JPH07121852B2 - Cosmetics - Google Patents

Description

TECHNICAL FIELD The present invention relates to a novel cosmetic, more specifically, mucopolysaccharide, vitamin E, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, Cosmetics characterized by essentially containing a mixed inorganic salt constituting a physiological salt solution selected from magnesium sulfate, sodium hydrogen carbonate, disodium hydrogen phosphate, sodium dihydrogen phosphate and potassium dihydrogen phosphate. It is about fees.

An object of the present invention is to provide a cosmetic composition which prevents dryness and rough skin, and imparts elasticity and flexibility to the skin, which is excellent in a moisturizing effect and a skin protecting effect.

[Prior Art] Regarding the moisturizing mechanism in the skin, there are still many unclear points because complicated factors are involved, but among them, the water content of each stratum corneum depends on the shape and function of the stratum corneum. It is an important factor for maintaining a proper amount of water, and in the stratum corneum of healthy skin, an appropriate amount of water is maintained by the balance between water supply from inside and outside the body and water evaporation from the skin. However, if this balance is lost due to dry skin with less sebum secretion or due to seasonal changes, the water content of the stratum corneum decreases and the skin becomes bulky, and in extreme cases cracks and cracks occur. Sometimes.

From this point of view, generally, cosmetics containing a humectant such as glycerin, sodium pyrrolidonecarboxylate, and sodium lactate have been used in order to maintain the water content of the stratum corneum.

Further, conventionally, attempts have been made to incorporate mucopolysaccharides, allantoin, collagen, various plant extracts and the like into cosmetics as having effects of preventing rough skin, healing wounds, etc. (JP-A-57-183707). , 60-116619 and others).

On the other hand, vitamin Es have long been attracting attention for their antioxidant effect, and have been blended in cosmetics as antioxidants and the like.

[Problems to be Solved by the Invention] However, a so-called moisturizer has a function of supplying water to the stratum corneum, but has only a temporary effect, and, in a low humidity environment, conversely, moisture is removed from the stratum corneum. It has the drawback of taking away.

Further, mucopolysaccharides, allantoin, collagen and plant extracts have excellent cosmetic effects as described above, but those having a satisfactory moisturizing effect have not yet been obtained, and various studies have been conducted. Is the current situation.

[Means for Solving Problems] In view of the above points, the present inventors have earnestly studied to obtain a cosmetic having an excellent moisturizing effect, and as a result, mucopolysaccharide, vitamin Es, sodium chloride, and chloride. Essentially a mixed inorganic salt that constitutes a physiological salt solution selected from potassium, calcium chloride, magnesium chloride, magnesium sulfate, sodium hydrogen carbonate, disodium hydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate. It has been found that a very remarkable moisturizing effect can be obtained by blending, and the present invention has been completed.

That is, the present invention provides a mucopolysaccharide and / or a derivative thereof, a vitamin E and / or a derivative thereof, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, magnesium sulfate, sodium hydrogencarbonate, disodium hydrogenphosphate and phosphorus. Sodium dihydrogen acid, potassium dihydrogen phosphate, a mixture of inorganic salts constituting a physiological salt solution is essential, characterized by containing a cosmetic, excellent in moisturizing effect, also having a skin protection effect It is provided.

Examples of the mucopolysaccharide and / or its derivative used in the present invention include hyaluronic acid, hyaluronic acid-protein complex, chondroitin 4 sulfate, chondroitin 6 sulfate, chondroitin 4,6 disulfate, dermatan sulfate, and dermatan.
Examples thereof include 4,6 disulfate, keratan sulfate, heparan sulfate, chitin, and salts and derivatives thereof. Mucopolysaccharide is one of the constituents of the skin and may be derived from animals, microorganisms or synthetic products. That is, the origin, extraction method, and purification treatment method are not particularly limited.

When the amount of the mucopolysaccharide and / or its derivative in the cosmetic is too small, there is no effect, and a range of 0.0001 to 5.0% by weight is preferable in terms of usability, and is sufficient for the purpose of the present invention. , 0.001 to 3.0% by weight is more preferable.

In addition, as vitamin E and / or its derivative used in the present invention, natural vitamin E, α-tocopherol, β-tocopherol, γ-tocopherol, δ-
Examples thereof include vitamin E such as tocopherol, and derivatives such as tocopherol acetate and tocopherol nicotinate.

The amount of vitamin E and / or its derivative in the cosmetic is 0.0001 to 5.0% by weight, which is effective for the present invention, but 0.001 to 2.0% by weight is more preferable.

