JPH0742206B2 - Contact lens composition - Google Patents

Description

TECHNICAL FIELD The present invention relates to a composition for contact lenses, a method for cleaning and / or sterilizing a contact lens using the composition, and a method for stabilizing the composition for contact lenses. INDUSTRIAL APPLICABILITY The present invention is used, for example, for cleaning and / or sterilizing a known contact lens containing polymethyl methacrylate, silicone-containing methacrylate, hydroxyethyl methacrylate, butyl acrylate, etc. as a main component. And / or cleaning contact lenses
Alternatively, it is preferably used for sterilization treatment.

[Prior Art] A composition for removing dirt adhering to contact lenses (hereinafter referred to as a cleaning composition) or a composition for sterilizing bacteria and fungi adhering to contact lenses (hereinafter referred to as sterilizing composition) The compositions disclosed in JP-A-63-47722 and JP-A-1-160902, respectively, are known.

In each of the compositions of the above publications, an oxidizing agent for cleaning or sterilizing a contact lens and a reducing agent for detoxifying the oxidizing agent still remaining after cleaning or sterilization are contained in the same package. The oxidizer has a property or form that the main part of the oxidizer dissolves relatively faster than the main part of the reducing agent when the package is opened and then put into water. The purpose of cleaning or sterilization can be achieved effectively in time, and the detoxification process can be performed reliably thereafter, and when the reducing agent is a tablet, the end of the detoxification process can be easily judged with the naked eye. It was useful.

[Problems to be Solved by the Invention] However, all of the above-mentioned compositions contain an oxidant as a component, but the oxidant, particularly an effective chlorine compound, is inherently unstable and easily decomposed. is there. In addition, sodium hydrogen carbonate, potassium hydrogen carbonate, etc., which are components that are optionally added to give effervescent tablets, tend to become unstable due to the presence of an acid, and the added acid may also be citric acid, for example. Etc. themselves have strong hygroscopicity and are unstable. Therefore, due to the above factors and the like, none of the above-mentioned cleaning composition and sterilizing composition have sufficiently satisfactory stability.

The present invention has been made to solve the above-mentioned problems, and an object of the present invention is the advantage of the above-described conventional contact lens cleaning composition and contact lens sterilizing composition, that is, (i) short time Can effectively clean and / or sterilize contact lenses, (ii) after achieving the purpose of cleaning and / or sterilization, it is possible to reliably detoxify the oxidizing agent, and (iii) the reducing agent is a tablet In this case, the object is to provide a composition for a contact lens, which has the point that the end of the detoxification treatment can be easily judged with the naked eye as it is, and solves the disadvantage of insufficient stability.

Another object of the present invention is to provide a method for cleaning and / or sterilizing a contact lens using the above-mentioned composition for contact lenses.

Another object of the present invention is to provide a method for stabilizing a composition for contact lenses.

[Means for Solving the Problems] As a result of earnest studies to achieve the above-mentioned object, the present inventors have found that
When sodium sulfate is contained in the above-mentioned conventional contact lens agent composition, the advantages of the conventional contact lens agent composition are maintained as they are, and decomposition of an effective chlorine compound into an oxidant, which is a drawback thereof, is prevented. It was found that the contact lens composition was stabilized.

Furthermore, the present inventors have found that when the sodium sulfate described above is used in combination with at least one phosphate selected from the group consisting of dipotassium hydrogen phosphate, calcium hydrogen phosphate and calcium phosphate, the phosphate is oxidized. Further suppress the decomposition of the agent, and stabilize carbonates such as sodium hydrogencarbonate and potassium hydrogencarbonate used to make the reducing agent into effervescent tablets, and hygroscopic acids such as citric acid used as the reducing agent, It has been found that the agent composition for contact lenses is further stabilized.

