JPH0452684Y2 - - Google Patents

Description

[Detailed description of the invention] Industrial application field The invention relates to an electrolyte measuring device.
The present invention provides an electrolyte measuring device with a measuring part having a nozzle integrated into an electrode assembly, which is particularly suitable for aspiration of a measuring liquid from a sample cup on an autosampler, and also suitable for aspiration from a syringe or a cavity. be.

Conventional technology Conventionally, electrolyte measurement devices dilute particularly small amounts of samples using automatic diluters and dispensers, and continuously and automatically measure Na, K, etc. in whole blood, plasma, serum, and urine using an electrode method. In this case, the following operations are performed. For example, to explain an electrolyte measuring device using the ion electrode method, in the calibration operation, standard solution 1 and standard solution 2 provided in the device are used, standard solution 2 is first aspirated, and the Store the electrode potential in memory. (This is referred to as _E2 ) Next, after the washing step, standard solution 1 is aspirated and the potential of standard solution 1 is stored in memory. (Set this as E ₁
) First, sample 1 is aspirated, and the potential of sample 1 is stored in memory. (This is referred to as E _x1 .) Next, after the washing step, the standard solution is aspirated and the potential of the standard solution is stored in memory. (Let this be E _11. ) This E _x1 ,
The ion concentration C _x1 of the sample 1 is determined from E ₁₁ , E ₂ , E ₁ stored at the time of calibration, and fixed constants C ₂ , C ₁ using equation [1]. Exactly the same steps and calculations are performed for the second and subsequent samples to obtain the results. That is, the potential of sample 2 is set to E _x2 , and the potential of standard solution 1 thereafter is set to E ₁₂ , and the rest is the same as for the first sample.

In the conventional electrolyte measuring device as mentioned above, an autosampler is movably provided with respect to a fixed nozzle.

Problems that the invention aims to solve In the conventional electrolyte measuring device as mentioned above, the nozzle is fixed at a fixed position, so if an interrupt measurement is required during continuous measurement, the autosampler must be reset. However, the workability was poor.

Furthermore, as a conventional electrolyte measuring device,
As disclosed in No. 54-43096, an ion-selective electrode is installed at an angle on the lid of the outer tank of the sample tank, its tip is inserted into the sample tank, and the sample injected into the sample tank through the lid is collected. Measurement using electrodes, as disclosed in Japanese Patent Application Laid-open No. 58-30651,
The electrode for biological component analysis is attached to the measurement cell at an angle to the reaction chamber, so that the tip of the electrode faces the reaction chamber, and the ions of the liquid to be measured are carried by the nozzle and injected into the reaction chamber. A method is known in which the concentration is measured using an electrode.

However, the conventional devices disclosed in each of the above publications,
Of course, the electrode part is separate from the nozzle, but the electrode part is fixed to the outer tank lid of the sample tank or the measurement cell, and is not configured to be movable between it and the autosampler, but is always in a fixed position. Since it has a structure that cannot be moved, it can be used for sample aspiration and continuous measurement from the autosampler during continuous measurement of multiple samples, and for interruption measurement in the event of an emergency during continuous measurement. The configuration is not such that the aspiration and measurement operations from the autosampler can be performed simultaneously or selectively at the same time, but after the aspiration and measurement operations from the autosampler are stopped, interrupt measurement of a single sample is performed, and then the autosampler is This method had poor workability, such as having to set up the system, making it unsuitable for interrupt operation in an emergency during continuous measurement.

The purpose of this invention is to support continuous suction from an autosampler by supporting a measurement unit that has a nozzle integrated with an electrode assembly so that it can slide left and right and rotate between vertical and inclined positions. The purpose is to enable simultaneous measurement and interruption measurement by suction from a syringe, capillary, etc. in an emergency by freely and easily switching between the two.

Means for Solving the Problems In the present invention, the measuring section is equipped with an electrode assembly consisting of an electrode section in which a plurality of ion electrodes are arranged side by side and a flow sensor, and a nozzle for sucking the sample into the electrode section of the measuring section is integrated. A main shaft is connected to the main shaft and supported horizontally, and the measuring section is supported on this main shaft so that it can slide left and right through a bearing and can rotate at a predetermined angle around the axis through a bearing. The electrode assembly and the nozzle can be switched between a vertical position and an inclined position by movement, and a rotation angle control means for controlling rotation of the measuring section is provided on the main shaft. This is a characteristic feature.

