JPH0759865A - Injection container - Google Patents

Abstract

PURPOSE:To ensure easy and hygienic injection of drugs by moving a container body relatively in a longitudinal direction of a gasket and sliding this gasket in this container body, thereby discharging the material existing in the container body via a tubular body. CONSTITUTION:The tubular body 11 is disposed in the gasket 10 in such a manner as to communicate both ends and to project from the front end. A liquid chemical 60 is sealed into the container body 20. The tubular body 11 has a side hole 111 at its front end and a terminal hole 112 at its terminal part. Both holes are respectively communicated by a flow passage 12. The length in the longitudinal direction of the gasket 10 is set larger than the length in the longitudinal direction on the inside surface of the container body 20. The front end of a needle pipe 11 of the gasket 20 is pressed and pricked to and through the elastic plug of a transfusion bag. A covering member 13 covering the needle pipe 11 is also pricked at this time. The container body 20 is then moved in the longitudinal direction of the gasket 10 and the gasket 10 is slid in the container body 20 to discharge the liquid chemical 60 from the side hole 111 via the flow passage 12 to the transfusion bag.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an injection container, and more particularly to an injection container in which a drug is enclosed and which can be aseptically injected into an infusion bag or the like.

[0002]

2. Description of the Related Art When administering an infusion solution to a patient in need thereof, if necessary, injecting a drug compounded in the infusion solution in an infusion bag, such as vitamins, heparin or antibiotics. There is. Usually, injection of such a compounded drug is performed using a syringe.When the drug is liquid, the needle of the syringe is pierced into the vial container in which the drug is sealed, and the plunger is pulled to collect the drug in the syringe. Then, puncture the infusion bag with a needle and push the plunger to perform injection. If the drug is a solid preparation such as a powder, collect the infusion solution with a syringe and inject it into a vial container in which the solid preparation is enclosed, shake the vial container well to dissolve the solid preparation well in the infusion solution, and then solidify it. The infusion solution in which the preparation is dissolved is collected with a syringe and injected into an infusion bag. However,
Such an injection method has a problem that it is unfavorable in terms of hygiene, because the operation is complicated and the operation time is long, and since medicines are often transferred, bacteria and foreign substances may be mixed.

[0003]

SUMMARY OF THE INVENTION In view of the above problems, the present invention is to provide an infusion container that allows easy and hygienic injection of a drug.

[0004]

The above problems can be solved by the present invention described below. (1) A bottomed cylindrical container body having one end opened, and a cylindrical gasket capable of sliding in a liquid-tight manner along the inner surface of the container body, the gasket being at least the inner surface of the container body. Has a total length longer than the length in the longitudinal direction and has a tubular body extending in the longitudinal direction inside thereof, and the container body is moved in the longitudinal direction relative to the gasket to slide the gasket in the container body. An infusion container characterized in that the substance existing in the container body is discharged through the tube body by moving. (2) The infusion container according to (1) above, in which a drug is injected into an infusion bag. (3) The injection container according to (1) or (2), wherein the tubular body projects from at least one end of the gasket.

(4) The infusion container according to the above (1) to (3), wherein the end of the needle tube projecting from the gasket is covered. (5) The above-mentioned (1)-
The infusion container described in (4). (6) The injection container according to (1) to (5) above, wherein the inside of the container body is maintained in a reduced pressure state. (7) The infusion container according to (1) to (6) above, wherein, in addition to the gasket according to (1) above, at least one gasket having a needle tube inside is provided in the container body. (8) The injection container according to (2), wherein the drug is a liquid or a solid drug. (9) The infusion container according to (1) to (8) above, which has a lid body connected to an open end of the container body.

[0006]

DETAILED DESCRIPTION OF THE INVENTION The injection container of the present invention will be described in detail below with reference to the preferred embodiments of the accompanying drawings. FIG. 1 shows a vertical sectional view of an example of an embodiment of an injection container according to the present invention.
The injection container 1 of the embodiment is mainly composed of a gasket 10 and a container body 20. Also, in some cases, the lid 3
0 is provided. As shown in FIG. 1, in the gasket 10, both ends (hereinafter, an end portion not in contact with the container body 20 (upper portion in the drawing) is referred to as a tip portion, and an end portion in contact with the bottom surface of the container body 20 (lower portion in the drawing) is referred to as a tip portion. A tube body 11 is provided so as to communicate with the distal end portion) and to project from the tip end portion.
In this embodiment, the container body 20 is filled with a chemical solution 60.

