JPH0655220B2 - Artificial bone for implant - Google Patents
Artificial bone for implantInfo
- Publication number
- JPH0655220B2 JPH0655220B2 JP61101773A JP10177386A JPH0655220B2 JP H0655220 B2 JPH0655220 B2 JP H0655220B2 JP 61101773 A JP61101773 A JP 61101773A JP 10177386 A JP10177386 A JP 10177386A JP H0655220 B2 JPH0655220 B2 JP H0655220B2
- Authority
- JP
- Japan
- Prior art keywords
- zro
- artificial bone
- coating film
- implant
- implants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- Materials For Medical Uses (AREA)
Description
【発明の詳細な説明】 ［産業上の利用分野］ 本発明はインプラント用人工骨に係り、特に生体内で長
期間使用しても特性が低下することがないインプラント
用人工骨に関する。Description: TECHNICAL FIELD The present invention relates to an artificial bone for implants, and more particularly to an artificial bone for implants which does not deteriorate in properties even when used for a long period of time in a living body.
［従来の技術］ 人工骨補綴材、骨中継材、人工関節、人工歯根等の各種
のインプラント用人工骨は、整形外科、歯科等の分野に
おいて既に臨床的に用いられている。[Prior Art] Artificial bones for implants such as artificial bone prosthesis materials, bone relay materials, artificial joints and artificial tooth roots are already clinically used in fields such as orthopedics and dentistry.
従来、インプラント用人工骨は金属製のものが殆どであ
ったが、近年、金属製に代る優れた人工骨として、各種
セラミックス製の人工骨が開発、使用されている。Conventionally, most artificial bones for implants have been made of metal, but in recent years, various ceramics artificial bones have been developed and used as excellent artificial bones instead of metal.
例えば、歯根用のインプラント用人工骨としては、金属
Ｔｉ、Ｃｏ−Ｃｒ合金あるいはＦｅ−Ｎｉ−Ｃｒ合金系
インプラント用人工骨に代るものとして、近年、アルミ
ナ（Ａｌ２Ｏ３）あるいはジルコニア（ＺｒＯ２）など
のセラミック製人工骨が開発され、歯科臨床に用いられ
つつある（例えば、ファインセラミックス技術P.１８
５、工業調査会、１９８３）。セラミック製人工骨は生
体に及ぼす影響も全くなく、強度や硬度が高く、耐摩耗
性に優れ、また、成形加工性も良い等の利点を有する。For example, the implant artificial bone for tooth roots, metals Ti, as an alternative to the artificial bone for the Co-Cr alloy or Fe-Ni-Cr alloy based implant, in recent years, alumina (Al 2 O 3) or zirconia (ZrO Artificial bones made of ceramics such as 2 ) have been developed and are being used in clinical dentistry (for example, fine ceramics technology P.18).
5, Industrial Research Council, 1983). The artificial bone made of ceramic has no effects on the living body, has high strength and hardness, is excellent in abrasion resistance, and has good processability.
しかして、このようなセラミック製人工骨の材質とし
て、特にＺｒＯ２、とりわけイットリア（Ｙ２Ｏ３）等
を含むＺｒＯ２が良好なバイオイナート材質として有望
視されている。Thus, as the material of such a ceramic artificial bone, the ZrO 2 including in particular ZrO 2, especially yttria (Y 2 O 3) or the like is promising as a good Bio-inert material.
即ち、ＺｒＯ２は化学的に極めて安定で耐食性に優れた
材料であるが、下記のような相転移を示す。That is, ZrO 2 is a material that is chemically extremely stable and has excellent corrosion resistance, but exhibits the following phase transition.
単斜晶正方晶立方晶 このため、ＺｒＯ２の相転移を防止するべく、Ｙ
２Ｏ３、ＣａＯ、ＭｇＯ等を固溶させた安定化ジルコニ
アや部分安定化ジルコニアが広く利用されている。Monoclinic tetragonal cubic system Therefore, in order to prevent the phase transition of ZrO 2 , Y
Stabilized zirconia and partially stabilized zirconia in which 2 O 3 , CaO, MgO, etc. are solid-dissolved are widely used.