The present invention has been completed based on such findings, and the present invention provides (A) an oxidizing agent for cleaning and / or sterilizing a contact lens, and after subjecting the contact lens to cleaning and / or sterilizing treatment. A reducing agent for detoxifying the remaining oxidizing agent and sodium sulfate are contained in the same package, and the oxidizing agent and the reducing agent do not substantially react in the same package. A contact lens agent composition, characterized in that, after the package is opened, the main part of the oxidizing agent dissolves relatively faster than the main part of the reducing agent when poured into water, B) At least one selected from the group consisting of dipotassium hydrogen phosphate, calcium hydrogen phosphate and calcium phosphate together with the above-mentioned oxidizing agent, reducing agent and sodium sulfate.
A contact lens composition containing the same type of phosphate in the same package, (C) a package containing the contents of the contact lens composition (A) or the contact lens composition (B) After unsealing, the mixture was poured into water to dissolve the main part of the oxidizing agent relatively faster than the main part of the reducing agent, and macroscopically, the contact lens was washed and / or sterilized with the oxidizing agent first. After that, cleaning and / or cleaning of a contact lens characterized by performing detoxification treatment of an oxidizing agent with a reducing agent
Or a sterilization method, (D) the same oxidant for cleaning and / or sterilizing the contact lens and the reducing agent for detoxifying the oxidant still remaining after being subjected to the cleaning and / or sterilization treatment The oxidizer and the reducing agent contained in the package do not react substantially in the same package, and the main part of the oxidizing agent is the main part of the reducing agent when the package is opened and then put into water. SUMMARY OF THE INVENTION A method for stabilizing a contact lens agent composition is characterized in that sodium sulfate is contained in a contact lens agent composition having a property or morphology that dissolves relatively faster than the parts. is there.

Hereinafter, the present invention will be specifically described.

The oxidizing agent which is the first essential component in the agent composition for a contact lens (A) of the present invention is for cleaning and / or sterilizing a contact lens, and its preferable example is an effective chlorine compound, for example, Examples thereof include coconut powder, chloramine, chloramine T, chloramine B, harazone, calcium hypochlorite, and chlorinated isocyanuric acid. Among them, porridge powder, chloramine T, and chlorinated isocyanuric acid are particularly preferable.

The reducing agent, which is the second essential component in the contact lens agent composition (A) of the present invention, is for detoxifying the remaining oxidizing agent after being subjected to cleaning and / or sterilization treatment. , And preferred examples thereof include sodium thiosulfate, citric acid, malic acid, tartaric acid, ascorbic acid, and aliphatic carboxylic acids such as their sodium, potassium, and calcium salts, or salts thereof, among which sodium thiosulfate or ascorbine is preferred. Acids, citric acid or sodium citrate are particularly preferred.

Further, sodium sulfate, which is the third essential component in the contact lens agent composition (A) of the present invention, is for preventing the above-mentioned oxidizing agent from decomposing, and the contact lens agent composition of the present invention. It is extremely important as a component for improving the stability of the product (A).

The agent composition for contact lenses (B) of the present invention comprises at least one phosphate selected from the group consisting of dipotassium hydrogen phosphate, calcium hydrogen phosphate and calcium phosphate in the agent composition for contact lenses (A). By containing this phosphate,
The stability of the agent composition for contact lenses is further improved.

As the package containing these oxidizing agent, reducing agent, sodium sulfate, and phosphate, any material can be used as long as it is a material that does not substantially affect the oxidizing agent, reducing agent, sodium sulfate, and phosphate. Although it can be used, typical examples thereof include an aluminum three-way seal package, an aluminum stick package, a moisture-proof plastic container, and the like.

The above-mentioned oxidizing agent and reducing agent that compose the contact lens agent compositions (A) and (B) of the present invention must have a form that satisfies the following requirements (i) and (ii).

(I) The oxidizing agent and the reducing agent do not substantially react in the same package.

(Ii) After opening the package, the main part of the oxidizing agent dissolves relatively faster than the main part of the reducing agent when it is put into water.