The tubular body 11 has a side hole 111 at the tip and a terminal hole 112 at the end, and they are communicated with each other through a flow path 12. When the gasket 10 is slid on the inner surface of the container body 20 by the flow path 12, the chemical solution 60 is supplied to the container body 2
It is configured so that it can be discharged from within 0. In the present embodiment, the above-mentioned purpose, which will be described later in detail with reference to FIG. 2, is a commonly used infusion bag, and specifically, a rubber plug portion or the like that pierces an infusion line. The tip of the tube 11 is sharply formed so that it can be punctured for the purpose. The tubular body 11 is a tubular body 11 in the gasket 10.
A jaw 113 is provided to prevent the deviation of the jaw.
Further, in order to maintain the strength of the tubular body 11, the tubular body 11 may be formed to be thicker than the tip portion except the tip portion.

The portion of the pipe 11 protruding from the gasket 10 is covered with a covering member 13 in order to keep the inside of the flow path 12 and the container body 20 in a sterile state and prevent the chemical solution 60 from flowing out. There is. Further, depending on the case, there is also an effect of maintaining a reduced pressure state when the freeze-dried drug is enclosed. Although the covering member 13 is integrally formed of the same material as the gasket 10 in this embodiment, the covering member 13 may be joined to the gasket 10 and provided as a separate body. Further, the covering member 13 must have such strength and thickness that it can be pierced by the sharply formed tip of the tube 11. The covering portion 13 is housed in the concave portion 15 while being folded into a bellows shape when pierced by the tip portion of the tubular body 11 (see FIG. 2).

A protrusion 14 is provided on the entire circumference of the circumferential surface of the gasket 10. The protrusion 14 improves the slidability of the gasket 10 in the container body 20 and maintains the air-tightness and liquid-tightness in the container. Further, the gasket 10 can be prevented from coming off from the container body 20 by coming into contact with the gasket removal preventing portion 21 provided on the inner surface near the opening of the container body 20 described later. The effect is improved by providing a plurality of protrusions 14, although not particularly limited thereto. In addition, the protrusion 14 is the gasket 10
However, it may be provided as a separate member later.

The longitudinal length of the gasket 10 must be at least the longitudinal length of the inner surface of the container body 20. Further, the diameter of the gasket 10 or the portion where the gasket 10 and the protrusion 14 are combined is shorter than the inner diameter of the container body 20 when inserted into the container body 20, so that the airtightness / liquid tightness in the container body 20 is maintained. The length is not particularly limited as long as the airtightness and the liquidtightness are reliably maintained by the protrusions 14.

The gasket 10, the protrusion 14 and the covering member 1
3 is various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, and silicone rubber (particularly vulcanized), polyurethane-based, polyester-based, polyamide-based, olefin-based , Various styrene-based elastomers,
Alternatively, it is made of an elastic material such as a mixture thereof. The gasket 10 is not limited to the one made of the above-mentioned material as a whole, and at least the protrusion 14 may be made of the above-mentioned material.

The container body 20 is a bottomed cylindrical body having one end opened, and the gasket 10 is inserted through the opening to slide on the inner surface of the container body 20. Gasket 10
Is slid toward the bottom surface of the container body 20 and the volume inside the container body 20 is reduced, whereby the chemical liquid 60 is discharged to the outside of the container body 20 through the flow path 12. Further, when a solid preparation (eg, powder, granules, etc.) is used instead of the drug solution 60, if the inside of the container body 20 is kept in a reduced pressure state, a liquid (infusion agent, etc.) is introduced to dissolve from the flow path 12. Can be easily performed and can be similarly discharged as a solution.

The container body 20 is provided with restriction means for restricting the longitudinal position of the gasket 10. Specifically, the gasket removal prevention portion 2 is provided on the inner peripheral surface near the opening.
1 is provided and contacts the protrusion 14 of the gasket 10,
It is possible to prevent the gasket 10 from coming off. The gasket removal prevention portion 21 may be provided on the entire circumference of the inner peripheral surface or may be provided on a part thereof. Further, a fitting convex portion 22 is provided on the outer peripheral surface near the opening, and a fitting concave portion 31 provided on the inner peripheral surface near the opening of the lid 30 described later.
And the container body 20 and the lid 30 are detachably joined to each other. The fitting convex portion 22 and the fitting concave portion 31 may be provided on the entire circumference of the inner peripheral surfaces of the main body container 20 and the lid 30 or may be provided on a part thereof.

