JPH06199648A - Solubilized cosmetic - Google Patents

Abstract

PURPOSE:To provide a solubilized cosmetic capable of compounding the chloride of glycyrrhetinic acid without causing the precipitation by chelating a zinc ion with a carboxylic acid and excellent in astringent and anti-inflammatory effects and stability. CONSTITUTION:The subject solubilized cosmetic contains (A) a compound capable of forming a zinc ion in an aq. soln. such as zinc sulfate, zinc chloride, zinc stearate and zinc p-phenolsulfonate, (B) a salt compound of glycyrrhetinic acid such as a di-potassium salt compound and an ammonium salt compound and (C) a carboxylic acid having a chelating coefficient to zinc ion of 10<-2>-10<-6> such as citric acid, tartaric acid, oxalic acid and histidine and its salt. The amount of A is 0.01-5wt.% (preferably 0.01-1.0wt.%), that of B is 0.01-1wt.% (preferably 0.5wt.%), that of C is 0.01-5wt.% and the C/A ratio is 1/1 to 20/1 (wt.mol. ratio).

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a solubilized cosmetic composition, more specifically, by chelating zinc ions with a carboxylic acid or a salt thereof, a glycyrrhizic acid salt compound can be compounded without precipitation. The present invention relates to a solubilized cosmetic composition having excellent astringent effect and anti-inflammatory effect and excellent stability.

[0002]

2. Description of the Related Art Generally, solubilizing cosmetics such as lotions and beauty essences are applied after thoroughly removing dirt adhering to the skin with a facial cleanser etc., so that the stratum corneum of the skin is appropriately moisturized and moisturized. It is used for the purpose of supplying ingredients to regulate the physiological activity of the skin.

Solubilized cosmetics currently in use are classified into soft lotion, astringent lotion, cleansing lotion, etc. according to the quality of the skin of the user, the condition of the skin, the season or the intended use. ing. Among them, cosmetics having astringent action such as astringent lotion are intended to have an effect of tightening the skin by suppressing excessive secretion of oil in the skin by adjusting the astringent contained therein or adjusting the water content. To do.

Conventionally, in order to obtain an astringent effect, a salt compound of a divalent metal represented by zinc has been blended as an astringent in such cosmetics. Further, when excess oil and water are present in the skin, the skin is likely to be inflamed, so that a salt compound of glycyrrhizic acid has been blended for the purpose of suppressing the inflammation.

However, when a compound that produces zinc ions in an aqueous solution and a salt compound of glycyrrhizic acid are simultaneously mixed, there is a problem that insoluble zinc glycyrrhizinate is formed and its precipitation occurs.

[0006]

Therefore, the compound containing a zinc ion-forming compound and a salt compound of glycyrrhizic acid in an aqueous solution has an excellent astringent action and is stable without causing precipitation of the salt compound of glycyrrhizinate. It has been desired to develop a cosmetic having good properties.

[0007]

Under the circumstances, as a result of intensive studies by the present inventors, as a result of adding carboxylic acid having zinc ion and a specific chelate constant or a salt thereof to a cosmetic containing zinc ion. By forming a chelate compound of zinc ion and carboxylic acid, a salt compound of glycyrrhizinic acid can be compounded without precipitation, and a cosmetic product having an astringent effect and good stability can be obtained. Therefore, the present invention has been completed.

That is, the present invention provides the following component (a),
(B) and (c) (a) Compound that produces zinc ion in aqueous solution (b) Salt compound of glycyrrhizic acid (c) Carboxylic acid having chelate constant with zinc ion of 10 ^-2 to 10 ^-6 and its The present invention provides a solubilized cosmetic composition, which comprises one or more selected from salts.

In the present invention, the solubilized type means a state in which the salt compound of glycyrrhizic acid does not precipitate,
The chelate constant means a chelate formation constant derived from the formula (2) when a chelate (A _p B _q ) is formed by the reaction shown in (1) below.

[0010]

[Equation 1]

[In the formula, A represents a zinc ion, B represents a carboxylic acid as a ligand, and K represents a chelate constant.]

The compound which produces zinc ions in the aqueous solution of the component (a) in the present invention is not particularly limited as long as it has been conventionally blended in cosmetics and the like as an astringent, and zinc sulfate, zinc chloride. , Zinc stearate, zinc laurate, zinc p-phenolsulfonate, and other zinc salt compounds, and zinc oxide.

As the component (a), one selected from these compounds can be used alone or in combination of two or more, and the compounding amount thereof is 0.001 to 5 in the total amount of the cosmetic. %, Especially 0.01 to 1.0% by weight is preferred.

