JPH0754259Y2 - Skin patch - Google Patents
Skin patchInfo
- Publication number
- JPH0754259Y2 JPH0754259Y2 JP1989049612U JP4961289U JPH0754259Y2 JP H0754259 Y2 JPH0754259 Y2 JP H0754259Y2 JP 1989049612 U JP1989049612 U JP 1989049612U JP 4961289 U JP4961289 U JP 4961289U JP H0754259 Y2 JPH0754259 Y2 JP H0754259Y2
- Authority
- JP
- Japan
- Prior art keywords
- layer
- polyethylene terephthalate
- skin patch
- polyolefin
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007933 dermal patch Substances 0.000 title claims description 9
- 239000010410 layer Substances 0.000 claims description 35
- -1 polyethylene terephthalate Polymers 0.000 claims description 27
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 19
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 19
- 229940079593 drug Drugs 0.000 claims description 18
- 239000003814 drug Substances 0.000 claims description 18
- 229920000098 polyolefin Polymers 0.000 claims description 15
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims description 8
- 239000000006 Nitroglycerin Substances 0.000 claims description 8
- 239000000853 adhesive Substances 0.000 claims description 8
- 230000001070 adhesive effect Effects 0.000 claims description 8
- 229960003711 glyceryl trinitrate Drugs 0.000 claims description 8
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 4
- 238000010030 laminating Methods 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 description 4
- 239000012790 adhesive layer Substances 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 150000003902 salicylic acid esters Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Description
【考案の詳細な説明】 〔考案の目的〕 本考案は皮膚貼付剤に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Object of the Invention] The present invention relates to a skin patch.
皮膚貼付剤は、皮膚に貼付したときに剥れ難く、違和感
を感じさせないことが要求されるが、剥れ難くするため
に粘着剤の粘着力を高くすると皮膚に対する刺激が強く
なるし、剥すときに無理やり剥すことになつて痛みを感
ずるようになるので、粘着力を低目に設定して、支持体
に皮膚の動きに追従する柔軟性を持たせることが効果的
である。A skin patch is required to be hard to peel off when applied to the skin, and it is required that it does not cause discomfort, but if the adhesive strength of the adhesive is increased to make it hard to peel off, irritation to the skin becomes stronger, and when it is peeled off. It is effective to set the adhesive strength to a low level so that the support has the flexibility to follow the movement of the skin, because the pain will be felt as it is forcibly removed.
また、ニトログリセリン、サリチル酸エステル、メント
ールその他の揮発性を有する薬剤を含有する貼付剤にお
いては、貼付時に支持体を透過して薬剤が揮発し、含有
薬剤が有効に利用されなくなるので、支持体には薬剤が
透過、揮散しないようなものが望まれる。Further, in a patch containing a volatile drug such as nitroglycerin, salicylic acid ester, menthol, the drug volatilizes through the support during application, and the drug contained is no longer effectively used. It is desirable that the drug does not permeate or volatilize.
考案者らは、柔軟性を有し、かつ揮発性を有する薬剤を
吸着したり、またこれを透過させたりしないような支持
体について種々研究した結果、ポリエチレンテレフタレ
ートのシートはニトログリセリン等の揮発性薬剤に対し
て極めて良好なバリヤー性を有することを知つた。しか
しこのポリエチレンテレフタレートのシートは硬い感じ
のものであつて、皮膚の動きに追従することができる柔
軟性に乏しいが、このポリエチレンテレフタレートシー
トとポリオレフインシートを積層することによつて、上
記した希望のものが得られることが判つた。As a result of various researches by the inventors on a support which is flexible and does not adsorb or permeate a volatile drug, a polyethylene terephthalate sheet has a volatile property such as nitroglycerin. It has been found that it has a very good barrier property to drugs. However, this polyethylene terephthalate sheet has a hard feeling and is poor in flexibility capable of following the movement of the skin, but by laminating the polyethylene terephthalate sheet and the polyolefin sheet, the above-mentioned desired one is obtained. It was found that
本考案は上記知見に基づき、ポリエチレンテレフタレー
ト層とポリオレフイン層と揮発性の薬剤を含有する粘着
剤層を積層形成するようにしたものである。The present invention is based on the above findings and is formed by laminating a polyethylene terephthalate layer, a polyolefin layer, and an adhesive layer containing a volatile drug.
