JPH0769852A - Dental plaque-dyeing agent containing cochineal as pigment component - Google Patents

Abstract

PURPOSE:To obtain a dental plaque-dyeing agent not giving unpleasant feeling and irritation during use and capable of simply decolonizing by blending a pigment ingredient which is harmless to living bodies. CONSTITUTION:This dental plaque-dyeing agent is obtained by blending cochineal as a pigment component in an amount of 1-20wt.%, preferably 4-10wt.%, expressed in terms of 100% pigment. The dyeing agent is used in a form of an aqueous solution, a get-like coating agent, a dentifrice, a chewing tablet, a mouth-washing agent, etc. and e.g. when the agent is used in a medical office by a dentist, the agent can be applied as 2-20wt.% aqueous solution to tooth of a patient using a small cotton globe and the agent can also be used as mouth cleaning agent having 1.5-3wt.% cochineal concentration by brushing the tooth using a tooth paste having 5-6wt.% cochineal concentration. After using, the tooth can readily be decolonized by removing the dental plaque by brushing.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a plaque dyeing agent containing cochineal as a pigment component.

[0002]

2. Description of the Related Art Caries or periodontal disease has come to be considered as an infection caused by bacteria present in dental plaque, and removal of dental plaque is an essential treatment for the initial treatment of these diseases. ing. However, plaque is difficult to identify with the naked eye, and it is difficult to accurately confirm the attachment site and degree.Therefore, plaque should be treated with a plaque stain containing various pigments when brushing instructions. Stains plaque,
In general, it is performed by demonstrating the existing site of dental plaque. Among the currently marketed plaque stains, erythrosine
Tar pigments such as (Red No. 3) and Phloxine (Red No. 104) are frequently used as pigment components. However, it has become clear that these pigment components have carcinogenicity, gene damage, and other biological hazards, and are overseas. Prohibited or new use has been suppressed.

[0003]

In view of the above circumstances, the inventors of the present invention have conducted extensive studies using various available natural pigments in order to obtain a plaque dyeing agent using a pigment component that is not harmful to living organisms. It was As a result, they have found that cochineal, which is a pigment containing carminic acid as a main component and extracted from the scale insect, Enzymushi, which parasitizes the cactus, specifically stains plaque, and completed the present invention.

[0004]

DISCLOSURE OF THE INVENTION The present invention provides a plaque dyeing agent characterized by containing cochineal as a pigment component.

The cochineal used as a pigment component in the present invention is a pigment approved by the FAO / WHO Joint Food Additives Expert Committee as a food colorant, and is also used as an edible pigment in Japan. Has shown that there is no carcinogenicity or teratogenicity even when a large amount of carminic acid is administered at a dose of 500 to 1000 mg / kg body weight / day.

[0006] In general, cochineal is commercially available as a cochineal dye preparation prepared by mixing an extract obtained by extracting a dried form of Enzymushi with a solvent such as water with an excipient or diluent such as lactose. However, such formulations can be used. Some commercially available cochineal dye formulations contain dye stabilizers such as sodium tartrate, potassium aluminum sulphate, sodium carbonate and calcium carbonate, but such formulations do not stain plaque, so simply Use only as a mixture with agents or diluents. In the present invention, based on the total weight of the plaque stain, cochineal is 1 to 20 in terms of 100% dye.
It is blended in a ratio of wt%, preferably 4 to 10 wt%.
If the blending amount is too small, the desired plaque dyeing state cannot be obtained, and even if it exceeds this range, further improvement of the dyeing effect cannot be expected, which is economically disadvantageous.

The plaque dyeing agent of the present invention can be made into a dosage form such as an aqueous solution, a gel-like coating agent, a dentifrice such as a toothpaste, a tablet such as a chewable tablet, and a mouthwash according to a method known per se. ,
As other ingredients, those known as the ingredients of these dosage forms can be used as long as they do not inhibit the plaque dyeing of cochineal. Thus, the plaque stain of the present invention can be applied to a patient's tooth with a cotton swab as an aqueous solution of 2 to 20% by weight of cochineal, for example, for use by a dentist in a clinic. it can. Further, toothpaste having a cotinyl concentration of 5 to 6% by weight can be used for brushing.
Further, it can be used as a mouthwash having a cochineal concentration of 1.5 to 3% by weight.

[0008]

The present invention will be described in more detail with reference to examples and experiments, but the invention is not limited thereto. In the examples and experiments, "%" means% by weight. Example 1 Commercially available cochineal dye preparation in distilled water (cochineal content 8
0%) was dissolved at a concentration of 3% to obtain a plaque dyeing agent in the form of a solution. Example 2 In the same manner as in Example 1, a plaque dyeing agent in the form of a 6% solution of the cochineal dye preparation was obtained. Example 3 A plaque dyeing agent in the form of a 10% solution of a cochineal dye preparation was obtained in the same manner as in Example 1. Example 4 In the same manner as in Example 1, a plaque dyeing agent in the form of a 20% solution of the cochineal dye preparation was obtained.