Further, the salt compound of glycyrrhizic acid, which is the component (b) in the present invention, is not particularly limited as long as it is a compound generally used as a blending component of cosmetics. Examples thereof include dipotassium salt and ammonium salt.

The glycyrrhizic acid salt compound as the component (b) can be used alone or in combination of two or more kinds, and the compounding amount thereof is 0.01 to 1% by weight, and particularly 0.1% by weight based on the total amount of the cosmetic. 5% by weight is preferred.

Further, the carboxylic acid or salt thereof of the component (c) of the present invention has a chelate constant with zinc ion of 10 ^-2 to 1.
There is no particular limitation as long as it is 0 ⁻⁶ .
Here, when the chelate constant is 10 ^-2 or more, the components (a) and (b) react with each other to cause precipitation of zinc glycyrrhizinate, and when the chelate constant is less than 10 ^-6 , a convergence effect due to zinc ions is obtained. Will be damaged. (C)
Specific examples of the carboxylic acid as a component include citric acid, tartaric acid,
Examples thereof include hydroxycarboxylic acids such as lactic acid and malic acid, dicarboxylic acids such as oxalic acid and succinic acid, amino acids such as histidine, and the salts thereof include sodium salt, potassium salt, ammonium salt and the like.

The carboxylic acid or salt thereof as the component (c) may be used alone or in combination of two or more,
The blending amount thereof is preferably 0.01 to 5% by weight based on the total amount of the cosmetic. Further, the carboxylic acid or the salt thereof as the component (c) has a weight molar ratio of (c) / (a) = 1 / to the component (a).
It is preferably blended in an amount of 1 to 20/1.

In the solubilized cosmetic of the present invention, zinc ions derived from the component (a) and the carboxylic acid or the salt thereof as the component (c) form a water-soluble chelate compound.
Since the salt compound of glycyrrhizic acid as the component (b) does not form a salt with zinc ions, the component (a) and the component (b) can be blended without causing precipitation of the salt compound of glycyrrhizinate. .

If necessary, the cosmetic of the present invention may contain various optional components used in ordinary cosmetics, quasi drugs, pharmaceuticals, etc. other than the above-mentioned essential components, as long as the effects of the present invention are not impaired. can do.

Examples of such optional components include purified water,
Examples include alcohols, moisturizers, keratin softeners, surfactants, viscosity modifiers, medicinal agents, anti-fading agents, pigments, fragrances, preservatives, and texture-improving agents. Specific examples of alcohols include ethanol. As a moisturizer, glycerin, propylene glycol, dipropylene glycol, 1,3
-Butylene glycol, polyethylene glycol, amino acids and the like, keratin softening agents such as urea, and surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene castor oil, polyoxyethylene. Non-ionic surfactants such as hydrogenated castor oil, polyoxyethylene glutamic acid, polyoxyethylene isostearic acid diester, polyoxyethylene lauryl ether, polyoxyethylene hexyl decyl ether, etc., and natural gums such as xanthan gum as a viscosity modifier. Quality, high molecular compounds such as methyl cellulose, and the like, and 4-isopropyl-3-methylphenol, 2
-Antibacterial / bactericidal agents such as phenoxyethanol, vitamins such as dl-tocopherol and pyridoxine, and examples of anti-fading agents include ultraviolet absorbers,
Preservatives include methylparaben, ethylparaben and the like, and texture improvers include animal and plant extracts, 3-1-methoxypropane-1,2-diol and the like.

The solubilized cosmetic of the present invention can be produced by a conventional method, and can be made into various solubilized dosage forms such as lotion and beauty essence.

[0022]

EFFECTS OF THE INVENTION The solubilized cosmetic composition of the present invention can be blended without causing precipitation of the salt compound of glycyrrhizic acid by appropriately chelating zinc ions and carboxylic acid, and thus is good for long-term storage. It has excellent stability, and also has an excellent astringent effect and anti-inflammatory effect.

[0023]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.

Example 1 A cosmetic having the composition shown in Table 1 was prepared according to the following production method,
The astringent effect and stability were evaluated for each of the following methods. The results are shown in Table 1.

(Production Method) The carboxylic acids of (1) and (2) were completely dissolved in (4), and then (3) was added thereto and dissolved. (Evaluation method of astringent effect) Each cosmetic was applied to the eyes of a subject, and the presence or absence of tightness was sensory evaluated according to the following three-level evaluation criteria. ○: Hikimaru. Δ: Slightly tight. ×: Does not attract. (Stability evaluation method) Each cosmetic is applied at room temperature or -5 ° C for 1
The presence or absence of precipitation of a salt compound of glycyrrhizinic acid when stored for a week was visually observed and evaluated according to the following three-step evaluation criteria. ◯: No change. Δ: Precipitation occurred after 1 week. X: Precipitation occurred immediately after production.

