JPH06287136A - Ascites preventive agent for broiler and method for preventing ascites - Google Patents

Abstract

(57) [Summary] [Purpose] To effectively prevent ascites from broilers and improve the growth rate. [Structure] A composition containing a quinone represented by Chemical formula 1 as an active ingredient is administered to a broiler chicken. [Chemical 1] However, in the chemical formula 1, Y and Z are H, CH ₃ , or C ¹
Represents one of the double bonds between C ² and C ² , and n is 1
Represents an integer of -11.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an agent for preventing ascites from broilers, a growth rate improving agent, and a method for preventing ascites and improving the growth rate using these agents.

[0002]

2. Description of the Related Art In the broiler industry, in order to increase the productivity of broilers quickly and greatly in order to improve productivity,
We have been researching and developing breeding and breeding methods for the strains used. However, as a result of these researches and developments, the gain rate of broiler increased significantly, but this increase rate was not accompanied by the improvement of heart function, and the oxygen demand of broiler increased especially in winter or high altitude. Under the condition, it has become known that the heart is burdened and heart failure is accompanied by ascites.

The occurrence of this ascites causes adverse effects such as a lower broiler breeding rate and a lower weight gain, and has been regarded as a problem from around 1978, and this is still a great economic blow to the broiler industry. There is.

Conventionally, in order to prevent such ascites, measures have been taken such as changing the structure of the poultry house and appropriately controlling the temperature in winter in order to prevent the oxygen demand of the broiler from increasing. However, they have a problem that they are costly and economically heavy.

Therefore, there has been a demand for the development of an ascites-preventing agent for broilers that acts on broilers more economically and directly to prevent ascites, but a drug effective for ascites is still unknown. Not not.

By the way, quinones, such as ubiquinone (also called coenzyme Q), have been conventionally tried to be added to and fed to broiler feed. For example, British Patent Publication No. 918409 discloses that for the first 5 weeks of breeding, coenzymes Q _{2 to} Q ₁₀ are added to the broiler breeding feed in an amount of 1 to 1.
There is a report that 100 mg / kg is added to feed and improve weight gain. In addition, JP-A-50-82219 reports that a combination of α-tocopherol and coenzyme Q ₇ improves the egg laying rate.

However, each of these is before the problem of ascites, and is based on the effect of increasing the weight of broilers or improving the egg laying rate, and does not relate to the effect of preventing broiler ascites. Absent.

[0008]

SUMMARY OF THE INVENTION The present invention has been made from the above viewpoint, and it is an object of the present invention to provide a drug and a feed which can effectively prevent ascites disease of broilers and improve the growth rate. To do.

[0009]

Means for Solving the Problems As a result of intensive studies to solve the above-mentioned problems, the present inventor, when quinones were administered to broilers, prevented ascites from broilers and promoted the growth rate. This has led to the completion of the present invention.

That is, the present invention is an ascites-preventing agent for broilers containing the quinones represented by Chemical formula 2 as an active ingredient.

[0011]

[Chemical 2] However, in Chemical formula 2, Y and Z represent H, CH ₃ , or ^one covalent bond of the double bond between C ¹ and C ² , and n is 1 to 1
Represents an integer of 11. The present invention also provides a growth rate improving agent for broilers containing the quinones as an active ingredient, and a broiler containing one or more selected from these ascites disease preventing agents for broilers and growth rate improving agents for broilers. Provide forage. Furthermore, the present invention prevents the ascites disease of the broiler by administering the composition containing the quinone to the broiler at a rate of 0.05 to 50 mg / kg of body weight per day as the amount of the quinone, thereby preventing the growth rate. Provide a way to improve.

In the present invention, "improvement of growth rate" means
This means reducing the mortality rate during breeding and increasing the proportion of growing individuals. Hereinafter, the present invention will be described in detail. The ascites-preventing agent for broilers or the growth rate improving agent for broilers of the present invention contains, as an active ingredient, one or more of the compounds represented by the above Chemical Formula 2 (hereinafter, simply referred to as “quinones”). Among the quinones, ubiquinone in which Y and Z in the above Chemical Formula 2 represent a covalent bond between C ¹ and C ² and has a double bond between C ^{1 and} C ² is preferable, and n is 8 coenzyme Q _{1 0} enzyme Q ₉ and of 2 in which n is 9 in the present invention, particularly preferred.

Ubiquinone includes filamentous fungi such as Mucor and Mortierella, yeasts such as Candida and Saccharomyces, Pseudomonas, and Achromobacter.
It can be obtained by extraction and purification from bacteria such as Rhodopseudomonas or from ubiquinone-containing substances such as tobacco leaves, peach oil, malt oil and the like. In addition, quinones can be obtained by chemical synthesis, and commercially available products may be used.

The dosage forms of the ascites-preventing agent for broilers and the growth rate improving agent for broilers of the present invention are not particularly limited, and may be one kind of quinones or a mixture itself of two or more kinds,
These may be used as a composition together with diluents, carriers, excipients and the like that are harmless to breeding. Further, the crude product obtained from the above-mentioned quinone-containing material or the quinone-containing material may be used as it is when the quinone content is high. The broiler feed of the present invention can be obtained by adding these to the feed usually used for breeding broilers.

