JPH05103774A - Measuring device for metabolism information - Google Patents

Abstract

PURPOSE:To provide a metabolism information measuring device which can measure accurately and distributively the metabolism information of a living body tissue. CONSTITUTION:Plural light emitting and receiving windows 7a-7f are provided along the axial direction of a tip portion 5 at a side surface of the tip portion 5 of a probe 4, and functions to emit inspection light that measures the metabolism information of a living body tissue, to the tissue and at the same time to receive inspection light that has transmitted the inside of the tissue, at light emitting and receiving windows 7a-7f, are provided. When the tip portion 5 of the probe 4 inserted into the body cavity of the living body is pressed against the tissue and inspection light is emitted in order through plural light emitting and receiving windows 7a-7f, inspection light transmits the tissue while conducting scattering and reflecting, and is received at light receiving portions opposite to light emitting and receiving windows 7a-7f. By repeating this, the metabolism information of the tissue is measured distributively.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an apparatus for measuring metabolic information of biological tissue, which is suitable for measuring biological information such as oxygen saturation in biological tissue and organs such as heart and brain using light, that is, oxygen metabolism. Regarding

[0002]

2. Description of the Related Art Light in the red to near-infrared region has high permeability to living tissues and its light absorption and oxygen binding information to substances that control oxygen metabolism of living organisms such as hemoglobin, myoglobin, and cytochrome oxidase. It has features such as corresponding changes in absorption spectrum.

Utilizing such characteristics, USP422
As shown in 3680, US Pat. No. 4,281,645, a method of measuring oxygen metabolism of various organs such as heart and brain in a living body is known. This is 700-1300n
Light in the near-infrared region of m is applied to an organ or a tissue in a living body, reflected light reflected from the deep organ or tissue or light transmitted therethrough is detected, and light intensity between wavelengths is compared and calculated. It measures blood volume, hemoglobin and cytochrome oxygenation.

Here, the cytochrome is a pigment protein (oxidized Cu2 + reduced Cu +) having copper existing in the mitochondria of cells. Usually, 80% is an oxidative type, but during ischemia, it becomes a reducing type early. Therefore, the redox state of cytochrome can be measured from the absorption amount at each wavelength, and it can be used as an index of tissue oxygen metabolism.

When myocardial infarction occurs, myocardial necrosis is caused in the worst case, but in early or acute cases, myocardial activity is stopped but sometimes it is not. In such a case, PTCA and bypass are effective. So far
I used PET to diagnose whether myocardium was alive or dead, and decided to perform bypass surgery.
ET devices are extremely expensive and not very popular.

When the myocardial tissue is measured, the scope is actually inserted from the aorta of the lower extremity and, as shown in FIG. 20, the distal end portion 2 of the scope 1 is pressed against the myocardial tissue 3 and placed in advance in the coronary artery. Diagnosis is made by occluding a balloon for a predetermined period of time and measuring the metabolic changes in myocardium.
At this time, since there is no metabolic change when the myocardium is dead, it is possible to diagnose whether the myocardium is alive or dead.

By the way, Japanese Patent Application Laid-Open No. 59-230533, which is known as a conventional metabolic information measuring apparatus, projects light from a light source onto a living tissue through a light projecting fiber,
The reflected light from the living tissue is transmitted to the light receiving part using a plurality of optical fiber bundles, and after being separated by different wavelength filters provided on the end faces, the intensity of the reflected light is measured for each wavelength and the target living body It measures the information of the organization.

Further, Japanese Patent Publication No. 61-11614 discloses
Near-infrared regions including light of various wavelengths within a spectrum range of 700 to 1300 nm are alternately and intermittently projected onto a living tissue in a predetermined cycle, and reflected light from the living tissue is received by a light receiving unit, Information on the target biological tissue is measured by measuring the intensity of reflected light for each wavelength.

[0009]

By the way, USP42
In both patents of 23680 and USP 4281645,
The applicant emphasizes that when measuring oxygen metabolism using light in the near infrared region, the light path must be relatively long. In other words, the fact that it spans a long path can include the metabolic information of the deep part in the target tissue.

Further, in the case of irradiating and detecting the metabolism of an organ with light from one direction (this is called a reflection system), in order to achieve the above-mentioned object, the light irradiation part and the detection part are separated from each other by several centimeters. States that it is necessary. “Monitoring cerebral oxygen metabolism during external circulation using near-infrared biometrics” In artificial organ 19 (1) 535-538 (1990), the irradiation part and the detection part are 3 to measure oxygen metabolism in the brain. 4 cm apart.