In the present invention, although not absolutely necessary,
It is preferable to provide the lid 30 in order to maintain the sterilized state immediately before use. The lid 30 has a fitting projection 22 provided on the outer peripheral surface near the opening of the container body 20 in the opening of the container body 20, and a fitting protrusion 22 provided on the inner peripheral surface near the opening of the lid 30. The gasket 10 that is detachably joined by the fitting recess 31 and protrudes from the opening of the container body 20 can be aseptically covered.

In this embodiment, the bottomed cylindrical lid 3 is used.
0 is provided, and the fitting protrusion 22 is provided on the outer peripheral surface near the opening of the container body 20, and the fitting recess 31 is provided near the opening of the lid body 30 to join them. The fitting convex portion 22 and the fitting concave portion 31 are
When using, the container body 20 is fixed by the user's hand, and the lid 30
It is preferable to set so that it can be easily removed by pulling. Further, the joining method may be screwing or the like other than fitting. Further, if it is to be used only once, it is sanitarily preferable to integrally form the container body 20 and the lid body 30 with the same member through the thin portion.

The container body 20, the tube body 11 and the lid body 30 are
For example, polyvinyl chloride, polyethylene, polypropylene, polystyrene, poly- (4-methylpentene-
1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyester such as polyethylene terephthalate, butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6.6, nylon 6/10, nylon 12) ) Various resins or ceramics such as alumina,
Among them, polypropylene, polyester and poly- (4-methylpentene-1) are easy to mold.
Resins such as are preferred. In addition, it is preferable that these resins are substantially transparent in order to secure the internal visibility. Further, the tube body 11 may be made of a metal material such as stainless steel, titanium, aluminum or the like other than the above resin.

The inside of the container body 20 may be empty when not in use, but in this embodiment, the chemical solution 60 is enclosed. The type of drug solution is not particularly limited, and specific examples include vitamin agents, various amino acids, antithrombotic agents such as heparin, insulin, antibiotics, antitumor agents, analgesics, cardiotonics, intravenous anesthetics, antiparkinson. Examples of the drug include a drug solution, a drug for treating ulcer, a corticosteroid, a drug for arrhythmia, a correcting electrolyte and the like, or a solution in which a medicinal solution or a solid preparation that can be usually mixed with an infusion solution is dissolved. In some cases, a powder (granule) solid preparation or the like may be used, and in that case, the embodiment shown in FIG. 3 described later may be used.

Next, a method of using the embodiment shown in FIG. 1 will be described with reference to FIG. 2 which is a vertical sectional view. First,
The lid 30 is removed from the container body 20, and the distal end of the needle tube 11 provided on the gasket 10 is pressed against the elastic stopper 51 of the infusion bag 50 to pierce it. At this time, the covering member 13 that covers the needle tube 11 is also pierced by the tip portion of the needle tube 11 and folded into a bellows shape so as to be pushed into the elastic plug 51, and the recessed portion 1 is formed.
It is stored in 5. Next, the container body 20 is attached to the gasket 10
Relative to the longitudinal direction and sliding the gasket 10 in the container body 20 to discharge the drug solution 60 in the container body 20 from the side hole 111 to the infusion bag 50 through the flow path 12, It is injected into the drug solution 60 and the infusion solution 61.

After that, by moving the container body 20 in the longitudinal direction relatively in the opposite direction to the previous operation while the gasket 10 is fixed, the infusion agent 61 can flow into the container body 20, and the same operation is performed again. By repeating the operation, the chemical solution 60 can be discharged without remaining in the container body 20. This operation is particularly effective when a solid preparation in which the drug is powder (granule) is used.

After discharging the chemical solution 60, the tube body 11 is attached to the elastic stopper 51.
All the operations are completed by removing it from the. Further, the resealability of the elastic stopper 51 keeps the infusion bag 50 sterile. That is, according to the present invention,
Aseptic condition is maintained even after the operation of injecting the drug solution 60 into the infusion agent 61 and thereafter, which is hygienicly preferable.