［発明が解決しようとする問題点］ しかしながら、Ｙ２Ｏ３等を固溶させて得られたＺｒＯ
２質焼結体製の人工骨であっても、長期の使用により強
度、硬度や耐摩耗性が低下するという問題点がある。[Problems to be Solved by the Invention] However, ZrO obtained by solid solution of Y 2 O 3 and the like
Even an artificial bone made of a two- material sintered body has a problem that strength, hardness and wear resistance are deteriorated by long-term use.
［問題点を解決するための手段］ 本発明は上記従来の問題点を解決し、強度、硬度、耐摩
耗性等の特性が低下することなく極めて耐久性に優れた
インプラント用人工骨を提供するものであって、 ジルコニア質焼結体を基体とし、表面に耐水性の被覆膜
が形成されているインプラント用人工骨であって、該被
覆膜は、ＣＶＤ反応により形成された、Ｃ，Ａｌ
２Ｏ３，Ｓｉ３Ｎ４，ＴｉＮ，ＴｉＯ２及びＺｒＯ２よ
りなる群から選ばれる少なくとも１種の被覆膜であるこ
とを特徴とするインプラント用人工骨、 を要旨とするものである。[Means for Solving Problems] The present invention solves the above-mentioned conventional problems and provides an artificial bone for implants having extremely excellent durability without deterioration of properties such as strength, hardness, and wear resistance. What is claimed is: 1. An artificial bone for implant, comprising a zirconia-based sintered body as a base, and a water-resistant coating film formed on the surface thereof, the coating film being formed by a CVD reaction, C, Al
An artificial bone for implant characterized by being at least one kind of coating film selected from the group consisting of 2 O 3 , Si 3 N 4 , TiN, TiO 2 and ZrO 2 .
即ち、本発明者らは、ＺｒＯ２質焼結体製インプラント
用人工骨の特性劣化について検討した結果、Ｙ２Ｏ３等
を含有するＺｒＯ２質焼結体は、生体のように水分のあ
る環境下では、正方晶が徐々に単斜晶に変化してしま
い、このため焼結体の強度、硬度や耐摩耗性が低下する
ことを見い出した。That is, the present inventors have made study for the characteristic deterioration of the artificial bone for the ZrO 2 quality sintered body made of implants, ZrO 2 quality sintered body containing Y 2 O 3, etc., with water as a biological Under the environment, it was found that the tetragonal crystal gradually changed to a monoclinic crystal, which reduced the strength, hardness and wear resistance of the sintered body.
本発明はこのような知見に基いてなされたものであっ
て、人工骨を構成するＺｒＯ２質焼結体の表面に特定の
耐水性薄膜を形成することにより、ＺｒＯ２晶の単斜晶
への転移を防ぎ、その劣化を防止するようにしたもので
ある。The present invention has been made on the basis of such findings, and by forming a specific water-resistant thin film on the surface of a ZrO 2 sintered material that constitutes artificial bone, a ZrO 2 crystal monoclinic crystal is formed. It is intended to prevent the transfer of the, and prevent its deterioration.
以下に本発明を図面を参照して詳細に説明する。Hereinafter, the present invention will be described in detail with reference to the drawings.
本発明のインプラント用人工骨１は、第１図に示す如
く、ＺｒＯ２質焼結体よりなる基体２の表面に耐水性の
被覆膜３を形成したものである。The artificial bone 1 for implants of the present invention is, as shown in FIG. 1, formed by forming a water-resistant coating film 3 on the surface of a substrate 2 made of a ZrO 2 sintered material.
本発明において、基体となるＺｒＯ２質焼結体として
は、ＺｒＯ２にＹ２Ｏ３、ＭｇＯ、ＣａＯ、その他希土
類酸化物やＣｅＯ２等を固溶させたものが挙げられ、こ
れらのうち特に２〜８モル％程度のＹ２Ｏ３を含むＺｒ
Ｏ２質焼結体が好ましい。In the present invention, the ZrO 2 quality sintered body that becomes the base, ZrO 2 to Y 2 O 3, MgO, CaO , others include those obtained by solid solution of rare earth oxide and CeO 2 or the like, in particular among these Zr containing about 2 to 8 mol% Y 2 O 3
An O 2 sintered body is preferable.