In the above requirement (i), "not substantially reacting" means
After opening the package, the oxidizing agent and the reducing agent put into water have their respective intended purposes (cleaning and / or sterilizing the contact lens for the oxidizing agent, detoxifying the oxidizing agent for the reducing agent). In order to be able to achieve the above, it means that they do not react with each other or little while contained in the package. Therefore, a small proportion of the oxidizing agent and a small proportion of the reducing agent contact each other in the same package,
Even if the reaction occurs microscopically, there is no problem as long as the remaining unreacted oxidizing agent and reducing agent can achieve the above-mentioned intended purpose after being charged in water.

Further, in the above requirement (ii), "the main part of the oxidizer dissolves relatively faster than the main part of the reducing agent" means that the peak of dissolution of the oxidizer put in water was put in at the same time as the oxidizer. It means that it appears earlier than the peak of dissolution of the reducing agent. Therefore, even if the oxidant and the reducing agent are simultaneously dissolved at a certain point after being put into water, macroscopically, the contact lens is first cleaned and / or sterilized with the oxidant, and then the oxidant is nontoxic by the reducing agent. There is no problem as long as the conversion process is performed.

The forms of the oxidizing agent and the reducing agent satisfying the above requirements (i) and (ii) include a form in which the oxidizing agent is powder or granules and the reducing agent is a tablet. The reason why this form is preferable is that the oxidizing agent in the powder or granules and the reducing agent in the tablet are kept in a state in which the mutual contact ratio is less than in the case where both are both powders or granules, and both are substantially unreacted, Also, after the addition in water, the powder or granule oxidizer dissolves relatively faster than the tablet reducing agent.

Sodium sulphate, which is the third essential component of the contact lens agent composition of the present invention, is preferably mixed with the above-mentioned oxidizing agent to form an integrated form. The reason why this form is preferable is that as the ratio of mutual contact between sodium sulfate and the oxidizing agent increases, the effect of preventing decomposition of the oxidizing agent by sodium sulfate becomes more remarkable. Specifically, the following forms can be mentioned.

(A) Oxidizing agent: powder, sodium sulfate: powder (b) Oxidizing agent: powder, sodium sulfate: granule (c) Oxidizing agent: granule, sodium sulfate: powder (d) Oxidizing agent: granule, sodium sulfate: granule It is desirable that both forms are well mixed.
A suitable form is also one in which the granules obtained by mixing the form (a) and then granulating by a dry granulation method which is usually used.

If the oxidizing agent and / or sodium sulfate is used in powder or granule form, excipients such as sodium chloride, potassium chloride, lactose and / or glucose can be added to facilitate weighing. When sodium chloride, potassium chloride, or the like is added, the function of preventing the decomposition of the oxidizing agent of sodium sulfate can be improved.

When a tablet is used as the reducing agent, if the tablet is further coated with a coating agent, the reaction due to direct contact between the oxidizing agent and the reducing agent in the package is completely prevented, and the oxidizing agent is sufficiently effective in water. After exerting the effect, the reducing agent starts to dissolve and the remaining oxidant can be detoxified (the simultaneous occurrence of contact lens cleaning and sterilization treatment with the oxidizing agent and oxidizing agent detoxification treatment with the reducing agent is suppressed as much as possible. , Both can be used efficiently)
It is particularly preferable in terms of points.

Preferred coating agents include carboxymethyl ethyl cellulose, cellulose acetate phthalate, hydroxypropyl methyl cellulose phthalate, methacrylic acid-ethyl acrylate copolymer, methacrylic acid-methyl acrylate copolymer, etc., which dissolve in an aqueous solution of pH 5.5 or higher. If it is, it will not be particularly limited.

Further, it is preferable that the tablet containing the reducing agent is an effervescent tablet in order to more reliably perform the detoxification treatment, and components added to the effervescent tablet include sodium hydrogen carbonate, potassium hydrogen carbonate and the like. The purpose of foaming can be achieved by using any of the components.

In the agent composition for contact lenses (B) of the present invention, at least one phosphoric acid selected from the group consisting of dipotassium hydrogen phosphate, calcium hydrogen phosphate and calcium phosphate, as described above, for the purpose of enhancing its stability. Salt can be included. These phosphates further inhibit the decomposition of the above-mentioned oxidizing agent, and among other ingredients contained in the tablet containing the above-mentioned reducing agent, for example, reactive ingredients (sodium hydrogencarbonate, potassium hydrogencarbonate, etc.). Carbonate) and /
Alternatively, it exerts an action of suppressing harmful properties of the hygroscopic component (reducing organic acid such as citric acid).

