JPH0630202Y2 - Hollow fiber blood purification device - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial application] The present invention relates to a hollow fiber blood purification apparatus, and more specifically, it is easy to process the end portion of a hollow fiber bundle, and the end portion of the hollow fiber bundle is easy to process. The present invention relates to a hollow fiber blood purification device having a large sealing effect between a blood inlet / outlet member.

[Prior Art] FIG. 3 is a cross-sectional view of an end portion of a conventional hollow fiber blood purification apparatus.

As shown in the figure, the hollow fiber blood purification device 10 has a hollow fiber bundle 20 and a casing 30 that houses the hollow fiber bundle 20.

The hollow fiber bundle 20 is formed by bundling a plurality of hollow fibers 21.

The casing 30 is composed of a tubular casing body 31 with both ends open, and a pair of substantially cap-shaped blood inlet / outlet members 32 attached to both ends of the casing body 31, respectively. The blood lead-in / out member 32 is formed with a cylindrical blood lead-out inlet 33 protruding.

The vicinity of both ends of the hollow fiber bundle 20 is integrated by a sealant 22 filled in the gap between the hollow fibers 21, and
The casing main body 31 is integrally fixed inside both ends thereof.

Both ends of each hollow fiber 21 of the hollow fiber bundle 20 are open at end faces of both ends of the hollow fiber bundle 20.

The outer peripheral surfaces of both ends of the casing body 31 and the inner peripheral surface of the blood lead-in / out member 32 are joined and integrated by an adhesive 36 or ultrasonic waves, or by screwing.

FIG. 4 is a cross-sectional view near the end of another example of the conventional hollow fiber blood purification apparatus.

The basic configuration of this hollow fiber blood purification apparatus is substantially the same as that of the conventional hollow fiber blood purification apparatus described above.

However, in the hollow fiber blood purification apparatus 10 of this example, a ring-shaped projection 34 is formed inside the blood lead-in / out member 32.

When the blood inlet / outlet member 32 is fitted to the casing body 31, the ring-shaped protrusion 34 contacts the end surface of the hollow fiber bundle 20 so that blood flows only inside the protrusion 34.

[Problems to be Solved by the Invention] However, in the hollow fiber blood purification apparatus shown in FIG. 3, since the space 37 is formed at a position apart from the flow path of blood, the blood flows into this space 37. It was easy to stay in the space 37 and blood coagulation was easily formed in the space 37.

Further, in the hollow fiber blood purification apparatus shown in FIG. 4, the height of the ring-shaped projection 34 formed inside the blood inlet / outlet member 32 is too high, or the end of the hollow fiber bundle 20 is the casing body. If it protrudes too much from the end portion of 31, the connecting portion between the blood lead-in / out member 32 and the casing body 31 is reduced, and the attachment strength of the blood lead-in / out member 32 is reduced. Casing body 31
There was a risk of accidents such as blood leaking from the joint with.

When the height of the ring-shaped protrusion 34 formed inside the blood inlet / outlet member 32 is too low or the height of the portion of the hollow fiber bundle 20 protruding from the casing body 31 is too low, A gap is formed between the ring-shaped protrusion 34 and the end face of the hollow fiber bundle 20, blood leaks from this gap, and a space 38 formed outside the ring-shaped protrusion 34.
There was a risk that blood would accumulate in the blood and a coagulated product of blood would be formed there.

An object of the present invention is to provide a hollow fiber type blood purification device in which the end of the hollow fiber bundle can be easily processed and the sealing effect between the end of the hollow fiber bundle and the blood inlet / outlet member is great. is there.

[Means for Solving the Problems] The present invention for solving the above problems includes a tubular casing main body having both ends open, and a pair of blood inlet / outlet members respectively attached to both ends of the casing main body. A hollow fiber blood purification apparatus comprising: a casing main body, which stores the bundled hollow fiber bundles therein, and which fixes the hollow fiber bundles with a sealant in the vicinity of the opening of the casing body. An end portion of a sealant solidification portion obtained by fixing a bundle near the opening of the casing body is projected from the opening of the casing body, and an outer peripheral surface thereof is substantially the same as an inner peripheral wall surface of the blood inlet / outlet member. A hollow fiber blood purification apparatus characterized in that it is formed on an inclined taper surface.

