened titanium wire, wherein 00 ppm or less, carbon 400 ppm or less, impurities other than gas components are 100 ppm or less, and the balance is titanium. 16. After the final cold wire drawing, 400 ° C. to 90 ° C.
A gas component characterized by being annealed in a temperature range of 0 ° C. Oxygen 200 ppm or less, hydrogen 50 ppm or less, nitrogen 2
A method for producing a biologically fastened titanium wire, wherein 00 ppm or less, carbon 400 ppm or less, impurities other than gas components are 100 ppm or less, and the balance is titanium. 17. After the final cold wire drawing, 400 ° C. to 90 ° C.
A gas component characterized by being annealed in a temperature range of 0 ° C. Oxygen 100ppm or less, hydrogen 50ppm or less, nitrogen 2
A method for producing a biologically fastened titanium wire, wherein 00 ppm or less, carbon 400 ppm or less, impurities other than gas components are 100 ppm or less, and the balance is titanium. 18. After final cold drawing, 500 ° C. to 70 ° C.
16. Annealing in a temperature range of 0 ° C. 16.
18. The method for producing a titanium wire for fastening a living body according to any one of 17. 19. After the final cold drawing, the temperature is from 550 ° C. to 65.
16. Annealing in a temperature range of 0 ° C. 16.
18. The method for producing a titanium wire for fastening a living body according to any one of 17. 20. The method for producing a titanium wire for fastening a living body according to claim 15, wherein the hydrogen content is 30 ppm or less. 21. The method for producing a fastening titanium wire for living body according to claim 15, wherein the hydrogen content is 20 ppm or less. 22. The method for producing a titanium wire for fastening a living body according to claim 15, wherein nitrogen is 100 ppm or less. 23. The method for producing a fastening titanium wire for living body according to claim 15, wherein the nitrogen content is 50 ppm or less. 24. The method for producing a fastening titanium wire for living body according to any one of claims 15 to 21, wherein the nitrogen content is 20 ppm or less. 25. The method for producing a fastening titanium wire for living body according to any one of claims 15 to 24, wherein carbon content is 200 ppm or less. 26. The method for producing a fastening titanium wire for living body according to any one of claims 15 to 24, wherein carbon content is 100 ppm or less. 27. The method for producing a fastening titanium wire for living body according to any one of claims 15 to 24, wherein carbon content is 50 ppm or less. 28. The method for producing a titanium wire for biological fastening according to any one of claims 15 to 27, wherein impurities other than gas components are 50 ppm or less. 29. The method for producing a titanium wire for fastening a living body according to claim 15, wherein impurities other than gas components are 20 ppm or less. 30. The method for producing a titanium wire for fastening a living body according to any one of claims 15 to 29, wherein the average crystal grain size is 5 μm to 150 μm.