以下実施例について述べれば、ポリエチレンテレフタレ
ート層は少くとも約３μ程度以上の厚味を有するものが
よく、余り厚くすると硬くなつて皮膚への追従性が少く
なるので約40μ程度以下にするとよいことが多く、好ま
しくは３〜30μにする。この層に、ポリエチレン、ポリ
プロピレン等のポリオレフイン層を積層一体化し、この
ポリオレフイン層を通例３〜80μ程度とし、好ましくは
10〜30μにするとよく、ポリエチレンテレフタレート層
が比較的厚いときにはポリオレフイン層を薄目にする等
して調整するようにし、全体の厚味を通例約６〜120μ
程度、好ましくは14〜50μにするとよい。このポリエチ
レンテレフタレート層とポリオレフイン層を適宜積層し
て多層状に形成する場合には、その全体の厚味を同じく
上記の範囲内に納めるようにする。図示のものではポリ
エチレンテレフタレート層（１）を25μとし、ポリオレ
フイン層（２）を高密度ブレンドポリエチレンで25μに
している。この積層シートは通例ラミネート法により形
成されるが、その他適宜の方法によつて積層することが
できる。Examples will be described below. It is preferable that the polyethylene terephthalate layer has a thickness of at least about 3 μm or more. If the polyethylene terephthalate layer is too thick, the polyethylene terephthalate layer becomes stiff and less conformable to the skin, so about 40 μm or less is preferable. Many, preferably 3 to 30 μ. A polyolefin layer such as polyethylene or polypropylene is laminated and integrated on this layer, and the polyolefin layer is usually about 3 to 80 μm, and preferably
The thickness should be 10 to 30μ, and when the polyethylene terephthalate layer is relatively thick, adjust by adjusting the polyolefin layer to be thin, and the overall thickness is usually about 6 to 120μ.
The degree is preferably about 14 to 50 μ. When the polyethylene terephthalate layer and the polyolefin layer are appropriately laminated to form a multi-layered structure, the thickness of the entire layer should be within the above range. In the figure, the polyethylene terephthalate layer (1) has a thickness of 25 μ, and the polyolefin layer (2) has a thickness of 25 μ using high-density blended polyethylene. This laminated sheet is usually formed by a laminating method, but it can be laminated by any other appropriate method.
こうした支持体（３）に、必要に応じて適宜プライマー
層を形成し、その上にニトログリセリン、サリチル酸エ
ステル、メントールその他の揮発性を有する薬剤を含有
する粘着剤層（４）を形成する。図示のものでは、支持
体のポリオレフイン側に粘着剤層を形成しているが、反
対側に形成することもできる。この貼付剤（５）の粘着
剤の上には適宜剥離紙（６）を被せ、アルミニウムラミ
ネート袋等の薬剤が揮散しない袋に入れて保存するとよ
い。A primer layer is appropriately formed on the support (3) as needed, and a pressure-sensitive adhesive layer (4) containing nitroglycerin, salicylate, menthol and other volatile agents is formed thereon. In the illustrated example, the adhesive layer is formed on the polyolefin side of the support, but it may be formed on the opposite side. It is advisable to cover the adhesive of this patch (5) with a release paper (6) as appropriate, and store it in a bag such as an aluminum laminate bag in which the chemical does not volatilize.
上記ポリオレフインには、低密度のもの、高密度のも
の、延伸したもの、無延伸のもの、ブレンドしたものそ
の他各種のものが使用でき、担持する薬剤、貼付する部
位、貼付時間等を考慮してその種類、組合せ、厚さなど
が決められる。As the polyolefin, low density, high density, stretched, unstretched, blended and various other materials can be used, taking into consideration the drug to be carried, the site to be stuck, the sticking time, etc. The type, combination, thickness, etc. are determined.
第２図に示すものは、６μのポリエチレンテレフタレー
ト層（８）の一面を20μの高密度ブレンドポリエチレン
層（９）に、他面を10μの無延伸ポリプロピレン層（1
0）と三層にし、この支持体（11）の上記ポリプロピレ
ン層（10）の上に揮発性を有する薬剤を含有する粘着剤
層（４）を設けたものであるが、上記ポリエチレン層
（８）側に粘着剤層を形成することもできる。図示のも
のでは薬剤が粘着剤の中に混り合つているが、適宜ペー
スト状等にした薬剤を支持体上に塗布し、その上を粘着
剤で覆うようにしたりすることもある。As shown in FIG. 2, a 6μ polyethylene terephthalate layer (8) has a 20μ high-density blended polyethylene layer (9) on one side and a 10μ unstretched polypropylene layer (1) on the other side.