Operation When the bearing 11 for the sub-shaft is fitted between the main shaft 1 and the cantilevered sub-shaft 2, it becomes movable within a horizontal plane.
By doing this, when the autosampler is placed on the lower left side of the front view, continuous measurement is possible because the electrode moves up and down. Moreover, if the upper part of the measurement part is pushed, the subshaft bearing 11 is disengaged from the subshaft 2, so that it can rotate around the main shaft 1.

At this time, since the measuring section is connected to the rotary disk 5 via the rotation shaft 6, the measuring section can rotate within the range of the recess of the rotary disk 5. This allows easy drawing from a syringe or capillary.

When the nozzle integrated with the electrode assembly is moved onto the autosampler along the main axis, the nozzle is integrated with the electrode assembly and moves up and down sequentially for each sample, allowing continuous aspiration and measurement of the sample. If an emergency interruption measurement becomes necessary during this continuous measurement, the rotation angle control means is operated, and the measurement section including the electrode assembly and nozzle is rotated by a predetermined angle around the main axis to take an inclined position. Then, the nozzle tip protrudes forward. Therefore, the nozzle allows aspiration of a single sample from a syringe, capillary, etc., as well as continuous measurement using an electrode assembly. Since the nozzle is integrally connected to the electrode assembly, the aspirated sample is analyzed and measured continuously with the aspiration operation.

Embodiment Hereinafter, the configuration of the electrolyte measuring device of the present invention will be specifically explained based on the embodiment shown in the drawings.

1 to 4, a bearing 10 is fitted onto a horizontally supported main shaft 1 so as to be slidable left and right in the axial direction and rotatable around the axis. A measuring section is attached to this bearing 10. The measurement section includes an electrode assembly in which a plurality of electrodes 18, 19, 20, 21 and a flow sensor 23 are arranged side by side, and a nozzle 40 for sample suction is integrally connected to the electrode section of this electrode assembly.

The electrode assembly and nozzle 40 are supported on a vertically supported main vertical shaft 15 via a vertical bearing 17 so as to be vertically movable.

The measuring section includes a pump unit 32 and a three-way valve 3.
3, 34, etc. are incorporated.

A rotation angle control means for a measuring section including an electrode assembly and a nozzle 40 is assembled at one end of the main shaft 1 . The rotation angle control means includes a rotating shaft 6 and a rotating disk 5 having a recess attached to the rotating shaft 6.
, a spring 9 that biases the rotary disk 5 in the rotational direction, and a damper 7.

During continuous suction and measurement from the autosampler,
When the measurement unit is moved along the main axis 1 as shown in the imaginary line in Fig. 4, the electrode assembly and nozzle 40 are located on the autosampler, and they move up and down in unison with each intermittent feed of one sample. Continuous suction and measurement operations are possible. If an emergency interrupt measurement is required during this continuous measurement, when the rotation angle control means is operated, the entire measuring section including the electrode assembly and nozzle 40 is rotated and tilted about the tilt center, and the nozzle 40 is rotated forward. It sticks out. Therefore, it becomes possible to aspirate a single specimen from a syringe, capillary, etc. The entire measuring section is
It can slide left and right via a bearing 10 and can rotate by a predetermined angle around the main shaft. The rotation angle of the entire measuring section is determined by the shape of the recess provided in the rotary disk 5, that is, the shape of the cam.
In the illustration, it is set at 45 degrees. The nozzle 40 is therefore tilted at a 45 degree angle with the electrode assembly.

Furthermore, a sub-shaft 2 is supported in parallel to the main shaft 1 within the device, and a bearing 1 fitted to this sub-shaft 2
1 is equipped with a lock mechanism. A notch is provided in the sub-shaft 2, and the measuring part is slid from side to side by this notch.
The lock mechanism serves as a stopper when the measuring section slides along the main axis 1.

The electrolyte measuring device of the present invention can perform two types of specimen suction operations.