耐水性の被覆膜３の材質としては、耐水性を有し、基体
のＺｒＯ２質焼結体との接着性が良好でしかも生体との
なじみが良く、またその他の特性においても人工骨とし
て十分に満足し得るものであることから、Ｃ，Ａｌ２Ｏ
３，Ｓｉ３Ｎ４，ＴｉＮ，ＴｉＯ２及びＺｒＯ２よりな
る群から選ばれる１種で形成されたもの、或いは、２種
以上の混合膜、或いは複合膜を用いる。特に、被覆膜の
材質としては、基体のＺｒＯ２質焼結体との接着性の点
から、ＺｒＯ２が最も好ましい。The material of the water-resistant coating film 3 is water-resistant, has good adhesion to the ZrO 2 sintered material of the substrate, is well compatible with the living body, and has other characteristics as an artificial bone. Since it is sufficiently satisfactory, C, Al 2 O
A film formed of one kind selected from the group consisting of 3 , Si 3 N 4 , TiN, TiO 2 and ZrO 2 , a mixed film of two or more kinds, or a composite film is used. In particular, as the material of the coating film, ZrO 2 is most preferable from the viewpoint of adhesiveness with the ZrO 2 sintered material of the substrate.
被覆膜３の厚さには特に制限はないが、膜厚が薄過ぎる
と被覆膜による十分な耐水性向上保護効果が得られず、
逆に厚過ぎると被覆膜剥離の問題が起こる可能性が生じ
るため、これらの点を被覆膜の材質による耐水性と共に
勘案して適当な厚さに形成するのが良い。The thickness of the coating film 3 is not particularly limited, but if the film thickness is too thin, a sufficient water resistance improving protection effect due to the coating film cannot be obtained.
On the contrary, if it is too thick, the problem of peeling of the coating film may occur. Therefore, it is preferable to take these points into consideration together with the water resistance of the material of the coating film to form an appropriate thickness.
このような被覆膜は、ＣＶＤ法により形成する。被覆膜
をＣＶＤ反応で形成することにより、緻密で高強度な膜
が得られるため極めて有利である。Such a coating film is formed by the CVD method. By forming the coating film by the CVD reaction, a dense and high-strength film can be obtained, which is extremely advantageous.
以下に本発明のインプラント用人工骨を製造する方法に
ついて説明する。The method for producing the artificial bone for implant of the present invention will be described below.
本発明のインプラント用人工骨の製造にあたっては、ま
ず所望とする人工骨形状とほぼ同形状となるように、Ｚ
ｒＯ２質焼結体の基体を作成する。この基体の作製は常
法に従って行われ、例えばＹ２Ｏ３を配合したＺｒＯ２
質焼結体であれば、所要量のＹ２Ｏ３粉粒体及びＺｒＯ
２粉粒体と必要に応じてバインダーその他の添加剤を混
合し、これを成形、焼成して焼結体とする。In the production of the artificial bone for implants of the present invention, first, Z
A base body of a rO 2 sintered body is prepared. This substrate is manufactured by a conventional method, for example, ZrO 2 containing Y 2 O 3 is added.
If it is a high quality sintered body, the required amount of Y 2 O 3 powder and ZrO
Two powder particles and a binder and other additives are mixed if necessary, and the mixture is molded and fired to obtain a sintered body.
次いで、得られた焼結体の基体にＣＶＤ反応により被覆
膜を形成する。Next, a coating film is formed on the base body of the obtained sintered body by the CVD reaction.
被覆膜の形成には、まず基体をＣＶＤ反応の析出温度域
に加熱する。加熱方法は、特に限定されないが、断面楕
円形の筒状体内の２焦点に赤外線源を配置し、両焦点の
中間に基体をセットする赤外線加熱炉や、装置構成の簡
易な高周波誘導加熱炉等が有利である。その他、反応容
器の外側から加熱する外部加熱方法やレーザ加熱方法等
も採用可能である。To form the coating film, the substrate is first heated to the deposition temperature range of the CVD reaction. The heating method is not particularly limited, but an infrared heating furnace in which an infrared source is arranged at two focal points in a cylindrical body having an elliptical cross section and a base is set in the middle of both focal points, a high-frequency induction heating furnace having a simple apparatus configuration, etc. Is advantageous. In addition, an external heating method of heating from the outside of the reaction container, a laser heating method, or the like can be adopted.
