JPH0810325A - Syringe and container - Google Patents

Abstract

(57) [Summary] [Object] To provide a syringe / container capable of storing and storing a plurality of medicines in a divided room and continuously administering the medicines. [Composition] A syringe / container whose inside is divided into a plurality of chambers by an intermediate sealing plug, wherein a bypass is cut out in a groove shape in a syringe barrel to form a straight line or an L-shape extending to a base of a protruding portion for attaching an injection needle. And a linear bypass groove and an intermediate sealing plug having a projection at the tip, or an L-shaped bypass groove and an intermediate sealing plug having a projection or having no projection to form a flow path through which a drug can flow out. Realize continuous administration of.
The syringe barrel has a single cylindrical and simple structure, and is advantageous in manufacturing cost, manufacturing process, formulation cost, hygiene, operability of administration work, and reduction of pain to a patient.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a syringe / container, and more particularly, to an improvement of a syringe / container having two or more drug storage chambers capable of administering two or more kinds of drugs by inserting a single administration needle. It is a thing.

[0002]

2. Description of the Related Art As syringes which can store two kinds of liquid medicine, for example, JP-B-46-30627 and JP-B-49-306.
No. 27, etc., the two types of drug solutions A and B, which lose their potency when mixed in advance, are separated and stored, and each solution is sequentially administered at the time of administration, and both are treated at the affected site. There is a syringe / container that mixes liquids and exerts a medicinal effect. Further, JP-A-58-81047 and JP-A-58-1040
Japanese Patent No. 65 proposes a syringe in which a contrast medium fluid and a cleaning fluid are stored in one cylinder and the two fluids are continuously injected. Furthermore, actual fairness 4-1
No. 2990 proposes a syringe capable of sequentially injecting two or more different injection solutions by using a groove-shaped bypass provided in a collar portion of a base portion of an injection needle holder attached to a front portion of an injection cylinder as a flow path. There is.

[0003]

In the conventional two-chamber type syringe as described above, the structure of the syringe barrel, the stopper and the piston constituting the syringe is very complicated, and therefore the molding is difficult. Difficult and uneconomical, and also difficult to wash and sterilize in the manufacturing process, which is not preferable in terms of manufacturing cost, and there is no particular consideration given to the quality preservation of the drug in the syringe. , And so on. The present invention aims to solve the above-mentioned drawbacks of conventional products and to provide a syringe / container capable of accurately and sanitarily storing two or more drugs and continuously administering them.

[0004]

As a means for solving the above-mentioned problems, the present invention has a tubular projection for attaching an injection needle at the tip end thereof, and one or more intermediate sealing plugs are provided inside the plurality of chambers. By accommodating a plurality of medicines in one cylinder divided into, the opening side is sealed with a sealing and sealing plug, and at the time of drug administration, a push rod is attached to the sealing and sealing stopper and pushed into the cylinder. In the syringe and container that allows the drug to flow out from the protruding part,
(1) One or more L-shaped bypass grooves are cut out on the inner wall surface of the cylinder on the tip side to extend to the tip in the cylinder axis direction and further extend along the inner wall surface of the tip to the base of the protrusion. The shape is such that the length of the cylinder axial direction portion thereof is longer than the total length of the one or more intermediate sealing plugs in the cylinder axial direction, (2)
The first intermediate sealing plug is located closer to the opening than the bypass groove and is fitted into the cylinder to form a first chamber between the first intermediate sealing plug and the cylinder tip, and (3) the first intermediate sealing plug. A second chamber is formed between the sealed sealing plug and one or more intermediate sealing plugs are provided between the first intermediate sealing plug and the sealed sealing plug to form one or more chambers. (4) At the time of drug administration, the first intermediate sealing plug is dropped into the bypass groove side to form a flow path between the inner wall of the cylinder and the first intermediate sealing plug, so that Syringe / container, characterized in that the drug in the chamber is continuously discharged (5) or the drug in the third chamber or lower is likewise continuously discharged by dropping the next intermediate sealing plug into the bypass groove. I will provide a. In a particularly preferred embodiment of the syringe / container of the present invention, the first intermediate sealing stopper does not close the L-shaped bypass groove when pushed into the foremost position in the cylinder at the time of drug administration and does not bypass the bypass groove. A portion which is in close contact with the inner wall surface of the cylinder tip portion other than the above portion and can form a continuous flow path in the L-shaped bypass groove and the projection portion, or the first intermediate sealing plug has a plurality of protrusions on its tip surface. And having an L-shaped bypass groove, a gap between the inner wall of the cylinder tip and the protrusion, and a continuous flow path in the protrusion when pushed into the frontmost position in the cylinder during drug administration. That is.

