JPH0611698B2 - Patch - Google Patents

Description

TECHNICAL FIELD The present invention relates to a patch in which two kinds of plaster blocks are arranged on one surface of a support, and more specifically, the above-mentioned two kinds of plaster blocks each have a plaster block. The present invention relates to a patch containing different medicinal components.

2. Description of the Related Art In conventional patches, the medicinal components are incorporated into a single plaster.

Problems to be Solved by the Invention For this reason, when compounding two or more medicinal components in the plaster layer, there are many problems that some of the medicinal components are mixed with other medicinal components or plaster components. Therefore, it is difficult to stabilize the medicinal component, and it is also difficult to control the release of the medicinal component.

An object of the present invention is to mix two or more kinds of medicinal components which are problematic when mixed together in one patch without impairing the stability of medicinal components and the control of release of medicinal components.

Means for Solving the Problems As a result of intensive studies to achieve the above-mentioned object, the present inventors have made two kinds of plasters by combining a medicinal component and a plaster component which have no problem even if they are mixed together. The present invention has been completed based on the finding that it is possible to form a patch and form a plaster by arranging this plaster on one surface of a support without impairing the stability of the medicinal component and easily controlling the release of the medicinal component. .

That is, the present invention is a patch in which two types of plaster blocks are arranged on one side of a support, and each plaster block contains different medicinal components. Is.

In the present invention, the medicinal component is a drug that can be percutaneously absorbed or is commonly used in patches,
For example, corticosteroids (eg, prednisolone, prednisolone acetate, hydrocortisone, hydrocortisone acetate, hydrocortisone propionate butyrate, betamethasone, betamethasone valerate, fluocinolone acetocetonide, dexamethasone), anesthetics (eg,
Benzocaine, lidocaine, ethyl aminobenzoate, etc.), antihistamines (eg, diphenhydramine hydrochloride, isothipendyl hydrochloride, diphenylimidazole, etc.), antibacterial agents (eg, benzalkonium chloride, nitrofuran, etc.), antifungal agents (eg, nystatin, undecylen) Acids, tolnaftate, etc.), analgesic and anti-inflammatory agents (eg, indomethacin, diclofenac sodium, flufenamic acid, sodium salicylate, powdered oat, water-soluble azulene, etc.), antibiotics (eg, erythromycin, chloramphenicol, cephalexin, tetracycline, neomachine, etc.) Penicillin, Penicillin G sodium, etc., Ordinary patches (camphor, menthol, konjac, purple root, peppermint oil, thymol, acrinol, fungus extract, tuga) Shiekisu, etc.), and the like.

Among these medicinal ingredients, examples of those having a problem when blended with other medicinal ingredients or plaster components include water-soluble azulene and salicylic acid compounds (when blended in the same plaster, a stable pH range is obtained). Different), sodium penicillin G and glycerin (when combined in the same plaster decomposes sodium penicillin G), sodium salicylate and sodium carbonate (when mixed in the same paste, discolors sodium salicylate), buckwheat flour powder And kaolin (when mixed in the same plaster, the Oataku powder discolors), water-soluble azulene or purple root and acidic components (water-soluble azulene and purple root are unstable in the acidic region), indomethacin, diclofenac sodium or flufenum. Acids and acidic components (indomethacin, diclofenac sodium, fluf Nam acid is precipitated in an acidic region.), Salicylic acid ester and alkaline component (salicylic acid esters are unstable in the alkaline region.), And the like.

In the present invention, two or more types of medicinal components which are problematic when blended together as described above are separately blended in two types of plasters.
Therefore, each plaster contains one medicinal ingredient or two or more medicinal ingredients that are not problematic when mixed together.

The two types of plasters are, for example, hydrophilic plasters and lipophilic plasters.

As a mode of arranging two kinds of plasters, a stripe type in which different kinds of plaster blocks are alternately connected and arranged as shown in FIG. 1 or in a certain kind of plaster layer as shown in FIG. There is a spot type in which different kinds of small blocks are scattered.

When arranging two types of plaster blocks, the plaster blocks can be connected to form a continuous layer, or the plaster blocks can be separated to form a discontinuous layer.

The patch of the present invention can be prepared, for example, by the following method (here, two types of plasters are prepared as plaster (A) and plaster (B)).
As described below. ).

That is, the plaster (A) is sent to a hot-melt coating applicator by a pump to form strip-shaped or spot-shaped plaster blocks on a peeling piece (for example, a polyester film having one surface treated with silicon).

In addition, the plaster (B) is sent to another hot melt coating applicator by a pump, and the support (for example, non-woven fabric,
On a cotton cloth or the like), a plaster block corresponding to the void is formed at a position corresponding to the void of the peeling piece.

The paste (A) coating and peeling piece prepared in this manner and the paste (B) coating support are superposed and pressed through two rollers to form a continuous paste layer to form a striped type or A spot type patch of the present invention can be obtained.