As a method of administering the ascites-preventing agent for broilers, the growth rate improving agent for broilers, or the feed for broilers, either oral or parenteral can be selected, but oral administration is preferred. With regard to the dose, in oral administration, the desired effect can be expected when the amount of quinones is 0.05 to 50 mg / kg body weight per day. The administration time and period are not particularly limited, either.
It is more effective when administered to broilers after 4 weeks of age, and particularly effective when administered continuously for 4 weeks or more.

The broiler chicken species which can use the ascites disease preventing agent for broilers, the growth rate improving agent for broilers, and the feed for broilers of the present invention are not particularly limited.

[0017]

[Function] When the oxygen demand of the broiler increases, the hematocrit value increases and the energy demand of the heart increases,
It causes cardiac congestion and concurrent ascites. When the agent for ascites for broiler of the present invention is administered to a broiler, especially a broiler with a high oxygen demand, it is presumed that the energy requirement of the heart is satisfied, ascites is prevented, and as a result, the growth rate is improved. .

[0018]

EXAMPLES Examples of the present invention will be described below.

[0019]

[Example 1] First, as an example of an ascites-preventing agent for broilers, a growth rate improving agent for broilers, and a feed for broilers, feed containing ubiquinone will be described.

The ingredients shown in Table 1 were mixed to prepare an ascites inhibitor for broilers containing 20 ppm of coenzyme Q _{9 based} on the total feed amount. Similarly, as a comparative example, a feed containing α-tocopherol instead of coenzyme Q was produced.

[0021]

[Table 1]

In Table 1, the vitamin ADE agent contains 10000 IU / g vitamin A and 200 vitamin D ₃ .
0 IU / g, the vitamin E contained 10 IU / g, vitamin B agent, vitamin B ₁ 2 g / kg, vitamin B ₂ 1
0 g / kg, vitamin B ₆ 2 g / kg, nicotinamide 2 g / kg, calcium pantothenate 4 g / k
g, choline chloride 120 g / kg, iodic acid 1 g / kg
contains. The trace minerals are Mn 8.0%, F
0.6% e, 0.06% Cu, 0.1% I, Zn
5.0% is contained. Salinomycin is an anticoccidial agent and Virginiamycin is an antibiotic.

[0023]

Example 2 Next, an example of a method for preventing ascites and improving the growth rate will be described. Example 1 and Comparative Example 1
The ascites preventive agent for broilers of the present invention and the method for preventing ascites were evaluated by administering the above feed to a broiler.

<Administration Method> One-day-old male chickens of 100 chickens per group were bred in a windless poultry house for 56 days.
As for the breeding conditions, the temperature for raising chicks is a condition that easily induces ascites, that is, a cold sensitization period of 5 ° C. or lower from 14th to 21st days after the start of breeding, and 21 to 2 at other periods.
It was set and controlled within the range of 6 ° C. Table 2 shows the temperature during the breeding period.

[0025]

[Table 2]

For the first 21 days, all the broilers were fed with the normal feed having the composition shown in Table 3, and for the next 35 days, one group was fed with the feed of the Example and the other one group was compared with the feed. The animals were fed with the example feed.

[0027]

[Table 3] In Table 3, the same vitamin ADE agent, vitamin B agent, and trace minerals as those used in Example 1 were used.

<Evaluation> For broilers that died during the breeding period, the cause of death was investigated, and the incidence of ascites in each group was determined. After the breeding period was completed, the number of surviving broilers in each group was examined to determine the breeding rate. In addition, the body weight was measured and the average value thereof was calculated, and the value of the feed intake recorded during the rearing period was calculated for each body weight, which was used as the feed conversion rate. Table 3 shows the results of comparing the two groups with respect to the above values.

[0029]

[Table 4]

As is clear from these results, the broilers to which the ascites-preventing agent for broilers of the present invention was administered showed α
-The incidence of ascites is very low and the breeding rate is high compared to broilers administered tocopherol. Also, he gains weight effectively with less feed.

[0031]

The ascites preventive agent for broilers of the present invention comprises:
Ascites of broilers can be effectively prevented, the growth rate can be improved, and the growth promoting effect and feed efficiency can be improved.

Claims (6)

[Claims] 1. An ascites inhibitor for a broiler containing the quinone represented by Chemical formula 1 as an active ingredient. [Chemical 1] However, in chemical formula 1, Y and Z represent H, CH ₃ , or ^one covalent bond of the double bond between C ¹ and C ² , and n is 1 to 1
Represents an integer of 11. 2. The anti-ascites agent for broilers according to claim 1, wherein n in formula 1 is 8 or 9. 3. A growth rate improving agent for a broiler containing the quinone represented by the chemical formula 1 as an active ingredient. 4. A feed for broilers containing one or more selected from the ascites-preventing agent for broilers according to claim 1 or 2 and the growth rate improving agent for broilers according to claim 3. 5. The composition containing the quinones represented by the chemical formula 1 is used in an amount of 0.05 to 5 per day as an amount of quinones.
A method for preventing ascites from broilers and improving the growth rate by administering to broilers at a rate of 0 mg / kg body weight. 6. The ascitic fluid of a broiler according to claim 5, wherein at least one selected from the ascites disease preventing agent for broilers, the growth rate improving agent for broilers and the feed for broilers is administered to broilers after 4 weeks of age. Prevent the disease,
A method to improve the growth rate.