次いで、このようにして加熱された基体の表面に、ＣＶ
Ｄ反応ガスを供給してＣＶＤ反応させ、基体表面にＣＶ
Ｄ析出物を析出させる。析出物の析出量、即ち、被覆膜
の厚さは、ＣＶＤ反応ガスの供給量又は加熱時間を調節
することにより容易に調整し得る。Then, CV is applied to the surface of the substrate thus heated.
D reaction gas is supplied to cause CVD reaction, and CV is applied to the substrate surface.
D precipitate. The deposition amount of the deposit, that is, the thickness of the coating film can be easily adjusted by adjusting the supply amount of the CVD reaction gas or the heating time.
このようにして被覆膜を形成させた後、必要に応じて研
磨等の表面処理を施して、製品とする。After forming the coating film in this manner, surface treatment such as polishing is performed as necessary to obtain a product.
［作用］ 本発明のインプラント用人工骨は、耐水性を有し、基体
との接着姓が良好で、生体とのなじみが良く、その他の
特性においても人工骨として良好な特性を有し、かつ、
緻密で高強度な特定のＣＶＤ被覆膜で被覆されているた
め、基体のＺｒＯ２質焼結体のＺｒＯ２晶が生体内の水
分存在下において単斜晶に転移することが防止される。[Operation] The artificial bone for implants of the present invention has water resistance, has good adhesion to the substrate, is well compatible with the living body, and has other excellent properties as an artificial bone, and ,
Because it is covered by the dense high strength and specific CVD coating, it is possible to prevent the ZrO 2 crystals ZrO 2 quality sintered body of the substrate is transferred into monoclinic in the presence of water in the body.
このためＺｒＯ２晶の転移による、人工骨の強度、硬
度、耐摩耗性の低下が防止される。Therefore, it is possible to prevent the strength, hardness, and wear resistance of the artificial bone from being lowered due to the transformation of the ZrO 2 crystal.
［実施例］ 以下に本発明を実施例により更に具体的に説明するが、
本発明はその要旨を超えない限り、以下の実施例に限定
されるものではない。[Examples] Hereinafter, the present invention will be described in more detail with reference to Examples.
The present invention is not limited to the following examples unless it exceeds the gist.
実施例１ Ｙ２Ｏ３を３モル％含有する３×４×３６ｍｍの大きさ
のＺｒＯ２質焼結体の表面にＣＶＤ反応により、膜厚１
０μｍのＺｒＯ２膜を形成したものについて、下記要領
によりその水分環境下における強度低下の試験を行っ
た。Example 1 A film having a thickness of 1 was formed on the surface of a ZrO 2 sintered material having a size of 3 × 4 × 36 mm containing 3 mol% of Y 2 O 3 by a CVD reaction.
With respect to the ZrO 2 film having a thickness of 0 μm, a strength reduction test in a moisture environment was conducted according to the following procedure.
まず、ＺｒＯ２膜を有する前記焼結体を２００℃の水蒸
気雰囲気にて加熱し３００ｈｒ保持した。所定時間後降
温し、常温にて４点曲げ試験を実施した。測定は５本の
試験片について行い、それらの平均値を求めた。First, the sintered body having the ZrO 2 film was heated in a steam atmosphere at 200 ° C. and held for 300 hours. After a predetermined time, the temperature was lowered, and a 4-point bending test was performed at room temperature. The measurement was performed on five test pieces, and the average value thereof was calculated.
結果を第１表に示す。The results are shown in Table 1.
また、ＺｒＯ２膜を形成していないＺｒＯ２質焼結体に
ついても同時に試験し、その結果を第１表に併記した。Also tested simultaneously for ZrO 2 quality sintered body not forming the ZrO 2 film was also shown the results in Table 1.
第１表より、本発明のインプラント用人工骨は水分が存
在する生体内において、強度等の特性が低下することが
殆どないことが明らかである。 From Table 1, it is clear that the artificial bone for implants of the present invention hardly deteriorates in properties such as strength in a living body in which water is present.