Further, according to the present invention, a tubular protrusion for attaching an injection needle is provided at the tip end, and the inside is divided into a plurality of chambers by one or more intermediate sealing plugs. In a syringe / container in which a drug is housed and the opening side is sealed with a sealing / sealing stopper, and when a drug is administered, a push rod is attached to the sealing / sealing stopper and pushed into the cylinder to cause the drug to flow out from the protruding portion, (1) On the inner wall surface on the tip end side of the cylinder, a linear bypass groove reaching the tip end in the cylinder axis direction is formed into a notched groove shape, and the length of the intermediate sealing plug in the cylinder axis direction is 1 or 2 or more. (2) A first intermediate sealing plug having a plurality of protrusions on its tip surface is provided longer than the total length in the cylinder axis direction, and is fitted into the cylinder at a position closer to the opening than the bypass groove, and the cylinder tip is attached. And a second chamber between the first intermediate sealing plug and the sealing sealing plug. Or at least one intermediate sealing plug is provided between the first intermediate sealing plug and the sealing sealing plug to further form one or more chambers. (4) The first intermediate sealing when administering a drug By dropping the plug into the bypass groove side, a space between the bypass groove, the inner wall of the cylinder tip and the protrusion of the first intermediate sealing plug, and a continuous flow path are formed in the protrusion to form a drug in the first chamber. And the drug in the second chamber is continuously discharged,
(5) Or a syringe / container characterized in that the medicine in the third or lower chamber is similarly continuously discharged by dropping the next intermediate sealing plug into the bypass groove.

A first chamber having a plurality of chambers and an L-shaped or straight-lined bypass groove in the above-mentioned single cylinder. When the bypass groove is L-shaped, there is no protrusion or a protrusion at the tip. In the syringe-cum-container of the present invention, which is formed by combining an intermediate sealing plug and, when the bypass groove is linear, combining a first intermediate sealing plug having a protrusion at the tip, the cylinder has an outer periphery of a cross section orthogonal to the cylinder axis. A circular shape is a particularly preferred embodiment. Such a simple outer shape is advantageous in manufacturing and process. In the syringe / container of the present invention, it is a particularly preferred embodiment that a dosing needle is attached to the tubular projection for attaching the injection needle by an injection needle attaching device to form a syringe assembly.

[0007]

ACTION AND WORKING EXAMPLES The structure, working mechanism and features of the syringe / container of the present invention will be described in detail with reference to working examples.
The present invention is not limited to the examples. FIG.
FIG. 1 is a schematic sectional view of an embodiment of the present invention. Figure 1 (a)
In the syringe inner wall 4 of the syringe barrel 2 of the syringe / container 1 (hereinafter abbreviated as "cylinder"), a bypass groove extending from a position slightly distal to the tip 3 from the center of the barrel to the tip of the barrel in the length direction of the barrel. One or more 5 are provided, and the bypass groove 5 extends to the inner wall surface of the distal end portion to which the needle for administration is attached. Hereinafter, this extended portion is referred to as the bypass groove 6. The first chamber 10 is fitted in close contact with the inner wall surface 4 of the cylinder 2 at a substantially central portion thereof, and forms the first chamber 10 between the front end 3 and the cylinder.
The intermediate sealing plug 7 is provided with a plurality of protrusions, for example, 2 to 4 on its tip surface. Further, a sealing and sealing plug 11 is fitted on the opening side of the other end of the cylinder in close contact with the cylindrical inner wall surface 4, and the first intermediate sealing plug 7 together with the sealing and sealing plug 11 and the cylindrical inner wall surface. The second chamber 12 is configured.