It should be noted that lubricants and disintegrants which are generally used in tableting may be added.

As another form of the oxidizing agent and the reducing agent satisfying the above-mentioned requirements (i) and (ii), they are both in a powder or granular state, and the reducing agent is a bag for separating the oxidizing agent and the reducing agent. Examples include a form in which the oxidizing agent and the reducing agent put in water after opening the package are in the form of powder or granules. The object of the present invention is achieved because the oxidizing agent in the naked state dissolves relatively faster in water than the reducing agent contained in the bag or sprinkled with the coating agent.

The bag-shaped material described above is not particularly limited as long as it can be dissolved in an aqueous solution having a pH of 5.5 or more. As the coating agent used for dusting the powder or granules, the same one used for coating the tablets is used.

Further, even if the oxidizing agent and the reducing agent have the same form, as long as the former is more soluble than the latter, both can be used as they are.

The method for cleaning and / or sterilizing a contact lens using the agent composition for contact lenses (A) and (B) of the present invention will be described. The concentration of the oxidant after dissolution in water is 0.005 w / v% to 5.
0w / v% is suitable. For example, in the case of using the powdered saliva which is an effective chlorine compound as an oxidant, the concentration of the powdered salasi during cleaning and / or sterilization treatment is 0 after dissolution in water.
01 to 1.0 w / v% is suitable. If the concentration is less than 0.01 w / v%, the effect is low and long-term treatment is required. On the contrary, even if the amount exceeds 1.0 w / v%, the effect is not significantly increased.
A more preferable level of powdered salinity is 0.1 to 0.5 w / v after dissolution in water.
%. The concentration of reducing agent after dissolution in water is 0.05 w / v% ~ 1
0.0w / v% is suitable. For example, when sodium thiosulfate, citric acid and sodium citrate are used as the reducing agent, the concentration at the time of use should be an amount sufficient to detoxify the oxidizing agent (effective chlorine compound). When used alone, as the concentration after dissolution in water, sodium thiosulfate 0.1 to 2.0 w / v%, citric acid 0.1 to 2.0 w / v%, sodium citrate 0.5 to 5.0 w / v% are suitable. , And more preferably, sodium thiosulfate in the range of 0.2 to 1.0 w / v%, citric acid in the range of 0.2 to 1.0 w / v%, and sodium citrate in the range of 1.0 to 3.0 w / v%. In addition, when a plurality of the reducing agents are used in combination, the total amount of the reducing agents may be sufficient to reduce the oxidizing agent.

The concentration of sodium sulfate after dissolution in water is 0.5w / v%
〜10.0w / v% is suitable. If it is less than 0.5 w / v%, the effect of preventing the decomposition of the oxidant is not exhibited, and if it exceeds 10.0 w / v%, the solubility is deteriorated and the cleaning and / or sterilizing action of the oxidant cannot be exhibited. A more preferable sodium sulfate concentration is 1.0 to 5.0 w / v% after dissolution in water.

The concentration of at least one phosphate selected from the group consisting of dipotassium hydrogen phosphate, calcium hydrogen phosphate and calcium phosphate, which is a component added to the agent composition for contact lenses (B) of the present invention. After dissolving in water
0.01 to 0.5 w / v% is suitable. If the concentration is less than 0.01 w / v%, the stabilizing effect of the contact lens composition will not be exhibited, and if it exceeds 0.5 w / v%, the solubility will be poor. A more preferable concentration is 0.05 to 0.3 w / v% after dissolution in water.