0) and three layers, and a pressure-sensitive adhesive layer (4) containing a volatile drug is provided on the polypropylene layer (10) of the support (11). It is also possible to form an adhesive layer on the () side. In the illustrated example, the drug is mixed in the adhesive, but it is also possible to apply the drug in a paste form or the like on a support and cover it with the adhesive.
上記したポリエチレンテレフタレート及びポリオレフイ
ンのシートについて、揮発性を有する薬剤についての揮
散性（透過性）について下記のとおり試験を行つた。The above-mentioned polyethylene terephthalate and polyolefin sheets were tested as described below for volatility (permeability) of a volatile drug.
（試験方法） ニトログリセリンを１cm3当り1.1mg含有する粘着剤を下
記の４種のシートに厚さ40μに塗布し、シリコーン処理
した剥離紙を重ねて覆い、これを37℃の恒温槽の中に入
れ、24時間経過後にニトログリセリンの揮散量を測定し
て揮散率を求めた。(Test method) An adhesive containing 1.1 mg of nitroglycerin per cm 3 was applied to the following 4 types of sheets to a thickness of 40μ, and covered with silicone-coated release paper, which was then placed in a 37 ° C constant temperature bath. After 24 hours, the volatilization amount of nitroglycerin was measured to obtain the volatilization rate.
（考察） ポリエチレンテレフタレートシートは薄くてもニトログ
リセリンの揮散を充分に阻止しているが、ポリエチレン
系のフイルムは厚いものでもニトログリセリンは揮散し
ている。 (Discussion) Even though the polyethylene terephthalate sheet is thin, the volatilization of nitroglycerin is sufficiently prevented, but even if the polyethylene-based film is thick, nitroglycerin is volatilized.
本品は、適宜剥離紙を剥して皮膚に貼付すれば、薬剤は
経皮的に確実に投与され、上記支持体は揮発性の薬剤の
揮散を防ぐと共にこれを吸着することもないから、薬剤
のロスがなく効率的な投与ができる。また、この貼付剤
は柔軟性に富んでいるので、皮膚にしつかりとなじんで
皮膚の動きに順応することができ、剥れたり、違和感を
感じることも少く、これに伴つて粘着性の比較的低い粘
着剤が使えるので、使用済後に剥すことも容易で痛みも
少い。With this product, if the release paper is appropriately peeled off and applied to the skin, the drug is surely administered transdermally, and the support does not volatilize the volatile drug and does not adsorb it. There is no loss and efficient administration is possible. In addition, since this patch is highly flexible, it can conform to the skin and adapt to the movement of the skin, and it is less likely to come off or feel uncomfortable. Since a low pressure-sensitive adhesive can be used, it can be easily peeled off after use and is less painful.
図面は本考案の実施例を示し、第１図は断面図、第２図
は他例の断面図である。 （１）…ポリエチレンテレフタレート層、（２）…ポリ
オレフイン層、（３）…支持体、（４）…粘着剤層、
（５）…貼付剤、（６）…剥離紙The drawings show an embodiment of the present invention. FIG. 1 is a sectional view and FIG. 2 is a sectional view of another example. (1) ... Polyethylene terephthalate layer, (2) ... Polyolefin layer, (3) ... Support, (4) ... Adhesive layer,
(5) ... Patch, (6) ... Release paper
Claims (6)
一体にされたポレオレフイン層と、上記いずれかの層に
付着され揮発性を有する薬剤を含有する皮膚に貼付され
るべき粘着剤層を具備する皮膚貼付剤。1. A skin patch comprising a polyethylene terephthalate layer, a poreorefin layer integrated with the polyethylene terephthalate layer, and a pressure-sensitive adhesive layer to be applied to the skin containing a volatile drug adhered to any one of the above layers. Agent.
オレフイン層とが多層に形成されている請求項１記載の
皮膚貼付剤。2. The skin patch according to claim 1, wherein the polyethylene terephthalate layer and the polyolefin layer are formed in multiple layers.
インの層を複数積層してシート状に形成し、このシート
状の支持体に揮発性を有する薬剤と粘着剤を担持させた
皮膚貼付剤。3. A skin patch in which a plurality of layers of polyethylene terephthalate and polyolefin are laminated to form a sheet, and a volatile drug and an adhesive are carried on the sheet-shaped support.
