JPH0430520Y2 - - Google Patents

Description

[Detailed description of the invention] [Industrial application field] This invention is suitable for dispensing and titrating a sample such as blood in small amounts into the test holes of a titration plate and reacting it with a reagent. - Concerning improvements to the tip for dispensing and titration in a dispensing and titration device that is used to be attached to the nozzle of a titration device.

[Prior Art] The above-mentioned chip 30 has the following characteristics in the conventional case.
It is usually made of a synthetic resin material and is formed into a conical cylindrical body, as shown in FIG. 14, with a large diameter opening at the upper end serving as the fitting port 30a and a small diameter opening at the lower end serving as the dripping port 30b. .

When dispensing and titrating a sample, the large-diameter fitting opening 30a at the upper end of the tip 30 is installed in the dispensing head of the dispensing/titration device A, as shown in FIG. Each of the test tubes in the group of test tubes set on the elevating mounting table of the dispensing/titration apparatus A or each test hole 32 of the titration plate B is attached to the tip side of a large number of nozzles 31. The dripping ports 30b at the lower end of each tip 30 are made to face each other, and by the operation of a pump device that communicates with the connecting nozzles 31...
Each test hole 32 of the aforementioned test tube or titration plate B
A predetermined amount of the sample or reagent is sucked and held in each chip, and then the sample or reagent is exchanged and set on the mounting table by the operation of the pump device into each test hole 32 of another titration plate B. After the titration is completed, remove it from each connection nozzle 31 and discard it.
A new tip 30 is attached to the tip 1 and the sample is titrated again, so that a large number of samples can be tested without having to clean the dispensing/titration device A and without contaminating each other. used for

However, in the conventional tips 30 for dispensing and titration of this kind, when the tips 30 are molded from a synthetic resin material, the 15th
As shown in the figure, a rigid strip 38 is integrally and continuously molded, and a plurality of chips 30...
However, the strip plates 38 are formed so as to be arranged in parallel at predetermined intervals in the longitudinal direction, and when used, the strip plates 38 are formed with perforations 34 formed in advance in the strip plates 38. There is a configuration in which the tip is divided into individual chips 30, which are attached to individual nozzles 31 of a dispensing head.

[Problem to be solved by the invention] The conventional tip 30 requires an operator to attach one tip to each tip of a large number of nozzles 31 provided in the dispensing head of the dispensing/titration device A. It is done by grasping one piece with your hands and fitting it in, and the work of removing it after use is done by hand in the same way.
Since this is done by pulling out one piece at a time, there is the problem that it takes time. Moreover, in order to avoid mixing and contamination between samples, the used tip must be removed and a new one installed each time the dispensing and titration of a single sample is completed. The time required for decontamination has become a large proportion of the time required for the entire process of dispensing, titrating, and testing the sample, and has become an obstacle to speeding up the entire testing process. There is a problem.

The present invention was devised in order to solve the problems of the prior art.
A dispensing/titration device that enables easy loading and unloading of tips from the numerous nozzles provided in the dispensing head of the titration device, resulting in labor savings and efficiency in the entire sample testing process. The purpose of this study is to provide a new means for configuring chips for dispensing and titration in

[Means for Solving the Problems] The present invention, as a means to achieve the above-mentioned object, includes mounting a large number of chips on a flexible band in alignment on a dispensing head. A dispensing method in which the strips are held in parallel at a predetermined interval corresponding to the pitch of the nozzles in a posture orthogonal to the longitudinal direction, and the strips are wound and set on a reel so that they can be freely fed out.・It proposes a tip for dispensing and titration in a titration device.

[Example] Next, an example of implementation will be described in detail with reference to the drawings. Note that the drawing numbers use the same reference numerals as in the conventional means for constituent members having the same effect.

Figure 1 shows the tip a for dispensing and titration of the present invention.
A dispensing/titration apparatus A is shown equipped with a test tube b and a titration plate c.

As shown in Fig. 2, a number of tips 2 for dispensing and titration are fixed to a flexible band 1 at predetermined intervals in a posture perpendicular to the longitudinal direction of the band 1. The strip 1 is held and the chips 2 held in parallel thereto are set on a rail 3 so that they can be wound up and fed out freely.

The band 1 may be made of film, paper, other materials, threads, strings, etc., but water-resistant materials are often used to make it suitable for cleaning.

In order to securely hold a large number of chips 2 in parallel on the strip 1, as shown in FIG. Place each strip 1 facing each other so that
Chips 2... are sandwiched between the two strips 1a, 1b by gluing the parts of a and 1b that are joined to each other within the space between the parallel chips 2 and 2 with adhesive. etc. as appropriate.