According to the method for cleaning and / or sterilizing contact lenses using the agent composition for contact lenses (A) and (B) of the present invention, the oxidizing agent and the reducing agent have the above-mentioned properties or forms, so that the oxidizing agent and the reducing agent are oxidized. The main part of the agent dissolves relatively faster than the main part of the reducing agent, and the cleaning and / or sterilization of the contact lens is started, and the reducing agent gradually dissolves, and the oxidizing agent serves its purpose (contamination on the contact lens). The remaining oxidants are detoxified after having been cleaned and / or sterilized of bacteria and fungi adhering to the contact lens).
The detoxification process ends when the reducing agent is completely dissolved.
When the reducing agent is a tablet, the dissolved state can be clearly grasped by visually confirming the presence or absence of the tablet, which is particularly preferable.

According to a preferred embodiment of the present invention, which is a reducing agent-coated tablet, the oxidizing agent dissolves and the washing and / or sterilization of the contact lens is started, and at the same time, the coating agent applied to the tablet begins to gradually dissolve, After a lapse of minutes, the reducing agent in the tablet begins to dissolve while foaming, and a detoxification reaction to the oxidizing agent is started. Therefore, it is particularly preferable that the cleaning and / or sterilization treatment of the contact lens with the oxidizing agent and the detoxification treatment of the oxidizing agent with the reducing agent are performed before and after the time.

The cleaning and / or sterilizing method of the present invention can be used for cleaning and / or sterilizing all known contact lenses, but particularly in the case of a hydrous contact lens containing hydroxyethyl methacrylate as a main component, the osmotic pressure of the treatment liquid. , PH may change the shape of the lens, and at the same time, considering the compatibility with the eye, it is desirable that the treatment-completed liquid is isotonic with the lacrimal fluid and has an equal pH. To this end, the addition of commonly used isotonic agents such as sodium chloride, potassium chloride, glucose, and buffering agents such as boric acid, sodium borate, sodium hydrogen phosphate, sodium acetate, sodium carbonate. You can

Contact lens agent composition (A), (B) of the present invention
Is used regularly as follows, for example, daily, weekly, or biweekly. That is, after removing the contact lens from the eye, it is lightly washed with water, and a container containing a predetermined volume of water (tap water or purified water) is used. Soak for a minute. In the first half of the immersion treatment, the contact lens is washed and / or sterilized with the oxidizing agent, and then the reducing agent gradually dissolves and the detoxification treatment is completed. When a tablet is used as the reducing agent, the completion of the detoxification treatment can be visually confirmed by the presence or absence of the tablet in the treatment liquid. After completion of the treatment, the lens is worn or stored, but even if it is worn as it is, there is no damage to the eyes and it is safe.

[Examples] Hereinafter, the present invention will be described in more detail with reference to Examples.

Examples 1 to 18 and Comparative Examples 1 and 2 Powders and coating agent-treated tablets having the respective component composition amounts as shown in Table 1 below were prepared and filled in an aluminum three-way seal package, an aluminum stick package or a moisture-proof plastic container. did. In Table 1, the aluminum three-sided sealed package is indicated by T, the aluminum stick package is indicated by S, and the moisture-proof plastic container is indicated by P.

The compositions of Examples 1 to 18 and the compositions of Comparative Examples 1 and 2 shown in Table 1 were evaluated by the following tests.

(A) Stability test For each composition filled in the package shown in Table 1,
Store at a temperature of 40 ± 0.3 ℃ and a humidity of 75 ± 2.5% for 30 days.
The stability of each composition was evaluated by measuring the amount of available chlorine after the passage of time. The effective chlorine content was measured by dissolving the composition in purified water or distilled water, shaking it well, adding potassium iodide and acetic acid, and titrating the liberated iodine with a sodium thiosulfate solution.

The residual rate of the available chlorine amount after 30 days is shown in Table 1 in%.

While the compositions of Comparative Examples 1 and 2 all have low residual rates of available chlorine of 62% and 47%, Examples 1 and 2
The residual ratio of the effective chlorine amount of each composition of 18 is 90% or more, which is a very high numerical value, and it is confirmed that each composition of Examples 1 to 18 has excellent stability. Was done.