[Operation] In the present invention, the sealant solidification portion obtained by solidifying the hollow fiber bundle with the sealant is slightly projected from the opening of the casing main body, and the outer peripheral surface of the projected sealant solidification portion is the inside of the blood lead-in / out member. Since it is formed on the tapered surface having substantially the same inclination as the peripheral wall surface, when the blood inlet / outlet member is attached to the opening of the casing body, the taper surface of the sealant solidification portion is attached to the inner peripheral wall surface of the blood inlet / outlet member. In close contact. Therefore, even if the blood inlet / outlet member is not tightly joined to the casing body with an adhesive, ultrasonic waves, or the like, the close contact or sealing property between the blood inlet / outlet member and the casing body is guaranteed. As described above, when the adhesiveness or the sealing property is ensured, an O-ring is provided to prevent leakage of blood from the mating portion of the blood inlet / outlet member and the sealant body, or the O-ring is attached to the O-ring. It is not necessary to provide an alternative protrusion inside the blood lead-in / out member. Therefore, problems such as blood retention and blood leakage caused by an improper relationship between the position of the O-ring or the protrusion and the position of the opening of the hollow fiber opening at the end surface of the sealant solidification portion are eliminated.

Further, as long as the outer peripheral surface of the sealant solidification portion is formed into a taper surface, the length of the sealant solidification portion protruding from the opening of the casing body does not need to be set strictly, and therefore, the sealant solidification portion after the formation of the sealant When the end faces of the solidified portion are cut and aligned, the complexity of precisely determining the cutting position is eliminated. In other words, there is a certain degree of freedom in cutting the sealant solidified portion, which facilitates manufacturing.

[Embodiment] Next, an embodiment of the present invention will be described with reference to the accompanying drawings.

FIG. 1 is a partial cross-sectional view showing a cross section of one end of a hollow fiber blood purification apparatus according to an embodiment of the present invention.

As shown in this figure, the hollow fiber blood purification device 10 includes a hollow fiber bundle 20 and a casing 30 that houses the hollow fiber bundle 20.
Have and.

The hollow fiber bundle 20 is formed by bundling a plurality of hollow fibers 21.

The casing 30 is composed of a tubular casing body 31 with both ends open, and a pair of substantially cap-shaped blood inlet / outlet members 32 attached to both ends of the casing body 31, respectively. The blood lead-in / out member 32 is formed with a cylindrical blood lead-out inlet 33 protruding.

The material forming the casing body 31 is appropriately determined in consideration of the pressure resistance because the casing body 31 is under pressure or pressure reduction.

Examples of such a material include polycarbonate,
Polystyrene, copolymer of acrylonitrile and polystyrene, polymethylmethacrylate, ABS resin, AB
Resins are preferred.

Further, other ordinary polymer materials and metal materials can be appropriately adopted depending on the purpose of use.

The vicinity of both ends of the hollow fiber bundle 20 is integrated by a sealant 22 filled in the gaps between the hollow fibers 21, and is also integrally fixed to both ends of the casing body 31 from the inside.

Both ends of each hollow fiber 21 of the hollow fiber bundle 20 are open at the end faces of both ends of the hollow fiber bundle 20.

The hollow fiber 21 is not limited according to its material and characteristics such as shape, but may be, for example, cellulose,
Cellulose diacetate, cellulose triacetate, etc., cellulose derivatives such as cellulose ethers, polyamide derivatives, polyester derivatives, methacrylic or acrylic polymers such as polymethylmethacrylate, polyvinyl polymers such as polyvinyl chloride, polyurethane, and Hollow fibers such as polyolefins such as polyethylene and polypropylene may be mentioned. The outer diameter of the hollow fiber is usually about 10 to 600 μm.

As the sealant 22, for example, a curable polymer composition for polyurethane resin, silicone resin, or epoxy resin can be used.

FIG. 2 is an enlarged view of part A of FIG.

As shown in the figure, the end portion of the hollow fiber bundle 20 is protruded from the end portion of the casing body 31 with a predetermined length.
3 is formed, and a taper is formed on the outer peripheral surface 24 of the projecting end portion 23.

The taper angle α (angle at which the axis of the casing body and the tapered surface intersect) is 5 to 30 °, preferably about 15 °.

Further, a contact surface 35 having a taper of the same inclination angle as the taper of the outer peripheral surface 24 of the protruding end portion 23 is provided on the inner peripheral side of the blood inlet / outlet member 32 at a portion facing the outer peripheral surface 24 of the protruding end portion 23. Has been formed.

The inner peripheral surface of the blood lead-in / out member 32 and the outer peripheral surface of the casing body 32 are joined and integrated by a joining means such as an adhesive 36. Note that the joining means is not limited to an adhesive, and sealing by ultrasonic waves, mechanical attachment by screwing, or the like can be appropriately adopted.

Next, a case of manufacturing this hollow fiber blood purification device will be described.