Furthermore, the mixed inorganic salts constituting the physiological salt solution essential to the present invention are physiologically acceptable salts, such as sodium chloride, potassium chloride, calcium chloride,
It is selected from magnesium chloride, magnesium sulfate, sodium hydrogen carbonate, disodium hydrogen phosphate, sodium dihydrogen phosphate and potassium dihydrogen phosphate.

Consists of a physiological salt solution selected from sodium chloride, potassium chloride, calcium chloride, magnesium chloride, magnesium sulfate, sodium hydrogen carbonate, disodium hydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate in cosmetics The blending amount of the mixed inorganic salt is 0.01 to
The range of 5.0% by weight is effective, and there is no adverse effect due to interaction with other components in the cosmetic, which is preferable. Further, it constitutes a physiological salt solution selected from the above-mentioned sodium chloride, potassium chloride, calcium chloride, magnesium chloride, magnesium sulfate, sodium hydrogen carbonate, disodium hydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate. In addition to the mixed inorganic salt, the addition of other components such as glucose, which are usually used as components of physiological salt solutions, does not hinder the effects of the present invention.

Sodium chloride, potassium chloride, calcium chloride,
When blending a mixed inorganic salt that constitutes a physiological salt solution selected from magnesium chloride, magnesium sulfate, sodium hydrogen carbonate, disodium hydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate into cosmetics Is sodium chloride, potassium chloride, calcium chloride, magnesium chloride, magnesium sulfate, sodium hydrogen carbonate,
A mixed inorganic salt that constitutes a physiological salt solution selected from disodium hydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate, individually blended or dissolved in purified water in advance. May be prepared and blended, and the blending method is not particularly limited. A mixed inorganic that constitutes a physiological salt solution selected from the above sodium chloride, potassium chloride, calcium chloride, magnesium chloride, magnesium sulfate, sodium hydrogen carbonate, disodium hydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate. It is appropriate that the pH of the salt solution is in the range of 4.0 to 8.0, since it does not cause irritation to the skin.

As described above, the cosmetic of the present invention comprises a mucopolysaccharide and / or a derivative thereof, vitamin E and / or a derivative thereof, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, magnesium sulfate, sodium hydrogen carbonate, hydrogen phosphate. It is characterized in that it essentially contains a mixed inorganic salt constituting a physiological salt solution selected from disodium, sodium dihydrogen phosphate, and potassium dihydrogen phosphate, but in addition to this, usually Surfactants, oils, moisturizers, UV absorbers, alcohols used in cosmetics,
A chelating agent, a pH adjuster, an antiseptic, a thickener, a dye, a fragrance and the like may be appropriately added as needed.

The cosmetics referred to in the present invention are cosmetics for the purpose of protecting the skin, and are particularly used as water-based cosmetics such as skin lotions, calamine lotions, astringent lotions, hair lotions and body lotions.

EXAMPLES Next, the present invention will be further described with reference to examples. These do not limit the invention in any way.

First, Table 1 shows the formulations [1] and Comparative Examples [1].
Eight types of samples (lotion) of [7] to [7] were prepared by a usual method, the moisturizing effect was measured, and the sensory test was performed to compare the effects.

The values in the table show% by weight.

i) Measurement of moisturizing effect Twenty women aged 20 to 40 were used as subjects, and each of the left and right forearm flexion lateral parts 4
1 sample for each test site
It was applied twice a day, morning and evening. The period of use was 2 weeks in winter.

After the application period above, the impedance meter (IB
S. Co., Model IB355) was used to measure the electrical conductivity of the test site. The higher the conductivity value, the higher the water content in the stratum corneum.

The judgment was made by assigning a score to each person as follows, and the sum of the scores was obtained as an evaluation point.

Table 2 shows the number of people judged in each rank and the evaluation points.

ii) Sensory evaluation 49 women with dry skin aged 20 to 40 years were used as subjects, 7 groups in each group, 7 groups in total, and 1 sample in each group was used in Example [1] and Comparative Examples [1] to [6]. I did a test. The evaluation was performed by relative evaluation with respect to the three items of "effect of imparting elasticity to skin", "moisturizing effect" and "effect of preventing rough skin" with Comparative Example [7] as a control, and scored as follows. Was calculated as the evaluation point.

Table 3 shows the number of people evaluated in each rank and the evaluation points.

As is clear from the above evaluation results, the lotion of Example [1] contains mucopolysaccharides, vitamin Es, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, magnesium sulfate, sodium hydrogen carbonate, and dihydrogen phosphate. It shows a remarkable moisturizing effect compared to the case where the mixed inorganic salts constituting the physiological salt solution selected from sodium, sodium dihydrogen phosphate and potassium dihydrogen phosphate are used alone or in combination of two kinds. In addition, it also has an excellent skin protecting effect that is rich in moist feeling, imparts elasticity to the skin, and has an effect of preventing rough skin.

