JPH0624951A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:To obtain a composition for oral cavity, capable of suppressing and improving inflammation of the gingiva and producing excellent effects on prevention of pyorrhea alveolaris and gingivitis. CONSTITUTION:This composition for oral cavity is characterized by preserving a raw leaf of green tea under anaerobic conditions, then subjecting the preserved raw leaf of the green tea to steam heating and/or drying treatment, pulverizing the resultant leaf of the green tea and blending the prepared powder therein.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition having an excellent anti-inflammatory effect on gingiva.

[0002]

2. Description of the Related Art Conventionally, caries, that is, dental caries, has been commonly associated with sucrose, which is present in the mouth.
It is said to occur due to the overlapping of three conditions of oral bacteria and tooth quality, and its mechanism is considered as follows. That is, sucrose contained in food and drink produces glucan, which is a sticky / insoluble polysaccharide, under the action of glucosyltransferase, which is an enzyme secreted by Streptococcus mutans present in the oral cavity. In addition to the formation of plaque, the bacteria in the plaque decompose sugars to produce acid, which decalcifies the enamel surface of the tooth and promotes caries. In addition, due to the rapid progress of the aging society in recent years, the disease rate of so-called periodontal disease has increased, and it is an urgent need to prevent it.

Periodontal disease refers to all the diseases that occur in the tissues around the teeth, and unless proper care such as tooth brushing is performed, inflammation becomes chronic, and the tissues supporting the teeth are destroyed, eventually Will lose teeth. This periodontal disease has various types of disease that appear depending on the progress of the medical condition and the age of the patient. First of all, plaque and tartar adhere to the surface of the hairline, causing the gums surrounding the tooth to swell and become red and inflamed.
If this inflammation continues for a long time, a gap is created between the teeth and gums, forming a so-called periodontal pocket, and further progressing causes the alveolar bone at the bottom to gradually disappear. This periodontal disease is a chronic inflammation that progresses without pain and without subjective symptoms, but is often accompanied by bleeding from the gums, swelling of the gums, bad breath, and the like.

Conventionally, anti-inflammatory agents such as glycyrrhizin, ε-aminocaproic acid, vitamin Es, allantoin, and hinokitiol have been used as oral compositions for dentifrice etc. to improve gingival inflammation in such periodontal diseases. Although they are mixed, their anti-inflammatory effects are insufficient, and the above problems have not been solved yet.

The present inventors have conducted intensive studies in view of the above problems, and as a result, have found that an excellent anti-inflammatory effect can be obtained by incorporating a ground tea leaf product preserved under anaerobic conditions. The invention has been completed, and an object thereof is to provide an oral composition capable of suppressing inflammation of the gingiva and having an excellent effect in preventing alveolar pyorrhea and gingivitis.

[0006]

The composition for oral cavity of the present invention which achieves the above object is obtained by subjecting fresh tea leaves to a preservation treatment under anaerobic conditions, followed by a steam heating treatment and / or a drying treatment. It is characterized by blending powder obtained by crushing tea leaves.

The details of the configuration of the present invention will be described below. The ground tea leaves according to the present invention are, for example, 3 hours at room temperature after air is sufficiently replaced with an inert gas such as carbon dioxide gas or nitrogen gas in a container containing freshly picked tea leaves and the container is hermetically closed. After being left as it is (tea leaves are preserved under anaerobic conditions), the tea leaves are steam-heated for 10 to 30 minutes,
It can be naturally dried or put in a dryer at 80 ° C. or higher for 5 hours or more to dry, and then powdered by a pulverizer.