［発明の効果］ 以上詳述した通り、本発明のインプラント人工骨は、Ｚ
ｒＯ２質焼結体の基体表面に耐水性を有する特定材質の
ＣＶＤ被覆膜が形成されているため、生体内で経時的に
強度、硬度、耐摩耗性等が低下することが殆どなく、長
期にわたって、高い信頼性のもとに使用することができ
る。[Effects of the Invention] As described in detail above, the implant artificial bone of the present invention is
Since the CVD coating film of a specific material having water resistance is formed on the surface of the base body of the rO 2 sintered body, strength, hardness, wear resistance and the like hardly deteriorate with time in the living body. It can be used with high reliability for a long period of time.
第１図は本発明のインプラント用人工骨の実施例を示す
断面図である。 １……インプラント用人工骨、 ２……ＺｒＯ２質焼結体、 ３……耐水性被覆膜。FIG. 1 is a sectional view showing an embodiment of the artificial bone for implants of the present invention. 1 ... Artificial bone for implant, 2 ... ZrO 2 sintered material, 3 ... Water resistant coating film.
Claims (1)
水性の被覆膜が形成されているインプラント用人工骨で
あって、 該被覆膜は、ＣＶＤ反応により形成された、Ｃ，Ａｌ２
Ｏ３，Ｓｉ３Ｎ４，ＴｉＮ，ＴｉＯ２及びＺｒＯ２より
なる群から選ばれる少なくとも１種の被覆膜であること
を特徴とするインプラント用人工骨。1. An artificial bone for implants, which has a zirconia-based sintered body as a substrate and has a water-resistant coating film formed on the surface thereof, the coating film comprising C, Al 2
An artificial bone for implants, which is a coating film of at least one selected from the group consisting of O 3 , Si 3 N 4 , TiN, TiO 2, and ZrO 2 .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61101773A JPH0655220B2 (en) | 1986-05-01 | 1986-05-01 | Artificial bone for implant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61101773A JPH0655220B2 (en) | 1986-05-01 | 1986-05-01 | Artificial bone for implant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62258669A JPS62258669A (en) | 1987-11-11 |
| JPH0655220B2 true JPH0655220B2 (en) | 1994-07-27 |
Family
ID=14309533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61101773A Expired - Lifetime JPH0655220B2 (en) | 1986-05-01 | 1986-05-01 | Artificial bone for implant |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0655220B2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63277061A (en) * | 1987-05-08 | 1988-11-15 | Ngk Spark Plug Co Ltd | In vivo implant |
| JPH02286158A (en) * | 1989-04-27 | 1990-11-26 | Ishikawajima Harima Heavy Ind Co Ltd | Artificial joint |
| WO2014073343A1 (en) * | 2012-11-09 | 2014-05-15 | 学校法人愛知学院 | Dental implant material and method for manufacturing same |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60116342A (en) * | 1983-11-30 | 1985-06-22 | 株式会社日立製作所 | Ultrasonic receiving phasing circuit |
| JPS6140884A (en) * | 1984-07-31 | 1986-02-27 | 株式会社 香蘭社 | Ceramic member for vital prosthesis |
| JPS61201683A (en) * | 1985-03-06 | 1986-09-06 | オリンパス光学工業株式会社 | Composite material for artificial aggregate use |
| JPS61226053A (en) * | 1985-03-29 | 1986-10-07 | 日本電気硝子株式会社 | Production of living body material |
-
1986
- 1986-05-01 JP JP61101773A patent/JPH0655220B2/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60116342A (en) * | 1983-11-30 | 1985-06-22 | 株式会社日立製作所 | Ultrasonic receiving phasing circuit |
| JPS6140884A (en) * | 1984-07-31 | 1986-02-27 | 株式会社 香蘭社 | Ceramic member for vital prosthesis |
| JPS61201683A (en) * | 1985-03-06 | 1986-09-06 | オリンパス光学工業株式会社 | Composite material for artificial aggregate use |
| JPS61226053A (en) * | 1985-03-29 | 1986-10-07 | 日本電気硝子株式会社 | Production of living body material |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62258669A (en) | 1987-11-11 |
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