Next, another embodiment of the injection container of the present invention will be described. Injection container 3 whose vertical sectional view is shown in FIG.
Is a preferred form for encapsulating a freeze-dried solid preparation (medicine 62) in the container body 20 instead of the drug solution. The structure is different from the injection container 1 in that when freeze-drying, the inside of the container body 20 is in a depressurized state, and therefore the gasket stopper 23 is provided in order to prevent the gasket 10 from moving to the bottom of the container body 20 before use. This is the point provided.
At this time, the gasket stopper 23 must always be placed with the gasket fixed. However, when the drug 62 is discharged into the infusion solution, the container main body 20 is moved in the longitudinal direction with respect to the gasket 10 as in the embodiment shown in FIG. Must be moved relative to the above, and it is preferable that the curved surface is processed so as not to hinder the movement, and the height is adjusted accordingly.
Further, the container body 20 is provided with a lid 30 as needed.

The method of use is not different from that of the embodiment shown in FIG. Further, since the inside of the container body 20 is in a reduced pressure state, when the needle tube 11 is pierced into the infusion bag,
The infusate flows into the container body 20 and the force of the drug 62
It also has the effect of mixing infusions with. The types of drugs that can be used are the same as in the case of the injection container 1 described above.

The infusion container 4 shown in FIG. 4 is an embodiment for simultaneously discharging a plurality of different types of drug solutions 63 and 64 into an infusion bag. Inside the container body 20, the gasket 10
And a second gasket 40 is provided. Container body 20
The space formed by the gasket 10 and the gasket 10 is separated into two spaces by the second gasket 40, and two different types of chemical liquids 63 and 64 are enclosed.

The gasket 10 is similar to the gasket of the injection container 1 described above in that the needle tube 11, the covering member 13 and the protrusion 1 are provided.
4 are provided. A film 17 that can be pierced by a needle tube 41 provided in a second gasket 40, which will be described in detail later, is provided at the bottom of the gasket 10.

This film 17 is made of various rubber materials such as natural rubber, isoprene rubber, butadiene rubber, silicone rubber and latex rubber, polyvinyl chloride, polyethylene, polypropylene, ionomer, polyester such as polyethylene terephthalate, polystyrene, poly-.
(4-methylpentene-1), various resins such as polyamide, and a single layer made of metal foil such as aluminum foil,
Or two or more layers of these are laminated (laminate)
The laminated body is preferably used.

A needle tube 41 is provided inside the second gasket 40. The needle tube 41 is provided with a jaw portion 413 in a part thereof and is fixed to the second gasket 40 without being displaced. Further, in order to maintain its strength, the tubular body 41 may be formed to be thicker than the tip portion except the tip portion. The distal end portion of the tubular body 41 is sharply formed so as to be able to puncture the film 17 and the covering member 43 (described in detail later).

The portion of the tube 41 protruding from the second gasket 40 is covered with a covering member 43 to keep the flow path 412 and the container body 20 in a sterile condition and to prevent the drug solution 64 from flowing out. It is being appreciated. In this embodiment, the gasket 40 is integrally formed of the same material as that of the gasket 40, but it may be separately provided and joined to the second gasket 40. Further, the covering member 43 must have such strength and thickness that it can be pierced by the sharply formed tip of the tube 41.

The covering portion 43 is pierced by the tip portion of the tubular body 41 and pushed by the above-mentioned film 17,
It is stored in the recess 415 while being folded in a bellows shape. The second gasket 40 is provided with a protrusion 44 similar to the protrusion 14 of the gasket 10. In addition, in the container body 20,
A gasket removal prevention portion 21 is provided on the inner peripheral surface near the opening, and it is possible to prevent the gasket 10 from coming off by coming into contact with the protrusion 14 of the gasket 10. Further, a fitting convex portion 22 is provided on the outer peripheral surface near the opening, and the lid body 3 described later is provided.
The fitting main body 20 and the lid 30 are detachably joined to each other by fitting with the fitting concave portion 31 provided on the inner peripheral surface near the opening of No. 0.

Although not absolutely necessary in the present invention,
It is preferable to provide the lid 30 in order to maintain the sterilized state immediately before use. The lid 30 has a fitting projection 22 provided on the outer peripheral surface near the opening of the container body 20 in the opening of the container body 20, and a fitting protrusion 22 provided on the inner peripheral surface near the opening of the lid 30. The gasket 10 that is detachably joined by the fitting recess 31 and protrudes from the opening of the container body 20 can be aseptically covered. The length of each gasket does not have to be particularly limited as long as the sum of the lengths of the plurality of gaskets in the longitudinal direction is longer than that of the container body 20.

