JPH05286863A - Improvement of organic compound - Google Patents

Abstract

PURPOSE: To obtain a rehydrated composition for oral administration, especially suitable for an infant before ablactation, containing rice flour and powder of carrot in addition to usual hydrocarbon as a hydrocarbon source together with Na<+> and K<+> electrolyte. CONSTITUTION: This rehydrated composition for oral administration contains rice flour, preferably of pregelatinized state and powder of carrot, preferably of freeze-dried powder form in addition to usual hydrocarbon such as glucose polymers or maltodextrins as a hydrocarbon source together with in an amount sufficient for compensating loss of Na<+> and K<+> electrolyte. A weight ratio of rice flour to carrot is (5/1)-(1/5) and a weight ratio of hydrocarbon derived from rice flour and carrot to usual hydrocarbon is the range of (1/1)-(81/7), preferably (1/2)-(1/5). Preferably, a base (e.g. citrate) is contained to compensate metabolic acidosis. Preferably, 30-90meq. of Nb<+> electrolyte, 20-30meq. of K<+> electrolyte and 50-70g of hydrocarbon source are contained in 1L of drinking solution.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an oral rehydration preparation.

[0002]

BACKGROUND OF THE INVENTION Although the world infant mortality rate due to diarrhea has decreased remarkably over the last few decades, diarrhea remains a significant health problem. Diarrhea is usually defined as an excess loss of fluid and electrolytes from the gastrointestinal tract. This occurs when the balance between absorption and secretion, two intestinal functions, is broken. There are three types of infectious diarrhea pathophysiologically.
That is, the diarrhea can be viral or due to enterotoxins (enterotoxins) or due to microbial invasion of the intestinal mucosa. The following problems must be solved in the treatment of acute diarrhea. 1) Dehydration due to oversecretion of water and / or reduced absorption of water. 2) Insufficiency of intestinal absorption of nutrition. 3) Increased intestinal permeability, resulting in the possibility of protein passage through the mucous membrane and the appearance of allergies. 4) Intestinal effusion with mucosal and protein loss. Of all these problems, the most urgent need to resolve is the risk of dehydration. The rehydration requirement depends on the patient's dehydration, not on the etiology of diarrhea or the patient's age.
This can be easily measured by weight loss. The use of oral rehydration formulations specifically tailored to each situation includes diarrhea and illness fever, increased sweating, high exposure to the sun or thermal environment, strong (infant) activity, salivation due to tooth development. It is suitable for both prevention and treatment of dehydration due to other causes, such as increased and work with (adult) high fluid loss.

According to the invention, a particularly effective rehydration of the patient is achieved by using conventional carbohydrate, rice flour (rice flo).
It has been found that this can be achieved by orally administering to the patient a drink containing ur) and carrot powder as a carbohydrate source. That is, the present invention provides an oral rehydration preparation containing conventional carbohydrates, rice flour and carrot flour as a carbohydrate source, together with a sufficient amount of the above electrolytes to supplement the Na ⁺ and K ⁺ electrolytes. is there. Needless to say, the oral rehydration preparation according to the present invention can be used for infants and adults, but it is particularly suitable for infants who have not been weaned.

The rice flour is preferably in a pregelatinized form. The carrot is conveniently lyophilized and in powder form. The use of commercial products based on carrot allows control of the concentration of nitrite (which reacts to nitrates), making this food-based household product a small infant (4
Avoid the risk of methemoglobinemia seen when used in infants <months of age). It is preferred that the oral rehydrated formulation have a nitrite level of less than 4 mg per 100 g of product. The rice flour: carrot (preferably powdered) weight ratio can vary over a wide range, for example between 5: 1 and 1: 5. The use of rice flour and carrot flour as the carbohydrate source allows a higher carbohydrate supply with conventional carbohydrates alone, without significantly increasing the osmotic pressure after dissolution in water for ready-to-use beverages. Carrot flour enhances the flavor of the product and obviates the use of additives (sweeteners) despite the presence of potassium, which is known to be bitter in taste. The term conventional carbohydrate as used herein refers to glucose polymers or maltodextrins, such as maltodextrin D.
Used with respect to carbohydrates known to be suitable for use in oral rehydration formulations, such as E25.

Although the weight ratio of carbohydrates derived from rice flour and carrot to conventional carbohydrates can vary widely, it is preferred that the drink (beverage) liquor be selected to be slightly hypertonic and pleasant to drink. Generally, such results indicate that the weight ratio of carbohydrates derived from rice flour and carrot: conventional carbohydrates is 1: 1-1: 7, preferably 1: 2-1: 5, for example 1: 2.
Obtained when used in the range of 4. The composition of the rehydrated formulation is
It is preferred to choose to be slightly hypertonic when in the form of a drink. Therefore, the osmolality of the drink is preferably less than 300 milliosmol per kg of the liquid drink. Therefore, the osmolarity of the drink is 2
Preference is given to 10-290, for example 250 mOsmol / l of liquid drink.

The amount and type of carbohydrate source used is 30-90 g, preferably 50-7, per liter of liquid drink.
It is preferred to choose to provide 0 g, for example 60 g of carbohydrate / l. In addition to Na ⁺ and K ⁺ electrolytes,
The oral rehydration composition preferably contains a base to correct metabolic acidosis. Suitable bases for this purpose are bicarbonates, more suitably citrates, for example in the form of trisodium citrate dihydrate. The amounts of electrolyte and base to be added are preferably selected so that an appropriate concentration can be obtained when the solution is made into a drink. In the case of Na ⁺ , this concentration is preferably in the range of 30-90 milliequivalents per liter of drink liquid. Generally, low concentrations, eg 50-7
It is indicated to provide 0 meq / l, but in the case of diseases with a high degree of Na loss, such as cholera, high concentrations of Na, ie up to about 90 meq / l, are required. In the case of K ⁺ , this concentration is preferably 18-42 meq, especially 20-30, for example 25 meq / l.

