JPH06228013A - X-ray contrast composition for digestive tract - Google Patents

Abstract

PURPOSE:To obtain an X-ray contrast composition for digestive tracts, having high safety, easily swallowable and giving a clear X-ray image in contrast with conventional contrast agent composed of barium or iodine compound. CONSTITUTION:The contrast composition for digestive tracts for radiography is composed of a component containing nonmetallic elements having atomic number of <=8 (e.g. H, C, O and N) as main constituent elements. The composition is preferably produced by compounding 1-99% carbohydrates and 99-1% proteins in such a manner as to get a composition having a lipid content of <=0.5% and a density of 1.10-1.30g/cm<3>. The carbohydrate and the protein may be pure substances or a food rich in those substances, e.g. a food rich in carbohydrate (e.g. honey, starch syrup, reduced oligosaccharide, starch, sweet potato, potato and fruit) or a food rich in protein (e.g. kwalk, fresh cheese, various cheeses, defatted milk and concentrated whey protein).

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is directed to X-ray-C for the purpose of diagnosing digestive tract imaging effects and abdominal diseases by X-ray method.
The present invention relates to a composition having an excellent contrast effect in T image capturing, such as food and drink and a contrast agent.

[0002]

2. Description of the Prior Art Contrast agents for X-rays are used mainly for the purpose of observing the morphology of a living body by blocking the transmission of X-rays and projecting the shadows on the film. Therefore, usually X
The line contrast agent is composed of a compound composed of an element having a large atomic number, which makes it difficult for high-energy X-rays having a short wavelength to pass therethrough,
Moreover, the compound is a substance that is less toxic to the living body. Elements with a large atomic number are usually not essential elements for living organisms. Alternatively, when the element is essential, the required amount is extremely small, and when it is in excess, it is toxic. Therefore, since compounds used as general contrast agents are used in a form that is not absorbed by the living body, they are usually barium sulfate ( ⁵⁶ Ba) or iodine ( ⁵³ I).
Used in indigestible and non-absorptive forms such as compounds ("Chemical Encyclopedia 9" Kyoritsu Publishing (Sho 43-1-20)
p. 727-728).

On the other hand, as a development of the conventional contrast agents using barium and iodine compounds, elements having an atomic weight of 24 to 66, that is, elements corresponding to Zn having an atomic number of 12 to 30 have been used. A contrast agent for the digestive tract composed of the water-soluble metal compound used (patent: published patent publication Sho 63-502987) has been studied.

[0004]

In the abdominal region, digestive organs, urinary organs, reproductive organs, blood vessels, lymph vessels, nerves, soft tissues, bones and the like are intricately complicated. In order to clearly distinguish these from each other and improve the diagnostic accuracy, a means such as using a contrast medium to emphasize the lesion or facilitating the distinction between the digestive tract and the target organ is used.

In recent years, the X-ray CT method (Computed Tomography), which has seen rapid development, is a computerized image of the X-ray permeability of a living tissue and is visualized as a grayscale image. It is a powerful medical diagnostic system that is indispensable today. In its clinical use, it plays an important diagnostic role particularly in the abdominal region, not to mention the speed and accuracy of disease diagnosis.

However, when a barium preparation that is usually used for gastrointestinal tract imaging is used for diagnosis by the X-ray-CT method, the contrast agent is too concentrated, resulting in high brightness and artifacts (false images) during X-ray photography. It occurs and is not suitable. On the other hand, when used thinly, the viscosity is insufficient and sedimentation occurs. Further, the intestinal wall is not filled and causes an artifact, which is unsuitable as a contrast agent. Therefore, a study on the improved contrast of the digestive tract contrast agent mainly composed of conventionally used iodine compounds and barium sulfate preparations has been reported (Tatsuya Yamada et al .: The Journal of Japanese Medical Society, 48.
(11), 1381 to 1390, 1988, Michio Kono et al .: Basic and clinical, Vol. 25, No. 14, Nov.
91, p381-394).

However, these conventionally used components of the contrast agent are unnecessary components for the living body, and therefore, they are administered in a form that the living body does not digest and absorb, and finally excreted. Furthermore, these iodine compounds are difficult to swallow due to their taste and smell, and also cause nausea, vomiting, diarrhea,
Side effects such as allergies may be seen. In addition, general contrast media containing barium element as a main component cause symptoms such as diarrhea, abdominal pain and constipation. Therefore, it is necessary to replenish a large amount of water and administer a laxative after administration of the barium contrast agent.

[0008]

The contrast agent for digestive tract diagnosis must be a substance that can be clearly distinguished from other tissues in the living body. In particular, the contrast agent for digestive tract diagnosis is required to be a substance whose boundary with the wall of the digestive tract is clear. In addition, since the contrast agent for digestive tract diagnosis is orally ingested, the biotoxicity of its components is extremely important. Therefore, it is desirable that the components are composed of food components, and it is desirable to carry out examinations such as diagnosis or health examination for patients. It is also very important that the subject is easy to drink without giving stress to the subject.