Further, in the same manner, the plaster (A) is formed into a plaster block on the peeling piece, and a plaster block smaller than the void portion is formed on the support at a position corresponding to the void portion of the peeling piece. body
The (A) coated peeling piece and the plaster (B) coated support are put together and pressed through two rollers to obtain a patch of the present invention having a discontinuous plaster layer.

If necessary, each block can be colored by adding a coloring material to each plaster.

EFFECTS OF THE INVENTION The patch of the present invention is capable of containing the medicinal components necessary for the treatment of the affected area such as bruise, inflammation and skin disease without being restricted by the composition, and has good release of the medicinal components. ,
The therapeutic effect on the affected area can be significantly improved.

Examples Example 1 (1) High Coal K-230 18 parts Kurareprene IR-10
3 parts and Calflex DE-112 3 parts were mixed and dissolved, and Craprene LIR [viscosity (38 ° C) 1800 poise,
15 parts of about 10] of carboxyl groups per molecule were added and uniformly dissolved to form an oily continuous phase.

While stirring at room temperature, add Nikkor MGS-BSE-C to it.
1 part and 3 parts of magnesium stearate were added, and 40 parts of purified water and 1 part of water-soluble azulene were gradually added dropwise to this to emulsify and disperse in an oily continuous phase to form an emulsion.

Separately, 8 parts of kaolin, 1 part of titanium oxide and 1 part of magnesium oxide were uniformly dispersed in a mixer, and this was added to the above emulsion and mixed at 80 ° C. for about 30 minutes to homogenize. In addition to this, menthol-camphor 1: 1 (weight ratio) co-melt 1
Parts were dropped and mixed to prepare a hydrophilic plaster.

(2) SIS TR 1107 23.3 parts was impregnated with 14 parts of HiCoal K-230, and at 90-110 ° C 43 parts of Alcon P-85, 2 parts of titanium oxide, 1.5 parts of magnesium aluminometasilicate 1.5.
Parts and 5 parts of sodium carbonate were added and kneaded to homogenize.

Next, a eutectic liquid consisting of 2.6 parts of methyl salicylate, 2.6 parts of camphor and 7.5 parts of menthol was added and mixed to prepare a lipophilic plaster.

(3) Pump the hydrophilic paste prepared in (1) above to a hot-melt coating applicator with a pump, pull one end of the polyester film that has been silicon-treated on one side and roll it into a position to overlap with the nonwoven fabric. While guiding, a striped plaster block was formed on the silicon-treated surface.

In addition, the lipophilic plaster prepared in (2) above was sent to another hot melt coating applicator by a pump, and one end of the rolled non-woven fabric (manufactured by Japan Vilene Co., Ltd.) was pulled and overlapped with the polyester film. While being guided to the alignment position, a plaster block was formed on the surface of the polyester film at a position corresponding to the plaster cavity of the polyester film, the plaster block corresponding to the cavity.

The polyester block-forming polyester film thus prepared and the non-woven fabric forming a paste-block are laminated and pressed through two rollers to form a continuous paste layer, which is then cut to an appropriate size to form a striped type. The patch of the present invention was obtained.

Example 2 On the siliconized surface of the polyester film used in Example 1, spot-shaped plaster blocks were formed and arranged with the hydrophilic plaster prepared in Example (1), and the nonwoven fabric used in Example 1 was prepared.
Example 1 except that the lipophilic plaster prepared in Example 1 (2) was used to form a perforated plaster block having voids in the portions corresponding to the spot-shaped plaster blocks formed on the polyester film. According to this, a spot type patch of the present invention was obtained.

Example 3 A rectangular plaster block was formed and arranged on the siliconized surface of the polyester film used in Example 1 from the hydrophilic plaster prepared in Example 1 (1) to form a non-woven fabric used in Example 1. ,
In the lipophilic plaster prepared in Example 1 (2), a rectangular plaster block was formed so that a space was formed between the rectangular plaster block formed on the polyester film and the non-overlapping portion of the plaster block. Other than forming, according to Example 1,
The patch of the present invention having a discontinuous plaster layer in which two types of rectangular plaster blocks were arranged at intervals was obtained.

[Brief description of drawings]

FIG. 1 is a perspective view of a striped patch of the present invention in which a peeling piece is partially peeled off. FIG. 2 is a perspective view of a spot type patch of the present invention in which a peeling piece is partially peeled off. In each figure, 1 is a peeling piece, 2 is a support, and 3 and 4 are 2
Figure 4 shows a plaster block of a seed.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Kunitoshi Kawase 3-24-1 Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd. (72) Hideyuki Tanaka 3-24-1 Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd. (72) Inventor Kazuo Hayashi 3-24-1 Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd. (56) Reference JP-A-57-21316 (JP, A) JP-B-58- 26888 (JP, B2)

Claims (1)

[Claims] 1. A patch comprising two types of plaster blocks arranged on one side of a support, wherein each plaster block contains different medicinal components.