A sectional view taken along the line AA 'of FIG. 1 (a) is shown in FIG. 1 (c). Although the outer circumference of the cylinder has a perfect circular cross section, the bypass groove 5 is a groove formed by cutting out the inner wall surface of the cylinder as shown in the drawing.
In the illustrated example, two are provided along the inner wall of the cylinder. In the present invention, one or more bypass grooves 5 may be provided in any number. In the example of FIG. 1, the bypass groove 5 is formed in the vicinity of the base of the inner tube portion of the tip projection along the inner wall surface 4 of the cylinder tip and the inner wall surface 4 ′ of the cylinder tip portion having the protruding portion protruding in the shape of a taper. It is an L-shaped bypass groove reaching up to, and the cross-sectional area of the groove is designed to be slightly larger than the inner diameter of the administration needle attached to the tip during administration. FIG. 1B shows a push rod connected to the rear side recess of the sealing and sealing plug 11. (D) of the figure shows a dosing needle connected to a tubular protrusion at the tip 3 of the barrel 2. The first intermediate sealing plug and the sealing sealing plug, which are fitted in the cylinder 2, are the surfaces 13, 13 ', 13 "', 1 which come into contact with the medicine.
3 '''is laminated with a synthetic resin such as a fluorine resin film that does not contaminate the chemicals. The first intermediate sealing plug 7 of this example has a plurality of protrusions 8 on its tip surface, and when pushed into the foremost position, the protrusion 8 and the inner wall 4'of the tip portion together with the bypass groove 5 are formed. Since a flow path can be formed in the space between them, a smooth outflow of the drug can be realized. In addition, the tip 3 of the tube 2 has a tubular tube mouth protruding,
It has a protruding collar surrounding the tube and a luer taper tip, and the opening of the tube mouth is sealed with a synthetic resin laminated rubber stopper.

FIG. 2 is a schematic cross-sectional view of another embodiment of the present invention, in which a cylinder inner surface wall 18 of an injection cylinder (hereinafter abbreviated as "cylinder") 16 of a syringe / container 15 has a cylinder length direction. A bypass groove 19 is provided from a position slightly closer to the tip end portion 17 than the center of the cylinder to the tip end portion 17 of the cylinder. Protrusion 2 on the tip surface
The first intermediate sealing plug 20 having No. 1 is fitted into the cylinder to form the first chamber 23, and the second sealing chamber 24 is fitted into the cylinder at the opening 22 at the other end of the cylinder. 1 is the same as in the case of FIG. 1, but the bypass groove 19 is linear and does not extend along the inner wall of the tip portion, and when the first intermediate sealing plug is pushed to the foremost position, A continuous flow path is formed between the linear bypass groove, the gap formed between the protrusion at the tip of the first intermediate sealing plug and the inner wall of the tip, and the hollow portion in the protrusion to allow the drug to flow out. In addition, a cylinder, a sealing plug,
The shape of the rubber plug or the like at the tip end of the barrel is also an example different from that of FIG.

1 and 2 of the present invention.
6, the bypass groove 5 or 19 has an L-shape or a linear groove shape in which the inner wall surface of the cylinder is cut off as described above, and therefore a protrusion due to the presence of the bypass on the outer circumference of the cylinder is not necessary. The outer shape can be a simple shape with a cylindrical shape and the cross-section outer circumference with a circular shape. Moreover, in the present invention, the bypass groove is formed in the cylinder itself for holding the medicine, and is structurally very simple, and the hygiene in manufacturing is improved, and the manufacturing cost can be greatly reduced as compared with the conventional product having a complicated structure.

FIG. 3 is an explanatory view of the administration of the liquid medicine by the syringe / container of FIG. 2 of the present invention. A dosing needle 26 is firmly attached to the tip 17 of the cylinder 16 of the syringe of FIG. 2, a push rod 27 is attached to the rear part of the sealing and sealing plug 24, and the sealing and sealing plug 24 is pressed into the center of the barrel 16 by the pushing rod 27. As a result, the first intermediate sealing plug 20 is pushed into the first chamber 23, and the chemical liquid in the first chamber 23 is pushed out toward the protruding portion (cylindrical mouth) side of the cylinder tip by the press-fitting of the first intermediate sealing plug, and finally the first When the first intermediate sealing plug is pushed to the tip of the cylinder, the chemical is continuously formed in the bypass groove 5 in the cylinder and the gaps between the three projections 21 of the first intermediate sealing plug 20 and the inner wall surface of the tip part, and the projection part. It flows out through the flow path and is administered to the human body. After that, the chemical liquid in the second chamber 25 subsequently flows out through between the bypass groove 5 and the protrusion 21.