A perforation 4, a bar code 5, a code 6 for each sample to be tested, etc. are displayed on the band 1 at a portion located at intervals between the chips 2 held in parallel.

The spacing between the parallel chips 2... is shown in Figure 3.
As shown in FIG. 4, this corresponds to the spacing between a large number of nozzles 7 and test tubes 8 arranged in a dispensing head.

In the dispensing/titration apparatus A, a tip 2 held in parallel with a strip 1 of a tip a for dispensing/titration is...
To attach the chips 2 to the nozzles 7 provided in the dispensing head 10, as shown in Fig. 3, the chips 2 must be pivoted to the body of the dispensing/titration device A, or the chips 2 must be held in parallel from the reel 3. By unwinding a certain band 1 and holding its end symmetrically around an empty reel 3 pivotally supported on the machine body, a band is created in which chips 2 are held in parallel between these reels 3, 3. The body 1 is stretched, and the belt body 1 is held stationary by being sandwiched from both sides by attitude control clip arms 9, 9 provided on the machine body.Then, the dispensing head 10 is lowered, and as shown in FIG. As shown, a large number of nozzles 7 are arranged in a dispensing head 10.
This is done by inserting the chips into a large number of chips 2 held in parallel on the band 1. In FIG. 3, 11 is a pedestal, and 12 is a push-in operation section (cam).

As shown in FIG. 3, the test tubes b are arranged in series in the rack 13 at the same spacing as the nozzles 7, in which a plurality of test tubes 8 are arranged in line with the aforementioned dispensing head 10. It will be done. As shown in FIG. 1, the test tube b is installed so as to face into an elongated hole 15 cut into the plate passage 14 below the nozzle 7. And the long hole 15
The rack 13 facing the test tube (Fig. 3) is movable up and down, and during the rising process, the opening of each test tube 8 protrudes above the surface of the plate passage 14, and the tip connected to the nozzle 7... When the lower end of the corresponding tip 2 of 2... is inserted (Fig. 6), the sample is sucked in, and then when the rack 13 is lowered below the surface of the plate passage 14, the passage The titration plate c moves on the surface 14 as shown in FIG. 7 and is set in the elongated hole 15.

The titration plate c is provided with a plurality of test holes 16 vertically and horizontally at intervals corresponding to the chips 2. The titration plate c is movable back and forth and left and right on the surface of the passageway 14 in the vicinity of the elongated hole 15, and is designed to receive the sample sucked into each tip 2.

Next, the operation of the dispensing/titration apparatus configured as described above will be explained.

As shown in Fig. 1, a dispensing device is equipped with a chip a in which a band 1 holding a number of chips 2 in parallel is wound around a reel 3, a test tube b for loading a sample, and a titration plate c.・In order to dispense a sample to the titration plate c in the titration apparatus A, first, as shown in FIG. 5, the left and right posture control clip arms 9,
9 in the direction of standing up, and on both free end sides, rotate the band 1 fed out from the reel 3 and the chips 2 held parallel to it in the direction of palms facing B, B. After holding it still, press the dispensing head 10.
is lowered, and the tips of the nozzles 7 provided in the dispensing head 10 are inserted into each tip 2.

Next, the rack 13 is raised, and the test tubes 8 are raised in the direction of the arrow H as shown in FIG. The sample 17 in the test tube 8 is aspirated by the test tube 8.

After suctioning, the test tubes 8 are lowered, the titration plate c is transferred below the tips 2, as shown in FIG. 7, and the sample is dispensed and titrated from the tips 2 into the test holes 16 of the titration plate c.

After dispensing and titration, as shown in FIG. The dispensing head 10 is raised in the direction of the arrow, and the nozzles 7 provided in the dispensing head 10 are pulled out from the tips 2.

Chip 2... from which the nozzle 7 was pulled out is the 9th chip.
As shown in the figure, posture control clip arms 9, 9
By rotating the winding reel 3 in the lodging direction T, T and driving the winding reel 3, the whole belt 1 is rolled onto the winding reel 3 while being held parallel to the belt 1. be wound up.

By winding up the band 1, new chips 2 are unwound from the reel 3 and are held parallel to the band 1 below the nozzles 7 aligned with the dispensing head 10. The same operation as described above is repeated to dispense and titrate the sample into the predetermined test holes 16.

Next, how to use the tip a for dispensing and titration described above will be explained.

1. First, when using tip 2 for highly sensitive reaction measurements, it may not be possible to wash and reuse it, and according to tip a for dispensing and titration of the present invention, tip 2 that has been contaminated due to use cannot be reused. 10th
As shown in the figure, it is wound on a winding reel 3,
Alternatively, as shown in FIG. 11, it can be stored in a container 18 and used as is for disposal such as incineration.