First, the hollow fiber bundle 20 is housed in the casing body 31.

After that, a liquid sealant is put into the casing body 31, and the casing body 31 equipped with a molding frame whose inner surface is formed in a truncated cone shape is rotated at high speed to remove the liquid sealant from the hollow fiber bundle 20 and the casing body 31. Move to the end side.

After the sealant is solidified, the above-mentioned molding frame is removed from the casing body 31.

At this time, since the inner peripheral surface of the molding frame is formed into a truncated cone shape, the hollow fiber bundle 2 solidified with the sealant 22 is formed.
The outer peripheral surface 24 of the protruding end portion 23 of 0 is formed as a tapered surface having a predetermined angle.

Next, the end of the hollow fiber bundle 20 is cut at a position closer to the casing body 31 than a position where the hollow fiber 21 is exposed or close to the outer peripheral surface 24 of the protruding end 23 (line a in FIG. 2, b, c).

The blood lead-in / out member 3 is attached to the end of the casing body 31.
Fit two.

Then, the outer peripheral surface of the end portion of the casing body 31 and the inner peripheral surface of the blood lead-in / out member 32 are joined and integrated with each other by the adhesive 36 or ultrasonic waves.

Here, the protruding length of the hollow fiber bundle 20 is determined by the blood lead-in / out member 3
Since 2 does not relate to the depth of fitting into the casing body 31, the outer peripheral surface 24 of the projecting end portion 23 of the hollow fiber bundle 20 and the contact surface 35 of the blood inlet / outlet member 32 are always in close contact with each other.

For example, whether the protruding end portion 23 of the hollow fiber bundle 20 is cut at the position a, the position b, or the position c,
The outer peripheral surface 24 of the protruding end portion 23 of the hollow fiber bundle 20 and the inner peripheral side contact surface of the blood lead-in / out member 32 are always in close contact with each other.

Therefore, blood does not leak from between the outer peripheral surface 24 of the projecting end portion 23 of the hollow fiber bundle 20 and the inner peripheral side contact surface of the blood inlet / outlet member 32. Moreover, the attachment strength of the blood lead-in / out member 32 does not become insufficient.

[Advantage of the Invention] According to the present invention, the protruding length of the hollow fiber bundle does not affect the mounting depth of the blood lead-in / out member. The need for strict control is eliminated, and the manufacture of the hollow fiber blood purification device is facilitated.

Further, conventionally, a bundle of hollow fibers is tightly bundled at the ends and then solidified with a resin so that the ends of the hollow fibers are inside the protruding ends, and the protrusions formed inside the blood inlet / outlet member are hollow fibers. Care had to be taken to lie outside the edges of the, but this invention eliminates such strict control.

That is, according to the present invention, even if the end face of the hollow fiber is opened to any of the end faces of the projecting end, there is no inconvenience such as retention of blood as in the conventional case.

In addition, since the present invention does not have a structure in which a protrusion is formed on the inside of the blood inlet / outlet member, the end of the hollow fiber can be solidified in a considerably expanded state, and thus a space for blood to be retained is formed. It will not be done.

In addition, since the blood inlet / outlet member is joined to the outer peripheral surface of the protruding end, that is, the tapered surface, the adhesion and sealing properties are good, and the sealing effect is large.

[Brief description of drawings]

FIG. 1 is a partial sectional view showing an embodiment of the present invention, FIG. 2 is an enlarged view of a portion A of FIG. 1, and FIGS. 3 and 4 are partial sectional views of a conventional hollow fiber blood purification apparatus. is there. 10 ... Hollow fiber blood purification device, 20 ... Hollow fiber bundle, 21 ...
Hollow fiber, 22 ... Sealant, 23 ... Projection end part, 24 ... Outer peripheral surface, 30 ... Casing, 31 ... Casing body, 32
... blood inlet / outlet member, 33 ... blood outlet / inlet, 34 ... protrusion,
35 ... Adhesive surface, 36 ... Adhesive.

Claims (1)

[Scope of utility model registration request] 1. A hollow fiber bundle bundled in the casing body, comprising: a tubular casing body having both ends open; and a pair of blood inlet / outlet members respectively attached to both ends of the casing body. And a hollow fiber type blood purification device in which the hollow fiber bundle is fixed near the opening of the casing body with a sealant, wherein the hollow fiber bundle is fixed near the opening of the casing body. A hollow characterized in that the end of the solidified portion is projected from the opening of the casing main body, and the outer peripheral surface thereof is formed into a tapered surface having substantially the same inclination as the inner peripheral wall surface of the blood inlet / outlet member. Thread type blood purification device.