(B) Bactericidal efficacy test Using the bacteria shown in Table 2, a suspension of each bacteria was prepared so that the number of bacteria would be 10 ⁶ / ml. For each composition of Examples 1-18, immediately after filling the package and under the storage conditions described above.
After 30 days, the solution was dissolved in 10 ml of the bacterial suspension. After the tablets were completely dissolved, 1.0 ml of this solution was sampled, and the presence or absence of bacteria was examined based on the Japanese Pharmacopoeia sterility test method.

The results are shown in Table 2.

As is clear from Table 2, the bactericidal effect of each composition of Examples 1 to 18 was confirmed.

Further, it was confirmed that the bactericidal effect was not decreased even after storage for 30 days, and it was shown that the compositions of the respective examples are also excellent in stability.

(C) Cleaning Efficacy Test For each composition of Examples 1 to 17, the one immediately after being filled in the package and the one after 30 days under the above-mentioned storage conditions were opened and put into 10 ml of purified water, At the same time, one piece of high-oxygen permeable hard contact lens (Hoyahard / ⁵⁸ ) that had been actually worn and had dirt attached was immersed. About 5 to 30 minutes after the powder was dissolved, the tablet started to dissolve while foaming, and after about 30 to 60 minutes, the tablet was completely dissolved. Remove the lens from the treatment liquid, lightly rinse it with purified water, wipe off the water on the lens surface, and then use a stereomicroscope (made by Knights,
When observing the surface of the lens at 20 ×, it was found that the stain was completely removed from all the lenses.

Also, in the same manner, the soft contact lens (squirrel softening) actually worn on Example 17 and having dirt attached thereto.
/ ^T40 ) When one sheet was dipped and tested, the stain was completely removed.

Therefore, it was confirmed that each of the compositions of Examples 1 to 17 had a sufficient cleaning effect immediately after being filled in the package and after being stored for 30 days, and was also excellent in stability.

(D) Color tone test Regarding each composition of Examples 1 to 18, the one immediately after being filled in the package and the one after 30 days under the above-mentioned storage conditions were opened and put into 10 ml of purified water. One piece of contact lens was immersed. After the tablet was completely dissolved, the lens was taken out of the treatment liquid, lightly rinsed with purified water, and the water on the lens surface was wiped off. The above treatment is repeated 100 times for hard contact lenses (Hoyahard), oxygen permeable hard contact lenses (A company product), and high oxygen permeable hard contact lenses (Hoyahard / ⁵⁸ and A company product) to change the color tone. That is, the presence or absence of decolorization was examined by visual observation. The results are shown in Table 3.

As is clear from Table 3, it was confirmed that each of the compositions of Examples 1 to 18 did not change the color tone of the lens.

(E) Effect on lens shape With respect to each composition of Examples 1 to 18, the same treatment as in (d) above was performed using a composition immediately after being filled in a package and a composition after 30 days passed under the above-mentioned storage conditions. I did. That is, each composition of Examples 1 to 18 is for a high oxygen permeable hard contact lens (Hoyahard / ⁵⁸ ), and each composition of Examples 17 to 18 is for a soft contact lens (Hoyasoft / ^T40 ). Treatments such as dipping and rinsing are the same as in (d) above.
The measurement was repeated 100 times, and the change in the lens shape was examined by measuring the lens parameters [base curve (rear surface curvature), diameter (diameter), and central wall thickness (thickness of central portion)].

As a result, the shape of the lens used in each of the examples did not change at all.

Therefore, it was confirmed that the compositions of Examples 1 to 18 did not affect the lens shape when used for hard contact lenses. It was also confirmed that the compositions of Examples 17 to 18 did not affect the lens shape even when used for soft contact lenses.

(F) Safety test Regarding each composition of Examples 1 to 18, the presence or absence of residual active chlorine compounds in the respective treatment-terminated liquids immediately after being filled in the package and after 30 days under the storage conditions described above. Was examined by a color reaction with orthotolidine hydrochloride.

As a result, it was confirmed that none of the finished solutions of the compositions of Examples 1 to 18 caused coloration by orthotolidine hydrochloride and no residual effective chlorine compound. In addition, as a control, the same process was performed for the case where only the powder excluding the tablet was used, but a clear color was generated.