First, regarding the first suction operation, since the measuring section 41 is slidable left and right, if the measuring section 41 is moved to the left and the autosampler is placed below it, the nozzle 40, which is movable up and down, can be moved automatically. Samples can be successively aspirated and measured from the sampler cup on the sampler.

Regarding the second suction operation, the measuring section 41
can rotate around the main shaft 1, so the measurement unit 41
The nozzle 40 can be tilted so that the nozzle 40 protrudes toward the front, so that a syringe or the like containing a sample can be applied thereto and aspirated.

The reason why we made it possible to perform the above two operations for sample aspiration is that both when aspirating the sample in the sample cup set in the autosampler and when aspirating from other syringes, etc., the same nozzle is used. This is because the sample is aspirated in the same process so that the measurement situation does not change, and when an emergency sample arrives during continuous measurement using the autosampler, the emergency measurement can be performed quickly and easily and clearly for the user. By tilting, it is possible to save labor by directly aspirating a sample container, which was conventionally limited to a cup, from a syringe or capillary.

Another purpose is to move the measuring section left and right to secure space when setting the turntable on the autosampler. In such cases, in the past, the autosampler side often moved back and forth, but the mechanism in which the autosampler is fixed and the measuring section moves is a feature unique to this device. After the sample is aspirated, a predetermined measurement of the electrode potential of the sample is performed.

According to this embodiment, since the nozzle 40 and the electrode assembly are directly connected, the sample aspirated from the nozzle 40 can be measured in a continuous operation, and the amount of sample can be small. can prevent contamination. Further, since the electrode assembly itself can be moved up and down integrally with the nozzle 40, its adjustment can be easily performed.

Effects of the invention As explained above, the present invention integrates a nozzle with an electrode assembly consisting of a plurality of electrodes and a flow sensor, and allows the entire measuring section including this to be slid left and right along the main axis. The measuring section is supported so that it can rotate at a predetermined angle around the autosampler, and the entire measuring section, including the electrode assembly and nozzle, can be rotated and tilted as necessary, allowing two ways of sample suction.・Measurement operations can be performed simultaneously and selectively. In other words, the suction operation from the autosampler during continuous measurement, the syringe during interrupt measurement in an emergency,
You can arbitrarily switch between the suction operation of a single sample from a capillary, etc., and perform the two suction operations together.If suction operation from a syringe, capillary, etc. is required during continuous measurement, the operation can be changed to By switching, you can easily and freely perform emergency measurements using syringes, capillaries, etc.

[Brief explanation of the drawing]

The drawings show an embodiment of the present invention; FIG. 1 is a front view of the electrolyte measuring device of the present invention, FIG. 2 is a left side view, FIG. 3 is a right side view, and FIG. 4 is a plan view. 41... Measuring section, 15... Main vertical shaft, 17... Vertical bearing, 42... Electrode assembly, 32... Pump unit.

Claims (1)

[Claims for Utility Model Registration] (1) Equipped with an autosampler and a measuring section, a sample is sequentially aspirated from a sample cup on the autosampler through a nozzle, and the ion concentration of the sample component is analyzed by the measuring section. - In the electrolyte measuring device to be measured, the measuring section includes an electrode assembly consisting of an electrode section in which a plurality of ion electrodes are arranged in parallel and a flow sensor, and a nozzle for sucking the sample is integrally attached to the electrode section of the measuring section. A main shaft is connected and supported horizontally, and the measuring section is supported on the main shaft so as to be slidable to the left and right in the axial direction via a bearing, and to be rotatable around the axis by a predetermined angle via the bearing. , the electrode assembly and the nozzle can be switched between a vertical position and a position tilted at a predetermined angle by the rotation, and a rotation angle control means for controlling the rotation of the measuring section is provided on the main shaft. An electrolyte measuring device. (2) A main vertical shaft supported in the vertical direction is provided, and the electrode assembly of the measuring section is attached to a vertical bearing slidably fitted on the main vertical shaft, and as the vertical bearing slides, the electrode assembly 2. The electrolyte measuring device according to claim (1), which is a utility model, and is configured to be vertically movable integrally with a nozzle.