In recent years, an endoscope which uses an optical fiber bundle to observe not only the stomach and large intestine but also the inside of blood vessels has been used in general medicine. This endoscope has a characteristic that a disease can be diagnosed accurately and early by directly observing an organ that cannot be seen from the outside from the body cavity.

Furthermore, the endoscope is provided with a hole called a channel, and a treatment instrument such as biopsy forceps or an electric scalpel can be inserted into the body through the channel from the outside. Used for medical treatment.

Recently, an optical fiber probe for measuring oxygen saturation using this channel is inserted to diagnose metabolic information of a lesion site, or an optical probe is directly inserted under X-ray fluoroscopy to detect organs. Studies are being conducted to determine the oxygen metabolism of.

Regarding the optical probe, "Medical reflection spectrum analyzer using optical fiber probe" Medical Electronics and Biotechnology Vol.28 No3 (1990), JP-A-59-2305
Detailed in 33.

By the way, the above-mentioned optical fiber probe has a small outer diameter at the insertion portion of the probe so that it can be inserted into the body cavity, and therefore the irradiation portion for irradiating light and the detecting portion for detecting are extremely close to each other. Since it is arranged and uses pulsed light with a time width that is sufficiently longer than the speed of light,
It is designed to detect light that has passed through the tissue surface without crossing a relatively long path. That is, such a method measures the metabolic information only on the surface of the tissue, and the metabolic information in the deep tissue cannot be measured because it is strongly influenced by the epidermis of the tissue, the body fluid attached to the surface of the epidermis, and blood.

The present invention has been made in view of the above circumstances, and an object thereof is to provide a metabolic information measuring device capable of accurately measuring metabolic information of a living tissue in a distributed manner.

[0017]

In order to achieve the above object, the present invention provides an inspection light emitting means for emitting inspection light for measuring metabolic information of a tissue to a living tissue, and an inspection light emitting means for transmitting the inspection light. And a light receiving means for receiving the inspection light, wherein a plurality of at least one of the inspection light emitting section and the inspection light receiving section are arranged along the axial direction of the probe.

[0018]

[Function] When the tip of the probe inserted into the body cavity of the living body is pressed against the living tissue as the portion to be inspected and the inspection light is sequentially emitted from the plurality of inspection light emitting portions, the inspection light scatters and reflects the biological tissue. While being transmitted, it is received by the inspection light receiving portion corresponding to the inspection light emitting portion. By repeating this, metabolic information of the living tissue is measured in a distributed manner.

[0019]

Embodiments of the present invention will be described below with reference to the drawings.

1 to 4 show a first embodiment, and FIG. 1 shows a tip portion 5 of a metabolic information detecting probe 4. A plurality of optical fibers 6 are incorporated in the probe 4, and a plurality of transmitting / receiving windows 7a to 7g are arranged at equal intervals along the axial direction of the insertion portion on the side surface of the distal end portion 5 of each optical fiber 6. The tip surface is connected to each of the light transmitting / receiving windows 7a to 7g.

Further, as shown in FIG. 3, the end of each optical fiber 6 faces a laser diode 9 as a light source and a light receiving element 10 as a detector through a half mirror 8. Therefore, when the laser diode 9 emits pulsed light of a predetermined wavelength, it is reflected by the half mirror 8 and is transmitted / received by the optical fiber 6 to the light transmitting / receiving windows 7a ...
The reflected light guided to 7 g and received from the light transmitting / receiving windows 7 a to 7 g is guided by the optical fiber 6, passes through the half mirror 8, and is received by the light receiving element 10.

Therefore, the plurality of light transmitting / receiving windows 7a to 7g arranged at the tip portion 5 are used for both irradiation and light reception. Here, three transmitting / receiving windows 7a, 7b, 7c on the tip side are provided.
When the optical fiber 6 connected thereto is used for irradiation and the transmitting / receiving windows 7d, 7e, 7f are used for receiving light, the light A emitted from the transmitting / receiving window 7a is received by the transmitting / receiving window 7d, and the transmitting / receiving window 7b. The light B emitted from is received by the light transmitting / receiving window 7e, and similarly, the light C emitted from the light transmitting / receiving window 7c is received by the light transmitting / receiving window 7f.