2 Next, even if chip 2... can be reused,
As shown in FIG. 12, simply by setting the band 1 holding the chips 2 in parallel so that it passes continuously through a dedicated cleaning section 19 and a drying section 20, a large number of chips 2 can be efficiently processed. It can be thoroughly cleaned and reused. 21 is a motor for driving the reel.

3 Furthermore, as shown in FIG. 13, depending on the purpose of use, a band 1 holding chips 2 in parallel
can be drawn out to any length and cut for use. When setting up a multi-dispensing/titration device, use motor 2 for feeding drive.
After a strip 1 holding chips 2 of a predetermined length in parallel is fed out from a reel 3, it is cut with a cutter 22, and after use, it is stored in a used chip collection box 23. Make it.

4. By making marks, holes, etc. at the intervals between the chips 2 held in parallel on the band 1, it is possible to confirm the specimen, check the number of chips 2, etc., and attach a patient number.

[Effects of the invention] As described above, the tips for dispensing/titration in the dispensing/titration apparatus according to the present invention are such that a large number of tips 2 are attached to the flexible band 1, and the dispensing head 1
The strip 1 is held in parallel in a posture perpendicular to the longitudinal direction of the strip 1 with a predetermined spacing corresponding to the pitch of the nozzles 7 installed in alignment with each other. Chip 2 is structured so that it can be set freely.
... is installed in the dispensing head 10 through the nozzle 7...
When attaching it to the tip of the
While they are held parallel to the strip 1, insert them into the aligned nozzles 7,
Moreover, dispensing and titration can be performed in this state, and when the dispensing and titration work is finished, the strip 1
By raising and lowering the entire strip 1 with respect to the dispensing head 10 while holding the tip 2 in the tip 2, the tip 2 can be easily removed from the nozzle 7 aligned with the dispensing head 10. By winding the strip 1 onto the take-up reel 3, used chips 2... can be collected and new chips 2... can be fed out at the same time, speeding up the entire sample testing process. This will result in labor savings.

[Brief explanation of the drawing]

Fig. 1 is a perspective view of a dispensing/titration device equipped with the testing chip of the present invention, Fig. 2 is a partially enlarged perspective view showing the state in which the above dispensing/titration chip is connected, and Fig. 3 is a perspective view of the above dispensing/titration device. Note: Enlarged perspective view of the main parts of the titration device.
Figure 4 is a front view of the nozzle inserted into the corresponding tip, Figures 5 to 9 are illustrations of the dispensing operation using the same tip, and Figure 5 is a side view showing the operation of attaching the tip to the nozzle. 6 is a side sectional view showing the sample suction operation by the same tip as above, FIG. 7 is a side sectional view showing the sample dispensing and titration operation by the same tip, and FIG. 8 is a side sectional view showing the operation of pulling out the nozzle from the tip. FIG. 9 is a side sectional view of the same chip when it is being transferred and wound up, and FIG.
Figure 3 is an explanatory diagram of how to use the same tip for dispensing and titration as above, Figures 10 and 11 are explanatory diagrams of how to dispose of the tip when it is not reused, and Figure 12 is an explanatory diagram of how to dispose of it when it is not reused. FIG. 13 is an explanatory diagram of how to use the chip separately, FIG. 14 is a perspective view of a conventional chip, FIG. 15 is a perspective view of a chip formed into a conventional chip unit, and FIG. 1 is an overall schematic side view of a conventional dispensing/titration device with a chip unit attached thereto. Explanation of drawing symbols, A...Dispensing/titration device, B...
...titration plate, a...chip, b...test tube,
c...Titration plate, 1...Band, 1a...Strip, 1b...Strip, 10...Dispensing head, 11...
... Frame, 12... Push operation part, 13... Rack,
14... passage, 15... long hole, 16... test hole,
17...Sample, 18...Container, 19...Washing section,
2... Chips, 20... Drying section, 21... Motor, 22... Cutter, 23... Chip collection box,
3... Reel, 30... Chip, 30a... Fitting port, 30b... Dripping port, 31... Nozzle, 32...
...Test hole, 33...Reel, 34...Perforation,
35...unit, 38...band, 4...perforation, 5...barcode, 6...specimen code, 7...
... Nozzle, 8 ... Insertion test tube, 9 ... Clip arm.

Claims (1)

[Scope of utility model registration request] A large number of chips 2... are placed on a flexible band 1.
The strip 1 is held parallel to the reel 3 at a predetermined interval corresponding to the pitch of the nozzles 7 arranged in the dispensing head 10 and perpendicular to the longitudinal direction of the strip 1. A dispensing/titration tip for a dispensing/titration device that is rolled up and set so that it can be freely fed out.