JPH07112470B2 - Medical laser irradiation device - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention is to administer a fluorescent substance having an affinity for cancer cell tissues into the blood of a human body and the like, and then irradiate the lesion with laser light. The present invention relates to a medical laser irradiation device for diagnosing a lesion by exciting a fluorescent substance.

[Prior Art] When a fluorescent substance having affinity for cancer cell tissues, such as hematoprofilin derivative (abbreviated as “HPD”), is administered into human blood for about 48 hours, HPD is excreted in normal tissues, but is taken up and remains in cancer cells. When laser light is irradiated around the lesion in this state, HPD is excited and emits fluorescence.
Cancer cells can be discovered and diagnosed.

As one laser beam for exciting the HPD, 514.5 nm light, which is one of the oscillation wavelengths of the argon laser, is used. However, since the fluorescence emitted by being excited by laser light is generally very weak, when it is irradiated with a green monochromatic light having a wavelength of 514.5 nm, the irradiation light becomes fogged and the fluorescent portion becomes unclear. It was not uncommon to see the serious consequence of missing lesions.

An object of the present invention is to provide a medical laser irradiation apparatus which eliminates such a conventional defect, allows a fluorescent portion to be clearly visible, and has excellent diagnostic ability.

[Means for Solving Problems] A medical laser irradiation apparatus according to the present invention for solving the above problems includes an optical fiber for transmitting a laser beam and a wavelength for exciting a fluorescent substance in the optical fiber. It is characterized in that it comprises excitation laser light incidence means for injecting excitation laser light and toning laser light incidence means for injecting toning laser light having a wavelength different from that wavelength into the optical fiber.

[Operation] The excitation laser light and the color-adjusting laser light are incident on one optical fiber and are applied to a lesion or the like.

Therefore, the fluorescent substance is excited by the excitation laser light to emit fluorescence, and the excitation laser light and the color-matching laser light are mixed, and the fluorescence is emitted in a color that is easily visible.

[Embodiment] An embodiment of the present invention will be described with reference to the drawings.

FIG. 1 shows the overall construction of the first embodiment of the present invention, in which 1 is a known argon laser oscillator, which has a wavelength of 488 nm.
It emits laser light of wavelengths (blue-green) and 514.5 nm (green).

In front of the argon laser oscillator 1, for example, a color material 2 made of rhodamine 6G, which is a kind of xanthone dye, is arranged. Argon laser light has a wavelength of 630 nm by passing through the color material 2. Converted to red monochromatic argon / dye laser light.

Between the argon laser oscillator 1 and the color material 2, a rotating body 4 which is an optical path splitter, which is rotationally driven at high speed by a motor 3, faces the argon laser oscillator 1 and has an optical axis of 45 degrees. It is arranged at an angle.

For example, as shown in FIG. 2, the rotating body 4 has a circle in which a reflecting portion 5 for reflecting the argon laser light is formed in one portion and a transmitting portion 6 for transmitting the argon laser light is formed in the other portion. The plate is a plate, and the laser light is reflected laterally when the reflection part 5 blocks the optical axis, and when the transmission part 6 is on the optical axis, the laser light travels straight and enters the color material 2. In this way, the optical path of the laser beam is time-divided by the rotating body 4.

The shape of the rotating body may be, for example, as shown in FIG. 3, in which the reflecting portions 5 are symmetrically arranged, or another shape.

A mirror 7 is arranged at an angle of 45 degrees on the side of the rotating body 4 to reflect the laser light in the vertical direction, and an interference filter 8 and an ND filter 9 are connected in series on the reflected optical axis. The laser light is transmitted through these filters 8 and 9.

The interference filter 8 has a property of selectively weakening the intensity of one of the wavelength 488 nm and the wavelength 514.5 nm laser light included in the argon laser light. By adjusting the ratio, the mixing ratio of blue-green and green can be adjusted to an appropriate ratio.

Further, the ND filter 9 can evenly weaken the intensity of the laser light of both wavelengths, and make the mixing ratio with the argon / dye laser light (red) appropriate. The mixing ratio can also be adjusted by changing the area ratio of the reflection part 5 and the transmission part 6 of the rotating body 4 without causing a loss in the intensity of the laser light.

And each of the filters 8 and 9, when the laser light transmitted through the filter is mixed with the argon / dye laser,
Selected to be closest to white light.

In front of the filters 8 and 9, a mirror 10 is arranged at an angle of 45 degrees to reflect the laser light laterally, and the reflection of the argon / dye laser light passing through the reflection optical axis and the color material 2 is performed. It intersects with the optical axis. Then, at the intersection of the optical axes, light with a wavelength of 630 nm is transmitted, and 488 nm and 514.
A half mirror 11 that reflects light with a wavelength of 5 nm is installed, and the optical axes of all the laser lights are aligned there and directed upward.

A condenser lens 12 is arranged above the half mirror 11, and an incident end portion of an optical fiber 13 for transmitting laser light is arranged at a focal position of the lens 12, and three kinds of optical axes coincide with each other. All the laser light of the wavelength is made incident on the optical fiber 13. And that optical fiber 13
Is inserted into the forceps channel of a known endoscope 14, and the lesion area 16 in the body cavity 15 is irradiated with laser light from the emitting end of the optical fiber 13.