リプロピレンの層が含まれている請求項３記載の皮膚貼
付剤。4. The skin patch according to claim 3, wherein the polyolefin layer of the support contains a layer of unstretched polypropylene.
１または３記載の皮膚貼付剤。5. The skin patch according to claim 1, wherein the drug is nitroglycerin.
ンテレフタレートとポリオレフインを複層状態に貼り合
わせたシートからなることを特徴とする皮膚貼付剤用の
支持体。6. A support for a skin patch, comprising a sheet carrying a volatile drug and laminating polyethylene terephthalate and polyolefin in a multi-layered state.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1989049612U JPH0754259Y2 (en) | 1989-04-28 | 1989-04-28 | Skin patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1989049612U JPH0754259Y2 (en) | 1989-04-28 | 1989-04-28 | Skin patch |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02142434U JPH02142434U (en) | 1990-12-03 |
| JPH0754259Y2 true JPH0754259Y2 (en) | 1995-12-18 |
Family
ID=31567456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1989049612U Expired - Lifetime JPH0754259Y2 (en) | 1989-04-28 | 1989-04-28 | Skin patch |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0754259Y2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11199483A (en) * | 1998-01-12 | 1999-07-27 | Taisho Pharmaceut Co Ltd | Patch |
| JP6807195B2 (en) * | 2016-09-15 | 2021-01-06 | 日東電工株式会社 | Laminated body for biological attachment |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57150615A (en) * | 1981-03-13 | 1982-09-17 | Nitto Electric Ind Co Ltd | Preparation of complex pharmaceutical preparation |
| JPS59193819A (en) * | 1983-04-19 | 1984-11-02 | Toppan Printing Co Ltd | Base film for anti-inflammatory and analgesic plaster |
| JPS61112015A (en) * | 1985-11-13 | 1986-05-30 | Nitto Electric Ind Co Ltd | Pharmaceutical preparation |
| JPS63246325A (en) * | 1987-03-31 | 1988-10-13 | Sekisui Chem Co Ltd | Nitroglycerin plasta and its production |
-
1989
- 1989-04-28 JP JP1989049612U patent/JPH0754259Y2/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57150615A (en) * | 1981-03-13 | 1982-09-17 | Nitto Electric Ind Co Ltd | Preparation of complex pharmaceutical preparation |
| JPS59193819A (en) * | 1983-04-19 | 1984-11-02 | Toppan Printing Co Ltd | Base film for anti-inflammatory and analgesic plaster |
| JPS61112015A (en) * | 1985-11-13 | 1986-05-30 | Nitto Electric Ind Co Ltd | Pharmaceutical preparation |
| JPS63246325A (en) * | 1987-03-31 | 1988-10-13 | Sekisui Chem Co Ltd | Nitroglycerin plasta and its production |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02142434U (en) | 1990-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8449907B2 (en) | Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl | |
| US8151987B2 (en) | Peelable pouch for transdermal patch and method for packaging | |
| US5662925A (en) | Transdermal delivery system with adhesive overlay and peel seal disc | |
| DE3844247C2 (en) | ||
| JP2543457B2 (en) | Transdermal device | |
| JP5330832B2 (en) | Double-sided non-adhesive release film | |
| JPH06510043A (en) | Transdermal drug delivery device using membrane-protected microporous membrane to achieve drug efficacy delay | |
| EP0117027A1 (en) | Drug delivery device | |
| EP0242827A1 (en) | Surface shaped therapeutic system, method for its manufacture, and its application | |
| US20100076387A1 (en) | Twin Transdermal Drug Delivery Patch | |
| CA2065403C (en) | Transdermal delivery device having delayed onset | |
| US4788064A (en) | Transdermal delivery system | |
| JPH0754259Y2 (en) | Skin patch | |
| EP0559411A1 (en) | Titratable transdermal patch system and method for administration of therapeutic substances | |
| JP3172395B2 (en) | Transdermal drug release device | |
| JP2781016B2 (en) | Transdermal formulation | |
| JP3071839B2 (en) | Medical patch | |
| JP2820268B2 (en) | Skin treatment material for transdermal administration | |
| JPS639546Y2 (en) | ||
| JP3460092B2 (en) | Method for producing ointment-based patch | |
| JPS62230720A (en) | Laminated pharmaceutical | |
| JPS6038646Y2 (en) | Physiologically active substance supplier | |
| JPH0278617A (en) | Plaster | |
| JPS6054284B2 (en) | drug administration member | |
| JPH07215844A (en) | Skin cataplasm sheet |