Then, the probe 4 is inserted into the living body cavity,
With the tip 5 of the probe 4 pressed against living tissue,
As shown in FIG. 2, when pulsed light is sequentially emitted from the light transmitting / receiving windows 7a, 7b, 7c, the light A emitted from the light transmitting / receiving window 7a proceeds while diffusing in the living tissue and passes through a deep portion of the living tissue. The reflected light thus received is received by the light transmitting / receiving window 7d. Similarly, the light B emitted from the light transmitting / receiving window 7b is received by the light transmitting / receiving window 7e, and the light C emitted from the light transmitting / receiving window 7c is received by the light transmitting / receiving window 7f.

The pulsed light is, for example, near-infrared light having a wavelength of 700 nm to 950 nm which has absorption in cytochrome and hemoglobin containing oxygen metabolism information, and can effectively capture the reflected light that has passed through the deep part of the living tissue. This reflected light can be detected by the light receiving element 10 and the detection light of each wavelength is calculated to obtain the oxygen saturation levels of hemoglobin, myoglobin, and cytochrome.

Then, by scanning the light A, B, and C in this order, as shown in FIG.
It is possible to obtain the metabolic distribution of a region b with a large amount of metabolic activity, and to measure the metabolic state of living tissue not only locally but in a wide region at one time.

FIG. 5 shows a second embodiment. In this embodiment, one of the light-transmitting / receiving windows 7a on the most tip side of the tip portion 5 of the probe 4 is used for irradiation, and the remaining plurality of light-transmitting / receiving windows 7b, 7c.
Is used for receiving light. According to this embodiment, the interval between the irradiation unit and the light receiving unit can be changed by sequentially switching the light transmitting / receiving windows 7b, 7c ... For light reception, and the metabolic state from the shallow portion to the deep portion of the biological tissue can be changed. Can be measured in a distributed manner.

FIG. 6 shows a third embodiment. In this embodiment, a plurality of transmitting / receiving windows 7a, 7a are provided at the tip 5 of the probe 4.
b, 7c ... Are formed in a ring shape. According to this embodiment, for example, one of the most distal light-transmitting / receiving windows 7a is used for irradiation and the remaining plurality of light-transmitting / receiving windows 7b, 7c ... Are used for light reception, similar to the second embodiment. By sequentially switching the light transmitting / receiving windows 7b, 7c ... For light reception, the distance between the irradiation unit and the light receiving unit can be varied, and the metabolic state from a shallow portion to a deep portion of the biological tissue can be measured in a distributed manner. , 1 when measuring the lumen of a living body
The entire circumference can be measured by measuring the degree.

In each of the above-mentioned embodiments, the case where the probe 4 is inserted into the body cavity and the tip portion 5 is pressed against the living tissue, that is, the measurement is performed in a fixed state has been described. Providing rotation angle detection means at the end,
By rotating the probe 4 in the body cavity, it is possible to display it three-dimensionally or to display metabolic activity in a cross section of a plane perpendicular to the axis of the probe 4.

Further, when the optical fibers 6 for irradiation and light reception are exposed at right angles to the surface of the probe 4 due to the positional relationship of irradiation and light reception, the metabolic state on the curve connecting the irradiation and light reception positions is probable. It is based on the assumption that it will be reflected in large numbers. Therefore, for example, if there are bones having many reflections, air bodies, or different tissues having a large refractive index on this curve, a correct diagnostic result cannot be obtained. However, in the lumen of a uniform organ, the result that almost reflects the activity of metabolism is obtained, and the information about life and death of the tissue is obtained.

FIG. 7 shows the overall structure of the metabolic information measuring device, and 11 is a light source composed of four laser diodes (not shown). Reference numeral 12 is a probe which is an elongated flexible tube that can be inserted into the body cavity, such as the heart, stomach, large intestine, and brain.

Reference numeral 13 is a reference light detector for measuring the intensity of light applied to the living tissue, 14 is a detector for measuring the light reflected to the deep portion of the living tissue, and 15 is the light source 11. It is a control device that controls and calculates metabolism from the signals of the reference light detector 13 and the detector 14 in synchronization with it.

The probe 12 is formed by covering an optical fiber bundle of 6 bundles (not shown) with a flexible tube. The insertion portion 16 is inserted into the body cavity and the insertion portion 16 is inserted.
Curved portion 18 provided at the distal end portion 17 of this and this curved portion 18
An operation unit 20 having an angle operation unit 19 for performing a bending operation is provided.

Further, a universal cord 21 is connected to the operation section 20, and a plurality of optical transmission fibers 22a connected to the light source 11 via a connector 22 and a reference photodetector 13 are connected to the universal cord 21. A reference light detecting fiber 25 connected via 24 and a light receiving fiber 27 connected to the detector 14 via a connector 26 are incorporated.