Therefore, the present inventors have proposed a novel type of digestion that has not been used so far, which does not use barium or iodine compounds, which have many drawbacks, and is safe, easy to ingest, and effective. We decided to develop a contrast agent for tube diagnosis. And, compared to the conventional technology level that was caught by elements with a large atomic number such as barium and iodine and that food ingredients etc. could not be used at all, a major shift in idea was made, and food ingredients that were not prioritized at all I dared to pay attention to the new idea of bringing the technical field of food products into the technical field of contrast agents.

As a result of focusing on food components according to such a new idea, it is shown that the bones are expressed white in normal X-ray images (positive effect), and conversely, olive oil is black to gray (negative effect). For the first time, I paid attention to the points expressed in, and got the idea that food ingredients can be used for the first time. Therefore, we took a new viewpoint that it is composed of food ingredients without being bound by elements with large atomic numbers such as barium and iodine that have been used conventionally. As a result of screening a huge number of food components, attention has been paid to high-density substances composed of carbohydrates and proteins.

A high-concentration composition or a high-calorie composition (1 kcal to 1.5 kcal / m) for nutritional supplementation
The liquid food or the high-concentration nutritional component that is drunk as l) is composed of carbohydrates, proteins and lipids, which are the three major nutritional components, and its density is 1.02 to 1.1.
Since it is 0 g / cm ³ , an X-ray contrast effect cannot be expected. Therefore, in order to obtain a high-density composition, lipids, which are one of the three major nutritional components, are reduced to reduce carbohydrates such as honey, starch syrup, oligo-reducing sugars, fruits or concentrated juice thereof, and proteins such as fresh cheese and whey protein. , Etc. as the main component, and by combining various food components of different composition with general liquid foods or high-concentration nutrients, the specified density (1.10
The present invention has been completed by discovering a novel contrasting composition having a concentration of ˜1.30 g / cm ³ ) for contrasting purposes.

The gastrointestinal tract imaging composition according to the present invention comprises a component whose main constituent element is a nonmetallic element having an atomic number of 8 or less. Therefore, in the present invention, it is not an element having a large atomic number such as barium (atomic number 56) or iodine (atomic number 53), but a non-metallic element having an atomic number of 8 or less, such as carbon (atomic number 6) and hydrogen (the same). 1), oxygen (same as 8), nitrogen (same as 7) and the like are used. Carbohydrates and proteins are components composed of these elements, and many are available as foods and drinks.
Here, a new type of contrast agent that uses food and drink has been developed.

In the composition of the present invention, it is preferable that the main component is a carbohydrate and a protein, and 1 to 1
99%, protein about 99-1%, lipid 0.5
%, And the amount of lipid distributed is preferably small.
It is for obtaining a high-density composition as described below.

Since the composition according to the present invention is required to have a density of 1.10 to 1.30 g / cm ³ for use as a contrast agent, it is necessary to use a carbohydrate so as to obtain such a high density. The composition may be prepared by appropriately changing the kind and the amount of the protein or the protein.

The carbohydrates and proteins may be pure ones, but foods having a high content of these may also be used. Non-limiting examples of foods rich in carbohydrates include: honey, starch syrup, oligo-reducing sugar, starch, modified starch, sweet potato, potato, fruits, concentrated juice, and others. Non-limiting examples of foods with high protein content are: quark, fresh cheese, various cheeses, skim milk, whey protein concentrate (WPC), whey protein isolate (WPI), various dairy products. , And others.

The composition according to the present invention is adjusted to a predetermined density by adding water to these compounding ingredients if necessary, and then CT
It may be administered orally before photographing. Since this composition is originally a food or drink, it is not only extremely easy to take, but also has an excellent contrast effect, and, like barium, there is no side effect if no laxative is further administered after administration, and there is no safety at all. It is natural that there is no problem.

[0017]

[Function] When quark with high protein content, fresh cheese, etc. and honey containing a lot of carbohydrates, starch syrup, oligo-reducing sugars, fruits or concentrated juice thereof are used, the pH is lowered to around 4 and becomes relatively gastric juice. It has a close pH. Therefore, since the secretion of digestive juice due to the stimulation of the digestive tract is small and the high density composition can be maintained, the contrast effect for X-rays is exhibited. Furthermore, the acidification of the composition can be homogenized by soft-carding the protein before it is administered into the stomach, which prevents the heterogeneity of the contrast image due to a new protein aggregation phenomenon due to gastric acid secretion. To do.

[0018]

Example 1 Assuming tomography of the body of a body, about 200 ml of the prepared contrast medium composition (Table 1 and Table 2 below) was put in a polyethylene container (diameter 6 cm, height 9 cm) and laid down sideways. Then, the band was fixed with a band, and CT imaging (tube voltage: 120 kV, tube current: 25
0 mA).