The powder obtained in this way has a γ-
The content of aminobutyric acid is high, and the oral composition of the present invention in which the aminobutyric acid is mixed, together with the blood circulation promoting action of the gum, theophylline having a peripheral vasodilatory action contained in the extract, and a peripheral nerve stimulating action Caffeine, which has the effect of strengthening peripheral blood vessels, and flavonoids, which have anti-inflammatory effects, act synergistically to activate the periodontal tissue in the oral cavity, rapidly promote blood circulation, and significantly develop anti-inflammatory effects, and asparagine. The moisturizing action of amino acids such as acids, glutamic acid, alanine, serine, glutamine, and arginine exerts a mild action on the oral cavity.

The storage time of tea leaves under anaerobic conditions is usually 3 hours or longer at room temperature (25 ° C.), preferably 5 hours or longer, more preferably 8 hours or longer, but should not exceed 24 hours. It is preferable. Also, 1 tea leaves
After steam heating for 0 to 30 minutes, it is naturally dried or dried in a dryer at 80 ° C. or higher for 5 hours or longer to obtain stable tea leaves. If the storage time is short, the production of γ-aminobutyric acid or the like is not sufficient, and if the steam heating time and the drying time are insufficient, a stable ground tea leaf product cannot be obtained, and in any case the above-mentioned oral blood flow promotion of the purpose is promoted. , The anti-inflammatory effect is difficult to fully develop, and it is invincible.

The tea leaves used in the present invention are Yabukita seeds,
It can be applied to any variety such as Beni Fuji species, and the plucking time is not particularly limited.

In the present invention, the blended amount of the pulverized product of tea leaves obtained by performing the above treatment is 0.005 to 10% by weight based on the total amount of the oral composition as a solid component.
And preferably 0.01 to 3% by weight. If it is less than 0.005% by weight, the anti-inflammatory effect in the oral cavity aimed at by the present invention does not appear as expected, and if it exceeds 10% by weight, the effect commensurate with the increase cannot be expected. Not economically desirable.

Examples of the oral composition according to the present invention include toothpaste, powdered toothpaste, troches, pasta, and coating agents. In addition, chewing gum, candy, gummy candy, candy and the like can be mentioned.

The other compounding ingredients of the present invention are appropriately selected according to the kind of the oral composition. For example, in the case of toothpaste,
Calcium carbonate, which is commonly used as an abrasive,
Examples thereof include magnesium carbonate, dicalcium phosphate, tricalcium phosphate, magnesium phosphate, silica, zeolite, sodium metaphosphate, aluminum hydroxide, magnesium hydroxide, calcium pyrophosphate, red iron oxide, and calcium sulfate.

Further, a binder such as carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose, alginate, carrageenan, gum arabic, polyvinyl alcohol, methyl cellulose, magnesium oxide, alumina sol, calcium silicate, pectin, guar gum, kaolin, xanthan gum, etc.,
Blowing agents such as sodium lauryl sulfate, sodium dodecylbenzene sulfonate, sodium lauroyl sulfoacetate, sodium N-lauryl sulfonate, sodium N-lauroyl sarcosinate, sucrose fatty acid ester, polyoxyethylene sorbitan, and alkylolamide are used. It

Further, sweeteners such as sodium saccharin, stevisite, glycyrrhizin, chalcone, dihydrochalcone, moisturizers such as glycerin, sorbitol, propylene glycol, polyethylene glycol, chrysitol, dipropylene glycol, sodium lactate, maltitol, paraoxybenzoic scent. Preservatives such as acids, peppermint, spearmint essential oils, fragrances such as l-menthol, other aluminum lactate, edetate, pigments, BHT, etc. are used, and if necessary, other active ingredients such as lysozyme chloride, dextrase, Lytic enzyme, mutanase, sorbic acid, alexidine, cetylpyridinium chloride, alkylglycine, sodium chloride, allantoin, ε-aminocaproic acid, tranexamic acid, azulene, sodium fluoride, Fluoride such as sodium monofluorophosphate, isopropylmethylphenol, polyethylene glycol, polyvinylpyrrolidone, glycyrrhizin, glycyrrhizic acid, hinokitiol, vitamin E
Etc. can also be used. In addition, these components are mixed with water,
It is manufactured according to a conventional method. Also, in lozenges, chewing gum, candy, gummy candies, etc.,
Ingredients are appropriately mixed according to the properties of the product.