The laser light with which the lesion 16 is irradiated is a mixture of laser lights of different wavelengths in a time-division manner, but if the rotating body 4 is rotated at a high speed of a certain speed or higher, the It is perceived as if the laser lights of the above are simultaneously irradiated and mixed.

The first embodiment of the present invention is configured in this way, and the laser light emitted from the emitting end of the optical fiber 13 to the lesion 16 is a laser with a wavelength of 630 nm that excites HPD well to cause fluorescence. Including light (laser light for excitation), 488 nm and 51
Laser light with a wavelength of 4.5 nm (color-adjusting laser light) is mixed at an appropriate intensity and is perceived as a light beam that is close to white light as a whole. Therefore, if fluorescence is emitted from the cancer cell tissue of the lesion 16, the operator can easily confirm the fluorescence through the viewfinder of the endoscope 14 even if the fluorescence is weak.

FIG. 4 shows a second embodiment of the present invention, in which a toning laser light oscillation device for oscillating toning laser light is provided separately from the excitation laser light oscillation device, and the excitation laser light and the toning laser light are adjusted. The laser light for use enters the optical fiber at the same time.

In FIG. 4, 1 is an argon laser oscillator, 2 is rhodamine
It is a color material composed of 6G, and these form a pumping laser light incident means, and an argon / dye laser light with a wavelength of 630 nm (red) passes through the half mirror 11, and passes through a condenser lens 12 and an optical fiber 13 Is incident on.

On the other hand, 21 is an argon laser oscillator that oscillates a laser beam having a wavelength of 488 nm (blue-green), and 22 is a He-Cd laser oscillator that oscillates a laser beam having a wavelength of 530 nm (green). The axes are aligned by the half mirror 23, further reflected by the half mirror 11, and incident on the optical fiber 13 via the condenser lens 12.

As described above, in this embodiment, laser lights of three different wavelengths are simultaneously incident on the optical fiber 13, and the irradiation light is made to be close to white light by adjusting the outputs of the laser oscillators 1, 21, and 22, respectively. Can be displaced. Others are the same as those in the first embodiment, and the description thereof will be omitted.

[Advantages of the Invention] According to the medical laser irradiation apparatus of the present invention, the excitation laser light and the toning laser light are incident on one optical fiber,
Since they are mixed and irradiated on the lesion, the fluorescent material is excited by the laser light for excitation, and the irradiation light is
The fluorescence can be adjusted to a color that is easy to visually recognize, and therefore even weak fluorescence can be easily found, and an excellent diagnostic ability that does not miss a cancer lesion can be obtained.

[Brief description of drawings]

FIG. 1 is a schematic view showing the overall construction of the first embodiment of the present invention, FIG. 2 is a front view of the rotating body, FIG. 3 is a front view showing another example of the rotating body, and FIG. The figure is a schematic diagram showing the overall construction of a second embodiment of the present invention. 1 ... Argon laser oscillator, 2 ... Color material, 3 ... Motor, 4 ... Rotating body, 5 ... Reflecting part, 6 ... Transmitting part, 11
...... Half mirror, 13 …… Optical fiber, 16 …… Lesson,
21 …… Argon laser oscillator, 22 …… He-Cd laser oscillator, 23 …… Half mirror.

Claims (5)

[Claims] 1. An optical fiber for transmitting a laser beam, a pumping laser beam incidence means for injecting a pumping laser beam of a wavelength for exciting a fluorescent substance into the optical fiber, and a toning laser of a wavelength different from that wavelength. In a medical laser irradiation apparatus having a color-adjusting laser light incident means for making light incident on the optical fiber, the excitation laser light-incident means and the color-adjusting laser-light incident means are oscillated from one argon laser oscillator. The argon laser light is split by an optical path splitter, one of the split laser light is used as a toning laser light, and the other is passed through a color material to be used as an excitation laser light, and each is incident on a common optical fiber. The medical laser irradiation device is characterized in that the toning laser light and the excitation laser light are mixed to become almost white light. 2. The medical laser irradiation apparatus according to claim 1, wherein the color material is Rhodamine 6G. 3. The optical path splitter is a rotating body which is provided so as to face an argon laser oscillator and has a reflecting portion for reflecting the oscillated laser light and a transmitting portion for transmitting the laser light. The medical laser irradiation apparatus according to claim 1 or 2. 4. The color-adjusting laser light incident means has a wavelength of 488 nm and a wavelength of 514.5 nm in an optical path divided by an optical path divider.
5. The medical laser irradiation apparatus according to claim 1, further comprising a filter that selectively weakens one intensity of the laser light of claim 1. 5. The color-adjusting laser light incident means includes an ND filter in the optical path divided by the optical path divider,
The medical laser irradiation according to claim 1, 2, 3 or 4, wherein the ND filter has a concentration that makes mixed light of the excitation laser light and the toning laser light substantially white light. apparatus.