JPH0651395B2 - Drug-containing laminated film - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a drug-containing laminated film. More specifically, the present invention relates to a highly volatile component of a drug or a highly volatile drug (collectively referred to as “highly volatile component”),
The low volatility component of the drug or another low volatility drug (collectively simply "low volatility component") is contained in a separate layer, and a layer containing the low volatility component is laminated on the outside. The present invention relates to a drug-containing laminated film characterized in that the drug component can be evenly volatilized.

Here, “to be laminated on the outside” means to be laminated on the so-called outside of a laminate composed of a large number of layers, and also when a drug-containing laminated film is attached to a container, the layer is “attached so as to be on the outside”. Doing "is also included.

[Prior Art] Conventionally, various types of thermoplastic resin films containing a drug are known, and they can gradually volatilize the drug (sustained release). Volatility is different depending on the type, and highly volatile components volatilize rapidly and low volatility components remain.Therefore, from the middle to the end of use of the drug-containing film, the balance of the volatile drug components is It became different from the original one, and had the drawback that it could not enjoy the same effect as the initial one for a long time.

[Problems to be Solved by the Invention] The present invention has been made as a result of extensive studies to solve such problems. That is, an object of the present invention is to prevent each component of the drug from being volatilized unevenly from the drug-containing film as described above, and to evenly diffuse each component of the drug in the drug-containing film to the end. .

Another object of the present invention is to extend the effective life of the drug-containing film by making the volatilization rate of the drug uniform.

[Means for Solving Problems] In the drug-containing laminated film of the present invention, a highly volatile component of a drug or a highly volatile drug is contained in one layer, and a low volatile component of the drug or other low volatility is contained. It is characterized in that a sexual drug is contained in another layer, and a layer containing the low volatile component or the other low volatile drug is laminated on the outside.

The material of the laminated film in the method of the present invention, that is, the film base material of each layer is a material that can gradually diffuse the drug by mixing, impregnating, coating, or dissolving the drug, and is usually paper, nonwoven fabric, or heat. A film, sheet, foam or the like made of a plastic synthetic resin is used, but not limited thereto. As the thermoplastic resin, those which are not reactive with the drug and have good compatibility are preferable.

Synthetic resins compatible with drugs include petroleum resins, polybutene, polymethacryl resins, polyvinyl chloride resins,
Polystyrene resin, natural rubber or synthetic rubber unvulcanized rubber, carboxyl group-containing ethylene copolymer, etc.
Particularly, carboxyl group-containing ethylene copolymers such as ethylene-vinyl acetate copolymer (EVA) and ethylene-ethyl acrylate copolymer (EEA) are preferable.

Further, the drug that can be blended in each layer of the drug-containing laminated film is not limited, but, for example, a fragrance, a rust preventive, a fungicide, an antiseptic, an insect repellent, a rodenticide, a deodorant, an insecticide Agents, repellents and antifouling agents.

As fragrances, natural fragrances such as animal fragrances and plant essential oils,
There are various synthetic fragrances and their mixed fragrances. These fragrances are usually numerous perfume oils and solvents additional,
The volatilization rate of each component is different. Therefore, the high volatility component and the low volatility component are contained in separate layers, the layer containing the low volatility component is laminated on the outer side, and the layer containing the high volatility component is laminated on the inner side to obtain high volatility. It is possible to moderately volatilize the volatile component and evenly volatilize each component.

Specific examples of agents other than the above fragrances, salts of organic amines such as dicyclohexyl ammonium nitrite and benzotriazole, heterocyclic amines such as methylbenzotriazole, other vaporizable rust preventives, sorbic acid,
Preservatives for foods such as dehydroacetic acid, antifungal agents such as siabendazole, binazine, α-bromocinnamaldehyde, DDT agents, BHC agents, dolin agents, parathion agents,
Insecticides such as DDVP agents and PGP agents, formalin, salicylic acid, creosote, bactericides such as phenol, nitrofurazone and nitrofurylacrylic acid amide, phenylmercuric acetate, phenylmercuric oleate, copper naphthenate,
Antifouling agents such as copper oleate or rodenticides such as naramycin (trade name, manufactured by Tanabe Seiyaku Co., Ltd.), ramtalin (trade name, manufactured by Matsushita Electric Works, Ltd.), and cotomycin (trade name, manufactured by Osaka Kasei Co., Ltd.) Can be mentioned.

Among the above-mentioned agents, as the agents having a relatively high volatility, there are dicyclohexylammonium nitrite which is a rust preventive and α-bromocinnamaldehyde which is a fungicide.