Example [2] Lotion (prescription) (% by weight) (1) Citric acid 0.1 (2) Sodium citrate 0.2 (3) Sodium pyrrolidonecarboxylate 0.5 (4) Glycerin 0.5 (5) Hamamelis extract 2.0 (6) Polyoxyethylene polyoxypropylene cetyl ether (20E.O., 8P.O.) 0.5 (7) Ethyl alcohol 15.0 (8) Methyl paraoxybenzoate 0.05 (9) Perfume 0.1 (10) Acetic acid dl-α-tocopherol 0.05 ( 11) Hyaluronic acid 0.001 (12) Elastin 0.01 (13) Sodium chloride 0.65 (14) Potassium chloride 0.014 (15) Calcium chloride 0.012 (16) Sodium hydrogen carbonate 0.02 (17) Purified water residual amount (process) A (13) ~ Dissolve (16) in (17).

B (1) to (5), (11) and (12) are mixed and dissolved in A.

C (6) to (10) are mixed and dissolved, and then mixed with B.

Example [3] Lotion (prescription) (% by weight) (1) Citric acid 0.1 (2) Sodium citrate 0.4 (3) Sodium lactate 0.8 (4) Sodium pyrrolidonecarboxylate 0.8 (5) 1,3-Butylene glycol 10.0 (6) Sodium polyacrylate (0.5% aqueous solution) 0.8
(7) Polyoxyethylenesorbitan monooleate (20E.O.) 0.2 (8) Perfume 0.01 (9) Natural vitamin E 0.1 (10) Sodium chondroitin sulfate 0.001 (11) Collagen 0.01 (12) Sodium chloride 0.9 (13) Potassium chloride 0.02 (14) Calcium chloride 0.02 (15) Magnesium chloride 0.005 (16) Sodium hydrogen carbonate 0.1 (17) Sodium dihydrogen phosphate 0.004 (18) Glucose 0.1 (19) Purified water balance (production method) A (12) Dissolve ~ (18) in (19).

B (1) to (6), (10) and (11) are mixed and dissolved in A.

C (7) to (9) are mixed and dissolved, added to B, and mixed and stirred.

Example [4] Calamine lotion (formulation) (% by weight) (1) Silicic anhydride 0.35 (2) Kaolin 0.2 (3) Zinc oxide 0.3 (4) Light calcium carbonate 0.9 (5) Bengal 0.002 (6) 1,3 -Butylene glycol 3.0 (7) Ethyl alcohol 12.0 (8) Perfume 0.15 (9) Pyrrolidonecarboxylic acid 0.1 (10) α-tocopherol 0.01 (11) Hyaluronic acid-protein complex 0.01 (12) Sodium chloride 0.9 (13) Potassium chloride 0.042 (14) Calcium chloride 0.024 (15) Sodium hydrogen carbonate 0.02 (16) Glucose 0.1 (17) Purified water Residual amount (production method) A (12) to (16) are dissolved in (17).

B (1) is mixed with (9) in A and stirred.

Add (10) and (11) to CB, and further mix and stir.

The cosmetics of Examples [2] to [4] obtained as described above were all excellent in the moisturizing effect and had a good feeling in use.

[Effects of the Invention] As described in detail above, the present invention provides a mucopolysaccharide and / or a derivative thereof, vitamin E and / or a derivative thereof, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, magnesium sulfate, hydrogen carbonate. By essentially containing a mixed inorganic salt that constitutes a physiological salt solution selected from sodium, disodium hydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate, the effects of these components are synergistic. It is intended to provide a new cosmetic material that is effectively exhibited.

That is, according to the present invention, it has become possible to provide an extremely useful cosmetic composition which has an unprecedentedly remarkable moisturizing effect and is excellent in skin protection and water retention.

Continuation of the front page (56) Reference JP 62-187406 (JP, A) JP 59-1404 (JP, A) JP 59-7106 (JP, A) JP 59-173125 (JP , A) JP-A-59-173124 (JP, A) JP-A-59-130206 (JP, A) JP-A-54-52733 (JP, A) H. Kimime et al. 6 Handbook-Cosmetics / Pharmaceutical Raw Materials- (Showa 52) P. 809-817 Published by Nikko Chemicals Co., Ltd. 1

Claims (1)

[Claims] 1. A mucopolysaccharide and / or a derivative thereof, vitamin E and / or a derivative thereof, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, magnesium sulfate, sodium hydrogen carbonate, disodium hydrogen phosphate, phosphoric acid. A cosmetic, which essentially contains a mixed inorganic salt constituting a physiological salt solution selected from sodium dihydrogen and potassium dihydrogen phosphate.