Example 5 Commercially available cochineal dye preparation in distilled water (cochineal content 8
0%) was dissolved at a concentration of 6% and gelled using sodium carboxymethylcellulose by a method known per se to obtain a plaque dyeing agent in a gel form.

Example 6 Using 40% sucrose, 50% mannitol, 2% magnesium stearate, 3% talc, 1% flavoring and 4% commercial cochineal dye preparation (80% cochineal content),
A plaque dyeing agent in the form of a chewable tablet was obtained by a method known per se.

Example 7 5% of a commercially available cochineal dye preparation (cochineal content 80%) was kneaded into a dentifrice base to obtain a tooth dyeing agent in the form of a toothpaste. Example 8 Commercially available cochineal dye preparation in distilled water (cochineal content 8
0%) 6% was dissolved to obtain a plaque stain in the form of mouthwash.

Experiment 1 Experiment using the plaque stain of Example 2 on Wistar rats Experimental method: 10% sucrose aqueous solution was freely given as solid feed and drinking water, and after 10 days of breeding, the animals were exsanguinated to death. . Then, the cheek and tongue were cut and opened, and the plaque stain of Example 2 was applied to the right molar part, and a commercially available phloxine dye solution was applied to the left molar part as a control. After 1 minute, excess dye was thoroughly washed with distilled water and then observed. Experimental results: The cotinyl solution-applied part was dyed in blackish brown, and the phloxine solution-applied part was stained in red, and there was no significant difference in the dyeability.

Experiment 2 Experiment of Staining Property of Plaque Staining Agent of Example 2 Using Human Plaque Collected Experimental Method: Supral gingival plaque was collected from the oral cavity of 5 adult periodontitis patients. After being combined and washed with distilled water by centrifugation, dyeing was performed for 30 seconds using an excess amount of the plaque dyeing agent of Example 2. After dyeing, centrifugal washing was repeated with distilled water and the state was observed. Experimental results: Up to 5 times of centrifugal washing after staining, elution of excess dye was observed as the coloration of the centrifugal supernatant, but after 6 times, the coloration of the supernatant was not observed, and the plaque was stained reddish brown. After centrifugal sedimentation, the stainability of plaque was retained.

Experiment 3 Experiment of dyeability of the plaque stain of Example 2 applied to human dental plaque Experimental method (A): Two bilateral lower central incisors were used as test teeth and 4
After discontinuing brushing for a day to deposit plaque, plaque is removed from the center of the labial surfaces of the lower jaws of both lower jaws on the mesial side and ½ of the mesial side, and the right central incisor is stained with plaque of Example 2. The agent was applied with a commercially available phloxine solution using the left central incisor as a control. Experimental results: The distinction between the adhered part and the non-adhered part of the plaque staining agent of Example 2 was good, and no remarkable difference was observed from the case of phloxine staining. Experimental method (B): Eleven men without caries or missing teeth were used as subjects. Remove the tartar and polish the crown in advance, and immediately after that, stop brushing for 4 days to remove the tooth. 2
A test side and a control side were randomly set with eight media as the boundaries with the midline as the boundary, and the plaque stain of Example 2 was applied to one side of the upper and lower jaws, and the commercially available phloxine solution was applied to the other side. After measuring the amount of adhered plaque, immediately perform crown polishing, stop brushing again, and after 4 days, replace the test side with the control side, and apply the plaque stain of Example 2 and commercially available phloxine. It was Experimental results: No significant difference was observed between the first and second plaque attachment states on the same side.

Experiment 4 Experiment of Decoloring Property by Brushing of Plaque Dyeing Agent of Example 2 Experimental Method: It is desired that after the degree of adhesion of dental plaque is measured by dyeing dental plaque, it is decolorized by brushing. For that purpose, after applying and staining the plaque dye of Example 2, brushing was performed by the scrubbing method, and the relationship between the number of brushing strokes and the decolorizing property was examined. Experimental results: With the brushing stroke number of 15 to 20 or more, it was possible to almost completely decolorize as with the commercially available phloxine solution.

[0016]

INDUSTRIAL APPLICABILITY According to the present invention, Red No. 3 (erythrosine) and Red 104, which are currently used for plaque stains, are used.
There is provided a plaque dyeing agent capable of dyeing plaque into a noticeable blackish brown color, which is not harmful to the body such as carcinogenicity of No. (phloxine) or gene damage. The plaque dyeing agent of the present invention does not give an unpleasant taste and a feeling of irritation during use, and
It is a new and extremely useful plaque stain that can be decolorized by removing plaque by brushing after use.

Claims (7)

[Claims] 1. A plaque dyeing agent comprising cochineal as a pigment component. 2. The plaque dyeing agent according to claim 1, which contains 1 to 20% by weight of cochineal. 3. The plaque dyeing agent according to claim 1, which is an aqueous solution. 4. The plaque dyeing agent according to claim 1, which is a gel-like coating agent. 5. The plaque stain according to claim 1, which is in the form of a dentifrice. 6. The plaque dyeing agent according to claim 1, which is a chewable tablet. 7. The plaque dyeing agent according to claim 1, which is a mouthwash.