[0026]

[Table 1]

As is clear from the results shown in Table 1, the product of the present invention has excellent astringent effect and stability.

Example 2 A lotion having the composition shown in Table 2 was prepared according to the following method.
The astringent effect was evaluated by the same method as in Example 1. The results are shown in Table 2.

(Manufacturing method) After dissolving (5), (1) and (2) or (5), (3) and (4) in (7), (6) was added thereto and dissolved.

[0030]

[Table 2]

As is clear from the results shown in Table 2, the product of the present invention is excellent in the astringent effect, whereas when a carboxylic acid having a chelate constant smaller than 10 ^-6 is used as a ligand, the astringent effect by zinc ion is obtained. Disappear.

Example 3 A serum having the composition shown in Table 3 was prepared according to the following method,
When the astringent effect and the stability were evaluated by the same method as in Example 1, all of the astringent effect and the stability at room temperature and −5 ° C. were excellent.

(Manufacturing method) (3) to (6) are dissolved in (9), (7) and (8) are further added and completely dissolved, and (2) may be added to (1). To the swollen one was gently added and mixed.

[0034]

[Table 3]

Example 4 A lotion having the composition shown in Table 4 was prepared according to the following method,
When the astringent effect and the stability were evaluated by the same method as in Example 1, all of the astringent effect and the stability at room temperature and −5 ° C. were excellent.

(Manufacturing method) (1) to (3) were added to (13) and completely dissolved, to which was added (4) to (11) a mixture which became transparent, and then (12). Was completely dissolved.

[0037]

[Table 4]

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[Procedure amendment]

[Submission date] January 20, 1993

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be corrected] 0015

[Correction method] Change

[Correction content]

The salt compound of glycyrrhizic acid as the component (b) can be used alone or in combination of two or more, and the compounding amount thereof is preferably 0.01 to 1% by weight based on the total amount of the cosmetic.

[Procedure Amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0016

[Correction method] Change

[Correction content]

Further, the carboxylic acid or salt thereof of the component (c) of the present invention has a chelate constant with zinc ion of 10 ⁻² to.
There is no particular limitation as long as it is 10 ⁻⁶ . Here, when the chelate constant is 10 ⁻² or more, the components (a) and (b) react with each other to cause precipitation of zinc glycyrrhizinate, and when the chelate constant is less than 10 ⁻⁶ , the astringent effect due to zinc ions is obtained. Will be damaged.
Specific examples of the carboxylic acid as the component (c) include citric acid,
Hydroxycarboxylic acids such as tartaric acid, lactic acid, malic acid,
Examples thereof include dicarboxylic acids such as oxalic acid and succinic acid, amino acids such as histidine, and salts thereof, such as sodium salt, potassium salt, and ammonium salt.

[Procedure 3]

[Document name to be amended] Statement

[Correction target item name] 0020

[Correction method] Change

[Correction content]

Examples of such optional components include purified water,
Examples include alcohols, moisturizers, keratin softeners, surfactants, viscosity modifiers, medicinal agents, anti-fading agents, pigments, fragrances, preservatives, and texture-improving agents. Specific examples of alcohols include ethanol. As a moisturizing agent, glycerin, propylene glycol, dipropylene glycol, 1,3
-Butylene glycol, polyethylene glycol, amino acids and the like, keratin softening agents such as urea, and surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene castor oil, polyoxyethylene. Non-ionic surfactants such as hydrogenated castor oil, polyoxyethylene glutamic acid, polyoxyethylene isostearic acid diester, polyoxyethylene lauryl ether, polyoxyethylene hexyl decyl ether, etc., and natural gums such as xanthan gum as a viscosity modifier. And high molecular weight compounds such as methylcellulose, and the like, 4-isopropyl-3-methylphenol, 2
-Antibacterial / bactericidal agents such as phenoxyethanol, vitamins such as dl-tocopherol and pyridoxine, and examples of anti-fading agents include ultraviolet absorbers,
Preservatives include methylparaben, ethylparaben and the like, and texture improvers include animal and plant extracts, 3-1-menthoxypropane-1,2-diol and the like.

[Procedure amendment 4]

[Document name to be amended] Statement

[Name of item to be corrected] 0037

[Correction method] Change

[Correction content]

[0037]

[Table 4]

Claims (1)

[Claims] 1. The following components (a), (b) and (c) (a) A compound that produces zinc ions in an aqueous solution (b) A salt compound of glycyrrhizic acid (c) A chelate constant with zinc ions is 10. A solubilized cosmetic composition comprising one or more selected from carboxylic acids of ⁻² to 10 ⁻⁶ and salts thereof.