The quark used was prepared as follows.
After sterilizing skim milk by heating, Lacto is used as a starter.
bacillus bulgaricus, Strep
Tococcus thermophilus was added according to a conventional method, and after fermentation at about 40 ° C., the mixture was stirred and cooled (pH 4.0 ± 1) and sterilized by heating. Then, after concentration by centrifugation to remove whey, the mixture was homogenized and cooled to obtain quark. As other ingredients, commercially available honey (carbohydrate content: 80%), dextrin (pharmaceutical listing),
Apple concentrated fruit juice (1/6 concentrated), maltooligosaccharides (solid content 70%, water content 30%, sugar composition; 1 sugar 2-4%, 2 sugars 7
-10%, 3 sugars 9-11%, 4 sugars or more 75-80%),
Sweet potatoes and bananas were used.

[0020]

[Table 1]

[0021]

[Table 2]

As is clear from the above results, as the density of the composition increased, the X-ray-CT image showed a positive effect of becoming whiter. Therefore, the dense solution containing carbohydrates and proteins as main components was It was found to function as a contrast agent.

Further, CT imaging was performed by placing the above-mentioned object on the upper abdomen. When the X-ray-CT brightness was compared with that of living tissue, the results shown in Table 3 below were obtained.

[0024]

[Table 3]

As is clear from the above results, in particular, an equal mixture of high protein and high density quarg and high carbohydrate and high density honey has a sufficient brightness to be distinguished from each organ in X-ray CT images. It showed a positive effect.

[0026]

[Example 2] Fresh cheese (a component obtained by removing whey from fermented milk, protein content: 13%, carbohydrate content: 5%) and honey (the same product as in Example 1) were used, and the density was 1.20 g.
X-ray of the body when 400 ml of an X-ray contrast composition prepared by adding water so that the dose becomes / cm ³ was administered for the purpose of contrast-
CT tomographic image (tube voltage: 120 kV, tube current: 250 m
A) is shown in FIG.

The contrast composition in the stomach is expressed in white, which makes it easy to observe the morphology of the stomach and clarifies its distinction from other organs, and the gastrointestinal contrast effect of the composition according to the present invention is extremely effective. Met.

[0028]

[Example 3] Dextrin-concentrated juice solution Dextrin (Pharmaceutical listed product) ... 100 g Orange concentrated fruit juice (1/5 concentration) ... 70 g Fresh cheese (the same product as Example 2) 30 g Prepared by adding water to 300 ml (density: 1.
18 g / cm ³ ).

[0029]

[Example 4] Fresh cheese / concentrated juice solution Fresh cheese (same product as in Example 2) / 270 g Apple concentrated fruit juice (1/6 concentration) ........................ 100 g of water was added to make 400 ml ( Density: 1.
12 g / cm ³ ).

[0030]

[Example 5] Oligosaccharide / concentrated fruit juice solution Malto- oligo reducing sugar (the same product as in Example 1) 80 g Grape concentrated fruit juice (1/6 concentration) ... 80 g Fresh cheese (the same product as in Example 2) -80 g Prepare by adding water to 300 ml (density: 1.
15 g / cm ³ ).

[0031]

INDUSTRIAL APPLICABILITY According to the present invention, by using carbohydrates and proteins which are food ingredients and comprising an aqueous solution component which does not contain lipids as much as possible, a high density composition is obtained, which is excellent in X
A contrast effect in line image capturing can be obtained. In addition, since it is composed of food ingredients, it is possible to use various materials, and it is possible to administer a patient and a healthy person without causing stress and side effects, and to prepare a composition that suits the taste. I can.

[Brief description of drawings]

FIG. 1 shows an X-ray-CT tomographic image of the body when the composition according to the present invention is administered.

Front page continuation (72) Inventor Yu Kuwata 1-21-3 Sakaemachi, Higashimurayama, Tokyo Meiji Dairy Co., Ltd. (72) Ryoro Yamamoto 1-21-3 Sakaemachi, Higashimurayama, Tokyo Meiji Dairy Central Research Institute Co., Ltd. (72) Inventor Osamu Fujita 1-8-21-703 Tokiwadai, Toyono-cho, Toyono-gun, Osaka Prefecture (72) Inventor Nobuhito Sugi, 15-13 Besshohonmachi, Takatsuki-shi, Osaka Prefecture (72) Inventor Kumiko Hiraishi 3-19-13 Ichioka, Minato-ku, Osaka-shi, Osaka (72) Inventor Isamu Narabayashi 2-5-16-305 Rikyu Nishimachi, Suma-ku, Kobe

Claims (4)

[Claims] 1. A composition for gastrointestinal tract imaging for X-ray imaging, wherein the constituent elements are mainly composed of a non-metallic element having an atomic number of 8 or less. 2. A lipid containing 0.5 to 100% of a mixture containing 1 to 99% of carbohydrate and 99 to 1% of protein as a main component.
The liquid composition according to claim 1, wherein the liquid composition is composed of not more than%. 3. The composition has a density of 1.10 to 1.
The composition according to claim 1 or 2, wherein the composition is 30 g / cm ³ . 4. The composition according to any one of claims 1 to 3, wherein the composition is a food or drink and / or a contrast agent.