Suitable citrate concentrations, taking into account losses, are in the range of 25-30 milliequivalents per liter of drink. Chloride supply, especially when considering ensuring Na uptake due to increased transport of Na and glucose,
is important. A suitable concentration of chloride ions is 30-90 meq, for example 50 meq / liter of drink liquor, depending on the total content of Na ⁺ , K ⁺ and other anions. The liquid drink is 120-360, for example 20.
0-280 kcal, or 504-1512,
For example, it is preferable that the amount is 840-1176 KJ.

Examples of suitable oral rehydration formulations are as follows: Example 1 Ingredients per 100 g of product Maltodextrin * (DE25) 65.46 g Pregelatinized rice flour 13.40 g Freezing impression in powder form Carrot 13.00 g Trisodium citrate dihydrate 3.90 g Sodium chloride 2.50 g Chloride chloride Potassium 1.74 g Oral rehydration formulation 100.00 g *: Maltodextrin Elsidex (trademark) DE1
2 and Maltodextrin Elsidex ™ DE4
Mixture of 0 Oral rehydrated formulations may be prepared by mixing the inorganic salts, crushing, sieving the crushed product, adding the remaining ingredients and mixing the whole.

The product of Example 1 shows the following contents by analysis.

[Table 1] Target product 100 g Drink liquid 1 liter ** Carbohydrate 83.4 g 80 mM (61.0 g) Maltodextrin 63.3 g 54 mM Glucose polymer: Rice 10.7 g Combined carrot 9.4 g 26 mM Protein (N × 6. 25) 2.5g 1.8g Lipid 0.3g 0.2g Electrolyte Sodium 1.9g 60mEq Potassium 1.4g 25mEq Chlorine 2.5g 50mEq Citric Acid 2.4g 28mEq Energy Kcal 346 252 Kcal KJ 10 K Concentration 14K m / 0sm / l sol 250 Osmolality m / 0sm / kg H20 263 ** Contains 73.2g of product.

Needless to say, a diluted drink solution may be administered when a large amount of liquid is lost due to intense heat, fever, or vomiting. For example, for the treatment of diarrhea, 18.3 g of the product of Example 1 can be dissolved in 250 ml of water (content of 1 bottle), but if dehydration is significant it can be administered as a solution in 500 ml of water. Therefore, the amount of beverage administered daily depends on, among other things, liquid loss.

The following description serves as an index for proper use when the oral rehydration preparation of the present invention is used for infants. Stage 1 In stage 1, dehydration is measured by weight loss. Dehydration Weight loss Mild 5% or less Moderate 6-9% Severe 10% or more (For severe dehydration without shock symptoms, oral rehydration is indicated. If shock occurs, rehydration should be intravenous injection. 2nd stage During the first period of 6 hours, 100 ml of the liquid drink of Table 1 per 1 kg of body weight is administered to infants in moderate and severe cases over 4 hours and / or water per 1 kg of body weight. Administer 50 ml over 2 hours (or gently "on occasion" by the mother).
For mild dehydration, half of the above can be administered. Phase 3 Six hours later, reassess patient status. If rehydration is normal enough, feeding may begin. If rehydration is incomplete,
The second stage oral rehydration may continue for a further 6 hours. If no improvement is noted, intravenous rehydration is indicated. This and other procedures are performed according to the WHO recommended guidelines for treatment with oral rehydrated drinks.

 ─────────────────────────────────────────────────── ─── Continued Front Page (72) Inventor Montserrat Banque Moras Spain 08010 Barcelona, Burg 42-44 2/2

Claims (17)

[Claims] 1. A formulated rehydrated composition for oral administration comprising rice flour and carrot flour in addition to conventional carbohydrates as a carbohydrate source, together with said electrolytes to compensate for the loss of Na ⁺ and K ⁺ electrolytes. 2. The composition of claim 1, wherein the rice flour is in pregelatinized form. 3. The composition according to claim 1, wherein the carrot is in a freeze-dried powder form. 4. The weight ratio of rice flour: carrot is 5: 1 to 1: 5.
The composition according to any one of claims 1 to 3, which is within the range. 5. A composition according to any one of claims 1-4, wherein the conventional carbohydrate material is a glucose polymer. 6. A composition according to any one of claims 1-5, wherein the weight ratio of rice flour derived carbohydrate and carrot: conventional carbohydrate material is in the range of 1: 1-1: 7. 7. The composition according to claim 1, further comprising a base in an amount sufficient to correct metabolic acidosis. 8. The composition according to claim 7, wherein the base is a citrate. 9. The method according to claim 1, which is in a powder form.
The composition according to the item. 10. The composition according to claim 1, which is in a drink form. 11. 504-1 per liter of drink liquid
11. Containing an amount of carbohydrates to provide 512 KJ.
The composition as described. 12. 30-90 per liter of drink liquid
The composition according to claim 10 or 11, which comprises milliequivalents of Na ions. 13. 18-42 per liter of drink liquid
13. Any one of claims 1-12 comprising milliequivalent K ions.
The composition according to the item. 14. 25-35 per liter of drink liquid
The composition according to any one of claims 10 to 13, which comprises milliequivalents of citrate. 15. 30-90 per liter of drink liquid
The composition according to any one of claims 10 to 14, which comprises milliequivalent chlorine ions. 16. An osmolality of less than 300 milliosmoles per liter of drink liquor.
The composition according to any one of 0 to 15. 17. 30-90 per liter of drink liquid
17. Any one of claims 10-16, which supplies g of carbohydrates.
The composition according to the item.