In the injection container 4, the gaskets 10, 4
0, the coating agents 13 and 43, the material of the container body 20, the lid 30, and the liquid medicine to be sealed are all the above-mentioned injection container 1
It can be the same as In this embodiment, the number of gaskets is not particularly limited, and third and fourth gaskets having the same form as the second gasket may be used. At that time, except for the gasket located at the bottom, the film 17
Is preferably provided. Further, in the present embodiment, by providing a gasket stopper like the injection container 3,
It is also possible to use a solid preparation such as powder (granule).

A method of using this embodiment will be described. First, the lid 30 is removed from the container body 20, and the distal end of the needle tube 11 provided on the gasket 10 is pressed and pierced into the elastic plug (not shown) of the infusion bag. At that time, the needle tube 11
The covering member 13 for covering is also pierced by the distal end portion of the needle tube 11, is folded into a bellows shape so as to be pushed into the elastic plug, and is housed in the recess 15. Next, the container body 20 is moved relative to the gasket 10 in the longitudinal direction, and the gasket 10 is slid in the container body 20, whereby the flow path 1
The drug solution 63 in the container body 20 is discharged into the infusion bag through the side hole 111 via 2 and mixed with the infusion agent.

Next, the container body 20 is further attached to the gasket 1
The needle tube 41 of the second gasket 40 is pierced through the film 17 by moving the needle tube 41 relative to 0 in the longitudinal direction. At this time, the covering member 43 is also pierced at the same time, is pressed by the film 17 and is folded into a bellows shape, and is housed in the recess 415. Further, by moving the container body 20 relative to the gasket 10 in the longitudinal direction, the second gasket 40 is slid in the container body 20, and the chemical solution 64 is passed through the flow path 42.
To the side hole 411 via the flow path 12, and further discharged from the side hole 111 to the infusion bag via the flow path 12 to be mixed with the infusion agent. After discharging the chemical liquid 64, all the operations are completed by pulling out the tube body 11 from the elastic stopper. Further, the infusion bag is kept in a sterile state by the action of the resealability of the elastic stopper. That is, according to the present invention, the aseptic condition is maintained even after the operation of mixing the drug solution 63.64 with the infusion solution and thereafter, which is hygienicly preferable.

[0033]

As described above, according to the present invention, it is possible to easily mix a liquid medicine or a solid preparation into an infusion bag in a short time. Furthermore, a plurality of drugs having different components can be easily mixed in one container.
It can be easily formulated regardless of the form of the drug to be encapsulated (liquid, solid).

Further, by enclosing a predetermined amount, it is possible to prevent the compounding failure due to the amount. In addition, the infusion bag that is always mixed in the container body and the mixture is less likely to come into contact with the outside air, so that the infusion state can be maintained in a sterile state and contamination of bacteria and foreign substances can be prevented, which is hygienically preferable.

[Brief description of drawings]

FIG. 1 is a vertical sectional view showing an example of an embodiment of the present invention.

FIG. 2 is a vertical sectional view showing a method of using the present invention in FIG.

FIG. 3 is a vertical sectional view showing an example of an embodiment of the present invention.

FIG. 4 is a vertical sectional view showing an example of an embodiment of the present invention.

[Explanation of symbols]

1, 3, 4 ... Infusion container, 10 ... Gasket, 1
1,41 ... Needle tube, 111, 411 ... Side hole, 11
2, 412 ... end hole, 113, 413 ... jaw,
12, 42 ... Channel, 13, 43 ... Covering member, 1
4,44 ... projection, 15,415 ... recess, 20 ...
..Container body, 21 ... Gasket removal prevention section, 22
... Mating protrusions, 23 ... Gasket stoppers, 30 ...
・ Lid body, 31 ... Fitting recess, 40 ... Second gasket, 50 ... Infusion bag, 51 ... Elastic stopper, 60,
63, 64 ... Medicinal solution, 61 ... Infusion agent, 62 ...
Drug

Claims (1)

[Claims] 1. A bottomed tubular container body having one end opened, and a cylindrical gasket capable of sliding in a liquid-tight manner along an inner surface of the container body, the gasket being at least the container body. Has a length that is longer than the length of the inner surface of the container in the longitudinal direction, and has a tubular body that extends in the longitudinal direction inside, and moves the container body relative to the gasket in the longitudinal direction so that the gasket is inside the container body. An infusion container, characterized in that the substance existing in the container body is discharged through the tube body by sliding at.