The plurality of optical transmission fibers 22a are connected to the irradiation fiber 23, and the irradiation fiber 23 and the light receiving fiber 27 extend through the insertion portion 16 of the probe 12 to the tip portion 17. And
Explaining one of them, as shown in FIG. 8, the emitting end 23a of the irradiation fiber 23 and the incident end 27a of the light receiving fiber 27 are provided in the tip portion 17 in a direction perpendicular to the axial direction thereof. It is joined to the prisms 28 and 29 and is optically connected.

Therefore, the optical axes of the irradiation fiber 23 and the reception fiber 27 are prisms 28 and 29.
The prism 17 is adapted to be converted at a right angle to the longitudinal direction of the tip portion 17, and the reflecting surfaces 2 of both prisms 28 and 29 can be converted.
A reflective film of aluminum or the like is vapor-deposited on 8a and 29a for efficiently reflecting light.

In FIG. 9, instead of the prisms 28 and 29, the irradiation fiber 23 and the light reception fiber 27 are used.
The distal end portion of is curved at a right angle at the distal end portion 17 of the insertion portion 16, and the emission end 23a and the incident end 27a are directed toward the side surface of the distal end portion 17 and slightly protruded from the side surface. Further, the protruding portions of the emitting end 23a and the incident end 27a are provided with a protective portion 17a for preventing invasion of myself and living tissue.

The bending angles of the irradiation fiber 23 and the light reception fiber 27 do not have to be right angles.
The optical axis of the light emitted from the emitting end 23a and the incident end 2
The bending angle may be set such that the optical axis of the light detected by 7a spreads as it goes away from the tip portion 17. Next, the operation of the metabolic information measuring device configured as described above will be described.

First, the light source 11 sequentially generates pulsed lights of four different wavelengths. For example, this wavelength is absorbed by cytochrome and hemoglobin, which contain oxygen metabolism information.
It is near infrared light of 00 nm to 950 nm. Each of these lights is guided to the irradiation fiber 23 connected to the connector 22.

The light guided to the irradiation fiber 23 is guided to the tip portion 17 of the probe 11, and is uniformly irradiated to the living tissue 30 from the emitting end 23a through the prism 28. Here, since the irradiation fiber 23 is also connected to the reference light detector 14 through the reference light detection fiber 25, it is possible to measure the reflected light immediately after being irradiated to the biological tissue 30, that is, the irradiation light intensity. ..

The light applied to the living tissue 30 propagates while diffusing in the living tissue 30 due to light scattering by the tissue. Then, a part of this light, that is, the reflected light is incident on the incident end 27 a of the light receiving fiber 27 from the prism 29 which is separated from the prism 28 by about 5 mm to several cm, and is guided to the detector 14 via the light receiving fiber 27. Be illuminated.

Therefore, the reflected light that has passed through the deep portion of the living tissue 30 can be effectively captured, the lights of different wavelengths are sequentially detected, and the reference light of each wavelength and the detected light are mutually calculated. , Oxygen saturation of hemoglobin, myoglobin, and cytochrome are obtained and displayed on a display unit (not shown).

For example, when measuring the metabolism of the myocardium, the insertion portion 16 is inserted from the femoral artery under fluoroscopy, and the side portion of the tip portion 17 is pressed against the myocardium of the left ventricle through the aorta. At this time, the bending portion 18 is bent by operating the angle operation portion 19 so that the tip portion 17 hits the living tissue 30.
The prisms 28 and 29 provided on the tip portion 17 and the biological tissue 30 are brought into contact with each other without a gap.

Not only the metabolism of the myocardium but also the metabolism of the inner wall of the stomach can be measured while observing under the endoscope using the channel of the endoscope inserted into the stomach, and the probe 1 can be measured from the cerebral blood vessels.
2 may be inserted to measure the metabolism of the pancreas, liver sac, liver and the like.

10 to 12 show a tip end portion 32 of a probe insertion portion 31 having a suction function, and 33 is an irradiation window.
Reference numeral 34 is a light receiving window. Suction holes 35 are provided on both sides of the irradiation window 33 and the light receiving window 34. The suction hole 35 is connected to a vacuum pump (not shown) provided outside via a suction tube 36 inserted in the insertion portion 31.

Therefore, after the insertion portion 31 is inserted into the body cavity and the tip portion 32 is located in the living tissue 30, the suction hole 35 is made to have a negative pressure by the vacuum pump so that the tip portion 32 is attracted to the living tissue 30. The metabolic information of the living tissue 30 can be accurately measured.