FIG. 4 is a schematic sectional view of a syringe / container having three chambers, which is another embodiment of the present invention. In the figure, a first intermediate sealing plug 20, a second intermediate sealing plug 24, and a sealing sealing plug 28 are fitted in an injection cylinder (hereinafter abbreviated as “cylinder”) 16 as shown in the drawing, and the first chamber 23, the second chamber 25, and the third chamber 29 are formed, and each chamber holds a drug. Drug administration by the syringe / container of FIG. 4 is shown in a schematic explanatory view of FIG. Similarly to the bypass of FIG. 3, the sealing and sealing plug is press-fitted with the push rod to sequentially flow out the drug, but the state shown is the first intermediate sealing plug 20 and the first intermediate sealing plug 24.
Since the bypass groove 19 is designed to be slightly longer than the total length of the bypass groove 19 even if it is completely inserted into the bypass groove 19, the drug in the third chamber also passes through the bypass. And can be leaked.

FIG. 6 shows still another embodiment of the present invention,
It is a schematic explanatory view of a syringe-cum-container having an L-shaped bypass groove 19 and a first intermediate sealing stopper having a tip end surface that is similar in shape to the internal shape of the cylinder tip without a projection at the tip. A flow path is formed between the L-shaped bypass groove 19 and the inside of the protruding portion even when the first intermediate sealing plug is pushed into the foremost position. In this example, in the syringe / container The amount of drug remaining in is very small. In this example, the connecting device 30 is attached to the tube mouth portion sealed with a rubber stopper at the tip of the syringe / container, the double-ended needle 31 is attached to the connecting device 31, and the needle tip is covered with a cap. A solid is shown. The cap may also serve as the push rod.

FIG. 7A is a partial cross-sectional view of another specific example of the first intermediate sealing plug of the present invention, and FIG. 7B is a schematic explanatory view of the tip end surface. 8-1, 8-2, and 8-3 have three protrusions, and the surface contacting with the drug is a synthetic resin film 13 '.
It is laminated in.

As a material forming the syringe / container of the present invention, a material known in this kind of technical field can be used. For example, as a material for a cylinder, a push rod, a connecting device or the like, a synthetic resin, for example, a resin containing a cyclic olefin compound or a crosslinked polycyclic hydrocarbon compound as a polymer component, a polyolefin resin, a polycarbonate resin, a polymethylpentene resin is used. Selected resin and resin composition, the resin and / or
Or a mixture of a resin composition and an ethylene-vinyl acetate copolymer or a saponified product thereof, one or more selected from the group consisting of amorphous nylon and nylon, or one kind of silicon oxide or aluminum vapor-deposited resin film on the surface. Examples thereof include resins that are laminated and have improved barrier properties. As the material of the sealing stopper and the sealing rubber stopper of the present invention, rubbers generally used in this kind of syringe and container can be used. For example, polybutadiene (BR), polyisoprene (IR), isobutylene-isoprene copolymer Examples thereof include compound (IIR), IIR chlorinated rubber (CIIR) or IIR brominated rubber, and ethylene-propylene-non-conjugated polymer rubber (EPDM). It is also a preferred embodiment that a synthetic resin that does not contaminate the drug, such as a fluorine-based resin, is laminated on at least the surface of the rubber molding stopper that contacts the drug. The syringe / container of the present invention can be molded by applying a known molding technique, such as injection molding, molding using a mold, or the like, depending on its material and form.