Therefore, it was confirmed that the effective chlorine compounds contained in the compositions of Examples 1 to 18 were completely detoxified by the reducing agent after the treatment and were excellent in safety.

As is clear from the above test results, the stability of the composition of Comparative Example is insufficient, whereas the composition of Example,
All are excellent in safety. The stability of the compositions of Examples to which dipotassium hydrogen phosphate, calcium hydrogen phosphate and calcium phosphate were added was further improved.

Further, the compositions of Examples 1 to 18 can be used as a sterilizing composition for hard contact lenses, and the compositions of Examples 1 to 17 can be used as a cleaning composition for hard contact lenses. The 16 compositions have particularly good efficacy as compositions for cleaning and / or disinfecting hard contact lenses. Further, the composition of Example 17 has a particularly excellent effect as a composition for cleaning and / or sterilizing soft contact lenses, and the composition of Example 18 is effective as a composition for sterilizing soft contact lenses. Is.
Further, the compositions of the respective examples of the present invention have no influence on the color tone and shape of the lenses when used in hard contact lenses. And the compositions of Examples 17-18 have no effect on the shape of the lenses when used on soft contact lenses.

Since the compositions of Examples 1 to 16 are adjusted only to a degree that is safe for the eye in terms of pH and osmotic pressure, the shapes may temporarily change when used for soft contact lenses. However, after cleaning and / or sterilization, it is possible to restore the lens shape to a predetermined shape by means of, for example, boiling or rehydration, and when the effect of cleaning and / or sterilization is prioritized. Does not preclude the use of the compositions of these examples on soft contact lenses.

[Effects of the Invention] As described above in detail, according to the agent composition for a contact lens of the present invention and the method for treating a contact lens using the same, removal and / or sterilization of dirt adhering to the contact lens and sterilization against fungi. Can be performed reliably and in a short time, and since the composition contains sodium sulfate, excellent stability can be obtained. Furthermore,
By adding at least one phosphate selected from the group consisting of dipotassium hydrogen phosphate, calcium hydrogen phosphate and calcium phosphate, the stability of the contact lens agent composition of the present invention is further improved. Further, since the effective chlorine compound is detoxified with a single operation, the toxicity and harm of chlorine to the eyes are completely eliminated, and the safety is very high. However, since it can be used with confidence without causing irreversible changes such as color tone changes in contact lenses, it is extremely useful as a contact lens agent composition and a method for treating contact lenses.

Claims (4)

[Claims] 1. An oxidizing agent for cleaning and / or sterilizing a contact lens, a reducing agent for detoxifying the oxidizing agent still remaining after being subjected to the cleaning and / or sterilizing treatment, and sodium sulfate. In the same package, the oxidizing agent and the reducing agent do not react substantially in the same package, and the main part of the oxidizing agent is reduced when placed in water after the package is opened. An agent composition for contact lenses, which has a property or form that it dissolves relatively faster than the main part of the agent. 2. The same package further contains at least one phosphate selected from the group consisting of dipotassium hydrogen phosphate, calcium hydrogen phosphate and calcium phosphate.
The agent composition for contact lenses according to claim 1. 3. The contents of the contact lens agent composition according to claim 1 or 2 are put into water after opening the package, and the main part of the oxidizing agent is taken from the main part of the reducing agent. Also, the contact lens is characterized in that it is relatively quickly dissolved, and macroscopically, the contact lens is first cleaned and / or sterilized with an oxidizing agent, and then the oxidizing agent is detoxified with a reducing agent. And / or a sterilization method. 4. An oxidant for cleaning and / or sterilizing a contact lens and a reducing agent for detoxifying the oxidant still remaining after being subjected to cleaning and / or sterilization treatment in the same package. Contained in the above, the oxidizing agent and the reducing agent do not substantially react in the same package, and after opening the package, the main part of the oxidizing agent is more than the main part of the reducing agent. A method for stabilizing a contact lens agent composition, which comprises adding sodium sulfate to a contact lens agent composition having a property or form that dissolves relatively quickly.