FIG. 13 shows the tip portion 3 of the insertion portion 31 of the probe.
2 is provided with a pressing function, and 33 is an irradiation window and 34 is a light receiving window. A balloon 37 is provided on the side surface of the tip portion 32 located on the opposite side of the irradiation window 33 and the light receiving window 34. The balloon 37 is provided outside through an air supply tube 38 inserted in the insertion portion 31, and a control device 39
Connected to a compressor 40 controlled by.

Therefore, the insertion portion 31 is inserted into the lumen,
After the distal end portion 32 is positioned on the living tissue 30, the air is pumped to the balloon 37 by the compressor 40 so that the balloon 37 expands and presses one lumen wall, and the reaction force causes the distal end portion 32 to move the living tissue. It can be pressed against the target site of 30, and the metabolic information of the biological tissue 30 can be accurately measured.

FIG. 14 shows the tip portion 3 of the insertion portion 31 of the probe.
2 is provided with a liquid sending function, and 33 is an irradiation window and 34 is a light receiving window. A liquid feed port 42 communicating with the liquid feed channel 41 is provided on the side surface of the tip portion 32 located on the opposite side of the irradiation window 33 and the light receiving window 34. Liquid transfer channel 41
Is a reservoir 4 for storing a physiological saline solution via a pump 43.
It communicates with 4.

Therefore, the insertion portion 31 is inserted into the lumen,
After the distal end portion 32 is located in the living tissue 30, the physiological saline is pumped through the liquid feeding channel 41 by the pump 43, so that the physiological saline is ejected from the liquid feeding port 42 toward one lumen wall. The tip portion 32 can be pressed against the target site of the living tissue 30 by the reaction force,
The metabolic information of can be measured accurately.

FIGS. 15 to 17 show a probe 46 having a flat light-transmitting / receiving member 45 at its tip, and a flat portion of the light-transmitting / receiving member 45 has a plurality of irradiation windows 47 and one light-receiving window 48. It is provided.

The plurality of irradiation windows 47 are respectively connected to one ends of a plurality of irradiation fibers 49 inserted in the probe 46, and the light receiving window 48 is one light receiving fiber 50 also inserted in the probe 46. Is connected to one end of.

On the other hand, a dichroic mirror 52 is arranged on the optical paths of a plurality of laser diodes 51 as light sources, and a mirror 53 is installed on the reflected optical path.
Further, a prism 54 is provided on the reflection optical path of the mirror 53.
Is rotatably provided, and this prism 54 allows the irradiation light to be selectively incident on the incident end of the irradiation fiber 49. The other end of the light receiving fiber 50 is provided so as to face the light receiving element 55.

Therefore, when the probe 46 is inserted into the body cavity and the light transmitting / receiving member 45 is bonded to the target site of the living tissue 30, each of the plurality of laser diodes 51 emits light serially, the dichroic mirror 52 and the mirror 53. And the irradiation light is selectively incident on the incident end of the irradiation fiber 49 via the prism 54.

The irradiation light incident on the irradiation fiber 49 is irradiated onto the living tissue 30 through the irradiation window 47 of the light transmitting / receiving member 45, and the reflected light is received by the light receiving window 48. Then, the light is received by the light receiving element 55 through the light receiving fiber 50.

In this case, since a plurality of irradiation windows 47 are provided, the distance between the irradiation section and the light receiving section can be changed by selecting the irradiation window 47, and a portion from a shallow portion to a deep portion of the living tissue can be changed. The metabolic state up to can be measured in a distributed manner. Further, since the light transmitting / receiving member 45 has a flat shape, the irradiation unit and the light receiving unit can be brought into close contact with the biological tissue 30, and efficient information detection can be performed.

Further, as shown in FIG.
By scanning the light transmitting / receiving member 45 at the tip of the body tissue 30 on the living tissue 30, three-dimensional information in the depth direction can be obtained.

18 and 19, a probe 56 is provided with a spiral tip portion 57, and an irradiation window 58 and a light receiving window 59 are provided at this tip portion to improve the adhesion of the tip portion 57 to a living tissue. Is.

A wire 60 made of a shape memory alloy is inserted in the tip portion 57. The wire 60 is stored in a spiral shape and is straight when not energized, but is restored to a spiral shape by heating.