A syringe / container which has two or more chambers according to the present invention and in which the drug held in each chamber is continuously and sequentially discharged and administered to a human body, etc. is very advantageously applied. An example will be described below. In the first chamber, for example, procaine, tetracaine, ethyl aminobenzoate, oxyprocaine ester-based compound, lidocaine, mepivacaine, dibucaine, oxesazein (acid amide-based compound) are added in an amount of 0.1 to 0.1.
Local anesthetics such as those prepared by dissolving in 0.5% by weight of distilled water for injection or alcohol, and iodine contrast agents. Second
For example, tetracycline-type, quinoline-type, aminoglycoside-, macrolide-type, and other antibiotics such as steroid hormones, thyroid hormones, pituitary hormones, and other hormones, interferon, hyaluronic acid, and pyrin-type drugs are used in the chamber. Hormonal agents, interferons, antibiotics, etc., may be mixed with local anesthetics because of strong irritation at the time of injection. Problems such as deterioration, deterioration, and chemical damage will occur. As described above, the syringe / container of the present invention is applied to separate the first chamber and the second chamber to retain the drug, and first, the local anesthetic in the first chamber is administered to perform local anesthesia, and then, Since the drug in the second chamber is administered, the above problems can be solved, and the effect of the drug can be improved, the formulation can be simplified and facilitated, and the range of application of the drug can be expanded. Furthermore, according to the syringe / container separated into three chambers of the present invention, for example, the first
The local anesthetic can be administered from the chamber, the agent can be administered from the second chamber, and the saline can be administered from the third chamber.

[0017]

The effects of the syringe / container of the present invention are as follows. 1) Since the structure is relatively simple and the outer shape is a simple cylindrical portion, the manufacturing cost, sterilization work, storage, etc. are simple and economical. 2) Since the drug in the cylinder can be administered as a single item, the formulation of the unstable drug such as an antibiotic can be simplified. 3) Since two or three types of drugs can be continuously and hygienically administered from one syringe, the administration work can be simplified. 4) The continuous administration eliminates the decrease in drug efficacy and can be expected to have a combined effect. 5) Since the administration can be performed at a time difference instead of mixed administration, for example, antibiotics and the like can be continuously administered after local anesthesia, so that the patient's pain is reduced.

[Brief description of drawings]

FIG. 1 is a schematic cross-sectional view illustrating an embodiment of the syringe / container of the present invention.

FIG. 2 is a schematic sectional view for explaining another embodiment of the syringe / container of the present invention.

FIG. 3 is a schematic cross-sectional view illustrating a state in which the liquid medicine of the second chamber is being administered by the syringe / container of the present invention in FIG.

FIG. 4 is a schematic cross-sectional view illustrating a syringe / container having three chambers according to still another embodiment of the present invention.

FIG. 5 is a schematic cross-sectional view illustrating a state in which the liquid medicine of the third chamber is being administered in the syringe / container of the present invention in FIG.

FIG. 6 is a schematic cross-sectional view for explaining a double-headed syringe / container with a dosing needle according to still another embodiment of the present invention.

FIG. 7 is a schematic explanatory view of a specific example of a first intermediate sealing plug of the present invention, showing a partial cross section and a front view.

[Explanation of symbols]

1 syringe and container, 2 cylinders (syringe), 3
Tip part, 4 Inner surface of cylinder, 5, 5'Bypass groove, 6 Bypass groove, 7 First intermediate sealing plug, 8
Protrusion, 9 opening, 10 first chamber,
11 sealing and sealing plug, 12 second chamber, 1
3 ′, 13 ″, 13 ″ ″ synthetic resin film, 14
Color, tip of lure tip, 15
Syringe / container, 16 cylinders (injection cylinder), 17 tip part, 18 cylinder inner surface, 19 bypass groove,
20 first intermediate sealing plug, 21 protrusion, 2
2 Opening part, 23 1st chamber, 24 Sealing sealing stopper, 25 2nd chamber, 26 Dosing part, 2
7 Push rod, 28 2nd intermediate sealing plug, 29
3rd chamber, 30 connecting device, 31 double-ended needle.

Claims (8)