In addition, examples of low-volatility agents include pyrethroids which are insect repellents and ramtalin which is a rodent repellent.

Further, as a specific example of a combination of drugs, there are a pyrethroid insect repellent having a low volatility drug and an α-bromocinnamaldehyde fungicide having a high volatility drug.

As described above, in the present invention, the volatilization rate of each drug component is adjusted by laminating the layer containing the low-volatile component or the low-volatile drug on the outside, but other As an auxiliary means, a solvent or a normal filler may be added for the purpose of controlling the action of the drug component diffusing in the film base material, detaching from the base material and volatilizing.

Examples of such a solvent include terpene hydrocarbons such as pinene and limonene; paraffin hydrocarbons; phthalic acid diesters, etc., and by appropriately adding the solvent, controlled release by promoting diffusion and high concentration content And so on.

Examples of the filler include silica, mica, talc, stone powder, diatomaceous earth, clay, asbestos, and various other materials.

These fillers typically promote diffusion of the drug within the film substrate and facilitate desorption.

Further, in the present invention, the highly volatile component is volatilized by passing through the layer containing the low volatile component outside thereof. Therefore, the volatilization rate of the high volatility component inside is restricted by the thickness of the layer containing the low volatility component (outer layer). The intended purpose can also be achieved by applying the highly volatile component to the inner layer surface in contact with the outer layer, instead of containing it in the inner layer. Further, a highly volatile component can be prevented from evaporating inward by laminating a barrier film layer impermeable to the highly volatile component on the surface of the inner layer opposite to the surface contacting the outer layer.

Further, the amount of the chemicals added, the kneading method, the film forming and laminating method of the film and the like are not particularly limited and can be carried out in the same manner as in the past.

[Operation] In the present invention, when a layer having a high volatility component is contained in one layer and a layer having a low volatility component is contained in the other layer, and a layer containing a low volatility component is laminated on the outer side, The volatile component is released as it is or through the layer laminated or stuck on the outer side of the layer containing the low volatile component to the outside, but the high volatile component is separated into the layer containing the low volatile component. Since it passes through and volatilizes, its volatilization rate can be suppressed, and therefore, uniform volatilization of the components can be achieved as a whole.

[Examples] The present invention will be further described below with reference to Examples.

Example 1 Three kinds of 25 μm thick first polyolefin film containing 5% by weight of pyrethroids, 25 μm thick second polyolefin film containing 1% by weight of α-bromocinnamaldehyde, and 12 μm thick polyethylene terephthalate third film. The above films were laminated in this order to obtain a 72 μ thick laminated film.

When this laminated film was laid in a closet with the third film facing upward, the insect and mildew proofing effects were sufficient for about 2 months.

Comparative Example 1 50% by weight containing α-bromocinnamaldehyde
When a laminated film was obtained by laminating a μ-thick polyolefin first film and a 12 μ-thick polyethylene terephthalate second film, and laid in a closet with the second film facing upward, a mildew-proofing effect was observed for only one week. I couldn't.

Example 2 A lemon-based compounded fragrance was divided into two components, a highly volatile component (top note) and a low volatile component (middle note and end note), and two 25 μ thick polyolefin films containing 5% by weight of each component were prepared. The laminated film having a thickness of 50 μm, which was prepared and laminated, was attached to a window glass with the top note component film inside.

When left for 3 months, the scent of the lemon was slightly weakened, but the aroma was the same as the initial one.

Comparative Example 2 When a 50 μm-thick polyolefin film containing 5% by weight of a lemon-based compounded fragrance was attached to a glass window and left for 3 months, the fragrance was considerably weakened, and the fragrance tone also changed significantly, losing the lemoniness. Was there.

[Effect of the Invention] In the drug-containing laminated film of the present invention, volatilization of a highly volatile drug component is appropriately suppressed, so that it is possible to evenly disperse the drug component. It can be fully exerted for a long time.

Claims (3)

[Claims] 1. A highly volatile component of a drug or a highly volatile drug is contained in one layer, a low volatile component of the drug or another low volatile drug is contained in another layer, and A drug-containing laminated film, characterized in that a layer containing a volatile component or a low-volatile drug is laminated on the outside. 2. The drug-containing laminated film according to claim 1, wherein the highly volatile component and the low volatile component of the drug are fragrance components. 3. The low volatility drug is a pyrethroid drug, and the high volatility drug is an α-bromocinnamaldehyde antifungal agent.
A drug-containing laminated film according to item.