Therefore, for example, when the guide cylinder 62 is penetrated through the chest wall 61, the guide cylinder 62 is inserted into the body cavity, the membrane (not shown) leading to the heart 63 is cut, and the pericardium is incised, the myocardium is exposed. .. Myocardium is suspected to be myocardial infarction, and if the extent of infarction is small, it can be treated by coronary artery bypass surgery or the like to rescue the myocardium around myocardial infarction from ischemia.

In order to make this determination, while observing the myocardium under the thoracoscope as described above, the guide tube 62 is used as a guide to insert the probe 56 having the straight tip portion 57, and after insertion, the wire 60 is energized. Heat to make the tip 57 spiral and bond onto the muscle layer of the heart 63.

The irradiation window 58 and the light receiving window 59 are connected to the heart 6
3 in close contact with the muscle layer 3 through the irradiation window 58 to the heart 63
By irradiating toward, the metabolic information of the heart 63 can be accurately measured.

[0062]

As described above, according to the present invention, at least one of the inspection light emitting portion and the inspection light receiving portion is arranged along the axial direction of the probe, and the inspection light emitting portions are sequentially arranged. When the inspection light is emitted, the inspection light is transmitted through the living tissue while being scattered, reflected, and received by the inspection light receiving portion corresponding to the inspection light emitting portion. By repeating this, the metabolic information of the living tissue can be measured in a distributed manner, and there is an effect that a wide range can be accurately measured in a short time.

[Brief description of drawings]

FIG. 1 is a vertical sectional side view of a tip portion of a probe according to a first embodiment of the present invention.

FIG. 2 is a timing chart of the embodiment.

FIG. 3 is a perspective view showing an arrangement state of a light emitting unit and a light receiving unit of the embodiment.

FIG. 4 is a metabolic distribution map of the same example.

FIG. 5 is a perspective view of a probe according to a second embodiment of the present invention.

FIG. 6 is a perspective view of a probe according to a third embodiment of the present invention.

FIG. 7 is a schematic configuration diagram of an entire metabolic information measuring device.

FIG. 8 is a vertical sectional side view of a probe of the apparatus.

FIG. 9 is a vertical sectional side view of the probe of the apparatus.

FIG. 10 is a side view of a probe having a suction function.

11 is a sectional view taken along the line aa in FIG.

FIG. 12 is a side view of the probe in use.

FIG. 13 is a vertical sectional side view of a probe having a balloon.

FIG. 14 is a vertical cross-sectional side view of a probe having a jetting function for jetting physiological saline.

FIG. 15 is a schematic configuration diagram of an entire metabolic information measuring device having a flat light transmitting / receiving member at the tip of the probe.

FIG. 16 is a side view of the device in use.

FIG. 17 is a perspective view of the device in use.

FIG. 18 is a perspective view of a probe in which the tip portion is curved in a spiral shape in a usage state.

19 is a sectional view taken along the line bb of FIG.

FIG. 20 is a perspective view showing a general measurement state of myocardium.

[Explanation of symbols]

4 ... Probe, 6 ... Optical fiber, 7a-7f ... Transmitting / receiving window. 11 ... Light source, 14 ... Detector.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Yasuhiko Omagari 2-43-2 Hatagaya, Shibuya-ku, Tokyo Olympus Optical Co., Ltd. (72) Inventor Yoshio Tashiro 2-43-2 Hatagaya, Shibuya-ku, Tokyo Inside Olympus Optical Co., Ltd. (72) Inventor Issei Nakamura 2-43-2 Hatagaya, Shibuya-ku, Tokyo Inside Olympus Optical Co., Ltd. (72) Koichi Umeyama 2-43-2 Hatagaya, Shibuya-ku, Tokyo No. Olympus Optical Co., Ltd. (72) Inventor Yoshinao Daimei 2-43-2 Hatagaya, Shibuya-ku, Tokyo Olympus Optical Co., Ltd. (72) Inventor Shuichi Takayama 2-43-2 Hatagaya, Shibuya-ku, Tokyo No. Olympus Optical Co., Ltd. (72) Inventor Seiji Yamaguchi 2-43-2 Hatagaya, Shibuya-ku, Tokyo Olin Scan Optical Industry Co., Ltd. in

Claims (1)

[Claims] 1. A metabolic information measuring device comprising: a test light emitting means for emitting a test light for measuring tissue metabolic information with respect to a biological tissue; and a light receiving means for receiving the test light transmitted through the tissue, A metabolic information measuring device, wherein a plurality of at least one of the test light emitting section and the test light receiving section are arranged along the axial direction of the probe.