[Claims] 1. A plurality of medicines are contained in a single cylinder having a tubular projection portion for attaching an injection needle at a tip portion and having an interior divided into a plurality of chambers by one or more intermediate sealing stoppers. In the syringe / container in which the opening side is sealed with a sealing / sealing stopper, and when the drug is administered, a push rod is attached to the sealing / sealing stopper and pushed into the cylinder to allow the medicine to flow out from the protruding portion.
One or more L-shaped bypass grooves extending along the inner wall surface of the distal end portion of the cylinder extending in the axial direction of the cylinder to the base portion of the protruding portion and extending along the inner wall surface of the distal end portion in a notched groove shape, The length of the cylinder axial direction portion is provided longer than the total length of the one or more intermediate sealing plugs in the cylindrical axial direction, and (2) the first intermediate sealing plug is located closer to the opening than the bypass groove. And is fitted into the cylinder to form a first chamber between the cylinder and the tip,
(3) A second gap is provided between the first intermediate sealing plug and the sealing sealing plug.
Forming a chamber or providing one or more intermediate sealing plugs between the first intermediate sealing plug and the sealing sealing plug to further form one or more chambers; By dropping the sealing plug into the bypass groove side, a flow path is formed between the inner wall of the cylinder and the first intermediate sealing plug to continuously flow out the drug in the first chamber and the drug in the second chamber. 5) Alternatively, by dropping the next intermediate sealing plug into the bypass groove, the drug in the third chamber and thereafter can be continuously continuously discharged in the same manner. 2. The first intermediate sealing plug does not close the L-shaped bypass groove when pushed into the foremost position in the cylinder at the time of drug administration, and does not cover the inner wall surface of the cylinder tip portion other than the bypass groove portion. 2. The syringe / container according to claim 1, wherein a continuous flow path can be formed in close contact with the L-shaped bypass groove and in the protruding portion. 3. The first intermediate sealing plug has a plurality of protrusions on its tip surface, and when the first intermediate sealing plug is pushed into the foremost position in the cylinder during drug administration, the L-shaped bypass groove and the inner wall of the cylinder tip part. The syringe / container according to claim 1, wherein a continuous flow path can be formed in the space between the protrusion and the protrusion and in the protrusion. 4. A plurality of medicines are contained in a single cylinder, which has a tubular protrusion for attaching an injection needle at its tip and whose inside is divided into a plurality of chambers by one or more intermediate sealing stoppers. In the syringe / container in which the opening side is sealed with a sealing / sealing stopper, and when the drug is administered, a push rod is attached to the sealing / sealing stopper and pushed into the cylinder to allow the medicine to flow out from the protruding portion.
A linear bypass groove extending to the tip end in the cylinder axis direction is formed in a notched groove shape on the inner wall surface on the tip end side of the cylinder, and the length of the intermediate sealing plug in the cylinder axis direction is 1 or 2 or more in the cylinder axis direction. (2) A first intermediate sealing plug having a plurality of protrusions on its tip end surface is provided at a position closer to the opening than the bypass groove, and fitted into the cylinder to form a cylinder end. Forming a first chamber therebetween, and (3) forming a second chamber between the first intermediate sealing plug and the sealing sealing plug, or the first intermediate sealing plug and the sealing sealing plug. One or more intermediate sealing plugs are provided between the two to form one or more chambers. (4) When administering a drug, the first intermediate sealing plug is dropped into the bypass groove side so that the bypass groove and the tip end portion of the cylinder. A continuous flow path is formed in the space between the inner wall and the protrusion of the first intermediate sealing plug and the protrusion to connect the drug in the first chamber and the drug in the second chamber. Manner to flow out, (5) or a syringe-cum-container further characterized by the following intermediate sealing plug thereby flow out the third chamber following drug by dropping it into the bypass groove likewise continuously. 5. The syringe / container according to any one of claims 1 to 4, wherein the cross-section of the cylinder orthogonal to the cylinder axis has a circular outer periphery. 6. The syringe / container according to any one of claims 1 to 5, wherein an injection needle is attached to the tubular projection for attaching the injection needle by an injection needle attaching device to form a syringe assembly. 7. A resin containing a cyclic olefin compound or a cross-linked polycyclic hydrocarbon compound as a polymer component, a polyolefin resin, a polycarbonate resin, and polymethylpentene, except for the sealing and intermediate sealing plugs. A resin and a resin composition selected from resins, a mixture of the resin and / or the resin composition and an ethylene-vinyl acetate copolymer or a saponified product thereof, and one or more selected from the group consisting of amorphous nylon and nylon, or The syringe / container according to any one of claims 1 to 6, further comprising one or more kinds of silicon oxide or aluminum vapor-deposited resin film laminated on the surface. 8. The sealing cap and the intermediate sealing plug are rubber molding plugs, and are formed by laminating a synthetic resin film which does not contaminate the drug on at least the surface in contact with the drug. The syringe and container according to any one of claims 1 to 6.