[0016]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. (Method for producing tea leaf extract treated under anaerobic conditions) 500 g of freshly harvested tea leaves was placed in a vacuum desiccator containing 2 liters, a porcelain porous plate was placed on the desiccator, and the lid was sealed with a grease-coated lid. After making the vacuum, connect it to a nitrogen cylinder and allow nitrogen to flow into the container. When the pressure inside the container reached 0.8 atm, stop the flow of nitrogen and leave it at room temperature 25 ° C for about 10 hours. did. Then, the tea leaves treated under anaerobic conditions were taken out of the container, put in a steamer, steamed with steam for 30 minutes, spread on a dry towel, and left in a room at 25 ° C for 2 days and nights to be naturally dried.

100 g of the tea leaves thus obtained were pulverized by a fine pulverizer and a freeze pulverizer and sieved to obtain an 80 mesh pass product. Table 1 shows the results of the component contents of the ground tea leaves obtained by this production method.

[0018]

[Table 1]

Example 1 Toothpaste A toothpaste (Example 1) containing the composition of Table 2 and the ground tea leaves obtained by the above-mentioned production method and a toothpaste of Comparative Example (Comparative Example 1) were prepared by a conventional method. The inflammatory changes in the gingiva were observed by adjusting and continuously using the following method.

[0020]

[Table 2]

(Continuous Use Test Method) A continuous use test for 4 weeks was carried out on 20 persons who had periodontal disease on the upper part of the upper jaw and the lower part of the lower jaw. About 10 g of the toothpaste of Example 1 was applied to a toothbrush twice a day for 10 people, and the toothpaste of Comparative Example 1 was similarly used for the remaining 10 people.
At the time of use, the same toothbrush was used by all 20 people, and the brushing method was also explained so that the same conditions were achieved as much as possible. Then, gingival redness, gingival swelling, and gingival bleeding were observed before and after the test. The results are shown in Table 3.

[0022]

[Table 3]

From these results, it becomes clear that the composition for oral cavity of the present invention (toothpaste) is superior in all of the various properties to the composition of Comparative Example.

Example 2 Toothpaste A toothpaste of the present invention was obtained with the composition shown in Table 4 by a conventional production method.

[0025]

[Table 4]

Example 2 Toothpaste Toothpaste of the present invention was obtained with the composition shown in Table 5 by a conventional production method.

[0027]

[Table 5]

Example 4 Chewing gum A chewing gum of the present invention was obtained with the composition shown in Table 6 by a conventional production method.

[0029]

[Table 6]

Example 5 Oral pasta Oral pasta of the present invention was obtained by the usual production method using the composition shown in Table 7.

[0031]

[Table 7]

Example 6 Candy A candy of the present invention having the composition shown in Table 8 was obtained by a conventional production method.

[0033]

[Table 8]

Example 7 Gummy candy With the composition shown in Table 9, a gummy candy of the present invention was obtained by an ordinary production method.

[0035]

[Table 9]

1 of each of the oral compositions of Examples 2 to 7 above
As a result of being used by 0 subjects for one month, an improvement effect on redness of gingiva, swelling of gingiva, bleeding of gingiva, etc. was observed.
Moreover, no discomfort such as bitterness was felt during use.

[0037]

As described above, the present invention has an excellent effect of improving inflammation associated with gingival redness, swelling, bleeding, etc.
Furthermore, it is clear that the present invention provides a useful oral composition which is effective in preventing alveolar pyorrhea, gingivitis and the like.

Claims (1)

[Claims] 1. After storing fresh tea leaves under anaerobic conditions,
A composition for oral cavity, which comprises blending powder obtained by pulverizing tea leaves obtained by steam heating treatment and / or drying treatment.